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New Study Reveals How Brushing Your Teeth Keeps Your Heart Healthy

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Numerous studies have suggested a link between gum disease and heart disease. Now, new research clarifies how bacteria in our mouths can lead to cardiovascular health problems. (You might want to go brush and floss before you continue reading.)

Porphyromonas gingivalis is an oral bacteria that causes periodontitis, a more advanced stage of the common gum disease gingivitis. Oral bacteria can break free during chewing or toothbrushing and enter the bloodstream, binding to blood cells and making their way to blood vessels. This is particularly likely to occur in people with serious gum infections.

Scientists have previously identified P. gingivalis in the arterial plaque of heart attack patients, and animal studies show that P. gingivalis can both cause and accelerate the buildup of plaque inside the coronary and aortic arteries, a condition known as atherosclerosis. The accumulation of plaque provokes inflammation, which is thought to be a crucial component of atherosclerosis.

But exactly how P. gingivalis participates in that process has remained mysterious—until now. A team of researchers led by Torbjörn Bengtsson of Örebro University in Sweden infected aortic smooth muscle cells with P. gingivalis. They observed that the bacteria altered gene expression in a way that dramatically increased inflammationThis is the first time the chemical process has been observed at a molecular level. Their findings were recently published in the journal Infection and Immunity.

In addition to identifying the mechanism by which P. gingivalis provoked inflammation, the researchers discovered that the combination of the bacteria and stress may amplify the risk of a heart attack. “P. gingivalis markedly increases the sensitivity of platelets … to adrenaline, which means that a combination of periodontitis and stress increases the risk for [blood clot and heart attack],” said Bengtsson.

Now that they better understand the mechanism linking periodontitis to heart disease, the researchers will continue searching for biomarkers that could help diagnose and treat the disease more quickly. Nearly half of adults over age 30 in the United States suffer from periodontal disease, according to the Centers for Disease Control and Prevention.

After controlling for factors such as high blood pressure, diabetes, obesity, alcohol consumption and smoking, the prevalence of cardiovascular diseases in patients with periodontitis is still 25–50 percent higher than in people who don’t have the gum disease, said Bengtsson, who also emphasized the importance of good oral hygiene.

“Taking care of your teeth by careful brushing and flossing and going to the dentist regularly is of course basic and very important,” he said, adding that removal of plaque through regular dental cleanings to prevent periodontitis is still the general treatment.

However, his team is also testing new methods of controlling oral bacteria before they cause serious gum disease. It turns out that a protein in some lactobacillus—the so-called “good” bacteria that help the body fight a multitude of ailments from diarrhea to yeast infections—may also hold promise for preventing and treating periodontitis.

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Aflac's Robotic Duck Comforts Kids with Cancer
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Aflac

Every year, close to 16,000 children in the U.S. are diagnosed with cancer. That news can be the beginning of a long and draining battle that forces kids and their parents to spend large amounts of time with medical providers, enduring long and sometimes painful treatments. As The Verge reports, a bit of emotional support during that process might soon come from an unlikely source: the Alfac duck.

The supplemental insurance company announced at the 2018 Consumer Electronics Show (CES) that it has partnered with the medical robotics company Sproutel to design and manufacture My Special Aflac Duck, a responsive and emotive sim-bird intended exclusively for children undergoing cancer treatment.

When a child cuddles the fuzzy robotic duck, it can cuddle back. It reacts to being cradled and stroked by quacking or moving its head. Kids can also touch special RFID chips emblazoned with emoji on the duck's chest to tell it how they’re feeling, and the device will mimic those emotions.

But the duck isn’t solely for cuddling. In “IV Mode,” which can be switched on while a child is undergoing IV therapy, the duck can help the user relax by guiding them through breathing exercises. Accessories included with the toy also allow children to "draw blood" from the duck as well as administer medication, a kind of role-playing that may help patients feel more comfortable with their own treatments.

Aflac approached Sproutel with the idea after seeing Sproutel’s Jerry the Bear, a social companion robot intended to support kids with diabetes. Other robotic companions—like the Japanese-made seal Paro and Hasbro's Joy for All companion pets for seniors—have hinted at a new market for robotics that prioritize comfort over entertainment or play.

My Special Aflac Duck isn’t a commercial product and won’t be available for retail sale. Aflac intends to offer it as a gift directly to patients, with the first rollout expected at its own cancer treatment center in Atlanta, Georgia. Mass distribution is planned for later this year.

[h/t The Verge]

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The Body
12 Fantastic Facts About the Immune System
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The human body is an amazing thing. For each one of us, it's the most intimate object we know. And yet most of us don't know enough about it: its features, functions, quirks, and mysteries. Our series The Body explores human anatomy, part by part. Think of it as a mini digital encyclopedia with a dose of wow.

