13 Surprising Facts About the Armpit

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The human body is an amazing thing. For each one of us, it's the most intimate object we know. And yet most of us don't know enough about it: its features, functions, quirks, and mysteries. Our series The Body explores human anatomy, part by part. Think of it as a mini digital encyclopedia with a dose of wow.

Tucked away in that damp crevice between your arm and torso, the armpit—a.k.a. the axilla—is often the source of unpleasant odors and embarrassing wetness, and a hairy font of annoyance. But it's also an important juncture that protects important lymph nodes and soft tissue. Mental Floss spoke to microbiologist Alex Berezow, a senior fellow of biomedical science with the American Council on Science and Health, about this often overlooked spot. Here are 13 things we learned.

1. YOUR ARMPITS ARE CHOCK FULL OF LYMPH NODES.

In the small hollow of each armpit are a surprisingly large number of lymph nodes, approximately 20, in two clumps, though you can't usually feel them unless they're swollen. (One clump is closer to the surface than the other.) These lymph nodes are actually an important part of your body's immune system and serve to filter toxins out of tissues. They also produce a variety of immune cells known as lymphocytes that fight infection. In some kinds of breast cancer, these affected lymph nodes may have to be surgically removed.

2. THEY PRODUCE A DIFFERENT KIND OF SWEAT FROM OTHER BODY PARTS.

Not all sweat is created equal. In fact, your skin has two types of sweat glands that help to cool you down: eccrine glands and apocrine glands. Eccrine glands cover most of the surface of your body, and are responsible for that thin sheen of sweat on your brow and extremities during heat and exercise. However, your armpits are abundant in apocrine glands (also found in your groin). These glands are copious in places with more hair follicles, and the sweat they secrete tends to be thicker.

3. YOUR PITS ARE TEEMING WITH BACTERIA.

Your skin is home to many different kinds of bacteria, some of which are quite beneficial, collectively known as a microbiome. This microbiome can vary depending on the body part—so the bacteria on your hand can be vastly different from the moist, warm, dank environment of your armpits.

"Because of oil and sweat secretion, the armpit provides a nice home for many different kinds of bacteria," Berezow tells Mental Floss. Compared to other parts of our skin, armpits are rather densely populated, he explains. Not only that, but armpit microbiomes vary from person to person. "One study showed, after sampling nine people, that there were three types of armpit bacterial communities: One was dominated by Betaproteobacteria, a second by Corynebacterium, and a third by Staphylococcus. So one person's armpit bacteria won't necessarily be the same as somebody else's."

4. IT'S NOT YOUR SWEAT THAT STINKS.

"The secretions our armpits make don't stink. Bacteria break down the compounds, and those breakdown products stink," says Berezow. The bacteria that live in the moist crevices of your armpits interact with your sweat, which contains volatile fatty acids and odorous steroids (among other compounds). That creates a product known as thioalcohols, whose oniony, meaty scents you're likely familiar with if you've ever been stuck in a crowded elevator, subway, or gym at peak workout time.

5. SCIENTISTS ARE WORKING ON A DEODORANT THAT WOULD KILL ONLY SOME BACTERIA…

The researchers plan to engineer a deodorant that would kill only the stink-producing bacteria, instead of the entire armpit microbiome. That's because some good bacteria also live under there, like those that help protect you against fungal infections.

6. …BECAUSE REGULAR DEODORANTS CHANGE YOUR ARMPIT MICROBIOME.

…and not necessarily for the better. "Deodorants change the composition of the microbiome," Berezow says. He cites a study that found "antiperspirant reduces the number of bacteria in our armpits, but interestingly seems to encourage a greater diversity of microbes." He adds, "deodorant seems to increase the number of bacteria compared to people who don't wear deodorant."

Scientists have also found that the pits of people who usually use antiperspirants or deodorants, but stopped for a couple of days as part of the study, grew crowded with an overabundance of Staphylococcaceae—the bacteria that causes staph infections. The individuals who habitually did not use products were dominated by the friendlier—and yet stinkier—Corynebacterium. We just can't win. 

7. WHY DON'T YOUNG KIDS' PITS STINK?

While teenagers often exist in a funk so tangible you can almost see it, most children do not begin to have stinky pits until their tweens. A process called adrenarche begins around age eight for some kids (but often even later) in which the adrenal glands start to secrete hormones called androgens. While these are typically thought of as male hormones, both boys and girls produce them in different quantities. At this stage, not only can sweat start to take on its pungent stench, but children can begin to grow armpit and groin hair. Not much is understood about adrenarche, except that it may be a necessary step in order to trigger puberty. Which may explain why middle school locker rooms do tend to get whiffy.

