13 Facts About Ovaries

iStock.com/magicmine
iStock.com/magicmine

Ovaries are only about the size of large grapes, but they’re one of the most important organs in the female body. Their primary responsibilities include producing eggs and secreting sex hormones that promote fertility. In this way, the future of humanity depends on them. Read on to learn more about these tiny but mighty organs.

1. THEY’RE THE FEMALE GONADS.

Go ahead and laugh, but gonads was a scientific term long before it became slang for a man’s testicles. It actually refers to the reproductive glands of both sexes: ovaries for women, and testes for men. When an embryo is in the early stages of development (around the seventh week), its gonads have the potential to develop into either female or male sex organs through a process called sexual differentiation. By this point, the sex has already been pre-determined by chromosomes (XX or XY), and in the absence of a Y chromosome, the gonads turn into ovaries. One study of adult mice found that ovaries could be turned into testes by deleting a single gene called FOXL2, which is constantly working to suppress the development of male anatomy in mammals. However, it's unknown what effect the modification of this gene would have on humans.

2. THEY’RE CONTROLLED BY THE BRAIN.

The hypothalamus and pituitary gland both play pivotal roles in ensuring the ovaries function as they should. Neither is located anywhere near the ovaries, though. “If you put your finger between your eyes and shoved it backwards into your brain, first you would knock into your pituitary gland, which is a little pea-sized gland,” Randi Epstein, a New York City-based medical doctor and writer, tells Mental Floss. “And if you kept ramming backwards, then you would hit the hypothalamus.” (Of course, she doesn’t recommend actually trying this.)

The hypothalamus is the hormone control center, while the pituitary gland is called the body’s "master gland" because it controls the thyroid and adrenal glands, as well as the ovaries and testicles. Essentially, the hypothalamus tells the pituitary gland to send hormones to the ovaries, and the ovaries respond by secreting their own batch of hormones. A signal is then sent back to the hypothalamus to let it know if the levels of estrogen and progesterone are too high or too low. The cycle then continues, but we don't fully understand what triggers the hypothalamus and kicks off the process in the first place, Epstein says.

3. IT’S HARD TO ACCURATELY PREDICT WHEN OVARIES WILL KICK OFF MENOPAUSE.

Because of the previously mentioned unknowns, there’s no way of telling when puberty or menopause will occur. In the latter case, scientists have been looking at different genetic markers in an attempt to predict when the ovaries will shut down the processes of menstruation and ovulation—otherwise known as menopause—but "nothing is definitive" right now, according to Mary Jane Minkin, an obstetrician-gynecologist in New Haven, Connecticut, who also teaches at the Yale School of Medicine.

However, family history and age offer some clues. The average age for menopause in the U.S. is 51, but if all the women in your family went through menopause in their forties, there’s a good chance you will, too. Women who have had hysterectomies may also go through menopause one or two years earlier than they normally would, even if they have otherwise healthy ovaries. That's because the surgery is believed to reduce the flow of blood to the ovaries, resulting in a lower supply of hormones and therefore earlier ovarian failure.

4. SMOKING CAN ALSO TRIGGER EARLIER MENOPAUSE.

The effects of smoking on internal organs aren’t pretty, and the ovaries are no exception. “Smoking rots ovaries,” Minkin tells Mental Floss. “Basically, if you want to go through menopause earlier, smoke cigarettes.” Doing so can accelerate the onset of menopause by one to two years, and studies have shown that smoking hurts overall ovarian function as well.

5. THEY CHANGE SHAPE OVER TIME.

Ovaries get bigger and morph into the shape of an almond when girls reach adolescence, eventually reaching roughly 1.4 inches in length. Later in life, once menopause has occurred and the ovaries have fulfilled their purpose, they dwindle to under an inch long. “They just sort of poop out and they shrink, so the size gets exponentially smaller,” Minkin says.

6. WHEN A GIRL IS BORN, HER OVARIES HOLD ALL THE EGGS SHE’LL EVER HAVE ...

Female fetuses can carry as many as 7 million oocytes (immature eggs) in their ovarian follicles, and by the time they’re born, that number drops to about 2 million. Here's a mind-boggling fact: If a woman is pregnant with a girl, that means she’s also carrying her potential grandchildren, too.

Many of these eggs die off before a girl reaches reproductive age, though. By the time she starts going through puberty, she has about 300,000 left. About 1000 or so eggs are lost each month after that. When it’s all said and done, only about 400 mature eggs go through ovulation, at which point they’re dropped from the ovaries, through the fallopian tubes, and into the uterus.

