15 Facts About Rosalind Franklin

Robin Stott, via Flickr // CC BY-SA 2.0
Robin Stott, via Flickr // CC BY-SA 2.0

Today would have been the 98th birthday of English chemist Rosalind Franklin, a brilliant and dedicated scientist best known for the honor denied her: the 1962 Nobel Prize for discovering the structure of DNA. Here are 15 facts about her.

1. SHE KNEW HER CALLING EARLY, BUT HER FATHER RESISTED EDUCATING A DAUGHTER.

Rosalind Elsie Franklin was born in London in 1920. She was one of five children born into a wealthy Jewish family. She decided she wanted to become a scientist at 15, and passed the admissions exam for Cambridge University. However, her father, Ellis, a merchant banker, objected to women going to college and refused to pay her tuition. Her aunt and mother finally managed to change his mind, and she enrolled at Cambridge's all-female Newnham College in 1938.

2. SHE ATTENDED COLLEGE WITH ANOTHER WOMAN WHO DIDN'T GET FULL CREDIT FOR HER WORK.

Bletchley Park cryptanalyst Joan Clarke was a few years older than Franklin, but they were both at Newnham in the late 1930s. Clarke would go on to be recruited for the war effort, cracking the German Enigma codes. The full scope of Clarke's work is still unknown, due to government secrecy.

3. HER SCHOLASTIC ACHIEVEMENTS WERE DENIED BY HER UNIVERSITY FOR YEARS.

Newnham College, Cambridge
Azeira, Wikimedia Commons // Public Domain

Despite Newnham College having been at Cambridge since 1871, the university refused to accept women as full members until 1948, seven years after Franklin earned the title of a degree in chemistry. Oxford University started granting women's degrees in 1920.

4. HER RESEARCH ON COAL HELPED THE AEROSPACE INDUSTRY.

After graduation, Franklin got a job at the British Coal Utilization Research Association (BCURA), where she researched coal and charcoal, and how it could be used for more than fuel. Her research formed the basis for her 1945 doctoral dissertation; it and several of her later papers on the micro-structures of carbon fibers played a role in the eventual use of carbon composites in air- and spacecraft construction.

5. HER MALE COLLEAGUES WERE HOSTILE AND UNDERMINED HER RESEARCH.

Franklin had a direct nature and was unwilling to be traditionally feminine. One reason she left Cambridge to work on coal was that her doctoral supervisor did not like her and believed women would always be less than men. When she was hired in 1951 at King's College, London, to work on DNA, she clashed with researcher Maurice Wilkins, who had thought she was his assistant, not his equal. Meanwhile, Franklin was under the impression that she'd be completely independent. Their relationship got worse and worse the longer they worked together. Wilkins went so far as to share Franklin's research without telling her with James Watson and Francis Crick—even though they were technically his competitors, funded by Cambridge University. Watson was particularly nasty about Franklin in his 1968 book, The Double Helix, criticizing her appearance and saying she had to be “put in her place.”

6. HOW EVENTS UNFOLDED IN THE DISCOVERY OF DNA'S STRUCTURE IS STILL DEBATED TODAY.

Double helix of DNA
Altayb, iStock

Many books have been written hashing over events, either criticizing Watson and Crick, saying they stole Franklin's research, or defending the duo, saying her research helped them but that Franklin would not ultimately have reached their conclusions on her own. Though Franklin and Watson never became friendly, Crick and his wife welcomed Franklin into their home while she was being treated for ovarian cancer.

7. HER WORK MAY HAVE LED TO HER UNTIMELY DEATH.

Franklin died of cancer in 1958. She was 37. Though genetics likely played a part in her illness, her work with crystal x-ray diffraction, which involved constant exposure to radiation, did not help. She is not the first woman in science to risk her health for her research. Marie Curie died from aplastic anemia, which has been tied to radiation exposure. Many of Curie's personal belongings, including her cookbooks, are too radioactive to handle even today.

