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French Scientists Are Paying Men $17,000 to Lie in Bed for Two Months

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French researchers are seeking young, healthy men willing to embrace their inner sloth for science. As The Guardian reports, scientists from the Institute for Space Medicine and Physiology (Medes) need male volunteers to spend two months in bed so they can study the effects of microgravity—the state of virtual weightlessness—on the human body. Subjects will be paid around $17,000.

According to experiment coordinator Arnaud Beck, the goal is to reproduce the weightlessness experienced by astronauts at the International Space Station. Prolonged weightlessness can affect the cardiovascular system, and can also cause vertigo and low blood pressure, in addition to bone density loss, muscle atrophy, and other side effects. These effects can differ depending on whether an astronaut is male or female, as NASA has found. Still, this study includes only men.

Arnaud and his colleagues want to study the harmful physical effects of prolonged weightlessness, and find ways to prevent them. The end goal is “to enhance astronauts’ performance and to ready them for their return to Earth,” according to a press release issued by the Centre National d'Études Spatiales (CNES), the French space agency.

During the experiment's first 15 days, scientists will run tests on the subjects. After that, the bed-ridden men will spend 60 days on their backs, their upper bodies positioned in a slight downward incline. As the CNES explains, this position simulates the effects of weightlessness, as it shifts blood towards the upper body, “causing the same changes in blood volume, cardiac performance and vascular resistance as in space.”

In addition, half of the volunteers will take antioxidant and anti-inflammatory food supplements, and the other half will serve as a control group. Subjects will be monitored, so researchers can see how the drug cocktail affects their bodies as the physical side effects of weightlessness kick in.

Subjects can’t get up to eat, bathe, or even go to the bathroom, as they’re required to keep at least one shoulder touching the bed or its frame at all times. (In short, participants should be prepared—and willing—to use a bedpan for two months.) During the experiment's final 15 days, subjects will spend time recovering from their “weightless” two months, and the scientists will conduct additional tests to see how the experience—and the supplements—affected them.

The upcoming bed-rest study is technically part of a two-part experiment, launched by the Institute for Space Medicine and Physiology last winter. One group of volunteers stayed in bed from January 2017 until April 2017, and the incoming group will remain prostrate from September to November.

Want to get paid to spend two months in bed? Volunteers must be non-smoking males, between the ages of 20 and 45, who are healthy and in good physical shape. The application is available online.

[h/t The Guardian]

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technology
Man Buys Two Metric Tons of LEGO Bricks; Sorts Them Via Machine Learning
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Jacques Mattheij made a small, but awesome, mistake. He went on eBay one evening and bid on a bunch of bulk LEGO brick auctions, then went to sleep. Upon waking, he discovered that he was the high bidder on many, and was now the proud owner of two tons of LEGO bricks. (This is about 4400 pounds.) He wrote, "[L]esson 1: if you win almost all bids you are bidding too high."

Mattheij had noticed that bulk, unsorted bricks sell for something like €10/kilogram, whereas sets are roughly €40/kg and rare parts go for up to €100/kg. Much of the value of the bricks is in their sorting. If he could reduce the entropy of these bins of unsorted bricks, he could make a tidy profit. While many people do this work by hand, the problem is enormous—just the kind of challenge for a computer. Mattheij writes:

There are 38000+ shapes and there are 100+ possible shades of color (you can roughly tell how old someone is by asking them what lego colors they remember from their youth).

In the following months, Mattheij built a proof-of-concept sorting system using, of course, LEGO. He broke the problem down into a series of sub-problems (including "feeding LEGO reliably from a hopper is surprisingly hard," one of those facts of nature that will stymie even the best system design). After tinkering with the prototype at length, he expanded the system to a surprisingly complex system of conveyer belts (powered by a home treadmill), various pieces of cabinetry, and "copious quantities of crazy glue."