If it weren't for our immune system, none of us would live very long. Not only does the immune system protect us from external pathogens like viruses, bacteria, and parasites, it also battles cells that have mutated due to illnesses, like cancer, within the body.

Here are 12 fighting facts about the immune system.

1. THE IMMUNE SYSTEM SAVES LIVES.

The immune system is a complex network of tissues and organs that spreads throughout the entire body. In a nutshell, it works like this: A series of "sensors" within the system detects an intruding pathogen, like bacteria or a virus. Then the sensors signal other parts of the system to kill the pathogen and eliminate the infection.

"The immune system is being bombarded by all sorts of microbes all the time," Russell Vance, professor of immunology at University of California, Berkeley and an investigator for the Howard Hughes Medical Institute, tells Mental Floss. "Yet, even though we're not aware of it, it's saving our lives every day, and doing a remarkably good job of it."

2. BEFORE SCIENTISTS UNDERSTOOD THE IMMUNE SYSTEM, ILLNESS WAS CHALKED UP TO UNBALANCED HUMORS.

Long before physicians realized how invisible pathogens interacted with the body's system for fighting them off, doctors diagnosed all ills of the body and the mind according to the balance of "four humors": melancholic, phlegmatic, choleric, or sanguine. These criteria, devised by the Greek philosopher Hippocrates, were divided between the four elements, which were linked to bodily fluids (a.k.a. humors): earth (black bile), air (blood), water (phlegm) and fire (yellow bile), which also carried properties of cold, hot, moist, or dry. Through a combination of guesswork and observation, physicians would diagnose patients' humors and prescribe treatment that most likely did little to support the immune system's ability to resist infection.

3. TWO MEN WHO UNRAVELED THE IMMUNE SYSTEM'S FUNCTIONS WERE BITTER RIVALS.

Two scientists who discovered key functions of the immune system, Louis Pasteur and Robert Koch, should have been able to see their work as complementary, but they wound up rivals. Pasteur, a French microbiologist, was famous for his experiments demonstrating the mechanism of vaccines using weakened versions of the microbes. Koch, a German physician, established four essential conditions under which pathogenic bacteria can infect hosts, and used them to identify the Mycobacterium tuberculosis bacterium that causes tuberculosis. Though both helped establish the germ theory of disease—one of the foundations of modern medicine today—Pasteur and Koch's feud may have been aggravated by nationalism, a language barrier, criticisms of each other's work, and possibly a hint of jealousy.

4. SPECIALIZED BLOOD CELLS ARE YOUR IMMUNE SYSTEM'S GREATEST WEAPON.

The most powerful weapons in your immune system's arsenal are white blood cells, divided into two main types: lymphocytes, which create antigens for specific pathogens and kill them or escort them out of the body; and phagocytes, which ingest harmful bacteria. White blood cells not only attack foreign pathogens, but recognize these interlopers the next time they meet them and respond more quickly. Many of these immune cells are produced in your bone marrow but also in the spleen, lymph nodes, and thymus, and are stored in some of these tissues and other areas of the body. In the lymph nodes, which are located throughout your body but most noticeably in your armpits, throat, and groin, lymphatic fluid containing white blood cells flows through vein-like tubules to escort foreign invaders out.

5. THE SPLEEN HELPS YOUR IMMUNE SYSTEM WORK.

Though you can live without the spleen, an organ that lies between stomach and diaphragm, it's better to hang onto it for your immune function. According to Adriana Medina, a doctor who specializes in hematology and oncology at the Alvin and Lois Lapidus Cancer Institute at Sinai Hospital in Baltimore, your spleen is "one big lymph node" that makes new white blood cells, and cleans out old blood cells from the body.

It's also a place where immune cells congregate. "Because the immune cells are spread out through the body," Vance says, "eventually they need to communicate with each other." They do so in both the spleen and lymph nodes.

6. YOU HAVE IMMUNE CELLS IN ALL OF YOUR TISSUES.

While immune cells may congregate more in lymph nodes than elsewhere, "every tissue in your body has immune cells stationed in it or circulating through it, constantly roving for signs of attack," Vance explains. These cells also circulate through the blood. The reason for their widespread presence is that there are thousands of different pathogens that might infect us, from bacteria to viruses to parasites. "To eliminate each of those different kinds of threats requires specialized detectors," he says.

7. HOW FRIENDLY YOU'RE FEELING COULD BE LINKED TO YOUR IMMUNE SYSTEM.

From an evolutionary perspective, humans' high sociability may have less to do with our bigger brains, and more to do with our immune system's exposure to a greater number of bacteria and other pathogens.