7. ... BUT STEM CELL RESEARCH COULD CHANGE THAT.

Research in recent years has suggested that ovarian stem cells could someday be used to grow new egg cells, or to delay or stop menopause in women. Both of these tasks have already been successfully carried out in mice. "If we could gain control of the [human] female biological clock ... you could arguably delay the time of ovary failure, the primary force behind menopause,” researcher Jonathan Tilly told National Geographic in 2012.

For now, women faced with a diminishing supply can have their unfertilized eggs frozen through the process of cryopreservation. It’s meant to improve a woman’s chances of conceiving at a later date, but it isn’t guaranteed to work. “It’s getting better, but it’s hardly perfect,” Minkin says. “You can freeze the eggs, but you don’t know how viable they’re going to be in the long-term.”

8. SCIENTISTS HAVE CREATED 3D-PRINTED OVARIES FOR MICE.

In 2017, scientists used “porous scaffolds from a gelatin ink” to 3D-print synthetic ovaries for mice, The Guardian reported. Those ovaries were then filled with follicles containing immature egg cells, which allowed the mice to give birth to healthy babies. Scientists hope this technique will someday be used to restore fertility to women whose ovaries have been damaged by cancer treatments.

9. OVARIES CHILL OUT ON BIRTH CONTROL PILLS.

Oral contraceptives prevent ovulation by providing all the estrogen and progesterone that the body needs. With the ovaries’ job taken care of, they get to go on “vacation,” Minkin says. When contraceptive pills are used for five or more years, they reduce a woman’s risk of ovarian cancer by 50 percent. That’s because “funky things can happen” during ovulation, at which time the ovaries are at greater risk of an aberration, Minkin says. On the other hand, if the ovaries aren’t releasing eggs, there’s less of an opportunity for mistakes to happen. The ovaries are also less exposed to naturally occurring hormones that may promote the growth of cancer.

10. SOME CHRONIC CONDITIONS AFFECT THE OVARIES.

One of the most common problems affecting the ovaries are cysts. These fluid-filled sacs can form when an egg isn’t properly released from an ovarian follicle, or if the empty follicle sac doesn’t shrink after it bursts open to release an egg. Fortunately, these cysts often go away on their own. They only become a problem if they grow, or multiple cysts form. Strange things can happen, though. In one recent case, surgeons found a cyst containing a miniature skull and brain tissue inside the ovary of a 16-year-old girl. Yes, you read that right. It's called a teratoma —from the Greek word for monster—and it happens when the reproductive cells go rogue and start developing their own way.

Another disorder that can sometimes affect the ovaries is endometriosis. This occurs when tissue that’s similar to the endometrium, which lines the uterus, starts growing somewhere outside the uterus and causes a chronic inflammatory reaction. It can attach to the bladder, bowel, ovaries, or other areas. Symptoms may be minimal, severe, or somewhere in between, and the tissue can be removed through a minor surgery if needed.

Polycystic ovary syndrome (PCOS) is another fairly common problem, and it’s caused by a hormonal imbalance that in turn creates problems for the ovaries. Ovulation may not go as smoothly, periods can be irregular, and cysts can develop. Since there’s no cure, it’s a lifelong condition, but the symptoms can be managed.

11. CUNNING SALESMEN ONCE SOLD ANTI-AGING OVARY TONICS.

Miracle elixirs made from animal ovaries and testes were a big “money-making fad” in the early 20th century, Epstein writes in her book Aroused: The History of Hormones and How They Control Just About Everything. According to the sales pitch at the time, sex organs give life, so it’s only logical that they would help boost your energy and libido. “We were taking rabbit ovaries, crushing them up, desiccating them, and using them as a fertility or anti-aging treatment,” Epstein tells Mental Floss. One of the first “cures” for menopause and menstruation symptoms wasn’t much better, either. The main active ingredient was alcohol.

12. BIRDS HAVE JUST ONE FUNCTIONAL OVARY.

Unlike their dinosaur ancestors, birds have only their left ovary. Scientists theorize that birds lost an ovary over the course of evolution because it helped reduce their weight, making it easier for them to fly. This explains why dinosaurs laid loads of eggs, but birds lay just a few at a time.

13. SOME ANIMALS CAN SWITCH SEXES BY CHANGING THEIR OVARIES.

All clownfish are born male, but they’re able to change sex at will. This is because they have both mature testes and immature ovaries, the latter of which can develop if the alpha female in a school of fish dies. (As Business Insider points out, a scientifically accurate Finding Nemo would have been significantly more disturbing.)

