14 Facts About Feet

iStock/pepifoto
iStock/pepifoto

The foot is one of the most overworked, under-appreciated parts of the human body. Think about it: In a single day, the average person takes 8000 to 10,000 steps. That works out to be four trips around the world over a lifetime, putting a lot of wear and tear on your intricate foot bones. The foot may be humble, but its design is essential to how we walk upright, and hoofing it on two feet is a defining feature of humanity. Here are some fun—and a few funky—facts about the human foot.

1. FOOT BONES MAKE UP ABOUT A QUARTER OF ALL THE BONES IN OUR BODIES.

There are 26 foot bones in each of your feet—one less than in each hand. When we’re born, those foot bones are mostly cartilage. They only completely harden around age 21.

2. HUMANS HAVE WORN SHOES FOR A VERY LONG TIME.

When did humans begin wearing shoes, anyway? About 40,000 years ago, according to research from Washington University in St. Louis that analyzed foot bones from Neanderthals and early humans. Older specimens had thicker, stronger toes, likely from gripping the ground as they walked barefoot. That’s around the same time that the archaeological record shows a burst of artistic and technological advancements among early humans, including the first stone tools, which may have aided in the production of shoes. The oldest preserved shoe, incidentally, is 5500 years old and was found in an Armenian cave, buried in sheep dung.

3. THE BIG TOE USED TO BE A KIND OF FOOT THUMB.

This grasping toe helped our predecessors climb trees and, when young, grip onto their mothers. Thanks to modern science, if you lose your thumb, you can now replace it with a toe: toe-to-thumb transplants are a surprisingly common procedure these days.

4. FOOT BONES HOLD BIG CLUES ABOUT THE EVOLUTION OF BIPEDALISM.

Scientists are studying Homo naledi, a specimen discovered in a South African cave in 2013 that many researchers believe is a new human relative. H. naledi had very human-like feet, but with somewhat curved toe bones that suggest it climbed trees. It could be that H. naledi was beginning to experiment with walking. 

5. THERE WAS A FOOT CHEESE EXHIBITION IN IRELAND.

Warm, sweaty feet make a perfect home for bacteria, which feed on our dead skin cells and produce gases and acids that emit those arresting foot odors. They're apparently also good at cultivating cheese. An exhibition in Dublin in 2013 displayed a variety of cheeses made with bacteria samples obtained from real people’s feet, armpits, and belly buttons. Delicious. (No one actually ate any of the cheeses.)

6. FEET ARE ONE OF THE MOST TICKLISH PARTS OF THE BODY.

There’s a good reason for that: Humans have nearly 8000 nerves in our feet and a large number of nerve endings near the skin. Having ticklish feet can be a good sign: Reduced sensitivity can be an indicator of peripheral neuropathy (numbness in the feet caused by nerve damage). 

7. FOOT NUMBNESS CAN CAUSE BIG PROBLEMS FOR DIABETICS.

Complications of diabetes include poor circulation and foot numbness that can lead to serious skin ulcers, which sometimes require amputation of toes or feet. In 2010 alone, 73,000 lower-limb amputations were performed on diabetics.

8. FOOT SIZES AND WIDTHS IN THE U.S. AND UK ARE INCREASING.

Feet are spreading to support extra weight as our populations pack on the pounds. According to a 2014 study by the College of Podiatry in the UK, the average foot has increased two sizes since the 1970s. As people have grown taller and heavier, feet respond by growing. It appears many people are still in denial about their expanding feet: Though retailers are starting to respond by making larger and roomier shoes, half of women and a third of men reported they buy poorly fitting shoes. Podiatrists say ill-fitting shoes are to blame for a significant portion of foot problems, especially among women.

9. MANY GLAMOROUS CELEBRITIES HAVE BIG FEET.

From the bound feet of female Chinese elites to Cinderella and Barbie, freakishly small feet are often celebrated as more feminine. But plenty of glamorous women both past and present have had larger than average feet, among them Jacqueline Kennedy, Oprah Winfrey, Uma Thurman, and Audrey Hepburn (size 10, 11, 11, and 10.5, respectively).

10. WOMEN HAVE FOUR TIMES AS MANY FOOT PROBLEMS AS MEN.

That painful fact is often attributed to wearing heels. Ironically, Western women started wearing heels to effect a more masculine look: European men adopted the look from Persian warriors in the 17th century, and women soon followed suit.

11. THE AVERAGE PERSON WALKS ABOUT 100,000 MILES IN A LIFETIME. 

That’s a lot of stress on our feet. It’s not surprising, then, that lower back pain, headaches, indigestion, and spine misalignment are often related to foot problems. Some runners blow way past this mark: They've logged at least 100,000 in running miles alone. One committed runner, Herb Fred, has run a whopping 247,142 miles.