Researchers at the University of Virginia School of Medicine have theorized that interferon gamma (IG), the immune cytokine that helps the immune system fight invaders, was linked to social behavior, which is one of the ways we become exposed to pathogens.

In mice, they found IG acted as a kind of brake to the brain's prefrontal cortex, essentially stopping aberrant hyperactivity that can cause negative changes in social behavior. When they blocked the IG molecule, the mice's prefrontal cortexes became hyperactive, resulting in less sociability. When they restored the function, the mice's brains returned to normal, as did their social behavior.

8. YOUR IMMUNE SYSTEM MIGHT RECRUIT UNLIKELY ORGANS—LIKE THE APPENDIX—INTO ITS SERVICE.

The appendix gets a bad rap as a vestigial organ that does nothing but occasionally go septic and create a need for immediate surgery. But the appendix may help keep your gut in good shape. According to Gabrielle Belz, professor of molecular immunology at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, research by Duke University's Randal Bollinger and Bill Parker suggests the appendix houses symbiotic bacteria that are important for overall gut health—especially after infections wipe out the gut's good microbes. Special immune cells known as innate lymphoid cells (ILCs) in the appendix may help to repopulate the gut with healthy bacteria and put the gut back on track to recovery.

9. GUT BACTERIA HAS BEEN SHOWN TO BOOST IMMUNE SYSTEMS IN MICE.

Researchers at the University of Chicago noticed that one group of mice in their lab had a stronger response to a cancer treatment than other mice. They eventually traced the reason to a strain of bacteria—Bifidobacterium—in the mice's guts that boosted the animals' immune system to such a degree they could compare it to anti-cancer drugs called checkpoint inhibitors, which keep the immune system from overreacting.

To test their theory, they transferred fecal matter from the robust mice to the stomachs of less immune-strengthened mice, with positive results: The treated mice mounted stronger immune responses and tumor growth slowed. When they compared the bacterial transfer effects with the effects of a checkpoint inhibitor drug, they found that the bacteria treatment was just as effective. The researchers believe that, with further study, the same effect could be seen in human cancer patients.

10. SCIENTISTS ARE TRYING TO HARNESS THE IMMUNE SYSTEM'S "PAC-MAN" CELLS TO TREAT CANCER.

Aggressive pediatric tumors are difficult to treat due to the toxicity of chemotherapy, but some researchers are hoping to develop effective treatments without the harmful side effects. Stanford researchers designed a study around a recently discovered molecule known as CD47, a protein expressed on the surface of all cells, and how it interacts with macrophages, white blood cells that kill abnormal cells. "Think of the macrophages as the Pac-Man of the immune system," Samuel Cheshier, lead study author and assistant professor of neurosurgery at Stanford Medicine, tells Mental Floss.

CD47 sends the immune system's macrophages a "don't eat me" signal. Cancer cells fool the immune system into not destroying them by secreting high amounts of CD47. When Cheshier and his team blocked the CD47 signals on cancer cells, the macrophages could identify the cancer cells and eat them, without toxic side effects to healthy cells. The treatment successfully shrank all five of the common pediatric tumors, without the nasty side effects of chemotherapy.

11. A NEW THERAPY FOR TYPE 1 DIABETES TRICKS THE IMMUNE SYSTEM.

In those with type 1 diabetes, the body attacks its own pancreatic cells, interrupting its normal ability to produce insulin in response to glucose. In a 2016 paper, researchers at MIT, in collaboration with Boston's Children's Hospital, successfully designed a new material that allows them to encapsulate and transplant healthy pancreatic "islet" cells into diabetic mice without triggering an immune response. Made from seaweed, the substance is benign enough that the body doesn't react to it, and porous enough to allow the islet cells to be placed in the abdomen of mice, where they restore the pancreatic function. Senior author Daniel Anderson, an associate professor at MIT, said in a statement that this approach "has the potential to provide [human] diabetics with a new pancreas that is protected from the immune system, which would allow them to control their blood sugar without taking drugs. That's the dream."

12. IMMUNOTHERAPY IS ON THE CUTTING EDGE OF IMMUNE SYSTEM RESEARCH.

Over the last few years, research in the field of immunology has focused on developing cancer treatments using immunotherapy. This method engineers the patient's own normal cells to attack the cancer cells. Vance says the technique could be used for many more conditions. "I feel like that could be just the tip of the iceberg," he says. "If we can understand better what the cancer and immunotherapy is showing, maybe we can go in there and manipulate the immune responses and get good outcomes for other diseases, too."

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