8. WOMEN'S PITS SMELL LIKE ONIONS AND MEN'S LIKE CHEESE.

Researchers from Firmenich, a company in Geneva, set out to understand the subtle nuances in body odor to better market deodorant products to consumers. In their 2009 study, published in Chemical Senses, they discovered that your unique bouquet may be different depending on whether you're a cisgender man or woman. Women's sweat contained higher levels of an odorless sulphur-containing compound that produces a pungent oniony thioalcohol when combined with the bacteria in the underarm. Men's sweat held higher levels of a fatty acid that produced a "cheesy" scent when the bacteria of the armpit came in contact with it.

9. WOMEN DIDN'T ALWAYS SHAVE THEIR ARMPITS.

Since women were socialized to keep most of their bodies covered for centuries, exposing an armpit was an unlikely event in a public place before 1915. However, an ad in Harper's Bazaar changed everything when it suggested that in order to engage in "Modern Dancing," women should first remove their "objectionable" underarm hair. By the Roaring Twenties, many women's pits were as hairless as the day they were born.

10. SOCIAL EXPECTATIONS SHAPE OUR COMFORT WITH ARMPIT HAIR.

Despite armpit hair being as natural as the hair on our heads—and everywhere else it grows—women's armpit hair tends to be controversial. A feminist scholar set out to explore some of the reasons for this in a 2013 study in the Psychology of Women Quarterly and found that social expectations play a huge role in women seeing body hair—on themselves and on other women—as "disgusting" or simply socially unacceptable. Even women who purposely grew their pit-hair out to flout societal expectations felt self-conscious showing armpit hair in social settings.

11. …AND SO MIGHT OUR ANIMAL NATURE.

The 2013 study, conducted by a professor at Arizona State University, suggests that this revulsion with armpit hair may be a Western aversion to our primal roots as animals. Other animals send out chemical signals called pheromones to attract mates. We still don't know whether pheromones exist in humans, but plenty of evidence indicates we are highly sensitive to each other's biochemicals. If pheromones do exist, body hair around the groin and armpits could be a likely place to find them. But as "civilized" people, we believe the process of finding a partner lies in our hearts and minds—not in our armpits. Maybe one day we'll find out it's all of the above. 

12. YOUR ARMPIT LYMPH NODES MAY WARN YOU OF BREAST CANCER.

Most of the time a swollen lymph node in the armpit is little more than a sign of a cold or flu virus attacking your body. However, it can also be an early symptom of inflammatory breast cancer, an aggressive form of cancer that is best treated when caught as early as possible. Other areas that may swell in this cancer are your breast itself, and around your collarbone. If you have these kinds of sudden swellings, it's a good idea to see a doctor.

13. SOME PEOPLE GET THEIR ARMPITS BOTOXED.

A condition known as hyperhidrosis—excessive sweating—can be frustrating for those who'd like to be able to simply wear clothing they don't drench. According to Dr. Sonam Yadav, medical director of a cosmetic dermatology clinic in New Delhi, India, Botox is used to treat underarm sweating (yes, here in the U.S. too). Yadav tells Mental Floss, "It works by regulating the synergy between the neuromuscular junction and the sweat glands."

‘Water’ in Kansas City Woman’s Ear Turned Out to Be a Venomous Brown Recluse Spider

N-sky/iStock via Getty Images
N-sky/iStock via Getty Images

Susie Torres, a resident of Kansas City, Missouri, woke up on Tuesday morning with the distinct feeling that water was lodged in her left ear. She likened it to the swooshing sensation that can often happen after swimming, WDAF-TV reports.

Instead of waiting for the problem to resolve itself, Torres went to the doctor—a decision that might have saved her from some serious pain. The medical assistant was the first to realize something was alarmingly amiss, and immediately called for backup.

“She ran out and said ‘I’m going to get a couple more people,’” Torres told 41 Action News. “She then said, ‘I think you have an insect in there.’” For many people, the thought of having any live insect stuck in an ear would be enough to cue a small- or large-scale freak-out, but Torres stayed calm.

The doctors “had a few tools and worked their magic and got it out,” Torres said. The “it” in question turned out to be a spider—and not just any harmless house spider (which you shouldn’t kill, by the way). It was a venomous brown recluse spider.

“Gross,” Torres told WDAF-TV. “Why, where, what, and how.”

