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Juan Carlos Izpisua Belmonte
Juan Carlos Izpisua Belmonte

Biologists Grow Human Cells Inside Pig Embryos

Juan Carlos Izpisua Belmonte
Juan Carlos Izpisua Belmonte

Let’s all take a deep breath. The lab-created “pig/human hybrid” being reported in the news this week is real, but it’s not quite the monster you might imagine. Researchers from the Salk Institute, who published their results in the journal Cell, have successfully coaxed human cells to grow inside pig embryos.

Chimeras (hybrid organisms) have always been a sticky issue both scientifically and ethically. Public opinion about this kind of science is hardly favorable, and the National Institutes of Health and other research bodies will not fund studies that involve the implantation of human stem cells into the eggs and embryos of other animals.

 

But many scientists, including the authors of the new paper, feel it’s important to keep doing it anyway. The first phase of the current research, which was funded by supporters of the Salk Institute, involved creating a cross between a rat and a mouse by implanting rat cells into mouse embryos. (Earlier this week, we reported on similar research in which scientists grew mouse organs inside rats, then transplanted them back into mice.) The researchers used gene editing to encourage those cells to develop into specific parts of the mice, including their eyes, hearts, or pancreata. They even coaxed the rat cells into becoming gallbladders—a very impressive feat, since rats don’t actually have gallbladders.

"This suggests that the reason a rat does not generate a gallbladder is not because it cannot,” co-author Jun Wu of the Salk Institute said in a statement, “but because the potential has been hidden by a rat-specific developmental program.”

Next, the team attempted to try the same technique with human cells and non-human animal hosts. They decided to use cows and pigs, since their organs are naturally similar in size to our own.

But rats and mice are much more closely related to each other than pigs and humans are, so the process proved much more complicated. Part of the difficulty involved timing: Pig embryos develop faster than humans do.

"It's as if the human cells were entering a freeway going faster than the normal freeway," said lead investigator Juan Carlos Izpisua Belmonte. "If you have different speeds, you will have accidents."

 

After four years of work by more than 40 people, the researchers achieved their goal. Human cells acclimated to pig embryos and grew inside them alongside the pigs’ own parts. The growth period was brief (3 to 4 weeks); the researchers cut the experiment short well before the embryos became piglets. They were not about to create actual ManBearpigs.

"The ultimate goal is to grow functional and transplantable tissue or organs, but we are far away from that," Izpisua Belmonte said. "This is an important first step."

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Anne Dirkse, Flickr // CC BY-SA 2.0
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Space
10 Astonishing Things You Should Know About the Milky Way
Anne Dirkse, Flickr // CC BY-SA 2.0
Anne Dirkse, Flickr // CC BY-SA 2.0

Our little star and the tiny planets that circle it are part of a galaxy called the Milky Way. Its name comes from the Greek galaxias kyklos ("milky circle") and Latin via lactea ("milky road"). Find a remote area in a national park, miles from the nearest street light, and you'll see exactly why the name makes sense and what all the fuss is about. Above is not a sky of black, but a luminous sea of whites, blues, greens, and tans. Here are a few things you might not know about our spiraling home in the universe.

1. THE MILKY WAY IS GIGANTIC.

The Milky Way galaxy is about 1,000,000,000,000,000,000 kilometers (about 621,371,000,000,000,000 miles) across. Even traveling at the speed of light, it would still take you well over 100,000 years to go from one end of the galaxy to the other. So it's big. Not quite as big as space itself, which is "vastly, hugely, mind-bogglingly big," as Douglas Adams wrote, but respectably large. And that's just one galaxy. Consider how many galaxies there are in the universe: One recent estimate says 2 trillion.

2. IT'S JAM-PACKED WITH CELESTIAL STUFF.

artist's illustration of the milky way galaxy and its center
An artist's concept of the Milky Way and the supermassive black hole Sagittarius A* at its core.
ESA–C. Carreau

The Milky Way is a barred spiral galaxy composed of an estimated 300 billion stars, along with dust, gas, and celestial phenomena such as nebulae, all of which orbits around a hub of sorts called the Galactic Center, with a supermassive black hole called Sagittarius A* (pronounced "A-star") at its core. The bar refers to the characteristic arrangement of stars at the interior of the galaxy, with interstellar gas essentially being channeled inward to feed an interstellar nursery. There are four spiral arms of the galaxy, with the Sun residing on the inner part of a minor arm called Orion. We're located in the boondocks of the Milky Way, but that is OK. There is definitely life here, but everywhere else is a question mark. For all we know, this might be the galactic Paris.

3. FOR A SPIRAL GALAXY, IT'S PRETTY TYPICAL …

If you looked at all the spiral galaxies in the local volume of the universe, the Milky Way wouldn't stand out as being much different than any other. "As galaxies go, the Milky Way is pretty ordinary for its type," Steve Majewski, a professor of astronomy at the University of Virginia and the principal investigator on the Apache Point Observatory Galactic Evolution Experiment (APOGEE), tells Mental Floss. "It's got a pretty regular form. It's got its usual complement of star clusters around it. It's got a supermassive black hole in the center, which most galaxies seem to indicate they have. From that point of view, the Milky Way is a pretty run-of-the-mill spiral galaxy."

4. …AND YET IT STANDS OUT AMONG ALL GALAXIES.

