A Chemical in Spider Venom Could Be a Key to Killing Skin Cancer Cells

Alan Couch, Flickr // CC BY 2.0
Alan Couch, Flickr // CC BY 2.0

Despite their formidable reputation in the eyes of arachnophobes, spiders contribute to human society in a number of positive ways. On a practical level, they can reduce the population of insects in your home by trapping them for meals. Outdoors, they keep pests from destroying gardens and crops, making sure we don't slip into a period of famine and anarchy. In the lab, scientists have identified a number of chemicals in their venom as possible building blocks for medicines treating everything from pain to muscular dystrophy.

That field of study has led to a promising discovery. In Australia, researchers have isolated one particular compound in a funnel-web spider's venom that can diminish skin cancer cells.

Scientists at QIMR Berghofer and the University of Queensland began studying the Australian funnel-web spider known as Hadronyche infensa after a similar Brazilian arachnid, Acanthoscurria gomesiana, was shown to carry a peptide in its venom called gomesin that has cancer-fighting properties. Identifying a similar peptide in the Australian spider, the researchers demonstrated that the chemical was effective in killing skin cancer cells while leaving healthy skin cells alone.

The peptide was tested on human melanoma cells, eradicating the majority of them. In mice, it also slowed the growth of the melanomas. The peptide was even effective in killing cells found in facial tumors of Tasmanian devils, a marsupial susceptible to an aggressive form of skin cancer transmittable through biting. The results were published in the journal Scientific Reports.

These peptides are able to be manipulated, taking on different properties as scientists alter amino acids to create new and potentially more potent versions. It’s hoped that this line of research will lead to the development of treatments for skin cancer in humans.

It's something to think about the next time you consider swatting a spider—though if you happen to reside in Australia and see the funnel-web variety, you might not have a choice. While there are 35 different species of funnel-webs of varying potency, some are so formidable that their fangs can pierce fingernails, and their venom is able to kill a human in less than 15 minutes.

[h/t New Atlas]

Scientists Find Fossil of 150-Million-Year-Old Flesh-Eating Fish—Plus a Few of Its Prey

M. Ebert and T. Nohl
M. Ebert and T. Nohl

A fossil of an unusual piranha-like fish from the Late Jurassic period has been unearthed by scientists in southern Germany, Australian news outlet the ABC reports. Even more remarkable than the fossil’s age—150 million years old—is the fact that the limestone deposit also contains some of the fish’s victims.

Fish with chunks missing from their fins were found near the predator fish, which has been named Piranhamesodon pinnatomus. Aside from the predator’s razor-sharp teeth, though, it doesn’t look like your usual flesh-eating fish. It belonged to an extinct order of bony fish that lived at the time of the dinosaurs, and until now, scientists didn’t realize there was a species of bony fish that tore into its prey in such a way. This makes it the first flesh-eating bony fish on record, long predating the piranha. 

“Fish as we know them, bony fishes, just did not bite flesh of other fishes at that time,” Dr. Martina Kölbl-Ebert, the paleontologist who found the fish with her husband, Martin Ebert, said in a statement. “Sharks have been able to bite out chunks of flesh, but throughout history bony fishes have either fed on invertebrates or largely swallowed their prey whole. Biting chunks of flesh or fins was something that came much later."

Kölbl-Ebert, the director of the Jura Museum in Eichstätt, Germany, says she was stunned to see the bony fish’s sharp teeth, comparing it to “finding a sheep with a snarl like a wolf.” This cunning disguise made the fish a fearful predator, and scientists believe the fish may have “exploited aggressive mimicry” to ambush unsuspecting fish.

The fossil was discovered in 2016 in southern Germany, but the find has only recently been described in the journal Current Biology. It was found at a quarry where other fossils, like those of the Archaeopteryx dinosaur, have been unearthed in the past.

[h/t the ABC]

Could Leonardo da Vinci's Artistic Genius Be Due to an Eye Condition?

Young John the Baptist, Leonardo da Vinci (1513-16, Louvre, Paris).
Young John the Baptist, Leonardo da Vinci (1513-16, Louvre, Paris).
Christopher Tyler, JAMA Ophthalmology (2018)

Leonardo da Vinci was indisputably a genius, but his singular artistic vision may have been the result of seeing the world differently in more ways than one. A new paper argues that he had strabismus, a vision disorder where the eyes are misaligned and don’t look toward the same place at the same time. This disorder, visual neuroscientist Christopher Tyler argues, may have helped the artist render three-dimensional images on flat canvas with an extra level of skill.

Tyler is a professor at City, University of London who has written a number of studies on optics and art. In this study, published in JAMA Ophthalmology, he examined six different artworks from the period when Leonardo was working, including Young John the Baptist, Vitruvian Man, and a self-portrait by the artist. He also analyzed pieces by other artists that are thought to have used Leonardo as a model, like Andrea del Verrocchio’s Young Warrior sculpture. Leonardo served as the lead assistant in the latter artist’s studio, and likely served as the model for several of his works. Leonardo was also a friend of Benedetto da Maiano, and possibly served as a model for his 1480 sculpture of John the Baptist. Tyler also looked at the recently auctioned Salvator Mundi, a painting that not all experts believe can be attributed to Leonardo. (However, at least one scientific team that examined the painting says it’s legit.)

With strabismus, a person’s eyes appear to point in different directions. Based on the eyes in Leonardo’s own portraits of himself and other artworks modeled after him, it seems likely that he had intermittent strabismus. When he relaxed his eyes, one of his eyes drifted outward, though he was likely able to align his eyes when he focused. The gaze in the portraits and sculptures seems to be misaligned, with the left eye consistently drifting outward at around the same angle.

'Vitruvian Man' with the subject's pupils highlighted
Vitruvian Man, Leonardo da Vinci (~1490, Accademia, Venice)
Christopher Tyler, JAMA Ophthalmology (2018)

“The weight of converging evidence suggests that [Leonardo] had intermittent exotropia—where an eye turns outwards—with a resulting ability to switch to monocular vision, using just one eye,” Tyler explained in a press release. “The condition is rather convenient for a painter, since viewing the world with one eye allows direct comparison with the flat image being drawn or painted.” This would have given him an assist in depicting depth accurately.

Leonardo isn’t the first famous artist whose vision researchers have wondered about. Some have speculated that Degas’s increasingly coarse pastel work in his later years may have been attributed to his degenerating eyes, as the rough edges would have appeared smoother to him because of his blurred vision. Others have suggested that Van Gogh’s “yellow period” and the vibrant colors of Starry Night may have been influenced by yellowing vision caused by his use of digitalis, a medicine he took for epilepsy.

We can never truly know whether a long-dead artist’s work was the result of visual issues or simply a unique artistic vision, but looking at their art through the lens of medicine provides a new way of understanding their process.

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