12. FOOT SIZE HAS ZERO TO DO WITH PENIS SIZE.

In a study published in 2015, researchers synthesized data from 17 previous studies that included the penis measurements of more than 15,000 men from around the world. The results: There is little evidence that penis size is linked to height, body mass, or shoe size.

13. THERE'S A REASON GRANDPA'S TOENAILS LOOK LIKE THAT.

Ever heard someone describing their toenails as “horse hooves”? As we get older, our toenails tend to thicken, making them hard to trim. This happens because toenails grow more slowly as we age, causing the nail cells to accumulate. Stubbing toes, bad shoes, and dropping things on your feet can also cause thickening, as can fungal infections and peripheral arterial disease, which narrows arteries and reduces the blood flow to limbs.

14. THERE'S A GUINNESS WORLD RECORD FOR MOST FEET AND ARMPITS SNIFFED.

Odds are you don’t have any job-related tasks nearly as revolting as this one: In the 15 years that Madeline Albrecht worked for an Ohio lab that tests Dr. Scholl products, she sniffed more than 5600 feet and untold numbers of armpits. Albrecht currently holds the Guinness World Record for—yes, this is a category—the number of feet and armpits sniffed.

11 Squeaky-Clean Facts About Spit

iStock/fotolinchen
iStock/fotolinchen

Though most people find the thought of saliva rather disgusting, spit plays a vital role in our lives. It allows us to comfortably chew, swallow, and digest. It fights off bacteria in our mouths and elsewhere, and leads the mouth’s bold fight against cavities. Here are 11 facts that might have you reconsidering that unsung hero of bodily fluids: spit.

1. Spit is mostly water.

Saliva consists of about 99 percent water. The other 1 percent is made up of electrolytes and organic substances, including digestive enzymes and small quantities of uric acid, cholesterol, and mucins (the proteins that form mucus).

2. There's a medical standard for how much spit you should have.

Healthy individuals accumulate between 2 and 6 cups of spit a day. That’s without stimulation from activities like eating or chewing gum, which open the spit floodgates [PDF].

3. Saliva production has a circadian rhythm.

Your body typically produces the most saliva in the late afternoon, and the least at night. Salivation is controlled by the autonomic nervous system (much like your heartbeat), meaning it’s an unconscious process.

4. There are five different kinds of spit.

Salivation has five distinct phases, most triggered by the passage of food through the body. Not all of them are a good thing. The first type of salivation is cephalic, the kind that occurs when you see or smell something delicious. The buccal phase is the body’s reflexive response to the actual presence of food in the mouth (which aids in swallowing). The esophageal involves the stimulation of the salivary glands as food moves through the esophagus. The gastric phase happens when something irritates your stomach—like when you’re just about to puke. The intestinal phase is triggered by a food that doesn’t agree with you passing through the upper intestine.

5. Spit can battle bacteria.

There’s a reason the phrase “lick your wounds” came about. Spit is full of infection-battling white blood cells. And, according to a 2015 study in the journal Blood, neutrophils—a type of white blood cell—are more effective at killing bacteria if they come from saliva than from anywhere else in the body. So adding saliva to a wound gives the body a powerful backup as it fights off infection.

6. Spit keeps you from getting cavities.

The calcium, fluoride, and phosphate in saliva strengthen your teeth. Spit also fights cavity-causing bacteria, washes away bits of food, and neutralizes plaque acids, reducing tooth decay and cavities. That’s why chewing gum gets dentists’ stamp of approval—chewing increases the flow of saliva, thus protecting your oral health.

7. You need spit if you want to taste anything.

Saliva acts like a solvent for tastes, ferrying dissolved deliciousness to the sites of taste receptors. It also keeps those receptors healthy by preventing them from drying out and protecting them from bacterial infection. Many people who have dry mouth (or xerostomia) find their sense of taste affected by their oral cavity’s parched conditions. Because many medications have dry mouth as a side effect, scientists have developed artificial saliva sprays that mimic the lubrication of real spit.

8. Swapping spit exchanges millions of bacteria.

A 10-second kiss involves the transfer of some 80 million bacteria, one study found.

9. People aren’t born drooling.

Babies don’t start drooling until they’re 2 to 4 months old. Unfortunately, they also don’t really know what to do with their spit. They don’t have full control of the muscles of their mouth until they’re around 2 years old, so they can’t really swallow it effectively. Which is why we invented bibs.

