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Do Certain Sounds Enrage You? Neurologists May Know Why

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If the sound of a co-worker repeatedly clicking his pen can send you into a flaming furor, take heart: You’re not being hypersensitive, and you’re not alone. Neurologists in the UK have spotted physical differences in the brains of people with this sound-related rage, although whether these differences are the cause or the result of the disorder remains to be seen. The scientists published their findings in the journal Current Biology.

The technical term for that noise-triggered irritation and rage is misophonia (“hatred of sound”). People who have it experience uncontrollable and intense negative emotions after hearing certain repetitive noises like chewing, lip-smacking, pen-clicking, and foot-tapping.

It’s a relatively new concept within the medical community, although people have been complaining of symptoms for a long time. To those who’ve never experienced misophonia, it may sound silly or made-up—which is what many doctors have concluded. Others have categorized it as a form of anxiety or obsessive-compulsive disorder.

The authors of the current paper wondered if the problem might not be psychological but neurological. They recruited 20 British adults with misophonia and 22 without, and gave them all questionnaires to gauge their responses to various noises. Then they put each participant inside MRI and fMRI machines and played them all sorts of noises, including the benign (a kettle whistling, rain), the universally unpleasant (a baby crying, someone screaming), and common misophonia triggers (breathing, chewing).

As the researchers suspected, the results for the two groups looked very different. People with misophonia had more myelin, or insulation, around the gray matter in their prefrontal cortex. They also showed abnormal connections between this cortex and the anterior insular cortex, which is involved in processing information and emotions.

Hearing the trigger noises caused a spike in activity in both cortices for people with misophonia. For people without it, activity only increased in the prefrontal cortex. The trigger sounds also provoked a clear stress response in people with misophonia. Their heart rates increased and they began sweating.

Lead researcher Sukhbinder Kumar is a neuroscientist at Newcastle University and University College London. He says his team’s research should reassure people with misophonia and validate the condition’s existence to their doctors.

“Patients with misophonia had strikingly similar clinical features, and yet the syndrome is not recognized in any of the current clinical diagnostic schemes,” he said in a statement. “This study demonstrates the critical brain changes as further evidence to convince a skeptical medical community that this is a genuine disorder."

It also suggests a possible way of treating the condition. “My hope is to identify the brain signature of the trigger sounds,” Kumar said. “Those signatures can be used for treatment such as for neuro-feedback, for example, where people can self-regulate their reactions by looking at what kind of brain activity is being produced."

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technology
Man Buys Two Metric Tons of LEGO Bricks; Sorts Them Via Machine Learning
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Jacques Mattheij made a small, but awesome, mistake. He went on eBay one evening and bid on a bunch of bulk LEGO brick auctions, then went to sleep. Upon waking, he discovered that he was the high bidder on many, and was now the proud owner of two tons of LEGO bricks. (This is about 4400 pounds.) He wrote, "[L]esson 1: if you win almost all bids you are bidding too high."

Mattheij had noticed that bulk, unsorted bricks sell for something like €10/kilogram, whereas sets are roughly €40/kg and rare parts go for up to €100/kg. Much of the value of the bricks is in their sorting. If he could reduce the entropy of these bins of unsorted bricks, he could make a tidy profit. While many people do this work by hand, the problem is enormous—just the kind of challenge for a computer. Mattheij writes:

There are 38000+ shapes and there are 100+ possible shades of color (you can roughly tell how old someone is by asking them what lego colors they remember from their youth).

In the following months, Mattheij built a proof-of-concept sorting system using, of course, LEGO. He broke the problem down into a series of sub-problems (including "feeding LEGO reliably from a hopper is surprisingly hard," one of those facts of nature that will stymie even the best system design). After tinkering with the prototype at length, he expanded the system to a surprisingly complex system of conveyer belts (powered by a home treadmill), various pieces of cabinetry, and "copious quantities of crazy glue."

