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Harvard Medical School

Watch Bacteria Evolve to Become Antibiotic Resistant

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Harvard Medical School

Antibiotic resistance is one of the “biggest threats to global health today,” according to the World Health Organization, and as antibiotic use has become more widespread, bacteria are evolving to survive what used to be lethal doses of medicine. Now, you can view that evolution for yourself, as Gizmodo reports. The research is published in the latest issue of Science.

Researchers from Harvard Medical School and Technion-Israel Institute of Technology built a giant rectangular Petri dish—two-by-four-feet wide!—and dumped in 14 liters of agar, the jelly substance used to culture bacteria in the lab. They divided the Petri dish into sections, then watched as E. coli bacteria reacted to various doses of antibiotics in each part of the dish. The outermost section of the dish contained no antibiotics, the next just enough antibiotics to kill the bacteria, and so on. The highest dose of antibiotic administered (seen in the center of the dish) was 1000 times stronger than the lowest dose. Over the course of two weeks, scientists used a ceiling camera to watch as the bacteria adapted to their new environment, then turned the footage into a timelapse.

The bacteria could move through the sections of antibiotics, and as the bacteria reproduced and mutated, they moved into higher and higher dosed sections. The high doses of antibiotic initially killed many of the bacteria, but some microorganisms that started out in the lower doses of antibiotics mutated and evolved, allowing their descendants to survive more and more of the drug. After 10 days, some of the bacteria had evolved to survive the highest dose of antibiotics.

While Petri dishes aren’t an exact analog for the way bacteria evolve in real-life settings like hospitals, the visualization provides a scary glimpse into how bacteria can mutate to confound modern drugs. Watch it below, and remember: Take antibiotics only as prescribed, and skip the antibacterial soaps entirely! (They'll be banned soon anyway.)

[h/t Gizmodo]

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Big Questions
What Is the Difference Between Generic and Name Brand Ibuprofen?
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What is the difference between generic ibuprofen vs. name brands?

Yali Friedman:

I just published a paper that answers this question: Are Generic Drugs Less Safe than their Branded Equivalents?

Here’s the tl;dr version:

Generic drugs are versions of drugs made by companies other than the company which originally developed the drug.

To gain FDA approval, a generic drug must:

  • Contain the same active ingredients as the innovator drug (inactive ingredients may vary)
  • Be identical in strength, dosage form, and route of administration
  • Have the same use indications
  • Be bioequivalent
  • Meet the same batch requirements for identity, strength, purity, and quality
  • Be manufactured under the same strict standards of FDA's good manufacturing practice regulations required for innovator products

I hope you found this answer useful. Feel free to reach out at www.thinkbiotech.com. For more on generic drugs, you can see our resources and whitepapers at Pharmaceutical strategic guidance and whitepapers

This post originally appeared on Quora. Click here to view.

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science
2017 Ig Nobel Prizes Celebrate Research on How Crocodiles Affect Gambling and Other Odd Studies
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The Ig Nobel Prizes are back, and this year's winning selection of odd scientific research topics is as weird as ever. As The Guardian reports, the 27th annual awards of highly improbable studies "that first make people laugh, then make them think" were handed out on September 14 at a theater at Harvard University. The awards, sponsored by the Annals of Improbable Research, honor research you never would have thought someone would take the time (or the funding) to study, much less would be published.

The 2017 highlights include a study on whether cats can be both a liquid and a solid at the same time and one on whether the presence of a live crocodile can impact the behavior of gamblers. Below, we present the winners from each of the 10 categories, each weirder and more delightful than the last.

PHYSICS

"For using fluid dynamics to probe the question 'Can a Cat Be Both a Solid and a Liquid?'"

Winner: Marc-Antoine Fardin

Study: "On the Rheology of Cats," published in Rheology Bulletin [PDF]

ECONOMICS

"For their experiments to see how contact with a live crocodile affects a person's willingness to gamble."

Winners: Matthew J. Rockloff and Nancy Greer

Study: "Never Smile at a Crocodile: Betting on Electronic Gaming Machines is Intensified by Reptile-Induced Arousal," published in the Journal of Gambling Studies

ANATOMY

"For his medical research study 'Why Do Old Men Have Big Ears?'"

Winner: James A. Heathcote

Study: "Why Do Old Men Have Big Ears?" published in the BMJ

BIOLOGY

"For their discovery of a female penis, and a male vagina, in a cave insect."

Winners: Kazunori Yoshizawa, Rodrigo L. Ferreira, Yoshitaka Kamimura, and Charles Lienhard (who delivered their acceptance speech via video from inside a cave)

Study: "Female Penis, Male Vagina and Their Correlated Evolution in a Cave Insect," published in Current Biology

FLUID DYNAMICS

"For studying the dynamics of liquid-sloshing, to learn what happens when a person walks backwards while carrying a cup of coffee."

Winner: Jiwon Han

Study: "A Study on the Coffee Spilling Phenomena in the Low Impulse Regime," published in Achievements in the Life Sciences

NUTRITION

"For the first scientific report of human blood in the diet of the hairy-legged vampire bat."

Winners: Fernanda Ito, Enrico Bernard, and Rodrigo A. Torres

Study: "What is for Dinner? First Report of Human Blood in the Diet of the Hairy-Legged Vampire Bat Diphylla ecaudata," published in Acta Chiropterologica

MEDICINE

"For using advanced brain-scanning technology to measure the extent to which some people are disgusted by cheese."

Winners: Jean-Pierre Royet, David Meunier, Nicolas Torquet, Anne-Marie Mouly, and Tao Jiang

Study: "The Neural Bases of Disgust for Cheese: An fMRI Study," published in Frontiers in Human Neuroscience

COGNITION

"For demonstrating that many identical twins cannot tell themselves apart visually."

Winners: Matteo Martini, Ilaria Bufalari, Maria Antonietta Stazi, and Salvatore Maria Aglioti

Study: "Is That Me or My Twin? Lack of Self-Face Recognition Advantage in Identical Twins," published in PLOS One

OBSTETRICS

"For showing that a developing human fetus responds more strongly to music that is played electromechanically inside the mother's vagina than to music that is played electromechanically on the mother's belly."

Winners: Marisa López-Teijón, Álex García-Faura, Alberto Prats-Galino, and Luis Pallarés Aniorte

Study: "Fetal Facial Expression in Response to Intravaginal Music Emission,” published in Ultrasound

PEACE PRIZE

"For demonstrating that regular playing of a didgeridoo is an effective treatment for obstructive sleep apnoea and snoring."

Winners: Milo A. Puhan, Alex Suarez, Christian Lo Cascio, Alfred Zahn, Markus Heitz, and Otto Braendli

Study: "Didgeridoo Playing as Alternative Treatment for Obstructive Sleep Apnoea Syndrome: Randomised Controlled Trial," published by the BMJ

Congratulations, all.

[h/t The Guardian]

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