10. Stress can leave you spit-less.

The body’s fight-or-flight response is designed to give you the energy and strength needed to overcome a near-death experience, like, say, running into a bear or giving a big presentation at work. Your blood pressure goes up, the heart beats faster, and the lungs take in more oxygen. This is not the time to sit around and digest a meal, so the digestion system slows down production, including that of saliva.

11. A lack of spit was once used as an admission of guilt.

In some ancient societies, saliva was used as a basic lie detector. In ancient India, accused liars had to chew grains of rice. If they were telling the truth, they would have enough saliva to spit them back out again. If someone was lying, their mouth would go dry and the rice would stick in their throat.

13 Facts About Genes

iStock.com/IPGGutenbergUKLtd, stock_colors, RapidEye, b-d-s
iStock.com/IPGGutenbergUKLtd, stock_colors, RapidEye, b-d-s

In 2003, after 13 years of study, international researchers working on the groundbreaking Human Genome Project published their findings. For the very first time, the genetic building blocks that make up humans were mapped out, allowing researchers “to begin to understand the blueprint for building a person,” according to the project's website. Humans are now known to have between 20,000 and 25,000 genes, but researchers still have much to learn about these small segments of DNA. Below, we’ve listed a few facts about gene expression, genetic diseases, and the ways genes make us who we are.

1. The word gene wasn’t coined until the 20th century.

Although “father of genetics” Gregor Mendel conducted his pea plant experiments in the mid-1800s, it wasn’t until 1909 that Danish botanist Wilhelm Johannsen became the first person to describe Mendel's individual units of heredity. He called them genes—derived from pangenesis, the word Charles Darwin used for his now-disproven theory of heredity (among other ideas, Darwin suggested that acquired characteristics could be inherited).

2. On a genetic level, all humans are more than 99 percent identical.

Humans have a lot more in common than we might be inclined to believe. In fact, more than 99 percent of our genes are exactly the same from one person to the next. In other words, the diversity we see within the human population—including traits like eye color, height, and blood type—is due to genetic differences that account for less than 1 percent. More specifically, variations of the same gene, called alleles, are responsible for these differences.

3. Genes can disappear or break as species evolve.

Thanks to a combination of genes, most mammals are able to biologically produce their own Vitamin C in-house, so to speak. But some point throughout the course of human history, we lost the ability to make Vitamin C when one of those genes stopped functioning in humans long ago. “You can see it in our genome. We are missing half the gene,” Dr. Michael Jensen-Seaman, a genetics researcher and associate professor of biological sciences at Duquesne University in Pittsburgh, tells Mental Floss. “Generally speaking, when a species loses a gene during evolution, it’s usually because they don’t need it—and if you don’t use it, you lose it. All our ancestors probably ate so much fruit that there was never any need to make your own Vitamin C.” Jensen-Seaman says humans also lost hundreds of odorant receptors (proteins produced by genes that detect specific smells) because we rely mostly on vision. This explains why our sense of smell is worse than many other species.

4. Elizabeth Taylor’s voluminous eyelashes were likely caused by a genetic mutation.

A mutation of the aptly named FOXC2 gene gave Hollywood icon Elizabeth Taylor two rows of eyelashes. The technical term for this rare disorder is distichiasis, and while it may seem like a desirable problem to have, there can be complications. According to the American Academy of Ophthalmology, this extra set of lashes is sometimes “fine and well tolerated,” but in other cases they should be removed to prevent eye damage.

5. Genes involved in sperm are some of the most rapidly evolving genes in the animal kingdom.

Throughout much of the natural world, a class of genes called sperm competition genes are becoming better and better at fertilizing eggs. This is true for various species, including some primates and marine invertebrates. Consider promiscuous primates, like chimpanzees, whose females mate with multiple males in a short period of time. As a result, the males are competing at the genetic level—via their sperm—to father offspring. “What’s happening, we think, is there’s sort of an arms race among genes that are involved in either sperm production or any aspect of male reproduction,” Jensen-Seaman says. Essentially, the proteins in these genes are changing to help males rise to the occasion.

6. A “zombie gene” in elephants might help protect them from cancer.

In a 2018 study published in Cell Reports, researchers from the University of Chicago found that a copy of a cancer-suppressing gene that was previously “dead” (or non-functioning) in elephants turned back on at some point. They don’t know why or how it happened, but this reanimated “zombie gene” might explain why elephants have such low rates of cancer—just 5 percent die from the disease, compared to 11 to 25 percent of humans. Some have suggested that a drug could theoretically be created to mimic the function of this gene in order to treat cancer in humans.

7. Octopuses can edit their own genes.

Cephalopods like squids, cuttlefish, and octopuses are incredibly intelligent and wily creatures—so much so that they can rewrite the genetic information in their neurons. Instead of one gene coding for one protein, which is normally the case, a process called recoding lets one octopus gene produce multiple proteins. Scientists discovered that this process helps some Antarctic species “keep their nerves firing in frigid waters,” The Washington Post notes.

