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9 Up-Close Scientific Images from the Wellcome Image Awards

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One winning image: A baby Hawaiian bobtail squid. Image Credit: Mark R Smith, Macroscopic Solutions

 
Each year, the Wellcome Image Awards highlight some of the most fascinating scientific images from around the world, as chosen by a panel of experts from the fields of science communications and medicine. The awards go to photographers and researchers who create “informative, striking and technically excellent images that communicate significant aspects of healthcare and biomedical science,” according to the Wellcome Trust, a biomedical research charity based in the UK. Here are nine of this year’s winning images:

ZEBRAFISH EYE AND NEUROMASTS

Ingrid Lekk and Steve Wilson, University College London

In this 4-day-old zebrafish embryo, a certain gene expressed in the lens of the eye and other parts of the visual system glows red when it’s activated. You can see the lens of the eye, the head, and neuromasts (those red dots around the rim of the image) glowing red, while the nervous system glows blue.

BLOOD VESSELS OF THE AFRICAN GREY PARROT

Scott Birch and Scott Echols

This image was created using a 3D reconstruction of a euthanized parrot. It models the system of blood vessels in the parrot’s head and neck down to the capillary level.

INTRAOCULAR LENS IRIS CLIP

Mark Bartley, Cambridge University Hospitals NHS Foundation Trust

Iris clips can treat nearsightedness, cataracts, and other eye issues. This photo shows an iris clip fitting on the eye of a 70-year-old patient. He regained nearly all his vision after the surgery.

BRAIN-ON-A-CHIP

Collin Edington and Iris Lee, Koch Institute at MIT

Researchers are developing ways to grow miniature organs on plastic chips in order to make drug testing more efficient. Instead of testing pharmaceuticals on people, scientists may one day test them on something like this—neural stem cells grown on a synthetic gel.

#BREASTCANCER TWITTER CONNECTIONS

Eric Clarke, Richard Arnett and Jane Burns, Royal College of Surgeons in Ireland

Here is a visualization of discussions on Twitter using the hashtag #breastcancer. Each dot represents a Twitter user, and its size is based on how many other dots (or nodes) it is connected to. Each line represents a relationship with another Twitter user, and the thicker the line, the more that relationship shows up in the data. This part of the visualization relates to trending data—one tweet retweeted thousands of times.

PIGEON THERMOREGULATION

Scott Echols, Scarlet Imaging and the Grey Parrot Anatomy Project

No, this isn’t just an avian parody of The Scream. It shows the network of blood vessels, visualized using technology created by the same researcher as the parrot image above, under the skin of a pigeon. This dense network allows pigeons to control their body temperatures.

MICRORNA SCAFFOLD CANCER THERAPY

João Conde, Nuria Oliva and Natalie Artzi, Massachusetts Institute of Technology (MIT)

Because microRNAs control the function and growth of cells, they have a lot of potential in cancer therapies. MIT researchers are working on a system that could deliver these short genetic sequences to cancerous cells. It consists of two microRNAs woven like a net with a synthetic polymer.

DEVELOPING SPINAL CORD

Gabriel Galea, University College London

This image shows a mouse’s neural tube, the structure from which the spinal cord develops. In each of the three images, the blue color draws attention to a specific tissue type. In the left image, the blue is the neural tube itself, which forms the brain and spine. In the middle, the blue is the mesoderm, which will become the inner organs. On the right, the blue shows the surface ectoderm that becomes hair, skin, and teeth.

All images courtesy the Wellcome Image Awards

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Jamie McCarthy/Getty Images for Bill & Melinda Gates Foundation
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Medicine
Bill Gates is Spending $100 Million to Find a Cure for Alzheimer's
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Jamie McCarthy/Getty Images for Bill & Melinda Gates Foundation

Not everyone who's blessed with a long life will remember it. Individuals who live into their mid-80s have a nearly 50 percent chance of developing Alzheimer's, and scientists still haven't discovered any groundbreaking treatments for the neurodegenerative disease [PDF]. To pave the way for a cure, Microsoft co-founder and philanthropist Bill Gates has announced that he's donating $100 million to dementia research, according to Newsweek.

On his blog, Gates explained that Alzheimer's disease places a financial burden on both families and healthcare systems alike. "This is something that governments all over the world need to be thinking about," he wrote, "including in low- and middle-income countries where life expectancies are catching up to the global average and the number of people with dementia is on the rise."

