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The Key to Cancer Prevention May Lie Within Elephants

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The old adage “an elephant never forgets” might be a bit of an exaggeration, but something that an elephant is actually unlikely to do is to die of cancer. According to an estimate by pediatric oncologist Joshua Schiffman of the University of Utah, less than 5 percent of elephants will die of cancer—a significantly lower percentage than the 11 to 25 percent of humans who will succumb to the disease. And it all has to do with the pachyderms' genes. Two newly published studies by different teams of researchers found that elephants have multiple copies of the tumor protein 53 gene (TP53), which regulates cell division and may be saving the large mammals from deadly cancers.

The first study, published by Schiffman and colleagues in the Journal of the American Medical Association, examined necropsy data from 36 mammalian species of all sizes, from the rock hyrax to Asian and African elephants. The researchers found that cancer mortality did not increase with body size or maximum life span, and that while humans have one copy of the tumor suppressor TP53 gene, African elephants have at least 20. 

The team also subjected white blood cells from the elephants to treatments that damage DNA; such damage is a cancer trigger. The cells reacted to the damage with a "characteristic p53-mediated response": they killed themselves, a process of programmed cell death called apoptosis.

"It's as if the elephants said, 'It's so important that we don't get cancer, we're going to kill this cell and start over fresh," Schiffman said in a press statement. "If you kill the damaged cell, it's gone, and it can't turn into cancer. This may be more effective of an approach to cancer prevention than trying to stop a mutated cell from dividing and not being able to completely repair itself."

He added: "We think that making more p53 is nature's way of keeping this species alive."

Researchers conducting the second study, which was published in bioRxiv, came to the same conclusion about elephants and the TP53 gene. They also suggest that “an increase in the copy number of TP53 may have played a direct role in the evolution of very large body sizes and the resolution of Peto's paradox in Proboscideans.” Proboscidea is a taxonomic order of mammals that includes elephants, and Peto’s paradox, which is mentioned in both studies, is the observation by epidemiologist Richard Peto that cancer risk is not directly correlated to the number of cells in a body.

Schiffman told New Scientist that the results of the study could hold promise for the future of cancer prevention and treatment in humans. “Evolution has had 55 million years to figure out how to avoid cancer," he said. "Now I think it’s up to us to take a page out of nature’s playbook and learn how to take this information and apply it to those who need it most.”

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Animals
25 Benefits of Adopting a Rescue Dog
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According to the ASPCA, 3.3 million dogs enter shelters each year in the United States. Although that number has gone down since 2011 (from 3.9 million) there are still millions of dogs waiting in shelters for a forever home. October is Adopt a Shelter Dog Month; here are 25 benefits of adopting a shelter dog.

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Brooklyn Museum, Charles Edwin Wilbour Fund, 37.406E
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Art
New Smithsonian Exhibit Explains Why Felines Were the Cat's Meow in Ancient Egypt
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Brooklyn Museum, Charles Edwin Wilbour Fund, 37.406E

From bi-coastal cat cafes to celebrity pets like Lil Bub, felines are currently enjoying a peak moment in popular culture. That’s part of the reason why curators at the Smithsonian’s Arthur M. Sackler Gallery—which will re-open to visitors on Saturday, October 14, following a 3-month closure—decided to dedicate a new exhibition to ancient Egypt’s relationship with the animals.

Divine Felines: Cats of Ancient Egypt” looks at the cultural and religious importance of cats, which the Egyptians appreciated long before YouTube was a thing and #caturday was a hashtag. It's based on a traveling exhibition that began at the Brooklyn Museum in New York City. On view until January 15, 2018, it's one of several exhibits that will kick off the grand reopening of the Smithsonian’s Freer and Sackler galleries, the conjoined national museums of Asian and Middle Eastern Art.

The Freer has been closed since January 2016 for major renovations, and the Sackler since July 2016 for minor ones. The upgraded institutions will make their public debut on October 14, and be feted by a free two-day festival on the National Mall.

Featuring 80 artworks and relics, ranging from figurines of leonine deities to the tiny coffins of beloved pets, "Divine Felines" even has a cat mummy on loan from the Smithsonian’s National Museum of Natural History. These objects span from the Middle Kingdom (2008 to 1630 BCE) to the Byzantine period (395 to 642 CE).

An ancient Egyptian metal weight shaped like a cat, dating back to 305 to 30 BCE, on view at the Smithsonian’s Arthur M. Sackler Gallery
Weight in Form of a Cat, 305 to 30 BCE, Bronze, silver, lead
Brooklyn Museum, Charles Edwin Wilbour Fund, 36.114

The term “cat” is used loosely, as the Egyptians celebrated domestic mousers and fearsome predators alike.

