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What Makes These Dominican Children Grow Penises at Puberty?

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BBC via Youtube

In the Dominican Republic, the phenomenon of children who were raised female appearing to swap sexes at puberty is so common it even has a name. Guevedoces roughly translates to "penis [or "balls"] at 12," and it’s the result of a rare enzyme deficiency that delays crucial steps of male sexual development until puberty.

When guevedoces are born, they appear to have external female genitalia even though their genes and internal reproductive organs are male. Parents assume their children are girls and raise them as such. But when these children begin producing large amounts of testosterone at puberty, their testes descend and they grow a penis—in addition to all the other changes that come along with male adolescence. 

Sexual development normally begins in the womb, and the same is true for guevedoces. Whether the fetus has one X chromosome or two, for the first several weeks of development its genes follow the same blueprint for both sexes. Then, sometime around the eight-week mark, the sex chromosomes get to work. For males, the undeveloped gonads become testicles and they start to release male hormones, including testosterone. In a structure called the tubercle, an enzyme called 5-alpha-reductase converts the testosterone to a stronger hormone called dihydrotestosterone (DHT), which is necessary to develop external genitalia. It's this hormone that turns the tubercle into a penis; without it, it develops into a clitoris.

The rare enzyme deficiency found in guevedoces leaves them unable to develop external male genitalia in the womb. They still produce plenty of testosterone, which triggers the development of internal structures like the epididymis and vas deferens, but the lack of DHT makes the babies appear female at birth. It’s not until the second surge of testosterone these children receive at puberty that they grow testes and a penis. 

The condition is thought to be genetic, tracing back to the female founder of a small village in the Dominican Republic's mountainous hinterland. Outside of the nation, it’s incredibly rare.

For some guevedoces, being raised as female wasn’t an easy experience. “I never liked to dress as a girl, and when they bought me toys for girls, I never bothered playing with them,” Johnny, who had grown up as Felicita, told BBC Two, which features these kids in the second episode of the series Countdown to Life: The Extraordinary Making of You. “When I saw a group of boys, I would stop to play ball with them.” When Johnny, now 24, began to undergo physical changes, he was taunted at school and called nasty names by his classmates. He’s had a number of short-term girlfriends since going through puberty and dreams of one day getting married and starting a family. Another child named Carla began the process of transitioning to Carlos at age 9; he can be seen receiving a smile-inducing haircut in the photo above. 

Most people with this condition live out their adult lives as men, but some choose to undergo surgery and remain female. The discovery of this disorder in the 1970s led to the development of a best-selling drug called finasteride, which is commonly prescribed to treat benign enlargement of the prostate and male pattern baldness. (You may know it by the brand name Propecia.) The drug mimics the enzyme deficiency by blocking the action of 5-alpha-reductase.

You can learn more about this rare condition and the people who have it on the BBC Two series Countdown to Life: The Extraordinary Making of You

[h/t: BBC]

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Words
15 Subatomic Word Origins
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In July 2017, researchers at the European Organization for Nuclear Research (CERN) found evidence for a new fundamental particle of the universe: Ξcc++, a special kind of Xi baryon that may help scientists better understand how quarks are held together. Is that Greek to you? Well, it should be. The names for many of the particles that make up the universe—as well as a few that are still purely theoretical—come from ancient Greek. Here’s a look at 15 subatomic etymologies.

1. ION

An ion is any atom or molecule with an overall electric charge. English polymath William Whewell suggested the name in an 1834 letter to Michael Faraday, who made major discoveries in electromagnetism. Whewell based ion on the ancient Greek verb for “go” (ienai), as ions move towards opposite charges. Faraday and Whewell had previously considered zetode and stechion.

2. ELECTRON

George Stoney, an Anglo-Irish physicist, introduced the term electron in 1891 as a word for the fundamental unit of charge carried by an ion. It was later applied to the negative, nucleus-orbiting particle discovered by J. J. Thomson in 1897. Electron nabs the -on from ion, kicking off the convention of using -on as an ending for all particles, and fuses it with electric. Electric, in turn, comes from the Greek for “amber,” in which the property was first observed. Earlier in the 19th century, electron was the name for an alloy of gold and silver.

3. PROTON

The electron’s counterpart, the positively charged proton in the nuclei of all atoms, was named by its discoverer, Ernest Rutherford. He suggested either prouton or proton in honor of William Prout, a 19th-century chemist. Prout speculated that hydrogen was a part of all other elements and called its atom protyle, a Greek coinage joining protos ("first") and hule ("timber" or "material") [PDF]. Though the word had been previously used in biology and astronomy, the scientific community went with proton.

4. NEUTRON

Joining the proton in the nucleus is the neutron, which is neither positive nor negative: It’s neutral, from the Latin neuter, “neither.” Rutherford used neutron in 1921 when he hypothesized the particle, which James Chadwick didn’t confirm until 1932. American chemist William Harkins independently used neutron in 1921 for a hydrogen atom and a proton-electron pair. Harkins’s latter application calls up the oldest instance of neutron, William Sutherland’s 1899 name for a hypothetical combination of a hydrogen nucleus and an electron.

