12 Facts About the Gallbladder

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Don't feel too bad if you forgot you have a gallbladder—it's one of those body parts that people tend to ignore unless there's a problem. Here's a refresher: It's that small pouch beneath the liver whose primary function is to store bile, which helps you digest fats. So the next time you wolf down a Quarter Pounder with cheese, you can thank your gallbladder for doing its part. Here are a few other things you should know.

1. IT’S THE SIZE OF A SMALL PEAR, AND IT LOOKS LIKE ONE, TOO.

Right before you take your first bite of pizza, your gallbladder is full of bile—an alkaline fluid that's produced in the liver, transported to the gallbladder, and then released into the small intestine to help break down fat and bilirubin, a product of dead red blood cells. The organ can hold the equivalent of a shot glass of the yellow-green liquid, which causes it to swell up to the size of a small pear.

When you eat certain foods—especially fatty ones—the gallbladder releases the bile and deflates like a balloon. Although most gallbladders are roughly 1 inch wide and 3 inches long, there are notable exceptions. In 2017, a gallbladder removed from a woman in India measured nearly a foot long, making it the longest gallbladder in the world.

2. YOU CAN LIVE WITHOUT IT.

You don’t need your gallbladder to live a full and healthy life. Just ask British playwright Mark Ravenhill, who wrote an account for the BBC about getting his gallbladder removed after a gallstone—a solid object made of cholesterol or calcium salts and bilirubin—had moved painfully into his pancreas. "'The gallbladder's completely useless,'" Ravenhill recalled his doctor explaining. "'If it's going to be a problem, best just to take it out.'"

In addition to preventing more gallstones from forming, a physician may recommend that a patient’s gallbladder be removed due to other diseases, like cholecystitis (inflammation of the gallbladder) and cancer. In most cases, removing it doesn’t affect digestion, but there can be some complications. "People can certainly live without one, but they do have to watch their fat intake," says Ed Zuchelkowski, an anatomist and biology professor at California University of Pennsylvania. People who don't have gallbladders still produce bile, but it flows directly from the liver to the small intestine. The only difference is that "you would not have as much bile readily available to release," Zuchelkowski tells Mental Floss, which could cause minor problems like diarrhea if you're eating fatty foods.

3. OUR HUNTER-GATHERER ANCESTORS MAY HAVE NEEDED IT MORE THAN WE DO.

"[The gallbladder] probably was more important to people in days when they would eat fewer meals and larger meals," Zuchelkowski says. This was generally the situation that our hunter-gatherer ancestors found themselves in. As Ravenhill notes, "feast or famine was the general rule." Nomadic groups ate large slabs of meat about once a week, and the gallbladder helped to quickly digest the onslaught of protein and fat.

Even though our diets and eating habits have changed drastically since then, evolution hasn't caught up—we still have the same digestive system. It's probably for this reason that "most meat-eating animals have a gallbladder," Zuchelkowski says. "Dogs do, cats do—they can concentrate bile just like we do, but I think you’d find that in animals that only eat vegetation, that’s where it’s likely to be missing.” However, Zuchelkowski notes that the gallbladder also helps you absorb fat-soluble vitamins like A, D, E, and K, so it still serves a useful function in people who are vegetarians.

4. ASTRONAUTS ARE ENCOURAGED TO GET THEIRS REMOVED.

A 2012 report from the Canadian Journal of Surgery recommended that astronauts consider having their appendix and gallbladder removed—even if their organs are perfectly healthy—to prevent appendicitis, gallstones, or cholecystitis from setting in when they’re far, far away from Earth's hospitals. “The ease and safety of surgical prophylaxis currently appears to outweigh the logistics of treating either acute appendicitis or cholecystitis during extended-duration space flight,” the authors wrote.

5. ALEXANDER THE GREAT LIKELY DIED FROM A GALLBLADDER GONE BAD.

Alexander may have been great at conquering entire empires, but his organs weren’t exactly up to the task. The king of Macedonia died at the age of 34, and some historians believe that the cause was peritonitis (inflammation of the peritoneum, the tissue lining the abdomen), which itself was a result of acute cholecystitis. “Historians have suggested that the fatal biliary tract disease was fueled by excess consumption of alcohol and overeating at a banquet that Alexander threw for his leading officers in Babylon,” author Leah Hechtman writes in Clinical Naturopathic Medicine.

