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Scientists Have Found a Possible Cause of Severe PMS

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There’s no two ways about it: premenstrual syndrome (PMS) is awful. But for people with severe PMS (also known as premenstrual dysphoric disorder, or PMDD), “awful” is an understatement. Now scientists at the National Institutes of Health say they may have found the root of the problem: abnormal gene expression. They published their findings in the journal Molecular Psychiatry.

Experiencing PMDD symptoms is like having the volume turned up on the emotional elements of regular PMS. These extreme bouts of depression, anger, and anxiety can be so deep and persistent that they interfere with work or school, home, or relationships.

PMDD is not common; scientists estimate that it affects 2 to 5 percent of people who menstruate. But for those who have it, it can be disabling, and it sure would be nice to know what’s causing it.

Previous studies in the '90s concluded that people with PMDD appear to be hypersensitive to ordinary, menstrual-related fluctuations in steroid hormones like estrogen and progesterone. They still couldn’t tell us where this hypersensitivity came from, but they kept looking.

Fast-forward to 2015. Technology has advanced in ways that would have blown our minds 20 years ago. Behavioral endocrinologist Peter Schmidt, who led the earlier studies, teamed up with experts in neurogenetics and psychiatry to try a new approach.

They recruited 67 women between the ages of 18 and 48. Some of these women had been diagnosed with PMDD, while others said they had no trouble with severe PMS. One subgroup of participants with PMDD were given drugs that turned off their production of estrogen and progesterone. Their symptoms abated. When the researchers stopped the treatment, the women’s symptoms returned. These changes supported the theory that even normal changes in hormone levels could trigger big emotional changes for women with the condition. In other words, PMDD is quite literally PMS on steroids.

Next, the researchers extracted cell samples from 48 participants (24 with PMDD and 24 without) and sequenced their genetic code, looking for differences. They found them, all right: A large group of genes called the ESC/E(Z) complex was working overtime in women with PMDD. This makes a lot of sense, the researchers say, as the role of the ESC/E(Z) complex is to tell our genes how to respond to changes in our internal and external environment. Hypersensitivity there could definitely cause dramatic overreaction to hormonal changes.

The authors say these findings strike at the myth of the fragile, overly emotional woman. “This is a big moment for women’s health,” co-author and neurogeneticist David Goldman said in a statement. "It establishes that women with PMDD have an intrinsic difference in their molecular apparatus for response to sex hormones—not just emotional behaviors they should be able to voluntarily control.”

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Animals
Why Do Female Spotted Hyenas Give Birth Through Their Pseudo-Penises?
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At the zoo, you can sometimes tell the difference between male and female animals by noting their physical size, their behavior, and yes, their nether regions. Hyenas, however, flip the script: Not only are lady spotted hyenas bigger and meaner than their male counterparts, ruling the pack with an iron paw, they also sport what appear to be penises—shaft, scrotum, and all.

"Appear" is the key word here: These 7-inch-long phalluses don't produce sperm, so they're technically really long clitorises in disguise. But why do female hyenas have them? And do they actually have to (gulp) give birth through them? Wouldn't that hurt … a lot?

The short answers to these questions are, respectively, "We don't know," "Yes," and "OW." Longer answers can be found in this MinuteEarth video, which provides the full lowdown on hyena sex. Don't say we didn't warn you.

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science
Are Sex, Drugs, and Rock 'n' Roll Really Linked? Researchers Investigate
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Around the world, sex, drugs, and rock 'n' roll are said to go hand-in-hand. But do they? As PsyPost reports, a pair of Pennsylvania psychologists recently dove into the empirical evidence tying the three together, asking college students to talk about their drug use, sex lives, and music preferences and talents to suss out whether people who play and enjoy rock music really do have more active sex lives and drug use.

Published in the journal Human Ethnology Bulletin, the study [PDF] of 467 students relied on self-reporting, which isn't typically the most reliable evidence—people are wont to exaggerate how often they've had sex, for instance—but the survey also asked them about their desires, posing questions like "If you could, how frequently would you have sex?" It also asked about how often the students drank and what drugs they had tried in their lifetimes. They also described their musical experience and what kind of music they listened to.

The results were mixed, but the researchers identified a relationship between liking faster, "harder" music and having more sex and doing more drugs. Acoustic indie rock aficionados weren't getting quite as wild as heavy metal fans. High-tempo-music lovers were more likely to have taken hallucinogenic drugs like LSD, for example, and tended to have had more sexual partners in the previous year than people who favored slower types of music. According to the study, previous research has found that attention-seeking people are more likely to enjoy "hard" music.

The study didn't have a diverse enough group either in age or in ethnicity to really begin to make sweeping generalizations about humans, especially since college students (the participants were between 18 and 25) tend to engage in more risky behaviors in general. But this could lay the groundwork for future research into the topic. Until then, it might be more accurate to change the phrase to "sex, drugs, and heavy metal."

[h/t PsyPost]

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