8. HAD SHE LIVED LONGER, SHE MAY HAVE QUALIFIED FOR MORE THAN ONE NOBEL PRIZE.


Maurice Wilkins (on left), Francis Crick (third from left), and James Watson (fifth from left) accept their Nobel Prize in 1962.
Keystone, Getty Images

The first, of course, would have been awarded with Watson, Crick, and Wilkins, had they been made to share credit with her. (Pierre Curie had to ask the Nobel Committee to add his wife to the nomination in 1903.) As for the second, chemist Aaron Klug won the prize in 1982, carrying on work he and Franklin had started on viruses in 1953, after she left King's College. Because of the rules at the time of her death about awarding prizes posthumously (and in 1974 all posthumous awards were eliminated, the sole exception being in 2011), Franklin has none.

9. DESPITE BEING DENIED HER PRIZE, SHE'S BEEN HONORED BY MANY ACADEMICS.

In 2004, the Chicago Medical School renamed itself the Rosalind Franklin University of Medicine and Science. She has also had a number of academic programs, auditoriums, and labs named for her. In 2013, Newnham College principal Dame Carol Black helped install a plaque commemorating Franklin at the Eagle Pub in Cambridge. Crick and Watson, who already had a plaque in the pub, drank there often while working on the DNA project, and allegedly boasted about discovering “the secret of life” to other patrons.

10. SHE IS THE SUBJECT OF SEVERAL BIOGRAPHIES.

The first, 1975's Rosalind Franklin and DNA, was written by her friend Anne Sayre, largely as a reaction to Watson's The Double Helix. In 2002, Brenda Maddox published Rosalind Franklin: The Dark Lady of DNA.

11. AN OBJECT IN SPACE IS NAMED AFTER HER.

In 1997, amateur Australian astronomer John Broughton discovered an asteroid, which he named 9241 Rosfranklin.

12. AT LEAST ONE HISTORY RAP BATTLE IS ABOUT HER.

It was produced by seventh graders in Oakland, California (with some help from teacher Tom McFadden). And it is delightful.

13. SHE HAS BEEN IMMORTALIZED ON THE SMALL SCREEN AND THE BIG STAGE.

In 1987, BBC's Horizon series aired The Race for the Double Helix, starring Juliet Stevenson as Franklin. Jeff Goldblum played Watson. In 2011, playwright Anna Ziegler premiered a one-act about Franklin called Photograph 51. It opened on the West End in 2015, starring Nicole Kidman as Franklin.

14. THE 2015 RUN OF PHOTOGRAPH 51 RE-IGNITED THE OLD CONTROVERSY.

While Kidman got much praise from critics for her turn as Franklin in Photograph 51, Maurice Wilkins' friends and former colleagues have taken exception to a scene where Wilkins takes a photograph—the titular Photo 51, which showed evidence of DNA's structure—from Franklin's desk when she isn't there, saying he would never have done something so dishonorable.

15. THE PLAY MAY COME TO THE BIG SCREEN IN THE NEXT FEW YEARS.

In 2016, the West End production's director, Michael Grandage, told The Hollywood Reporter that he hopes to turn the play into a film—with Kidman reprising the role.

Alcohol-Producing Gut Bacteria May Harm Livers—Even if You Don't Drink

itakdalee/iStock via Getty Images
itakdalee/iStock via Getty Images

Teetotalers might think their liver is safe from the damaging effects of alcohol consumption, but new research is hinting that even non-drinkers and light drinkers might have cause for concern. It turns out a type of gut bacteria is capable of producing alcohol—and enough of it to potentially cause some pretty serious health consequences, including liver disease.

A study led by Jing Yuan at the Capital Institute of Pediatrics in Beijing, China and published in the journal Cell Metabolism offers details. After evaluating a patient with auto-brewery syndrome (ABS), a rare condition brought on by consumption and fermentation of sugary foods that leaves a person with high blood alcohol levels, researchers made an intriguing discovery. Rather than finding fermenting yeast that may have led to the condition, the patient’s stool contained Klebsiella pneumonia, a common gut bacteria capable of producing alcohol. In this subject, K. pneumonia was producing significantly more alcohol than in healthy patients.

The patient also had nonalcoholic fatty liver disease (NAFLD), characterized by fatty deposits in the liver. While many cases of NAFLD are relatively benign, too much fat can become toxic. Examining 43 other subjects with NAFLD, scientists found that that K. pneumonia was both present and potent, pumping out more alcohol than normal in 60 percent of participants with NAFLD. In the control group, a surplus was found in only 6.25 percent.