Gates's interest in Alzheimer's is both pragmatic and personal. "This is something I know a lot about, because men in my family have suffered from Alzheimer’s," he said. "I know how awful it is to watch people you love struggle as the disease robs them of their mental capacity, and there is nothing you can do about it. It feels a lot like you're experiencing a gradual death of the person that you knew."

Experts still haven't figured out quite what causes Alzheimer's, how it progresses, and why certain people are more prone to it than others. Gates believes that important breakthroughs will occur if scientists can understand the condition's etiology (or cause), create better drugs, develop techniques for early detection and diagnosis, and make it easier for patients to enroll in clinical trials, he said.

Gates plans to donate $50 million to the Dementia Discovery Fund, a venture capital fund that supports Alzheimer's research and treatment developments. The rest will go to research startups, Reuters reports.

[h/t Newsweek]

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Eye Doctors Still Use This 100-Year-Old Test for Color Blindness

You may have seen them at your ophthalmologist's office: large circular diagrams made up of colored dots. People with normal vision are able to discern a number among the dots of contrasting colors. People who are color blind might see only a field of spots.

These elegant, deceptively modern drawings were published 100 years ago by a Japanese ophthalmologist, Shinobu Ishihara. Thanks to the designs' simplicity and diagnostic accuracy, the Ishihara test is still the most popular and efficient way to identify patients with color vision deficiencies.

Born in Tokyo in 1879, Ishihara studied medicine at the prestigious Tokyo Imperial University on a military scholarship, which required him to serve in the armed forces. After graduating in 1905, he worked for three years as a physician specializing in surgery in the Imperial Japanese Army, and then returned to the university for postgraduate studies in ophthalmology. In his research, Ishihara focused on identifying and recruiting soldiers with superior vision, thereby increasing the overall effectiveness of the military. And that became of prime importance to Japan beginning in 1914.

As World War I spread across Europe, Asia, and the Pacific, the Japanese army asked Ishihara to develop a better way to screen draftees for color vision problems. The most popular method at the time was the Stilling test, invented by German ophthalmologist Jakob Stilling in 1878 as the first clinical color vision test. (Previous tools had asked patients to identify the colors of wool skeins or illuminated lanterns—useful skills for sailors and railway conductors, but an imprecise method for diagnosing vision issues.)

"Though popular, 'the Stilling' retained a distinctly 19th-century flavor, more treatise-like and less diagnostically incisive," according to Eye magazine.


Shinobu Ishihara
Wellcome Images // CC BY 4.0

Japanese army officials requested a new diagnostic tool that was easier to administer and interpret. The test Ishihara began to develop was based, like Stilling's, on the principle of pseudo-isochromatism—a phenomenon in which two or more colors are seen as the same (or isochromatic) when they're actually different. A person with normal vision could easily see the difference, while people with red-green deficiency, the most common form of color blindness, would have difficulty distinguishing those two opposing colors. Those with blue-yellow color blindness, a less common type, would have a hard time discerning reds, greens, blues, or yellows.

Ishihara hand-painted circular designs comprised of small dots of different areas and colors so that variations in the design could be discerned only by color and not shape, size, or pattern. Hidden in the field of dots was a figure of a contrasting color that people with normal vision could see, while those with deficiencies could not. Other plates in the series were designed to show figures that would be visible only to people with deficiencies. When physicians displayed the diagrams, patients said or traced the visible figure within the circle without needing to use ambiguous color names, which standardized the possible results.

The earliest sets of Ishihara plates, produced in 1916, were reserved exclusively for the army's use and featured Japanese characters within the diagrams. In 1917, in an effort to sell the series internationally, Ishihara redesigned it with the now-familiar Arabic numerals and published a set of 16 plates as Tests for Colour Deficiency.

The tests were adopted throughout the world beginning in the early 1920s, and eventually grew into a set of 38 plates. But their popularity almost led to their undoing. Unauthorized publishers printed their own version of the plates to meet demand, throwing the accuracy of the diagnostic colors into doubt. "The plates have been duplicated along with an easily memorized key by cheap color processes in the tabloid press, and exposed in public places, reducing the fifth edition [of the collection] to a parlor game," one psychologist warned in the Journal of the Optical Society of America in 1943.

Despite those obstacles, the tests proved indispensable for both practicing physicians and researchers. Ishihara continued to refine the designs and improve the color accuracy of the images into the late 1950s, while he also served as the chair of the ophthalmology department and then dean of the medical school at Tokyo Imperial University. In addition to Tests for Colour Deficiency, he also published an atlas, textbook, lectures, and research studies on eye diseases. But he is remembered most for the iconic charts that seamlessly blend art and science.

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