7 Filtered Facts About the Unappreciated Spleen

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The human body is an amazing thing. For each one of us, it’s the most intimate object we know. And yet most of us don’t know enough about it: its features, functions, quirks, and mysteries. Our series The Body explores human anatomy part by part. Think of it as a mini digital encyclopedia with a dose of wow.

1. IT'S SHAPED LIKE A SHOE.

The spleen is shoe-shaped, and it’s the largest organ in the lymphatic system at a whopping 5 inches, weighing as much as 6 ounces. The organ is situated between the fundus of the stomach and the diaphragm, and connected by one little ligament to your left kidney, too.

2. IT'S A BLOOD FILTER.

Your spleen is in charge of filtering blood as it moves through your body to control the production of red blood cells. It also defines the donut-like shape of red blood cells, which must squeeze through an opening in the spleen known as the interendothelial slit. This reshapes the cells before they pass back into the blood stream—or, if they are old, misshapen, or diseased, blocks them from returning.  

3. IT'S A POWERHOUSE INFECTION FIGHTER.

As recently as 2009, researchers discovered that the spleen plays host to a special cache of immune cells called monocytes. If the human body suffers a serious trauma, such as a heart attack, wound, or big infection, the spleen sends those monocytes into the blood stream to fight off infection.

4. ITS LOCATION IS BOTH IDEAL AND DANGEROUS.

From Anatomy of the Human Body by Henry Gray via Wikimedia Commons // Public Domain

 
The spleen is neatly tucked up under the left side of the rib cage, where it’s protected by those lateral bones. But this also means a broken rib could pierce the fragile organ and rupture it. If the organ is breached, usually during a traumatic injury like a car accident, it has to be removed immediately. Because the spleen has so many blood vessels, a person would otherwise bleed to death.

5. YOU CAN LIVE WITHOUT IT.

Unlike, say, your stomach or lungs, the spleen is not considered a “vital” organ, which simply means that it can be surgically removed and you’ll be mostly fine, though potentially prone to more infections.

6. THERE HAVE BEEN SPLEEN TRANSPLANTS.

A handful of these procedures have been done with some success on humans to boost infection-fighting power, but they are rare, and are usually transplanted in patients who have already lost their own spleens.

7. NO ONE LIKES A SPLEENFUL PERSON.

In medieval times, people believed your spleen was the source of “morose feelings and bad temper.” The connotation entered into common speech (via Latin, splen)—no one would want to be around you if you were spleenful, though spleenless was a prized way to be. Today, the word spleen is still in Webster’s Dictionary meaning “feelings of ill-will or anger, often suppressed.”

10 Smart Facts About Your Gut

Colorized scanning electron micrograph of E. coli, a common gut bacteria
Colorized scanning electron micrograph of E. coli, a common gut bacteria
National Institute of Allergy and Infectious Diseases, Flickr // CC BY 2.0

Gut feelings get all the press, but your gut may be more of a thinker than you know. Some scientists now consider it a second brain. While it won’t necessarily help you study for an exam or get a promotion, your gut can influence the chemistry of your mood, emotions, immune system, and long-term health. Research even suggests the gut can “learn” new tricks through conditioning. These powerful connections are part an emerging field of science called neurogastroenterology designed to study the gut-brain link. Here are 10 facts you may not know about your gut.

1. THE GUT DOESN'T NEED THE BRAIN'S INPUT. 

You might think of your gut as a rebel against authority. It doesn’t wait for your brain’s impulses to do the important work of digestion, because it doesn’t need to—it acts as its own “brain.” No other organ, not even the all-powerful heart, can pull that off.

2. THERE ARE MORE THAN 100 MILLION BRAIN CELLS IN YOUR GUT.

Your gut’s power to think for itself is no surprise; there are millions of neurons in its lengthy coils (9 meters of intestines, from esophagus to anus). That’s more neurons than are found in the spinal cord or peripheral nervous system.

3. YOUR GUT HAS ITS OWN NERVOUS SYSTEM.

The enteric nervous system—the controlling mechanism of digestion and elimination—is the overlord of your gut, and functions all on its own. Some scientists see it as part of the central nervous system, while others consider it its own entity. It likely evolved to give the gut the go-ahead when the “got to go” impulse strikes, without requiring the brain’s sign-off, particularly when you consider the helplessness of an infant with its brand-new brain.

4. THERE'S AN INFORMATION HIGHWAY FROM YOUR GUT TO YOUR BRAIN.

There’s one big visceral nerve embedded in your gut—the vagus nerve. Research has revealed that up to 90 percent of its fibers carry information from the gut to the brain, rather than the other way around. In other words, the brain interprets gut signals as emotions. So you really should trust your gut.