6. THE DOCTOR WHO CONDUCTED THE FIRST SUCCESSFUL GALLSTONE REMOVAL SURGERY DIDN'T KNOW WHAT HE WAS LOOKING FOR.

Gallbladder-related ailments have been afflicting humans for thousands of years, as evidenced by gallstones found in Egyptian mummies. And for thousands of years, people put up with it because they didn’t know what was wrong or how to fix it. In fact, it wasn’t until 1867 that the first cholecystotomy (removal of gallstones) was carried out. The surgery was performed by Dr. John S. Bobbs of Indianapolis, who had no idea what ailed his patient, 31-year-old Mary Wiggins, until he cut open a sac that he later realized was her gallbladder and “several solid bodies about the size of ordinary rifle bullets” fell out, according to The Indianapolis Star. Amazingly, Wiggins survived and lived to the age of 77. Fifteen years after this surgery, the first cholecystectomy (removal of the gallbladder) was performed in Germany.

7. THE WORLD RECORD FOR MOST GALLSTONES EVER REMOVED FROM A PERSON'S BODY STANDS AT MORE THAN 23,000.

Unlike the Guinness World Record for most Twinkies devoured in one sitting, this isn’t the kind of record you’d enjoy setting. In 1987, an 85-year-old woman complaining of severe abdominal pain showed up at Worthing Hospital in West Sussex, England, and doctors found a shockingly high number of gallstones—23,530, to be exact. In May 2018, a similar (albeit less severe) case of gallstones was reported in India, where a 43-year-old man underwent surgery to have thousands of them removed. “Usually we get to see two to 20 stones, but here there were so many and when we counted them, it was a whopping 4100,” the surgeon told Fox News.

8. SOME EASTERN CULTURES BELIEVE THERE’S A LINK BETWEEN THE GALLBLADDER AND HEADACHES.

Some practitioners of Eastern medicine—especially Traditional Chinese Medicine (TCM)—purport that gallbladder problems can cause certain kinds of headaches. TCM practitioners say our internal organs are connected to channels called meridians, which direct several fundamental substances—like blood, other bodily fluids, and qi (vital life energy)—throughout the body. The gallbladder meridian, for instance, runs along the side of the head near the temple. Through the practice of acupuncture, tiny needles are inserted into the skin along the gallbladder meridian in an effort to relieve tension and free up blocked qi. (Western scientists tend to disagree on what, if any, benefit acupuncture offers.)

9. IN CHINA, BOLD PEOPLE ARE SAID TO HAVE A “BIG GALLBLADDER.”

Speaking of China, the country's primary language, Mandarin, hints at a link between organ function and personality. For instance, a word that’s assigned to bold and daring people translates to “big gallbladder,” and brave people are said to have “gallbladder strength,” according to The Conceptual Structure of Emotional Experience in Chinese. The word for coward, on the other hand, translates to “gallbladder small like mouse.” (Interestingly, mice do in fact have gallbladders, but rats don’t.)

10. WESTERN PHILOSOPHERS ALSO THOUGHT ONE'S TEMPERAMENT HAD TO DO WITH THE GALLBLADDER.

You may remember learning something about the four humors during a high school lesson on ancient Greece. The theory, originating with Hippocrates, held that a person’s temperament was influenced by one of four bodily fluids: black bile, yellow bile, phlegm, and blood. Yellow bile, stored in the gallbladder, was said to make people choleric, or irritable. Disease was blamed on an imbalance of these four humors, and this remained a popular theory up until the 18th century. Because of this theory's longstanding influence, the word gall—a synonym for bile—also meant “embittered spirit” during medieval times. It wasn’t until 1882 that the word took on the meaning of "impudence" or "boldness" in American English—as in “I can’t believe he had the gall to finish that Netflix series without me.”

11. ANCIENT ETRUSCANS USED THEM FOR DIVINATION.

Well, not human gallbladders. Ancient Etruscans, a group of people who once lived in present-day Tuscany and whose civilization became part of the Roman empire, practiced a type of divination called haruspicy. The soothsayers were called haruspices (literally “gut gazers”), and they looked for clues from the gods in the markings, coloring, and shape of a sacrificial sheep’s liver and gallbladder. This was often done before the Romans went into battle, but the practice was never adopted as part of the state religion.

