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9 Up-Close Scientific Images from the Wellcome Image Awards

One winning image: A baby Hawaiian bobtail squid. Image Credit: Mark R Smith, Macroscopic Solutions

 
Each year, the Wellcome Image Awards highlight some of the most fascinating scientific images from around the world, as chosen by a panel of experts from the fields of science communications and medicine. The awards go to photographers and researchers who create “informative, striking and technically excellent images that communicate significant aspects of healthcare and biomedical science,” according to the Wellcome Trust, a biomedical research charity based in the UK. Here are nine of this year’s winning images:

ZEBRAFISH EYE AND NEUROMASTS

Ingrid Lekk and Steve Wilson, University College London

In this 4-day-old zebrafish embryo, a certain gene expressed in the lens of the eye and other parts of the visual system glows red when it’s activated. You can see the lens of the eye, the head, and neuromasts (those red dots around the rim of the image) glowing red, while the nervous system glows blue.

BLOOD VESSELS OF THE AFRICAN GREY PARROT

Scott Birch and Scott Echols

This image was created using a 3D reconstruction of a euthanized parrot. It models the system of blood vessels in the parrot’s head and neck down to the capillary level.

INTRAOCULAR LENS IRIS CLIP

Mark Bartley, Cambridge University Hospitals NHS Foundation Trust

Iris clips can treat nearsightedness, cataracts, and other eye issues. This photo shows an iris clip fitting on the eye of a 70-year-old patient. He regained nearly all his vision after the surgery.

BRAIN-ON-A-CHIP

Collin Edington and Iris Lee, Koch Institute at MIT

Researchers are developing ways to grow miniature organs on plastic chips in order to make drug testing more efficient. Instead of testing pharmaceuticals on people, scientists may one day test them on something like this—neural stem cells grown on a synthetic gel.

#BREASTCANCER TWITTER CONNECTIONS

Eric Clarke, Richard Arnett and Jane Burns, Royal College of Surgeons in Ireland

Here is a visualization of discussions on Twitter using the hashtag #breastcancer. Each dot represents a Twitter user, and its size is based on how many other dots (or nodes) it is connected to. Each line represents a relationship with another Twitter user, and the thicker the line, the more that relationship shows up in the data. This part of the visualization relates to trending data—one tweet retweeted thousands of times.

PIGEON THERMOREGULATION

Scott Echols, Scarlet Imaging and the Grey Parrot Anatomy Project

No, this isn’t just an avian parody of The Scream. It shows the network of blood vessels, visualized using technology created by the same researcher as the parrot image above, under the skin of a pigeon. This dense network allows pigeons to control their body temperatures.

MICRORNA SCAFFOLD CANCER THERAPY

João Conde, Nuria Oliva and Natalie Artzi, Massachusetts Institute of Technology (MIT)

Because microRNAs control the function and growth of cells, they have a lot of potential in cancer therapies. MIT researchers are working on a system that could deliver these short genetic sequences to cancerous cells. It consists of two microRNAs woven like a net with a synthetic polymer.

DEVELOPING SPINAL CORD

Gabriel Galea, University College London

This image shows a mouse’s neural tube, the structure from which the spinal cord develops. In each of the three images, the blue color draws attention to a specific tissue type. In the left image, the blue is the neural tube itself, which forms the brain and spine. In the middle, the blue is the mesoderm, which will become the inner organs. On the right, the blue shows the surface ectoderm that becomes hair, skin, and teeth.

All images courtesy the Wellcome Image Awards

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Karen Bleier, AFP/Getty Images
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Medicine
Bill and Melinda Gates Will Repay Nigeria's $76 Million Polio-Fighting Loan
Karen Bleier, AFP/Getty Images
Karen Bleier, AFP/Getty Images

Not long after announcing a $100 million donation to find a cure for Alzheimer's disease, Bill and Melinda Gates have agreed to pay off Japan's $76 million loan to Nigeria to stamp out polio, Quartz reports.