Parrotfish can change sex as well—mostly from female to male. During this transition, the ovaries dissolve and testes are grown. “In general, for species where big males can control access to females (think harem), it pays to be female when small (you get to reproduce with the dominant male) and then turn into a male when you are big enough to duke it out with a competing male to win access to a group of females,” writes Marah Hardt, author of Sex in the Sea.

14 Facts About Feet

iStock/pepifoto
iStock/pepifoto

The foot is one of the most overworked, under-appreciated parts of the human body. Think about it: In a single day, the average person takes 8000 to 10,000 steps. That works out to be four trips around the world over a lifetime, putting a lot of wear and tear on your intricate foot bones. The foot may be humble, but its design is essential to how we walk upright, and hoofing it on two feet is a defining feature of humanity. Here are some fun—and a few funky—facts about the human foot.

1. FOOT BONES MAKE UP ABOUT A QUARTER OF ALL THE BONES IN OUR BODIES.

There are 26 foot bones in each of your feet—one less than in each hand. When we’re born, those foot bones are mostly cartilage. They only completely harden around age 21.

2. HUMANS HAVE WORN SHOES FOR A VERY LONG TIME.

When did humans begin wearing shoes, anyway? About 40,000 years ago, according to research from Washington University in St. Louis that analyzed foot bones from Neanderthals and early humans. Older specimens had thicker, stronger toes, likely from gripping the ground as they walked barefoot. That’s around the same time that the archaeological record shows a burst of artistic and technological advancements among early humans, including the first stone tools, which may have aided in the production of shoes. The oldest preserved shoe, incidentally, is 5500 years old and was found in an Armenian cave, buried in sheep dung.

3. THE BIG TOE USED TO BE A KIND OF FOOT THUMB.

This grasping toe helped our predecessors climb trees and, when young, grip onto their mothers. Thanks to modern science, if you lose your thumb, you can now replace it with a toe: toe-to-thumb transplants are a surprisingly common procedure these days.

4. FOOT BONES HOLD BIG CLUES ABOUT THE EVOLUTION OF BIPEDALISM.

Scientists are studying Homo naledi, a specimen discovered in a South African cave in 2013 that many researchers believe is a new human relative. H. naledi had very human-like feet, but with somewhat curved toe bones that suggest it climbed trees. It could be that H. naledi was beginning to experiment with walking. 

5. THERE WAS A FOOT CHEESE EXHIBITION IN IRELAND.

Warm, sweaty feet make a perfect home for bacteria, which feed on our dead skin cells and produce gases and acids that emit those arresting foot odors. They're apparently also good at cultivating cheese. An exhibition in Dublin in 2013 displayed a variety of cheeses made with bacteria samples obtained from real people’s feet, armpits, and belly buttons. Delicious. (No one actually ate any of the cheeses.)

6. FEET ARE ONE OF THE MOST TICKLISH PARTS OF THE BODY.

There’s a good reason for that: Humans have nearly 8000 nerves in our feet and a large number of nerve endings near the skin. Having ticklish feet can be a good sign: Reduced sensitivity can be an indicator of peripheral neuropathy (numbness in the feet caused by nerve damage). 

7. FOOT NUMBNESS CAN CAUSE BIG PROBLEMS FOR DIABETICS.

Complications of diabetes include poor circulation and foot numbness that can lead to serious skin ulcers, which sometimes require amputation of toes or feet. In 2010 alone, 73,000 lower-limb amputations were performed on diabetics.

8. FOOT SIZES AND WIDTHS IN THE U.S. AND UK ARE INCREASING.

Feet are spreading to support extra weight as our populations pack on the pounds. According to a 2014 study by the College of Podiatry in the UK, the average foot has increased two sizes since the 1970s. As people have grown taller and heavier, feet respond by growing. It appears many people are still in denial about their expanding feet: Though retailers are starting to respond by making larger and roomier shoes, half of women and a third of men reported they buy poorly fitting shoes. Podiatrists say ill-fitting shoes are to blame for a significant portion of foot problems, especially among women.

9. MANY GLAMOROUS CELEBRITIES HAVE BIG FEET.

From the bound feet of female Chinese elites to Cinderella and Barbie, freakishly small feet are often celebrated as more feminine. But plenty of glamorous women both past and present have had larger than average feet, among them Jacqueline Kennedy, Oprah Winfrey, Uma Thurman, and Audrey Hepburn (size 10, 11, 11, and 10.5, respectively).

10. WOMEN HAVE FOUR TIMES AS MANY FOOT PROBLEMS AS MEN.

That painful fact is often attributed to wearing heels. Ironically, Western women started wearing heels to effect a more masculine look: European men adopted the look from Persian warriors in the 17th century, and women soon followed suit.