12. SOME GALLBLADDERS SPORT A PHRYGIAN CAP.

A crease called a "Phrygian cap" at the base of the gallbladder occurs in about 4 percent of people. Its odd name is something of a misnomer. It comes from its resemblance to a type of peaked felt hat called a pileus, worn by emancipated slaves in ancient Rome; the design was similar to the peaked caps then worn in Phrygia, a region in modern-day Turkey. Much later, during the French Revolution, people took to wearing Phrygian caps—which they likely confused with the pileus's style—as symbols of their freedom from tyranny. In the 20th century, the Smurfs started wearing them.

As for the aforementioned gallbladder abnormality, there’s no deeper symbolism in its name. The way it folds over just looks a lot like a Phrygian cap. Despite being a “congenital anomaly,” as a 2013 study published in Case Reports in Gastroenterology puts it, the condition typically causes no symptoms or complications.

11 Squeaky-Clean Facts About Spit

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iStock/fotolinchen

Though most people find the thought of saliva rather disgusting, spit plays a vital role in our lives. It allows us to comfortably chew, swallow, and digest. It fights off bacteria in our mouths and elsewhere, and leads the mouth’s bold fight against cavities. Here are 11 facts that might have you reconsidering that unsung hero of bodily fluids: spit.

1. Spit is mostly water.

Saliva consists of about 99 percent water. The other 1 percent is made up of electrolytes and organic substances, including digestive enzymes and small quantities of uric acid, cholesterol, and mucins (the proteins that form mucus).

2. There's a medical standard for how much spit you should have.

Healthy individuals accumulate between 2 and 6 cups of spit a day. That’s without stimulation from activities like eating or chewing gum, which open the spit floodgates [PDF].

3. Saliva production has a circadian rhythm.

Your body typically produces the most saliva in the late afternoon, and the least at night. Salivation is controlled by the autonomic nervous system (much like your heartbeat), meaning it’s an unconscious process.

4. There are five different kinds of spit.

Salivation has five distinct phases, most triggered by the passage of food through the body. Not all of them are a good thing. The first type of salivation is cephalic, the kind that occurs when you see or smell something delicious. The buccal phase is the body’s reflexive response to the actual presence of food in the mouth (which aids in swallowing). The esophageal involves the stimulation of the salivary glands as food moves through the esophagus. The gastric phase happens when something irritates your stomach—like when you’re just about to puke. The intestinal phase is triggered by a food that doesn’t agree with you passing through the upper intestine.

5. Spit can battle bacteria.

There’s a reason the phrase “lick your wounds” came about. Spit is full of infection-battling white blood cells. And, according to a 2015 study in the journal Blood, neutrophils—a type of white blood cell—are more effective at killing bacteria if they come from saliva than from anywhere else in the body. So adding saliva to a wound gives the body a powerful backup as it fights off infection.

6. Spit keeps you from getting cavities.

The calcium, fluoride, and phosphate in saliva strengthen your teeth. Spit also fights cavity-causing bacteria, washes away bits of food, and neutralizes plaque acids, reducing tooth decay and cavities. That’s why chewing gum gets dentists’ stamp of approval—chewing increases the flow of saliva, thus protecting your oral health.

7. You need spit if you want to taste anything.

Saliva acts like a solvent for tastes, ferrying dissolved deliciousness to the sites of taste receptors. It also keeps those receptors healthy by preventing them from drying out and protecting them from bacterial infection. Many people who have dry mouth (or xerostomia) find their sense of taste affected by their oral cavity’s parched conditions. Because many medications have dry mouth as a side effect, scientists have developed artificial saliva sprays that mimic the lubrication of real spit.

8. Swapping spit exchanges millions of bacteria.

A 10-second kiss involves the transfer of some 80 million bacteria, one study found.

9. People aren’t born drooling.

Babies don’t start drooling until they’re 2 to 4 months old. Unfortunately, they also don’t really know what to do with their spit. They don’t have full control of the muscles of their mouth until they’re around 2 years old, so they can’t really swallow it effectively. Which is why we invented bibs.

10. Stress can leave you spit-less.

The body’s fight-or-flight response is designed to give you the energy and strength needed to overcome a near-death experience, like, say, running into a bear or giving a big presentation at work. Your blood pressure goes up, the heart beats faster, and the lungs take in more oxygen. This is not the time to sit around and digest a meal, so the digestion system slows down production, including that of saliva.

11. A lack of spit was once used as an admission of guilt.

In some ancient societies, saliva was used as a basic lie detector. In ancient India, accused liars had to chew grains of rice. If they were telling the truth, they would have enough saliva to spit them back out again. If someone was lying, their mouth would go dry and the rice would stick in their throat.