Miraculously, the spider didn’t bite Torres. If it had, she would’ve ended up visiting the doctor with more than general ear discomfort: Brown recluse bites can cause pain, burning, fever, nausea, and purple or blue discoloration of the surrounding skin, according to Healthline.

Torres may have remained admirably level-headed throughout the ordeal, but that doesn’t mean she’s taking it lightly. “I went and put some cotton balls in my ears last night,” she told WDAF-TV. “I’m shaking off my clothes, and I don’t put my purse on the floor. I’m a little more cautious.”

Is this the first time an insect has posted up in the ear of an unsuspecting, innocent human? Absolutely not—here are six more horror stories, featuring a cockroach, a bed bug, and more.

[h/t WDAF-TV]

12 Fantastic Facts About the Immune System

monkeybusinessimages/iStock via Getty Images
monkeybusinessimages/iStock via Getty Images

If it weren't for our immune system, none of us would live very long. Not only does the immune system protect us from external pathogens like viruses, bacteria, and parasites, but it also battles cells that have mutated due to illnesses, like cancer, within the body. Here are 12 fascinating facts about the immune system.

1. The immune system saves lives.

The immune system is a complex network of tissues and organs that spreads throughout the entire body. In a nutshell, it works like this: A series of "sensors" within the system detects an intruding pathogen, like bacteria or a virus. Then the sensors signal other parts of the system to kill the pathogen and eliminate the infection.

"The immune system is being bombarded by all sorts of microbes all the time," Russell Vance, professor of immunology at University of California, Berkeley and an investigator for the Howard Hughes Medical Institute, tells Mental Floss. "Yet, even though we're not aware of it, it's saving our lives every day, and doing a remarkably good job of it."

2. Before scientists understood the immune system, illness was chalked up to unbalanced humors.

Long before physicians realized how invisible pathogens interacted with the body's system for fighting them off, doctors diagnosed all ills of the body and the mind according to the balance of "four humors": melancholic, phlegmatic, choleric, or sanguine. These criteria, devised by the Greek philosopher Hippocrates, were divided between the four elements, which were linked to bodily fluids (a.k.a. humors): earth (black bile), air (blood), water (phlegm) and fire (yellow bile), which also carried properties of cold, hot, moist, or dry. Through a combination of guesswork and observation, physicians would diagnose patients' humors and prescribe treatment that most likely did little to support the immune system's ability to resist infection.

3. Two men who unraveled the immune system's functions were bitter rivals.

Two scientists who discovered key functions of the immune system, Louis Pasteur and Robert Koch, should have been able to see their work as complementary, but they wound up rivals. Pasteur, a French microbiologist, was famous for his experiments demonstrating the mechanism of vaccines using weakened versions of the microbes. Koch, a German physician, established four essential conditions under which pathogenic bacteria can infect hosts, and used them to identify the Mycobacterium tuberculosis bacterium that causes tuberculosis. Though both helped establish the germ theory of disease—one of the foundations of modern medicine today—Pasteur and Koch's feud may have been aggravated by nationalism, a language barrier, criticisms of each other's work, and possibly a hint of jealousy.

4. Specialized blood cells are the immune system's greatest weapon.

The most powerful weapons in your immune system's arsenal are white blood cells, divided into two main types: lymphocytes, which create antigens for specific pathogens and kill them or escort them out of the body; and phagocytes, which ingest harmful bacteria. White blood cells not only attack foreign pathogens, but recognize these interlopers the next time they meet them and respond more quickly. Many of these immune cells are produced in your bone marrow but also in the spleen, lymph nodes, and thymus, and are stored in some of these tissues and other areas of the body. In the lymph nodes, which are located throughout your body but most noticeably in your armpits, throat, and groin, lymphatic fluid containing white blood cells flows through vein-like tubules to escort foreign invaders out.

5. The spleen helps your immune system work.

Though you can live without the spleen, an organ that lies between stomach and diaphragm, it's better to hang onto it for your immune function. According to Adriana Medina, a doctor who specializes in hematology and oncology at the Alvin and Lois Lapidus Cancer Institute at Sinai Hospital in Baltimore, your spleen is "one big lymph node" that makes new white blood cells and cleans out old blood cells from the body.

It's also a place where immune cells congregate. "Because the immune cells are spread out through the body," Vance says, "eventually they need to communicate with each other." They do so in both the spleen and lymph nodes.

6. You have immune cells in all of your tissues.

While immune cells may congregate more in lymph nodes than elsewhere, "every tissue in your body has immune cells stationed in it or circulating through it, constantly roving for signs of attack," Vance explains. These cells also circulate through the blood. The reason for their widespread presence is that there are thousands of different pathogens that might infect us, from bacteria to viruses to parasites. "To eliminate each of those different kinds of threats requires specialized detectors," he says.