5. QUARK

Protons and neutrons are composed of yet tinier particles called quarks. For their distinctive name, American physicist Murray Gell-Mann was inspired in 1963 by a line from James Joyce’s Finnegan’s Wake: “Three quarks for Muster Mark.” Originally, Gell-Mann thought there were three types of quarks. We now know, though, there are six, which go by names that are just as colorful: up, down, charm, strange, top, and bottom.

6. MESON

Made up of a quark and an antiquark, which has identical mass but opposite charge, the meson is a short-lived particle whose mass is between that of a proton and an electron. Due to this intermediate size, the meson is named for the ancient Greek mesos, “middle.” Indian physicist Homi Bhabha suggested meson in 1939 instead of its original name, mesotron: “It is felt that the ‘tr’ in this word is redundant, since it does not belong to the Greek root ‘meso’ for middle; the ‘tr’ in neutron and electron belong, of course, to the roots ‘neutr’ and ‘electra’.”

7., 8., AND 9. BOSON, PHOTON, AND GLUON

Mesons are a kind of boson, named by English physicist Paul Dirac in 1947 for another Indian physicist, Satyendra Nath Bose, who first theorized them. Bosons demonstrate a particular type of spin, or intrinsic angular momentum, and carry fundamental forces. The photon (1926, from the ancient Greek for “light”) carries the electromagnetic force, for instance, while the gluon carries the so-called strong force. The strong force holds quarks together, acting like a glue, hence gluon.

10. HADRON

In 2012, CERN’s Large Hadron Collider (LHC) discovered a very important kind of boson: the Higgs boson, which generates mass. The hadrons the LHC smashes together at super-high speeds refer to a class of particles, including mesons, that are held together by the strong force. Russian physicist Lev Okun alluded to this strength by naming the particles after the ancient Greek hadros, “large” or “bulky,” in 1962.

11. LEPTON

Hadrons are opposite, in both makeup and etymology, to leptons. These have extremely tiny masses and don’t interact via the strong force, hence their root in the ancient Greek leptos, “small” or “slender.” The name was first suggested by the Danish chemist Christian Møller and Dutch-American physicist Abraham Pais in the late 1940s. Electrons are classified as leptons.

12. BARYON

Another subtype of hadron is the baryon, which also bears the stamp of Abraham Pais. Baryons, which include the more familiar protons and neutrons, are far more massive, relatively speaking, than the likes of leptons. On account of their mass, Pais put forth the name baryon in 1953, based on the ancient Greek barys, “heavy” [PDF].

13. AXION

Quirky Murray Gell-Mann isn't the only brain with a sense of humor. In his 2004 Nobel Prize lecture, American physicist Frank Wilczek said he named a “very light, very weakly interacting” hypothetical particle the axion back in 1978 “after a laundry detergent [brand], since they clean up a problem with an axial current” [PDF].

14. TACHYON

In ancient Greek, takhys meant “swift,” a fitting name for the tachyon, which American physicist Gerald Feinberg concocted in 1967 for a hypothetical particle that can travel faster than the speed of light. Not so fast, though, say most physicists, as the tachyon would break the fundamental laws of physics as we know them.

15. CHAMELEON

In 2003, the American physicist Justin Khoury and South African-American theoretical physicist Amanda Weltman hypothesized that the elusive dark energy may come in the form of a particle, which they cleverly called the chameleon. Just as chameleons can change color to suit their surroundings, so the physical characteristics of the chameleon particle change “depending on its environment,” explains Symmetry, the online magazine dedicated to particle physics. Chameleon itself derives from the ancient Greek khamaileon, literally “on-the-ground lion.”

For more particle names, see Symmetry’s “A Brief Etymology of Particle Physics,” which helped provide some of the information in this list.

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Space
Look Up! The Orionid Meteor Shower Peaks This Weekend
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October is always a great month for skywatching. If you missed the Draconids, the first meteor shower of the month, don't despair: the Orionids peak this weekend. It should be an especially stunning show this year, as the Moon will offer virtually no interference. If you've ever wanted to get into skywatching, this is your chance.

The Orionids is the second of two meteor showers caused by the debris field left by the comet Halley. (The other is the Eta Aquarids, which appear in May.) The showers are named for the constellation Orion, from which they seem to originate.

All the stars are lining up (so to speak) for this show. First, it's on the weekend, which means you can stay up late without feeling the burn at work the next day. Tonight, October 20, you'll be able to spot many meteors, and the shower peaks just after midnight tomorrow, October 21, leading into Sunday morning. Make a late-night picnic of the occasion, because it takes about an hour for your eyes to adjust to the darkness. Bring a blanket and a bottle of wine, lay out and take in the open skies, and let nature do the rest.

Second, the Moon, which was new only yesterday, is but a sliver in the evening sky, lacking the wattage to wash out the sky or conceal the faintest of meteors. If your skies are clear and light pollution low, this year you should be able to catch about 20 meteors an hour, which isn't a bad way to spend a date night.

If clouds interfere with your Orionids experience, don't fret. There will be two more meteor showers in November and the greatest of them all in December: the Geminids.

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