Polio has been eradicated in most countries around the world, but it's still present in Nigeria, as well as in Afghanistan and Pakistan. In 2008, according to The Conversation, Nigeria accounted for 86 percent of all polio cases in Africa. This high number was thanks in part to low immunization rates and calls from extremists to boycott polio vaccinations out of fear that they were tainted with anti-fertility steroids.

National and international campaigns were launched to lower polio rates in Nigeria, and in 2014 the nation received the loan from Japan to boost disease-fighting efforts. Progress has been made since then, with no new cases of polio reported in Nigeria in 2017. Two children had contracted polio in 2016, two years after Nigeria's last known case.

Nigeria's loan repayments to Japan were slated to begin in 2018. The Bill & Melinda Gates Foundation agreed to cover the costs after Nigeria met its goal of "achieving more than 80 percent vaccination coverage in at least one round each year in very high risk areas across 80 percent of the country's local government areas," Quartz reports. The loan will be repaid over the next 20 years.

While the Gates Foundation is lending a hand to Nigeria, the Associated Press reports that health officials in Pakistan's eastern Punjab province recently launched a new chapter in the nation's ongoing struggle against the disease. Health workers will engage in a week-long, door-to-door vaccination campaign, though efforts like this are risky due to threats from the Taliban and other militant groups, who view vaccinations as a Western conspiracy and believe they sterilize children. Anti-polio efforts in Pakistan also suffered after the CIA used vaccinations as a cover to get DNA samples from the Bin Laden compound.

[h/t Quartz]

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George Mayerle, U.S. National Library of Medicine // Public Domain
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Design
This 1907 Vision Test Was Designed for People of All Nationalities
George Mayerle, U.S. National Library of Medicine // Public Domain
George Mayerle, U.S. National Library of Medicine // Public Domain

At the turn of the 20th century, San Francisco was a diverse place. In fact, Angel Island Immigration Station, located on an island in the San Francisco Bay, was known as the “Ellis Island of the West,” processing some 300,000 people coming to the U.S. in the early 1900s. George Mayerle, a German optometrist working in the city at the time, encountered this diversity of languages and cultures every day in his practice. So in the 1890s, Mayerle created what was billed as “the only [eye] chart published that can be used by people of any nationality,” as The Public Domain Review alerts us.

Anticipating the difficulty immigrants, like those from China or Russia, would face when trying to read a vision test made solely with Roman letters for English-speaking readers, he designed a test that included multiple scripts. For his patients that were illiterate, he included symbols. It features two different styles of Roman scripts for English-speaking and European readers, and characters in Cyrillic, Hebrew, Japanese, and Chinese scripts as well as drawings of dogs, cats, and eyes designed to test the vision of children and others who couldn't read.

The chart, published in 1907 and measuring 22 inches by 28 inches, was double-sided, featuring black text on a white background on one side and white text on a black background on the other. According to Stephen P. Rice, an American studies professor at Ramapo College of New Jersey, there are other facets of the chart designed to test for a wide range of vision issues, including astigmatism and color vision.

As he explains in the 2012 history of the National Library of Medicine’s collections, Hidden Treasure [PDF], the worldly angle was partly a marketing strategy on Mayerle’s part. (He told fellow optometrists that the design “makes a good impression and convinces the patient of your professional expertness.”)

But that doesn’t make it a less valuable historical object. As Rice writes, “the ‘international’ chart is an artifact of an immigrant nation—produced by a German optician in a polyglot city where West met East (and which was then undergoing massive rebuilding after the 1906 earthquake)—and of a globalizing economy.”

These days, you probably won’t find a doctor who still uses Mayerle’s chart. But some century-old vision tests are still in use today. Shinobu Ishihara’s design for a visual test for colorblindness—those familiar circles filled with colored dots that form numbers in the center—were first sold internationally in 1917, and they remain the most popular way to identify deficiencies in color vision.

[h/t The Public Domain Review]

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