CLOSE
Original image
iStock

Scientists Find a Way to Erase Memories of Drug Use in Addicted Mice

Original image
iStock

Scientists have found a way to erase very specific memories in mouse brains, helping drug-addicted lab rodents recover. 

Following up on a similar study they published in 2013, researchers from the Scripps Research Institute in Florida were able to selectively erase memories of methamphetamine in mice using a drug that disrupts a memory-related protein in the brain. 

In previous studies, the researchers found that memories of drug use are not stored in the same way as other memories. Actin, a protein that supports connections between neurons, normally stabilizes within a few minutes of a typical experience (like eating a really great dessert), but when it comes to drug memories like the thought of taking your first hit of meth, actin filaments keep changing in size, strengthening the connections between neurons even days after the original event. 

Neurobiologist Courtney Miller, one of the authors of the recent study in the journal Molecular Psychiatry, explains that a drug administered in the lab can be used to target only memories associated with addiction because of this unique instability. She writes in an email to mental_floss that “unlike the memory for food reward, the actin is cycling and, therefore, open to a breakdown of actin filaments (and consequently, spines) when the monomers are sequestered by Latrunculin [the treatment drug].” When the researchers targeted nonmuscle myosin IIB, a protein that drives actin polymerization (the process by which actin changes during memory storage), they were able to make lab mice forget memories associated with meth, but not erase other memories, such as those associated with a scary experience. 

Meth users might have developed associations with seemingly banal activities like handling money or chewing gum, meaning that reminders of their drug use (and the cravings that come along with them) are constantly lurking in everyday life. This technique removes the triggering memories that might induce drug cravings, helping prevent relapse, and could be a useful addition to rehabilitation therapy. 

However, the treatment is a long way from being ready for use by people. The researchers hope to start human trials in the next five years. And that’s if it even makes it to human trials—in cancer research, the success rate of a transfer from animal to human models is less than eight percent, and other fields face similar disappointments with treatments developed in animal models. 

[h/t: Washington Post]

Original image
iStock
arrow
Animals
Squirrels Are Probably More Organized Than You, Study Finds
Original image
iStock

Despite having a brain that's slightly bigger than the size of a peanut M&M, squirrels have a fascinating, razor-sharp instinct when it comes to survival. They know that acorns that are high in fat and sprout late are perfect for long-term storage, so they salvage them for winter and eat the less nutritionally dense white-oak acorns right away. They also tend to remember where they put their acorn stash rather than relying solely on smell. Like nature's perfect stunt performer, they can even fall out of trees in a way that minimizes physical damage. Now, researchers at the University of California, Berkeley have unveiled a newly discovered part of a squirrel's hoarding strategy, Atlas Obscura reports.

The researchers tracked 45 wild fox squirrels on the UC-Berkeley campus for nearly two years. They made available to the squirrels four different types of nuts—walnuts, pecans, almonds, and hazelnuts. Sometimes the animals were given a single type of nut, and other times the nuts were mixed. Either way, the squirrels promptly sorted and stored their food according to type—walnuts went in one hiding place, almonds in another, and so on.

This type of behavior is known as "chunking" and makes it easier to retrieve data in memory. In doing this, a squirrel won't have to visit several different places looking for pecans: They know just where the main supply is. Squirrels can stockpile up to 10,000 nuts a year, so it's essential for them to know which type of nut is where.

The study, published in Royal Society Open Science, also indicated that squirrels seem to understand nuts have weight, choosing to carry heavier acquisitions to a different location than lighter nuts.

Squirrels being squirrels, they were happy to be gifted an assortment of nuts during the experiment, but there was one wrinkle: Rather than stash them away, sometimes they'd just eat them on the spot.

[h/t Atlas Obscura]

Original image
iStock
10 Amazing Facts About Our Bond With Dogs
Original image
iStock

They’ve been our companions for tens of thousands of years. They share our beds, follow us into the bathroom, and star in our holiday cards. The beautiful friendship between Homo sapiens and Canis lupus familiaris has had some surprising effects on both species—read on to learn more about the ways we’ve helped each other along the way.

1. IMPROVED IMMUNITY

Living with furry friends, especially dogs, has been shown to decrease babies’ and kids’ risk for asthma, allergies, and other immune conditions. Some studies have found that the benefits can begin as early as the womb. Scientists aren’t completely sure why this happens; it may be that bacteria on the dogs’ bodies can help give our immune systems a boost during a crucial moment in our development.

2. INCREASED FOCUS

Keeping your phone loaded with pictures of your pet may pay off in the long run. In one 2012 experiment, people who looked at pictures of puppies scored higher on tasks that required their close attention. Photos of older dogs were less effective; the researchers say it might be that baby animals inspire a specific type of positive emotion and mental activation.

3. A THIRST FOR PRAISE

Dogs are social animals; that’s part of the reason we were able to tame them in the first place. And once we take them in, they really start to care what we think. Experiments with dogs and their owners have shown that when given the choice between snacks and praise, most prefer being told what good dogs they are.

4. MORE CHILL

Sharing your life with a drooling, adoring furry friend is good for your attitude and your stress levels. Spending time with dogs can ease tension and stress. Studies have found that this is especially true in high-stress situations like crises, natural disasters, and the office.

5. HEALTHIER HEARTS

Reduced stress is its own reward, but it can also have long-term health benefits, including lower blood pressure, lowered heart rate, and a decreased risk of heart disease. This works even in little doses: just petting a dog for a few minutes sends feel-good chemicals to the brain and can soothe a frazzled nervous system.

6. INTERSPECIES EMPATHY

All those millennia together have made a real impression on dogs’ brains. One 2016 study found that dogs could read and respond to the emotions on human faces, even in photographs. This is especially cool when you consider the major differences in body language between our two species. Dogs don’t smile, but they still know what our grin means when they see it.

7. MORE EXERCISE

There’s nothing like an “I’ve-got-to-pee-RIGHT-NOW” bark to get you up and out the door. For obvious reasons, dog owners get more casual exercise than other people. This, in turn, can also lower stress levels and improve heart health.

8. LANGUAGE LEARNING

Spoken language, like body language, differs drastically between our two species, but that hasn’t stopped dogs from trying to figure ours out. A series of Hungarian experiments using MRI scanners found that dogs’ brains responded to human voices speaking both positive words and with positive tone. This was true even when the positive words were spoken in a neutral tone (“good boy”) and the positive tone was applied to a neutral phrase (“however!!!”). They get us.

9. A SOFT, COMFY LIFE

The good news for dogs is that domestication has given them a steady source of food, shelter, and companionship. The bad news is that all this cushy living has dulled their edges somewhat. Compared to the wolves from which they descended, pet dogs have weaker senses of hearing and smell, and they’re worse at problem-solving tasks. But this isn’t a problem, per se; they’ve simply evolved and been bred to prioritize one set of survival skills (coexisting with people) over another (sharp senses and keen minds).

10. GENETIC CONNECTION

The bond between us and our dogs is real, and may trace all the way down into dogs’ DNA. Experiments have found that the most sociable pet dogs have genetic mutations that appear to make them more interested in people. Without these abnormalities, experts say, we might never have been able to domesticate dogs in the first place.

Dogs make our lives a whole lot happier and healthier. (You can’t argue with science!) Looking to return the favor? Consider a monthly subscription to BarkBox. Your favorite pup will get a package filled with treats, toys, and other goodies. Visit BarkBox to learn more.

SECTIONS

arrow
LIVE SMARTER