Here's a video showing the current system running at low speed:

The key part of the system was running the bricks past a camera paired with a computer running a neural net-based image classifier. That allows the computer (when sufficiently trained on brick images) to recognize bricks and thus categorize them by color, shape, or other parameters. Remember that as bricks pass by, they can be in any orientation, can be dirty, can even be stuck to other pieces. So having a flexible software system is key to recognizing—in a fraction of a second—what a given brick is, in order to sort it out. When a match is found, a jet of compressed air pops the piece off the conveyer belt and into a waiting bin.

After much experimentation, Mattheij rewrote the software (several times in fact) to accomplish a variety of basic tasks. At its core, the system takes images from a webcam and feeds them to a neural network to do the classification. Of course, the neural net needs to be "trained" by showing it lots of images, and telling it what those images represent. Mattheij's breakthrough was allowing the machine to effectively train itself, with guidance: Running pieces through allows the system to take its own photos, make a guess, and build on that guess. As long as Mattheij corrects the incorrect guesses, he ends up with a decent (and self-reinforcing) corpus of training data. As the machine continues running, it can rack up more training, allowing it to recognize a broad variety of pieces on the fly.

Here's another video, focusing on how the pieces move on conveyer belts (running at slow speed so puny humans can follow). You can also see the air jets in action:

In an email interview, Mattheij told Mental Floss that the system currently sorts LEGO bricks into more than 50 categories. It can also be run in a color-sorting mode to bin the parts across 12 color groups. (Thus at present you'd likely do a two-pass sort on the bricks: once for shape, then a separate pass for color.) He continues to refine the system, with a focus on making its recognition abilities faster. At some point down the line, he plans to make the software portion open source. You're on your own as far as building conveyer belts, bins, and so forth.

Check out Mattheij's writeup in two parts for more information. It starts with an overview of the story, followed up with a deep dive on the software. He's also tweeting about the project (among other things). And if you look around a bit, you'll find bulk LEGO brick auctions online—it's definitely a thing!

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Health
One Bite From This Tick Can Make You Allergic to Meat
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We like to believe that there’s no such thing as a bad organism, that every creature must have its place in the world. But ticks are really making that difficult. As if Lyme disease wasn't bad enough, scientists say some ticks carry a pathogen that causes a sudden and dangerous allergy to meat. Yes, meat.

The Lone Star tick (Amblyomma americanum) mostly looks like your average tick, with a tiny head and a big fat behind, except the adult female has a Texas-shaped spot on its back—thus the name.

Unlike other American ticks, the Lone Star feeds on humans at every stage of its life cycle. Even the larvae want our blood. You can’t get Lyme disease from the Lone Star tick, but you can get something even more mysterious: the inability to safely consume a bacon cheeseburger.

"The weird thing about [this reaction] is it can occur within three to 10 or 12 hours, so patients have no idea what prompted their allergic reactions," allergist Ronald Saff, of the Florida State University College of Medicine, told Business Insider.

What prompted them was STARI, or southern tick-associated rash illness. People with STARI may develop a circular rash like the one commonly seen in Lyme disease. They may feel achy, fatigued, and fevered. And their next meal could make them very, very sick.

Saff now sees at least one patient per week with STARI and a sensitivity to galactose-alpha-1, 3-galactose—more commonly known as alpha-gal—a sugar molecule found in mammal tissue like pork, beef, and lamb. Several hours after eating, patients’ immune systems overreact to alpha-gal, with symptoms ranging from an itchy rash to throat swelling.

Even worse, the more times a person is bitten, the more likely it becomes that they will develop this dangerous allergy.

The tick’s range currently covers the southern, eastern, and south-central U.S., but even that is changing. "We expect with warming temperatures, the tick is going to slowly make its way northward and westward and cause more problems than they're already causing," Saff said. We've already seen that occur with the deer ticks that cause Lyme disease, and 2017 is projected to be an especially bad year.

There’s so much we don’t understand about alpha-gal sensitivity. Scientists don’t know why it happens, how to treat it, or if it's permanent. All they can do is advise us to be vigilant and follow basic tick-avoidance practices.

[h/t Business Insider]

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