8. The premise of the 1986 film The Fly isn’t completely absurd.

After a botched experiment in The Fly, Jeff Goldblum morphs into a fly-like creature. Surprisingly, that premise might, uh, fly—at least on some genetic level. Although different researchers come up with different estimates, humans share about 52 percent of the same genes with fruit flies, and scientists figure that the number is roughly the same for house flies.

So, could Jeff Goldblum theoretically turn into a human-fly hybrid if his genes got mixed up with the insect's in a futuristic teleportation device? Not exactly, but there are some scientific parallels. “With genetic engineering, we can select genes and insert them into other organisms’ genomes,” DNA researcher Erica Zahnle tells the Chicago Tribune. “We do it all the time. Right now there’s a hybrid of a tomato that has a fish gene in it.”

9. Our genes might prevent us from living more than 125 years.

Despite advances in medicine, there might be a biological cap on how long humans can stick around. Several studies have suggested that we’ve already peaked, with the maximum extent for human life falling between 115 and 125 years. According to this theory, cells can only replicate so many times, and they often become damaged with age. Even if we’re able to modify our genes via gene therapy, we probably can’t modify them fast enough to make much of a difference, Judith Campisi from the Buck Institute for Research on Aging tells The Atlantic.

“For such reasons, it is meaningless to claim that most human will live for 200–500 years in the near future, thanks to medical or scientific progress, or that ‘within 15 years, we'll be adding more than a year every year to our remaining life expectancy,’” the authors of a 2017 study write in Frontiers in Physiology, citing previous studies from 2003 and 2010, respectively. “Raising false hopes without taking into account that human beings are already extremely ‘optimized’ for lifespan seems inappropriate.”

10. The idea that a single gene determines whether you have attached or unattached earlobes is a myth.

Forget what you may have learned about earlobes and genetics in middle school. While your genes probably play some role in determining whether you have attached earlobes (a supposedly dominant trait) or unattached earlobes, the idea that this trait is controlled by a single gene is simply untrue. On top of that, earlobes don’t even fall into two distinct categories. There’s also a third, which University of Delaware associate professor John H. McDonald calls intermediate earlobes. "It doesn't look to me as if there are just two categories; instead, there is continuous variation in the height of the attachment point," McDonald writes on his website. A better example of a trait controlled by a single gene is blood type. Whether you have an A, B, or O blood type is determined by three variations—or alleles—of one gene, according to Jensen-Seaman.

11. No, there isn’t a "wanderlust gene" or "music gene."

Every now and then, new studies will come out that seem to suggest a genetic source for various personality traits, preferences, or talents. In 2015, there was talk of a “wanderlust gene” that inspires certain people to travel, and several other reports have suggested musical aptitude is also inherited. However, like many things in science, the reality isn’t so simple. “Part of the problem is that when we’re in school, we learn examples of traits that are controlled by a single gene, like Mendel’s peas, and we start to think that all variation is determined by a single gene,” Jensen-Seaman says. “But other than a variety of rare genetic diseases, most of the interesting things in medicine, or in human behavior or human variation, are what we call complex traits.” These complex traits typically involve hundreds—if not thousands—of genes, as well as the environmental factors you’re exposed to throughout your life.

12. DNA testing kits can’t tell how smart you are.

Much like your talents and personality, intelligence is also a complex trait that's difficult to measure because it’s influenced by many different genes. One 2017 study identified 52 genes associated with higher or lower intelligence, but the predictive power of those genes—or ability to tell how smart you are—is less than 5 percent. Another study from 2018 identified 538 genes associated with intelligence, which have a 7 percent predictive power. Put simply, no DNA testing kit can accurately predict whether you're a genius or dunce, even if the company claims it can. And, even if scientists make improvements in this field of study, DNA tests can't account for the environmental factors that also influence intelligence.

13. Your genetic makeup determines whether you think your pee smells funky after eating asparagus.

Do you recoil from the scent of your urine after eating asparagus? If so, you’re among the nearly 40 percent of people who are able to detect the smell of metabolized asparagus in pee, according to a study of nearly 7000 people of European-American descent that was published in The BMJ's 2016 Christmas issue. (The BMJ has an annual tradition of publishing strange and light-hearted studies around this time of year, and the asparagus pee study is no exception.) Again, there isn’t one gene in particular to pin the blame on, though. Multiple olfactory receptor genes—and 871 sequence variations on said genes—are involved in determining whether you have a talent for sniffing out asparagus pee.

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