On the other hand, he tells Mental Floss, spiral galaxies in general tend to be larger than most other types of galaxies. "If you did a census of all the galaxies in the universe, the Milky Way would seem rather unusual because it is very big, our type being one of the biggest kinds of galaxies that there are in the universe." From a human perspective, the most important thing about the Milky Way is that it definitely managed to produce life. If they exist, the creatures in Andromeda, the galaxy next door (see #9), probably feel the same way about their own.

5. FIGURING OUT ITS STRUCTURE IS LIKE MARCHING IN A HALFTIME SHOW.


John McSporran, Flickr // CC BY 2.0

We have a very close-up view of the phenomena and forces at work in the Milky Way because we live inside of it, but that internal perspective places astronomers at a disadvantage when it comes to determining a galactic pattern. "We have a nice view of the Andromeda galaxy because we can see the whole thing laid out in front of us," says Majewski. "We don't have that opportunity in the Milky Way."

To figure out its structure, astronomers have to think like band members during a football halftime show. Though spectators in the stands can easily see the letters and shapes being made on the field by the marchers, the band can't see the shapes they are making. Rather, they can only work together in some coordinated way, moving to make these patterns and motions on the field. So it is with telescopes and stars.

6. WHEN DUST GETS IN OUR EYES, IT'S HARD TO SEE FAR.

Interstellar dust further stymies astronomers. "That dust blocks our light, our view of the more distant parts of the Milky Way," Majewski says. "There are areas of the galaxy that are relatively obscured from view because they are behind huge columns of dust that we can't see through in the optical wavelengths that our eyes work in." To ameliorate this problem, astronomers sometimes work in longer wavelengths such as radio or infrared, which lessen the effects of the dust.

7. THE MILKY WAY SPINS, BUT ITS SPEED DOESN'T ADD UP …

Astronomers can make pretty reasonable estimates of the mass of the galaxy by the amount of light they can see. They can count the galaxy's stars and calculate how much those stars should weigh. They can account for all the dust in the galaxy and all of the gas. And when they tally the mass of everything they can see, they find that it is far short of what is needed to account for the gravity that causes the Milky Way to spin.

In short, our Sun is about two-thirds of the way from the center of the galaxy, and astronomers know that it goes around the galaxy at about 144 miles per second. "If you calculate it based on the amount of matter interior to the orbit of the Sun, how fast we should be going around, the number you should get is around 150 or 160 kilometers [93–99 miles] per second," says Majewski. "Further out, the stars are rotating even faster than they should if you just account for what we call luminous matter. Clearly there is some other substance in the Milky Way exerting a gravitational effect. We call it dark matter."

8. … AND WE BLAME DARK MATTER FOR THAT.

Dark matter is a big problem in galactic studies. "In the Milky Way, we study it by looking at the orbits of stars and star clusters and satellite galaxies, and then trying to figure out how much mass do we need interior to the orbit of that thing to get it moving at the speed that we can measure," Majewski says. "And so by doing this kind of analysis for objects at different radii across the galaxy, we actually have a fairly good idea of the distribution of the dark matter in the Milky Way—and yet we still have no idea what the dark matter is."

9. THE MILKY WAY IS ON A COLLISION COURSE WITH ANDROMEDA. BUT DON'T PANIC.

andromeda galaxy
The Andromeda galaxy
ESA/Hubble & NASA

Sometime in the next 4 or 5 billion years, the Milky Way and Andromeda galaxies will smash into each other. The two galaxies are about the same size and have about the same number of stars, but there is no cause for alarm. "Even though there are 300 billion stars in our galaxy and a comparable number, or maybe more, in Andromeda, when they collide together, not a single star is expected to hit another star. The space between stars is that vast," says Majewski.

10. WE'RE THROWING EVERYTHING WE HAVE AT STUDYING IT.

There are countless spacecraft and telescopes studying the Milky Way. Most famous is the Hubble Space Telescope, while other space telescopes such as Chandra, Spitzer, and Kepler are also returning data to help astronomers unlock the mysteries of our swirling patch of stars. The next landmark telescope in development is NASA's James Webb Space Telescope. It should finally launch in 2019. Meanwhile, such ambitious projects as APOGEE are working out the structure and evolution of our spiral home by doing "galactic archaeology." APOGEE is a survey of the Milky Way using spectroscopy, measuring the chemical compositions of hundreds of thousands of stars across the galaxy in great detail. The properties of stars around us are fossil evidence of their formation, which, when combined with their ages, helps astronomers understand the timeline and evolution of the galaxy we call home. 

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science
What Pop Culture Gets Wrong About Dissociative Identity Disorder
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iStock

From the characters in Fight Club to Dr. Jekyll and Mr. Hyde, popular culture is filled with "split" personalities. These dramatic figures might be entertaining, but they're rarely (if ever) scientifically accurate, SciShow Psych's Hank Green explains in the channel's latest video. Most representations contribute to a collective misunderstanding of dissociative identity disorder, or DID, which was once known as multiple personality disorder.

Experts often disagree about DID's diagnostic criteria, what causes it, and in some cases, whether it exists at all. Many, however, agree that people with DID don't have multiple figures living inside their heads, all clamoring to take over their body at a moment's notice. Those with DID do have fragmented personalities, which can cause lapses of memory, psychological distress, and impaired daily function, among other side effects.

Learn more about DID (and what the media gets wrong about mental illness) by watching the video below.

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