5. MOST OF YOUR SEROTONIN IS IN YOUR GUT.

Some 95 percent of your body’s serotonin, that marvelous mood molecule that antidepressant drugs like Prozac keep in your body, can be found in the gut. So, it’s no wonder that diet, medications, and antibiotics can wreak havoc on one’s mood.

6. A HEALTHY GUT MAY PROTECT YOUR BONES.

In a study of the serotonin-gut relationship, scientists discovered an unexpected link between the gut and the bones. Inhibiting the gut’s release of serotonin counteracted the bone-density reduction of osteoporosis in mice. This research is going into studies on new osteoporosis-fighting drugs.

7. RESEARCH SHOWS LINKS BETWEEN AUTISM AND HAVING FEWER STRAINS OF GUT BACTERIA. 

In as many as nine out of 10 cases, autistic people have common gut imbalances such as leaky gut syndrome, irritable bowel syndrome, and fewer strains of “good” bacteria. Research on mice is looking at possible treatments of some of the behavioral disorders of autism by balancing microbes in the guts, though many warn that such treatments can’t produce a “cure” for autism.

8. FOOD REALLY DOES AFFECT YOUR MOOD. 

Different foods, when introduced to the gut via feeding tubes, have been shown to change a person's moods without the person’s awareness of what they were "eating." Fat, for instance, increased feelings of happiness and pleasure (no surprise there) because appeared to trigger the release of dopamine—the brain’s natural opiate. Carbohydrate consumption stimulated the release of serotonin, the “feel good” neurotransmitter.

9. YOUR GUT IS YOUR BEST FRIEND IN COLD AND FLU SEASON.

Not only does your gut hold brain cells, it also houses the bulk of your immune cells—70 percent—in the form of gut associated lymphoid tissue, or GALT, which plays a huge part in killing and expelling pathogens. GALT and your gut microbiome—the trillions of bacteria that live, like an immense microbial universe, in your gut—work hard to help you get over what ails you. That’s all the more reason to be careful with the use of antibiotics, which wipe out the good bacteria along with the bad.

10. YOUR GUT CAN BECOME ADDICTED TO OPIATES.

Inside your gut are opiate receptors, which are also found in the brain. The gut is just as susceptible to addiction as the brain and may contribute to the intense difficulty some addicts have trying to kick the habit.

What Causes Hiccups?

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iStock/damircudic

The cause of hiccups depends on whom you ask. The ancient Greek physician Galen thought hiccups were violent emotions erupting from the body, while others thought they were a sign of liver inflammation. Today, evidence points to spasms in the diaphragm, the large muscle between the chest and abdomen that aids airflow during breathing. This involuntary contraction can be brought on by a number of things that might irritate the nerves that control the movement of the muscle. A full stomach, heavy boozing, rapid shifts in temperature either inside or outside of the stomach, and certain emotions like shock or excitement are all common culprits.

No matter the cause, the result is the same: The diaphragm spasms and causes us to take a quick breath. The sudden rush of air causes the epiglottis (the flap that protects the space between the vocal cords) to shut and interrupt the breath, which makes the familiar "hic" sound.

WHAT CURES THEM?

The best cure for hiccups also depends on the person you ask. Almost all cures are based on one of two principles: One type works its magic by overwhelming the vagus nerve with another sensation. The vagus nerve is a cranial nerve that innervates the stomach and conveys sensory information about the body's organs to the brain. When distracted by overwhelming information of another sort, it basically tells the brain that something more important has come up and the hiccuping should probably be stopped (vagus nerve stimulation is also used to control seizures in epileptics and treat drug-resistant cases of clinical depression). The other method for curing hiccups is to interfere with the breathing, increasing the amount of carbon dioxide in the blood, and causing the body to focus on getting rid of the of the CO2 and not making hiccups.

Swallowing a spoonful of sugar is probably the most commonly prescribed hiccup cure and falls into the first category. A teaspoon of sugar is usually enough to stimulate the vagus nerve and make the body forget all about the hiccups. Even ardent supporters of the sugar cure disagree if the sugar should be taken dry or washed down with water, though.

If this home remedy doesn't work, and your hiccups are both severe and persistent, you may need to bring out the big guns. For chronic cases like this, doctors sometimes use a cocktail of Reglan (a gastrointestinal stimulant) and Thorazine (an anti-psychotic with sedative properties) to quiet things down. In some cases that resist these drugs, Kemstro, an anti-spasmodic, is also used. Other doctors have used vagus nerve stimulators implanted in the upper chest of patients. The pacemaker-like devices send rhythmic bursts of electricity through the vagus nerve to the brain to keep the hiccup cycle in check.

Many people prefer home remedies to battle their hiccups, which may include holding your breath, gargling ice water, or breathing into a paper bag. While the same people will swear by the treatment they've been using all these years, there's no firm scientific consensus that any of them actually work. But if it helps you, isn't that all that matters?

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

An earlier version of this article appeared in 2012.

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