The future of depression treatment might be chilling in the dairy case. A study published earlier this year in Nature Scientific Reports said that beneficial bacteria commonly found in yogurt can help relieve depression-like symptoms in mice.
Over the last few decades, scientists have begun exploring the connections between our brains and all the microbes that live on and inside our bodies, and they've learned that those little microbes have an awful lot of power. Some studies have shown that bacterial imbalances can affect nervous system function, while others have suggested that people with bacterial imbalances may be more prone to anxiety and depression.
To test these hypotheses, researchers at the University of Virginia decided to begin at the overlap between the nervous system and mood: stress. Stress increases depression risk; it also affects, and is affected by, the function of the nervous system.
The scientists began by collecting a group of unlucky mice and subjecting them to a variety of intense stressors. Some were kept in crowded cages; others had to sit under strobe lights or listen to loud noises. Predictably, the stressful situations took a toll, and the mice began exhibiting what the researchers called “despair behavior.”
The researchers collected poop samples from the mice before and after the stress sessions, then ran genetic analyses to determine the species and quantities of bacteria living in each mouse’s gut. The results showed that the stress resulted in a pretty significant drop in a microbe called Lactobacillus—the same type of so-called "good" bacteria found in yogurt.
But the rodents’ despair would not prove permanent. The researchers began giving the mice small doses of Lactobacillus with their meals, and, over time, their symptoms resolved.
Lead author Alban Gaultier. Image Credit: Josh Barney | University of Virginia Health System
"This is the most consistent change we've seen across different experiments and different settings we call microbiome profiles," co-author Ioana Marin said in a statement. "This is a consistent change. We see Lactobacillus levels correlate directly with the behavior of these mice."
The team hopes to take their experiments into the human body next. Lead author Alban Gaultier said he has “big hope” that probiotics could someday augment or even replace side-effect–heavy antidepressant drugs. “It would be magical just to change your diet,” he said, “to change the bacteria you take, and fix your health—and your mood.”
No matter where private or government space travel may take us in the future, NASA astronaut Neil Armstrong (1930-2012) will forever have a place as the first human to ever set foot on solid ground outside of our atmosphere. Taking “one small step” onto the Moon on July 20, 1969, he inspired generations of ambitious people to reach for the stars in their own lives. On the 50th anniversary of Apollo 11, we're taking a look back at the life of this American hero.
1. Neil Armstrong knew how to fly before he got a driver's license.
NASA/Hulton Archive/Getty Images
Born August 5, 1930 in Wapakoneta, Ohio, Armstrong became preoccupied with aviation early on. At around age 6, his father took him on a ride in a Ford Trimotor airplane, one of the most popular airplanes in the world. By age 15, he had accumulated enough flying lessons to command a cockpit, reportedly before he ever earned his driver’s license. During the Korean War, Armstrong flew 78 combat missions before moving on to the National Advisory Committee for Aeronautics (NACA), the precursor to NASA.
2. Neil Armstrong's famous quote was misheard back on Earth.
When Armstrong and Buzz Aldrin touched down on the Moon, hundreds of millions of television viewers were riveted. Armstrong could be heard saying, “That’s one small step for man, one giant leap for mankind.” But that’s not exactly what he said. According to the astronaut, he was fairly sure he stated, “That’s one small step for a man, one giant leap for mankind.” The “a” may have broken up on transmission or it may have been obscured as a result of his speaking patterns. (According to First Man: The Life of Neil A. Armstrong, Armstrong said, “I’m not particularly articulate. Perhaps it was a suppressed sound that didn’t get picked up by the voice mike. As I have listened to it, it doesn’t sound like there was time for the word to be there. On the other hand, I think that reasonable people will realize that I didn’t intentionally make an inane statement, and certainly the ‘a’ was intended, because that’s the only way the statement makes any sense. So I would hope that history would grant me leeway for dropping the syllable and understand that it was certainly intended, even if it wasn’t said—although it actually might have been.”) Armstrong claimed the statement was spontaneous, but his brother and others have claimed he had written it down prior to the mission.
3. We don't have a really good picture of Neil Armstrong on the Moon.
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One of the most celebrated human achievements of the 20th century came at a time when video and still cameras were readily available—yet there are precious few images of Armstrong actually walking on the surface of the Moon. (One of the most iconic shots, above, is Aldrin; Armstrong only appears as a reflection in his helmet.) The reason, according to Armstrong, is that he really didn’t care and didn’t think to ask Aldrin to snap some photos. “I don't think Buzz had any reason to take my picture, and it never occurred to me that he should,” Armstrong told his biographer, James R. Hansen. “I have always said that Buzz was the far more photogenic of the crew."
4. A door hinge may have made all the difference to the Apollo 11 mission.
Theories abound as to why it was Armstrong and not Buzz Aldrin who first set foot on the Moon. (On the Gemini missions, the co-pilot did the spacewalks, while the commander stayed in the craft. For Apollo 11, Armstrong was the commander.) The answer may have been the simple logistics of getting out of their lunar module. The exit had a right hinge that opened inwardly, with the man sitting on the left (Armstrong) having the most unobstructed path to the outside. Aldrin would have essentially had to climb over Armstrong to get out first.
