New Patient Test Could Suggest Whether Therapy or Meds Will Work Better for Anxiety

iStock
iStock

Like many psychological disorders, there's no one-size-fits-all treatment for patients with anxiety. Some might benefit from taking antidepressants, which boost mood-affecting brain chemicals called neurotransmitters. Others might respond better to therapy, and particularly a form called cognitive behavioral therapy, or CBT.

Figuring out which form of treatment works best often requires months of trial and error. But experts may have developed a quick clinical test to expedite this process, suggests a new study published in the journal Neuropsychopharmacology.

Researchers at the University of Illinois at Chicago have noted that patients with higher levels of anxiety exhibit more electrical activity in their brains when they make a mistake. They call this phenomenon error-related negativity, or ERN, and measure it using electroencephalography (EEG), a test that records the brain's electric signals.

“People with anxiety disorders tend to show an exaggerated neural response to their own mistakes,” the paper’s lead author, UIC psychiatrist Stephanie Gorka, said in a news release. “This is a biological internal alarm that tells you that you've made a mistake and that you should modify your behavior to prevent making the same mistake again. It is useful in helping people adapt, but for those with anxiety, this alarm is much, much louder.”

Gorka and her colleagues wanted to know whether individual differences in ERN could predict treatment outcomes, so they recruited 60 adult volunteers with various types of anxiety disorders. Also involved was a control group of 26 participants with no history of psychological disorders.

Psychiatrists gauged subjects’ baseline ERN levels by having them wear an EEG cap while performing tricky computer tasks. Ultimately, they all made mistakes thanks to the game's challenging nature. Then, randomized subjects with anxiety disorders were instructed to take an SSRI antidepressant every day for three months, or receive weekly cognitive behavioral therapy for the same duration. (Cognitive behavioral therapy is a type of evidence-based talk therapy that forces patients to challenge maladaptive thoughts and develop coping mechanisms to modify their emotions and behavior.)

After three months, the study's patients took the same computer test while wearing EEG caps. Researchers found that those who'd exhibited higher ERN levels at the study's beginning had reduced anxiety levels if they'd been treated with CBT compared to those treated with medication. This might be because the structured form of therapy is all about changing behavior: Those with enhanced ERN might be more receptive to CBT than other patients, as they're already preoccupied with the way they act.

EEG equipment sounds high-tech, but it's relatively cheap and easy to access. Thanks to its availability, UIC psychiatrists think their anxiety test could easily be used in doctors’ offices to measure ERN before determining a course of treatment.

No Venom, No Problem: This Spider Uses a Slingshot to Catch Prey

Courtesy of Sarah Han
Courtesy of Sarah Han

There are thousands of ways nature can kill, and spider species often come up with the most creative methods of execution. Hyptiotes cavatus, otherwise known as the triangle weaver spider, is one such example. Lacking venom, the spider manages to weaponize its silk, using it to hurl itself forward like a terrifying slingshot to trap its prey.

This unusual method was studied up close for a recent paper published in the Proceedings of the National Academy of Sciences by researchers at the University of Akron in Ohio. They say it's the only known instance of an animal using an external device—its web—for power amplification.

Hyptiotes cavatus's technique is simple. After constructing a web, the spider takes one of the main strands and breaks it in half, pulling it taut by moving backwards. Then, it anchors itself to a spot with more webbing in the rear. When the spider releases that webbing, it surges forward, propelled by the sudden release of stored energy. In the slingshot analogy, the webbing is the strap and the spider is the projectile.

This jerking motion causes the web to oscillate, tangling the spider's prey further in silk. The spider can repeat this until the web has completely immobilized its prey, a low-risk entrapment that doesn’t require the spider to get too close and risk injury from larger victims.

The triangle weaver spider doesn’t have venom, and it needs to be proactive in attacking and stifling prey. Once a potential meal lands in its web, it’s able to clear distances much more quickly using this slingshot technique than if it crawled over. In the lab, scientists clocked the spider’s acceleration at 2535 feet per second squared.

Spiders are notoriously nimble and devious. Cebrennus rechenbergi, or the flic-flac spider, can do cartwheels to spin out of danger; Myrmarachne resemble ants and even wiggle their front legs like ant antennae. It helps them avoid predators, but if they see a meal, they’ll drop the act and pounce. With H. cavatus, it now appears they’re learning to use tools, too.

[h/t Live Science]

Bad News: The Best Time of the Day to Drink Coffee Isn’t as Soon as You Wake Up

iStock.com/ThomasVogel
iStock.com/ThomasVogel

If you depend on coffee to help get you through the day, you can rest assured that you’re not the world's only caffeine fiend. Far from it. According to a 2018 survey, 64 percent of Americans said they had consumed coffee the previous day—the highest percentage seen since 2012.

While we’re collectively grinding more beans, brewing more pots, and patronizing our local coffee shops with increased frequency, we might not be maximizing the health and energy-boosting benefits of our daily cup of joe. According to Inc., an analysis of 127 scientific studies highlighted the many benefits of drinking coffee, from a longer average life span to a reduced risk for cancer, heart disease, type 2 diabetes, and Parkinson’s disease.

Sounds great, right? The only problem is that the benefits of coffee might be diminished depending on the time of day that you drink it. Essentially, science tells us that it’s best to drink coffee when your body’s cortisol levels are low. That’s because both caffeine and cortisol cause a stress response in your body, and too much stress is bad for your health for obvious reasons. In addition, it might end up making you more tired in the long run.

Cortisol, a stress hormone, is released in accordance with your circadian rhythms. This varies from person to person, but in general, someone who wakes up at 6:30 a.m. would see their cortisol levels peak in different windows, including 8 to 9 a.m., noon to 1 p.m., and 5:30 to 6:30 p.m. Someone who rises at 10 a.m. would experience cortisol spikes roughly three hours later, and ultra-early risers can expect to push this schedule three hours forward.

However, these cortisol levels start to rise as soon as you start moving in the morning, so it isn’t an ideal time to drink coffee. Neither is the afternoon, because doing so could make it more difficult to fall asleep at night. This means that people who wake up at 6:30 a.m. should drink coffee after that first cortisol window closes—roughly between 9:30 a.m. and 11:30 a.m.—if they want to benefit for a little caffeine jolt.

To put it simply: "I would say that mid-morning or early afternoon is probably the best time," certified dietitian-nutritionist Lisa Lisiewski told CNBC. "That's when your cortisol levels are at their lowest and you actually benefit from the stimulant itself."

[h/t Inc.]

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