7. How friendly you're feeling could be linked to your immune system.

From an evolutionary perspective, humans' high sociability may have less to do with our bigger brains, and more to do with our immune system's exposure to a greater number of bacteria and other pathogens.

Researchers at the University of Virginia School of Medicine have theorized that interferon gamma (IG), a substance that helps the immune system fight invaders, was linked to social behavior, which is one of the ways we become exposed to pathogens.

In mice, they found IG acted as a kind of brake to the brain's prefrontal cortex, essentially stopping aberrant hyperactivity that can cause negative changes in social behavior. When they blocked the IG molecule, the mice's prefrontal cortexes became hyperactive, resulting in less sociability. When they restored the function, the mice's brains returned to normal, as did their social behavior.

8. Your immune system might recruit unlikely organs, like the appendix, into service.

The appendix gets a bad rap as a vestigial organ that does nothing but occasionally go septic and create a need for immediate surgery. But the appendix may help keep your gut in good shape. According to Gabrielle Belz, professor of molecular immunology at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, research by Duke University's Randal Bollinger and Bill Parker suggests the appendix houses symbiotic bacteria that are important for overall gut health—especially after infections wipe out the gut's good microbes. Special immune cells known as innate lymphoid cells (ILCs) in the appendix may help to repopulate the gut with healthy bacteria and put the gut back on track to recovery.

9. Gut bacteria has been shown to boost immune systems in mice.

Researchers at the University of Chicago noticed that one group of mice in their lab had a stronger response to a cancer treatment than other mice. They eventually traced the reason to a strain of bacteria—Bifidobacterium—in the mice's guts that boosted the animals' immune system to such a degree they could compare it to anti-cancer drugs called checkpoint inhibitors, which keep the immune system from overreacting.

To test their theory, they transferred fecal matter from the robust mice to the stomachs of less immune-strengthened mice, with positive results: The treated mice mounted stronger immune responses and tumor growth slowed. When they compared the bacterial transfer effects with the effects of a checkpoint inhibitor drug, they found that the bacteria treatment was just as effective. The researchers believe that, with further study, the same effect could be seen in human cancer patients.

10. Scientists are trying to harness the immune system's "Pac-Man" cells to treat cancer.

Aggressive pediatric tumors are difficult to treat due to the toxicity of chemotherapy, but some researchers are hoping to develop effective treatments without the harmful side effects. Stanford researchers designed a study around a recently discovered molecule known as CD47, a protein expressed on the surface of all cells, and how it interacts with macrophages, white blood cells that kill abnormal cells. "Think of the macrophages as the Pac-Man of the immune system," Samuel Cheshier, lead study author and assistant professor of neurosurgery at Stanford Medicine, tells Mental Floss.

CD47 sends the immune system's macrophages a "don't eat me" signal. Cancer cells fool the immune system into not destroying them by secreting high amounts of CD47. When Cheshier and his team blocked the CD47 signals on cancer cells, the macrophages could identify the cancer cells and eat them, without toxic side effects to healthy cells. The treatment successfully shrank all five of the common pediatric tumors, without the nasty side effects of chemotherapy.

11. A new therapy for type 1 diabetes tricks the immune system.

In those with type 1 diabetes, the body attacks its own pancreatic cells, interrupting its normal ability to produce insulin in response to glucose. In a 2016 paper, researchers at MIT, in collaboration with Boston's Children's Hospital, successfully designed a new material that allows them to encapsulate and transplant healthy pancreatic "islet" cells into diabetic mice without triggering an immune response. Made from seaweed, the substance is benign enough that the body doesn't react to it, and porous enough to allow the islet cells to be placed in the abdomen of mice, where they restore the pancreatic function. Senior author Daniel Anderson, an associate professor at MIT, said in a statement that this approach "has the potential to provide [human] diabetics with a new pancreas that is protected from the immune system, which would allow them to control their blood sugar without taking drugs. That's the dream."

12. Immunotherapy is on the cutting edge of immune system research.

Over the last few years, research in the field of immunology has focused on developing cancer treatments using immunotherapy. This method engineers the patient's own normal cells to attack the cancer cells. Vance says the technique could be used for many more conditions. "I feel like that could be just the tip of the iceberg," he says. "If we can understand better what the cancer and immunotherapy is showing, maybe we can go in there and manipulate the immune responses and get good outcomes for other diseases, too."

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