5. Neil Armstrong was more concerned about landing on the Moon than he was walking on it.
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The romantic notion of a human stepping foot on space soil captured imaginations, but for Armstrong, it was getting there in one piece that was the real accomplishment. The lunar module Armstrong controlled had to be brought down on the Moon’s surface from 50,000 feet up, avoiding rocks, craters, and other obstacles as it jockeyed into a position for landing. Because there is no air resistance, nothing could slow their descent, and they used thrusters to guide the craft down. That meant there was only enough fuel to attempt it once. The “business” of getting down the ladder was, in Armstrong’s view, less significant.
6. Neil Armstrong was carrying a bag worth $1.8 million.
When Armstrong surveyed the surface of the Moon, he collected a bag of dust for NASA scientists to examine. Apollo moon samples are illegal to buy or sell, but that apparently wasn't the case with the “lunar collection bag” Armstrong used to hold the samples. In 2015, the bag was purchased by Chicago resident Nancy Lee Carlson from a government auction site for $995. But its sale was, apparently, an accident: When Carlson sent the bag to NASA to confirm its authenticity, NASA said it was their property and refused to send it back—so Carlson took the agency to court. A judge ruled it belonged to Carlson, and in 2017, she sold the bag for a whopping $1.8 million at a Sotheby’s auction.
7. Neil Armstrong and his fellow Apollo 11 astronauts had to spend three weeks in quarantine.
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When Armstrong, Aldrin, and Michael Collins (who remained behind in the command module while the other two touched down on the Moon) returned to Earth and were fetched by the USS Hornet, they got a king’s welcome. The only asterisk: They had to bask in their newfound fame from inside a sealed chamber. All three men were quarantined for three weeks in the event they had picked up any strange space virus. When President Richard Nixon visited, he greeted them through the chamber’s glass window.
8. Neil Armstrong's space suit was made by Playtex.
Yes, the undergarment people. In the early 1960s, NASA doled out contract work for their space suits to government suppliers, but it was Playtex (or more properly the International Latex Corporation) and their understanding of fabrics and seams that led to NASA awarding them responsibility for the Apollo mission suits. Their A7L suit was what Armstrong wore to insulate himself against the harsh void of space when he made his famous touchdown. The astronaut called it “reliable” and even “cuddly.”
9. Neil Armstrong became a university professor.
Following his retirement from NASA in 1971, Armstrong was reticent to remain in the public eye. Demands for his time were everywhere, and he had little ambition to become a walking oral history of his singular achievement. Instead, he accepted a job as a professor of engineering at the University of Cincinnati and remained on the faculty for eight years.
10. Neil Armstrong once sued Hallmark.
Hallmark was forced to defend itself when Armstrong took issue with the company using his name and likeness without permission for a 1994 Christmas ornament. The bulb depicted Armstrong and came with a sound chip that said phrases like, “The Eagle has landed.” The two parties came to an undisclosed but “substantial” settlement in 1995, which was, according to First Man, donated to Purdue University (minus legal fees).
11. Neil Armstrong was a Chrysler pitchman.
Armstrong’s preference to lead a private life continued over the decades, but he did make one notable exception. For a 1979 Super Bowl commercial spot, Armstrong agreed to appear on camera endorsing Chrysler automobiles. Armstrong said he did it because he wanted the struggling U.S. car maker to improve their sales and continue contributing to the domestic economy. The ads never mentioned Armstrong was an astronaut.
Argentinian heart surgeon René Favaloro is the subject of today’s Google Doodle, which features a sketched portrait of the doctor along with an anatomical heart and several medical tools, The Independentreports.
The renowned doctor was born on this day in 1923 in La Plata, the capital of Argentina’s Buenos Aires province, and pursued a degree in medicine at La Plata University. After 12 years as a doctor in La Pampa, where he established the area’s first mobile blood bank, trained nurses, and built his own operating room, Favaloro relocated to the U.S. to specialize in thoracic surgery at the Cleveland Clinic.
In 1967, Favaloro performed coronary bypass surgery on a 51-year-old woman whose right coronary artery was blocked, restricting blood flow to her heart. Coronary bypass surgery involves taking a healthy vein from elsewhere in the body (in this case, Favaloro borrowed from the patient’s leg, but you can also use a vein from the arm or chest), and using it to channel the blood from the artery to the heart, bypassing the blockage. According to the Mayo Clinic, it doesn’t cure whatever heart disease that caused the blocked artery, but it can relieve symptoms like chest pain and shortness of breath, and it gives patients time to make other lifestyle changes to further manage their disease.
Favaloro wasn’t keen on being called the “father” of coronary bypass surgery, but his work brought the procedure to the forefront of the clinical field. He moved back to Argentina in 1971 and launched the Favaloro Foundation to train surgeons and treat a variety of patients from diverse economic backgrounds.
Favaloro died by suicide on July 29, 2000, at the age of 77, by a gunshot wound to the chest. His wife had died several years prior, and his foundation had fallen deeply into debt, which Argentinian hospitals and medical centers declined to help pay, The New York Timesreported at the time.
“As a surgeon, Dr. Favaloro will be remembered for his ingenuity and imagination,” his colleague Dr. Denton A. Cooley wrote in a tribute shortly after Favaloro’s death. “But as a man ... he will be remembered for his compassion and selflessness.” Today would have been his 96th birthday.