To further observe a correlation, scientists fed the bacteria to healthy, germ-free mice, who began to see an increase in fat in their livers after only one month. While not conclusive proof that the bacteria prompts NAFLD, it will likely trigger additional research in humans.

It’s not yet known how K. pneumonia acts in concert with the bacterial profile of the gut or what might make someone carrying stronger strains of the bacteria. Luckily, K. pneumonia can be treated with antibiotics. That’s good news for people who might never touch a drink and still find themselves with a damaged liver.

[h/t Live Science]

5 Hilarious Discoveries from the 2019 Ig Nobel Prize Winners

andriano_cz/iStock via Getty Images
andriano_cz/iStock via Getty Images

Each September, the Ig Nobel Prizes (a play on the word ignoble) are given out to scientists who have wowed the world with their eccentric, imaginative achievements. Though the experiments are usually scientifically sound and the results are sometimes truly illuminating, that doesn’t make them any less hilarious. From postal workers’ scrotal temperatures to cube-shaped poop, here are our top five takeaways from this year’s award-winning studies.

1. Left and right scrota often differ in temperature, whether you’re naked or not.

Roger Mieusset and Bourras Bengoudifa were awarded the anatomy prize for testing the scrotum temperatures in clothed and naked men in various positions. They found that in some postal workers, bus drivers, and other clothed civilians, the left scrotum is warmer than the right, while in some naked civilians, the opposite is true. They suggest that this discrepancy may contribute to asymmetry in the shape and size of male external genitalia.

2. 5-year-old children produce about half a liter of saliva per day.

Shigeru Watanabe and his team nabbed the chemistry prize for tracking the eating and sleeping habits of 15 boys and 15 girls to discover that, regardless of gender, they each produce about 500 milliliters of spit per day. Children have lower salivary flow rates than adults, and they also sleep longer (we produce virtually no saliva when we sleep), so it seems like they may generate much less saliva than adults. However, since children also spend more time eating than adults (when the most saliva is produced), the average daily levels are about even—at least, according to one of Watanabe’s previous studies on adult saliva.

3. Scratching an ankle itch feels even better than scratching other itches.

Ghada A. bin Saif, A.D.P. Papoiu, and their colleagues used cowhage (a plant known to make people itchy) to induce itches on the forearms, ankles, and backs of 18 participants, whom they then asked to rate both the intensity of the itch and the pleasure derived from scratching it. Subjects felt ankle and back itches more intensely than those on their forearms, and they also rated ankle and back scratches higher on the pleasure scale. While pleasure levels dropped off for back and forearm itches as they were scratched, the same wasn’t true for ankle itches—participants still rated pleasurability higher even while the itchy feeling subsided. Perhaps because there’s no peace quite like that of scratching a good itch, the scientists won the Ig Nobel peace prize for their work.

4. Elastic intestines help wombats create their famous cubed poop.

In the final 8 percent of a wombat’s intestine, feces transform from a liquid-like state into a series of small, solid cubes. Patricia Yang, David Hu, and their team inflated the intestines of two dead wombats with long balloons to discover that this formation is caused by the elastic quality of the intestinal wall, which stretches at certain angles to form cubes. For solving the mystery, Yang and Hu took home the physics award for the second time—they also won in 2015 for testing the theory that all mammals can empty their bladders in about 21 seconds.

5. Romanian money grows bacteria better than other money.

Habip Gedik and father-and-son pair Timothy and Andreas Voss earned the economics prize by growing drug-resistant bacteria on the euro, U.S. dollar, Canadian dollar, Croatian luna, Romanian leu, Moroccan dirham, and Indian rupee. The Romanian leu was the only one to yield all three types of bacteria tested—Staphylococcus aureus, Escherichia coli, and Vancomycin-resistant Enterococci. The Croatian luna produced none, and the other banknotes each produced one. The results suggest that the Romanian leu was most susceptible to bacteria growth because it was the only banknote in the experiment made from polymers rather than textile-based fibers.

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