A Simple Skin Swab Could Soon Identify People at Risk for Parkinson's

iStock.com/stevanovicigor
iStock.com/stevanovicigor

More than 200 years have passed since physician James Parkinson first identified the degenerative neurological disorder that bears his name. Over five million people worldwide suffer from Parkinson’s disease, a neurological condition characterized by muscle tremors and other symptoms. Diagnosis is based on those symptoms rather than blood tests, brain imaging, or any other laboratory evidence.

Now, science may be close to a simple and non-invasive method for diagnosing the disease based on a waxy substance called sebum, which people secrete through their skin. And it’s thanks to a woman with the unique ability to sniff out differences in the sebum of those with Parkinson's—years before a diagnosis can be made.

The Guardian describes how researchers at the University of Manchester partnered with a nurse named Joy Milne, a "super smeller" who can detect a unique odor emanating from Parkinson's patients that is unnoticeable to most people. Working with Tilo Kunath, a neurobiologist at Edinburgh University, Milne and the researchers pinpointed the strongest odor coming from the patients' upper backs, where sebum-emitting pores are concentrated.

For a new study in the journal ACS Central Science, the researchers analyzed skin swabs from 64 Parkinson's and non-Parkinson's subjects and found that three substances—eicosane, hippuric acid, and octadecanal—were present in higher concentrations in the Parkinson’s patients. One substance, perillic aldehyde, was lower. Milne confirmed that these swabs bore the distinct, musky odor associated with Parkinson’s patients.

Researchers also found no difference between patients who took drugs to control symptoms and those who did not, meaning that drug metabolites had no influence on the odor or compounds.

The next step will be to swab a a much larger cohort of Parkinson’s patients and healthy volunteers to see if the results are consistent and reliable. If these compounds are able to accurately identify Parkinson’s, researchers are optimistic that it could lead to earlier diagnosis and more effective interventions.

[h/t The Guardian]

From Cocaine to Chloroform: 28 Old-Timey Medical Cures

YouTube
YouTube

Is your asthma acting up? Try eating only boiled carrots for a fortnight. Or smoke a cigarette. Have you got a toothache? Electrotherapy might help (and could also take care of that pesky impotence problem). When it comes to our understanding of medicine and illnesses, we’ve come a long way in the past few centuries. Still, it’s always fascinating to take a look back into the past and remember a time when cocaine was a common way to treat everything from hay fever to hemorrhoids.

In this week's all-new edition of The List Show, Mental Floss editor-in-chief Erin McCarthy is highlighting all sorts of bizarre, old-timey medical cures. You can watch the full episode below.

For more episodes like this one, be sure to subscribe here.

Game of Thrones Star Sophie Turner Opened Up About Her Struggles With Depression

Helen Sloan, HBO
Helen Sloan, HBO

Playing one of the main characters on the most popular show currently on television isn't always as glamorous as it seems. Sometimes, the pressures of fame can be too much. Sophie Turner realized this while playing Sansa Stark on Game of Thrones, and has recently revealed how being in the public eye took a toll on her mental health.

Turner took on the role of Sansa Stark in 2011, when she was just a teenager, and she quickly became a household name. Now, at 23, she's come forward to Dr. Phil on his podcast Phil in the Blanks to explain how negative comments on social media affected her self-image and mental health.

"I would just believe it. I would say, ‘Yeah, I am spotty. I am fat. I am a bad actress.' I would just believe it," Turned explained. "I would get [the costume department] to tighten my corset a lot. I just got very, very self-conscious."

Later on, these feelings led to major depression. Turner developed a sense of isolation after she realized that all of her friends and family were going off to colleege while she was pursuing a sometimes-lonely acting career.

"I had no motivation to do anything or go out. Even with my best friends, I wouldn't want to see them, I wouldn't want to go out and eat with them," Turner explained. "I just would cry and cry and cry over just getting changed and putting on clothes and be like, 'I can't do this. I can't go outside. I have nothing that I want to do.'"

The feelings of depression stayed with Turner for most of the time she was filming Game of Thrones, and it's a battle she's still fighting. "I've suffered with my depression for five or six years now. The biggest challenge for me is getting out of bed and getting out of the house. Learning to love yourself is the biggest challenge," she continued.

The actress shared that she goes to a therapist and takes medication for her depression—two things that have helped her feel better.

Between Game of Thrones ending and planning her wedding to fiancé Joe Jonas, Turner may not have the time to take on many new acting roles in the near future. However, we'll continue to see her as Sansa Stark in the final season of Game of Thrones, and as Jean Grey in Dark Phoenix, which hits theaters on June 7.

[h/t: E! News]

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