Jeff Kern via Wikimedia Commons // CC BY 2.0
Jeff Kern via Wikimedia Commons // CC BY 2.0

Retired Soccer Player Brandi Chastain Plans to Donate Her Brain to Science

Jeff Kern via Wikimedia Commons // CC BY 2.0
Jeff Kern via Wikimedia Commons // CC BY 2.0

As the conversation around traumatic brain injury (TBI) continues, more and more professional athletes have come forward to share their concerns and offer their bodies for research. Today, The New York Times reported that retired soccer star Brandi Chastain has arranged to donate her brain to science after she dies in order to further research into a form of TBI called chronic traumatic encephalopathy (CTE). 

CTE is a progressive, degenerative brain disease caused by repeated blows to the head. It was originally known as dementia pugilistica, or boxers’ dementia, for its prevalence among professional fighters. Like other forms of TBI, CTE can cause memory loss, confusion, impaired judgment, aggression, and, eventually, progressive dementia. There's currently only one reliable way to diagnose CTE: a postmortem brain examination.

In the United States, at least, the TBI discussion has recently been dominated by its effects on professional football players. But CTE can affect players of any contact sport, and scientists say that soccer players of all ages put themselves at risk by heading the ball. 

With both professional and youth sports on the line, researchers have ramped up their efforts to pinpoint the precise causes—and possible prevention of—CTE and other forms of TBI. But like so much research, there’s a huge gender imbalance in the study subjects. As The New York Times noted, Boston University CTE researchers have examined 307 brains, and only seven of those belonged to women. 

So Chastain decided to step up. At 47, the soccer star and youth coach has no plans to die anytime soon, but she’s glad to make the arrangements now. “People talk about what the '99 group did for women’s soccer,” she told The New York Times, referring to the 1999 World Cup win by the U.S. women's national soccer team. “They say, 'Oh, you left a legacy for the next generation.' This would be a more substantial legacy—something that could protect and save some kids, and to enhance and lift up soccer in a way that it hasn’t before.” 

Chastain is the second national women's soccer team player to decide to donate her brain; the first was Cindy Parlow Cone. Both brains will eventually go to a brain bank jointly run by the Concussion Legacy Foundation, the U.S. Department of Veterans Affairs, and the Boston University School of Medicine, the Washington Post reports.

Now Chastain intends to persuade some of her former teammates to do the same. “I’m trying to get [Abby Wambach] to come onboard because I think she will be an interesting brain study, decades from now, as the player who scored 75 goals with her head and probably put her head into places, like Michelle Akers, where they probably didn’t belong. How many times did she hit her head on the ground after being run over by somebody?” 

Learning about the research on CTE has convinced Chastain that heading the ball is a bad idea—especially for children. “My teams, my young team, U-10 Santa Clara Sporting, will not be heading the ball,” she told The New York Times. "And if it means giving up a goal, that’s O.K. Or we don’t score one, no problem.”

[h/t The New York Times]

Jamie McCarthy/Getty Images for Bill & Melinda Gates Foundation
Bill Gates is Spending $100 Million to Find a Cure for Alzheimer's
Jamie McCarthy/Getty Images for Bill & Melinda Gates Foundation
Jamie McCarthy/Getty Images for Bill & Melinda Gates Foundation

Not everyone who's blessed with a long life will remember it. Individuals who live into their mid-80s have a nearly 50 percent chance of developing Alzheimer's, and scientists still haven't discovered any groundbreaking treatments for the neurodegenerative disease [PDF]. To pave the way for a cure, Microsoft co-founder and philanthropist Bill Gates has announced that he's donating $100 million to dementia research, according to Newsweek.

On his blog, Gates explained that Alzheimer's disease places a financial burden on both families and healthcare systems alike. "This is something that governments all over the world need to be thinking about," he wrote, "including in low- and middle-income countries where life expectancies are catching up to the global average and the number of people with dementia is on the rise."