“The Egyptians were close observers of nature, so they were observing cat behaviors,” Antonietta Catanzariti, the exhibition's in-house curator, tells Mental Floss. “They noticed that cats and lions— in general, felines—have aggressive and protective aspects, so they associated those attributes to deities.”

The ancient Egyptians viewed their gods as humans, animals, or mixed forms. Several of these pantheon members were both associated with and depicted as cats, including Bastet, the goddess of motherhood, fertility, and protection; and Sakhmet, the goddess of war and—when appeased—healing. She typically has a lion head, but in some myths she appears as a pacified cat.

A limestone sculptor's model of a walking lion, on display at the Smithsonian's Arthur M. Sackler Gallery.
Sculptor's Model of a Walking Lion, ca. 664 to 630 BCE, limestone
Brooklyn Museum, Charles Edwin Wilbour Fund, 33.190

While Bastet was a nurturer, Sakhmet—whose name means “The Powerful One”—could use her mighty force to either slay or safeguard humanity. These characterizations are typical of the ancient Egyptian worldview, which perceived the universe in dualistic terms. “There’s always a positive and a negative,” Catanzariti explains.

Contrary to popular belief, however, ancient Egyptians did not view cats themselves as gods. “The goddess Sakhmet does have the features as a lion, or in some cases as a cat, but that doesn’t mean that the Egyptians were worshipping cats or lions,” Catanzariti says. Instead, they were simply noting and admiring her feline traits. This practice, to an extent, also extended to royalty. Kings were associated with lions and other large cats, as they were the powerful protectors of ancient Egypt’s borders.

These myriad associations prompted Egyptians to adorn palaces, temples, protective amulets, ceremonial vessels, and accessories with cat images. Depending on their context, these renderings symbolized everything from protection and power to beauty and sexuality. A king’s throne might have a lion-shaped support, for example, whereas a woman’s cosmetics case might be emblazoned with a cat-headed female goddess of motherhood and fertility.

An ancient Egyptian figurine of a standing lion-headed goddess, on display at the Smithsonian's Arthur M. Sackler Gallery.
Figurine of a Standing Lion-Headed Goddess, 664 to 630 BCE, Faience
Brooklyn Museum, Charles Edwin Wilbour Fund, 37.943E

While cats were linked with heavenly figures and kings, they were also popular domestic pets. Their ability to catch vermin made them an important addition to households, and owners loved and anthropomorphized their pets just like we do today.

Egyptians often named, or nicknamed, their children after animals; Miit (cat) was a popular moniker for girls. It's said that entire households shaved their eyebrows in mourning if a house cat died a natural death. Some also believe that cats received special legal protection. (Not all cats were this lucky, however, as some temples bred kittens specifically to offer their mummified forms to the gods.) If a favorite cat died, the Egyptians would bury them in special decorated coffins, containers, and boxes. King Tutankhamen, for example, had a stone sarcophagus constructed just for his pet feline.

An ancient Egyptian bronze cat head adorned with gold jewelry, on display at the Smithsonian's Arthur M. Sackler Gallery.
Cat's Head, 30 BCE. to third century CE, bronze, gold
Brooklyn Museum, Charles Edwin Wilbour Fund, 36.114

“Divine Felines” breaks down these facts, and more, into five thematic sections, including “Cats and Kings"; “Cats and Gods”; “Cats and Death”; “Cats and Protection”; and “Dogs as Guardians and Hunters.” Yes, there’s also an exhibition section for dog lovers—“a small one,” Catanzariti laughs, that explains why canines were associated with figures like Anubis, the jackal-headed god of mummification and the afterlife.

Did the ancient Egyptians prefer cats to dogs? “I would say that both of them had different roles,” Catanzariti says, as dogs were valued as hunters, scavengers, and guards. “They were appreciated in different ways for their ability to protect or be useful for the Egyptian culture.” In this way, "Divine Felines" is targeted to ailurophiles and canophiliacs alike, even if it's packaged with pointed ears and whiskers.

An ancient Egyptian cat coffin, on display at the Smithsonian's Arthur M. Sackler Gallery.
Coffin for a Cat, 664 to 332 BCE, or later, Wood, gesso, paint, animal remains
Brooklyn Museum, Charles Edwin Wilbour Fund, 37.1944Ea-b

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