13 Facts About Genes

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iStock.com/IPGGutenbergUKLtd, stock_colors, RapidEye, b-d-s

In 2003, after 13 years of study, international researchers working on the groundbreaking Human Genome Project published their findings. For the very first time, the genetic building blocks that make up humans were mapped out, allowing researchers “to begin to understand the blueprint for building a person,” according to the project's website. Humans are now known to have between 20,000 and 25,000 genes, but researchers still have much to learn about these small segments of DNA. Below, we’ve listed a few facts about gene expression, genetic diseases, and the ways genes make us who we are.

1. The word gene wasn’t coined until the 20th century.

Although “father of genetics” Gregor Mendel conducted his pea plant experiments in the mid-1800s, it wasn’t until 1909 that Danish botanist Wilhelm Johannsen became the first person to describe Mendel's individual units of heredity. He called them genes—derived from pangenesis, the word Charles Darwin used for his now-disproven theory of heredity (among other ideas, Darwin suggested that acquired characteristics could be inherited).

2. On a genetic level, all humans are more than 99 percent identical.

Humans have a lot more in common than we might be inclined to believe. In fact, more than 99 percent of our genes are exactly the same from one person to the next. In other words, the diversity we see within the human population—including traits like eye color, height, and blood type—is due to genetic differences that account for less than 1 percent. More specifically, variations of the same gene, called alleles, are responsible for these differences.

3. Genes can disappear or break as species evolve.

Thanks to a combination of genes, most mammals are able to biologically produce their own Vitamin C in-house, so to speak. But some point throughout the course of human history, we lost the ability to make Vitamin C when one of those genes stopped functioning in humans long ago. “You can see it in our genome. We are missing half the gene,” Dr. Michael Jensen-Seaman, a genetics researcher and associate professor of biological sciences at Duquesne University in Pittsburgh, tells Mental Floss. “Generally speaking, when a species loses a gene during evolution, it’s usually because they don’t need it—and if you don’t use it, you lose it. All our ancestors probably ate so much fruit that there was never any need to make your own Vitamin C.” Jensen-Seaman says humans also lost hundreds of odorant receptors (proteins produced by genes that detect specific smells) because we rely mostly on vision. This explains why our sense of smell is worse than many other species.

4. Elizabeth Taylor’s voluminous eyelashes were likely caused by a genetic mutation.

A mutation of the aptly named FOXC2 gene gave Hollywood icon Elizabeth Taylor two rows of eyelashes. The technical term for this rare disorder is distichiasis, and while it may seem like a desirable problem to have, there can be complications. According to the American Academy of Ophthalmology, this extra set of lashes is sometimes “fine and well tolerated,” but in other cases they should be removed to prevent eye damage.

5. Genes involved in sperm are some of the most rapidly evolving genes in the animal kingdom.

Throughout much of the natural world, a class of genes called sperm competition genes are becoming better and better at fertilizing eggs. This is true for various species, including some primates and marine invertebrates. Consider promiscuous primates, like chimpanzees, whose females mate with multiple males in a short period of time. As a result, the males are competing at the genetic level—via their sperm—to father offspring. “What’s happening, we think, is there’s sort of an arms race among genes that are involved in either sperm production or any aspect of male reproduction,” Jensen-Seaman says. Essentially, the proteins in these genes are changing to help males rise to the occasion.

6. A “zombie gene” in elephants might help protect them from cancer.

In a 2018 study published in Cell Reports, researchers from the University of Chicago found that a copy of a cancer-suppressing gene that was previously “dead” (or non-functioning) in elephants turned back on at some point. They don’t know why or how it happened, but this reanimated “zombie gene” might explain why elephants have such low rates of cancer—just 5 percent die from the disease, compared to 11 to 25 percent of humans. Some have suggested that a drug could theoretically be created to mimic the function of this gene in order to treat cancer in humans.

7. Octopuses can edit their own genes.

Cephalopods like squids, cuttlefish, and octopuses are incredibly intelligent and wily creatures—so much so that they can rewrite the genetic information in their neurons. Instead of one gene coding for one protein, which is normally the case, a process called recoding lets one octopus gene produce multiple proteins. Scientists discovered that this process helps some Antarctic species “keep their nerves firing in frigid waters,” The Washington Post notes.