Gates's interest in Alzheimer's is both pragmatic and personal. "This is something I know a lot about, because men in my family have suffered from Alzheimer’s," he said. "I know how awful it is to watch people you love struggle as the disease robs them of their mental capacity, and there is nothing you can do about it. It feels a lot like you're experiencing a gradual death of the person that you knew."

Experts still haven't figured out quite what causes Alzheimer's, how it progresses, and why certain people are more prone to it than others. Gates believes that important breakthroughs will occur if scientists can understand the condition's etiology (or cause), create better drugs, develop techniques for early detection and diagnosis, and make it easier for patients to enroll in clinical trials, he said.

Gates plans to donate $50 million to the Dementia Discovery Fund, a venture capital fund that supports Alzheimer's research and treatment developments. The rest will go to research startups, Reuters reports.

[h/t Newsweek]

A New Analysis of Chopin's Heart Reveals the Cause of His Death

For years, experts and music lovers alike have speculated over what caused celebrated composer Frederic Chopin to die at the tragically young age of 39. Following a recent examination of his heart, Polish scientists have concluded that Chopin succumbed to tuberculosis, just as his death certificate states, according to The New York Times.

When Chopin died in 1849, his body was buried in Paris, where he had lived, while his heart was transported to his home city of Warsaw, Poland. Chopin—who appeared to have been ill with tuberculosis (TB)—was terrified of the prospect of being buried alive, and nostalgic for his national roots. He asked for his heart to be cut out, and his sister later smuggled it past foreign guards and into what is now Poland.

Preserved in alcohol—likely cognac—and stored in a crystal jar, Chopin's heart was laid to rest inside Holy Cross Church in Warsaw. (It was removed by the Germans in 1944 during the Warsaw Uprising, and later returned.) But rumors began to swirl, as the same doctor tasked with removing the heart had also conducted an autopsy on the composer's body, according to the BBC.

The physician's original notes have been lost, but it's said he concluded that Chopin had died not from TB but from "a disease not previously encountered." This triggered some scholars to theorize that Chopin had died from cystic fibrosis, or even a form of emphysema, as the sickly musician suffered from chronic respiratory issues. Another suspected condition was mitral stenosis, or a narrowing of the heart valves.

Adhering to the wishes of a living relative, the Polish church and government have refused to let scientists conduct genetic tests on Chopin's heart. But over the years, teams have periodically checked up on the organ to ensure it remains in good condition, including once in 1945.

In 2014, a group of Chopin enthusiasts—including Polish scientists, religious officials, and members of the Chopin Institute, which researches and promotes Chopin's legacy—were given the go-ahead to hold a clandestine evening meeting at Holy Cross Church. There, they removed Chopin's heart from its perch inside a stone pillar to inspect it for the first time in nearly 70 years.

Fearing the jar's alcohol would evaporate, the group added hot wax to its seal and took more than 1000 photos of its contents. Pictures of the surreptitious evening procedure weren't publicly released, but were shown to the AP, which described Chopin's preserved heart as "an enlarged white lump."

It's unclear what prompted a follow-up investigation on Chopin's heart, or who allowed it, but an early version of an article in the American Journal of Medicine states that experts—who did not open the jar—have newly observed that the famed organ is "massively enlarged and floppy," with lesions and a white, frosted appearance. These observations have prompted them to diagnose the musician's cause of death as pericarditis, which is an inflammation of tissue around the heart. This likely stemmed from his tuberculosis, they said.

Some scientists might still clamor at the prospect of testing tissue samples of Chopin's heart. But Michael Witt of the Polish Academy of Sciences—who was involved in this latest examination—told The Guardian that it was unnecessary to disturb what many consider to be a symbol of national pride.

"Some people still want to open it in order to take tissue samples to do DNA tests to support their ideas that Chopin had some kind of genetic condition," Witt said. "That would be absolutely wrong. It could destroy the heart, and in any case, I am quite sure we now know what killed Chopin."

[h/t The New York Times]


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