Here's a video showing the current system running at low speed:

The key part of the system was running the bricks past a camera paired with a computer running a neural net-based image classifier. That allows the computer (when sufficiently trained on brick images) to recognize bricks and thus categorize them by color, shape, or other parameters. Remember that as bricks pass by, they can be in any orientation, can be dirty, can even be stuck to other pieces. So having a flexible software system is key to recognizing—in a fraction of a second—what a given brick is, in order to sort it out. When a match is found, a jet of compressed air pops the piece off the conveyer belt and into a waiting bin.

After much experimentation, Mattheij rewrote the software (several times in fact) to accomplish a variety of basic tasks. At its core, the system takes images from a webcam and feeds them to a neural network to do the classification. Of course, the neural net needs to be "trained" by showing it lots of images, and telling it what those images represent. Mattheij's breakthrough was allowing the machine to effectively train itself, with guidance: Running pieces through allows the system to take its own photos, make a guess, and build on that guess. As long as Mattheij corrects the incorrect guesses, he ends up with a decent (and self-reinforcing) corpus of training data. As the machine continues running, it can rack up more training, allowing it to recognize a broad variety of pieces on the fly.

Here's another video, focusing on how the pieces move on conveyer belts (running at slow speed so puny humans can follow). You can also see the air jets in action:

In an email interview, Mattheij told Mental Floss that the system currently sorts LEGO bricks into more than 50 categories. It can also be run in a color-sorting mode to bin the parts across 12 color groups. (Thus at present you'd likely do a two-pass sort on the bricks: once for shape, then a separate pass for color.) He continues to refine the system, with a focus on making its recognition abilities faster. At some point down the line, he plans to make the software portion open source. You're on your own as far as building conveyer belts, bins, and so forth.

Check out Mattheij's writeup in two parts for more information. It starts with an overview of the story, followed up with a deep dive on the software. He's also tweeting about the project (among other things). And if you look around a bit, you'll find bulk LEGO brick auctions online—it's definitely a thing!

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Health
One Bite From This Tick Can Make You Allergic to Meat
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We like to believe that there’s no such thing as a bad organism, that every creature must have its place in the world. But ticks are really making that difficult. As if Lyme disease wasn't bad enough, scientists say some ticks carry a pathogen that causes a sudden and dangerous allergy to meat. Yes, meat.

The Lone Star tick (Amblyomma americanum) mostly looks like your average tick, with a tiny head and a big fat behind, except the adult female has a Texas-shaped spot on its back—thus the name.

Unlike other American ticks, the Lone Star feeds on humans at every stage of its life cycle. Even the larvae want our blood. You can’t get Lyme disease from the Lone Star tick, but you can get something even more mysterious: the inability to safely consume a bacon cheeseburger.

"The weird thing about [this reaction] is it can occur within three to 10 or 12 hours, so patients have no idea what prompted their allergic reactions," allergist Ronald Saff, of the Florida State University College of Medicine, told Business Insider.

What prompted them was STARI, or southern tick-associated rash illness. People with STARI may develop a circular rash like the one commonly seen in Lyme disease. They may feel achy, fatigued, and fevered. And their next meal could make them very, very sick.

Saff now sees at least one patient per week with STARI and a sensitivity to galactose-alpha-1, 3-galactose—more commonly known as alpha-gal—a sugar molecule found in mammal tissue like pork, beef, and lamb. Several hours after eating, patients’ immune systems overreact to alpha-gal, with symptoms ranging from an itchy rash to throat swelling.

Even worse, the more times a person is bitten, the more likely it becomes that they will develop this dangerous allergy.

The tick’s range currently covers the southern, eastern, and south-central U.S., but even that is changing. "We expect with warming temperatures, the tick is going to slowly make its way northward and westward and cause more problems than they're already causing," Saff said. We've already seen that occur with the deer ticks that cause Lyme disease, and 2017 is projected to be an especially bad year.

There’s so much we don’t understand about alpha-gal sensitivity. Scientists don’t know why it happens, how to treat it, or if it's permanent. All they can do is advise us to be vigilant and follow basic tick-avoidance practices.

[h/t Business Insider]

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