8. The premise of the 1986 film The Fly isn’t completely absurd.

After a botched experiment in The Fly, Jeff Goldblum morphs into a fly-like creature. Surprisingly, that premise might, uh, fly—at least on some genetic level. Although different researchers come up with different estimates, humans share about 52 percent of the same genes with fruit flies, and scientists figure that the number is roughly the same for house flies.

So, could Jeff Goldblum theoretically turn into a human-fly hybrid if his genes got mixed up with the insect's in a futuristic teleportation device? Not exactly, but there are some scientific parallels. “With genetic engineering, we can select genes and insert them into other organisms’ genomes,” DNA researcher Erica Zahnle tells the Chicago Tribune. “We do it all the time. Right now there’s a hybrid of a tomato that has a fish gene in it.”

9. Our genes might prevent us from living more than 125 years.

Despite advances in medicine, there might be a biological cap on how long humans can stick around. Several studies have suggested that we’ve already peaked, with the maximum extent for human life falling between 115 and 125 years. According to this theory, cells can only replicate so many times, and they often become damaged with age. Even if we’re able to modify our genes via gene therapy, we probably can’t modify them fast enough to make much of a difference, Judith Campisi from the Buck Institute for Research on Aging tells The Atlantic.

“For such reasons, it is meaningless to claim that most human will live for 200–500 years in the near future, thanks to medical or scientific progress, or that ‘within 15 years, we'll be adding more than a year every year to our remaining life expectancy,’” the authors of a 2017 study write in Frontiers in Physiology, citing previous studies from 2003 and 2010, respectively. “Raising false hopes without taking into account that human beings are already extremely ‘optimized’ for lifespan seems inappropriate.”

10. The idea that a single gene determines whether you have attached or unattached earlobes is a myth.

Forget what you may have learned about earlobes and genetics in middle school. While your genes probably play some role in determining whether you have attached earlobes (a supposedly dominant trait) or unattached earlobes, the idea that this trait is controlled by a single gene is simply untrue. On top of that, earlobes don’t even fall into two distinct categories. There’s also a third, which University of Delaware associate professor John H. McDonald calls intermediate earlobes. "It doesn't look to me as if there are just two categories; instead, there is continuous variation in the height of the attachment point," McDonald writes on his website. A better example of a trait controlled by a single gene is blood type. Whether you have an A, B, or O blood type is determined by three variations—or alleles—of one gene, according to Jensen-Seaman.

11. No, there isn’t a "wanderlust gene" or "music gene."

Every now and then, new studies will come out that seem to suggest a genetic source for various personality traits, preferences, or talents. In 2015, there was talk of a “wanderlust gene” that inspires certain people to travel, and several other reports have suggested musical aptitude is also inherited. However, like many things in science, the reality isn’t so simple. “Part of the problem is that when we’re in school, we learn examples of traits that are controlled by a single gene, like Mendel’s peas, and we start to think that all variation is determined by a single gene,” Jensen-Seaman says. “But other than a variety of rare genetic diseases, most of the interesting things in medicine, or in human behavior or human variation, are what we call complex traits.” These complex traits typically involve hundreds—if not thousands—of genes, as well as the environmental factors you’re exposed to throughout your life.

12. DNA testing kits can’t tell how smart you are.

Much like your talents and personality, intelligence is also a complex trait that's difficult to measure because it’s influenced by many different genes. One 2017 study identified 52 genes associated with higher or lower intelligence, but the predictive power of those genes—or ability to tell how smart you are—is less than 5 percent. Another study from 2018 identified 538 genes associated with intelligence, which have a 7 percent predictive power. Put simply, no DNA testing kit can accurately predict whether you're a genius or dunce, even if the company claims it can. And, even if scientists make improvements in this field of study, DNA tests can't account for the environmental factors that also influence intelligence.

13. Your genetic makeup determines whether you think your pee smells funky after eating asparagus.

Do you recoil from the scent of your urine after eating asparagus? If so, you’re among the nearly 40 percent of people who are able to detect the smell of metabolized asparagus in pee, according to a study of nearly 7000 people of European-American descent that was published in The BMJ's 2016 Christmas issue. (The BMJ has an annual tradition of publishing strange and light-hearted studies around this time of year, and the asparagus pee study is no exception.) Again, there isn’t one gene in particular to pin the blame on, though. Multiple olfactory receptor genes—and 871 sequence variations on said genes—are involved in determining whether you have a talent for sniffing out asparagus pee.

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