11. THE AVERAGE PERSON WALKS ABOUT 100,000 MILES IN A LIFETIME. 

That’s a lot of stress on our feet. It’s not surprising, then, that lower back pain, headaches, indigestion, and spine misalignment are often related to foot problems. Some runners blow way past this mark: They've logged at least 100,000 in running miles alone. One committed runner, Herb Fred, has run a whopping 247,142 miles.

12. FOOT SIZE HAS ZERO TO DO WITH PENIS SIZE.

In a study published in 2015, researchers synthesized data from 17 previous studies that included the penis measurements of more than 15,000 men from around the world. The results: There is little evidence that penis size is linked to height, body mass, or shoe size.

13. THERE'S A REASON GRANDPA'S TOENAILS LOOK LIKE THAT.

Ever heard someone describing their toenails as “horse hooves”? As we get older, our toenails tend to thicken, making them hard to trim. This happens because toenails grow more slowly as we age, causing the nail cells to accumulate. Stubbing toes, bad shoes, and dropping things on your feet can also cause thickening, as can fungal infections and peripheral arterial disease, which narrows arteries and reduces the blood flow to limbs.

14. THERE'S A GUINNESS WORLD RECORD FOR MOST FEET AND ARMPITS SNIFFED.

Odds are you don’t have any job-related tasks nearly as revolting as this one: In the 15 years that Madeline Albrecht worked for an Ohio lab that tests Dr. Scholl products, she sniffed more than 5600 feet and untold numbers of armpits. Albrecht currently holds the Guinness World Record for—yes, this is a category—the number of feet and armpits sniffed.

11 Insightful Facts About Eyes

iStock.com/Paffy69
iStock.com/Paffy69

There are a lot of myths and misconceptions about the eyes. No, sitting too close to the TV won't damage your vision, and reading in dim light won’t hurt either. It’s understandable that various parts of the eye are so little understood, though. Each eye has more than a million optic nerve cells and over 106 million photoreceptor cells, making it one of the most complex organs we have. Here are a few more things you should know about your “windows to the soul.”

1. Newborn babies see the world in black and white—and red.

“It is a myth that babies see in black and white,” Anna Franklin, leader of the University of Sussex's Baby Lab, told The Guardian. While newborns do see black, white, and shades of gray, they can also detect red objects against a gray backdrop, Franklin says. The reason why they can’t see more colors is because the cones in their eyes—the photoreceptor cells responsible for picking up colors—are too weak to detect them. Those cells quickly get stronger, though. After about two months, babies can distinguish between red and green, and a few weeks later they can tell the difference between blue and yellow.

2. Your eyeballs grow as you age.

Another common misconception is that your eyes remain the same size from birth to adulthood. As a newborn, your eyes measure about three-fifths of an inch from front to back, compared to a little under an inch in adults. Your eyes actually grow a great deal in the first two years of life, and another growth spurt occurs when you go through puberty. The confusion likely stems from the fact that your eyes as a 6-month-old infant are two-thirds the size they will be when you’re an adult.

3. The length of your eye partly determines how well you'll be able to see.

If your eyeball is too long or too short, you might end up having problems with your vision. Nearsighted people have eyes that are longer than average, while farsighted people have eyes that come up a little short. If you were to magically add or remove a millimeter of length from your eye, it would completely change your prescription. Aside from eye length, the shape of your cornea (the outer part of the eye where contact lenses are placed) and lens (the part of the eye located behind the iris and pupil) are other key factors that determine the quality of your vision. That's because both of these parts work together to refract light.

4. Contact lenses can't really get lost behind your eye.

Although it may feel like a dislodged contact lens is stuck behind your eye, that isn’t exactly what’s happening. The thin membrane covering the white part of your eye and the underside of your eyelid—called the conjunctiva—forms a pouch and prevents objects from getting behind your eyeball. If a contact lens gets shifted out of place to the point where you can no longer see it, it’s just stuck underneath your upper eyelid, which isn’t nearly as scary.

5. Blue-eyed people share a common ancestor.

Originally, everyone in the world had brown eyes. It wasn’t until around 6000 to 10,000 years ago that the first blue-eyed person was born as a result of a genetic mutation, according to a 2008 study. That mutation of the OCA2 gene essentially “turned off the ability to produce brown eyes” and diluted the color to blue, Professor Hans Eiberg of the University of Copenhagen said in a statement.

6. Parts of the eye can get sunburned.

There’s a good reason you should wear sunglasses when it’s bright outside. Too much exposure to UV rays can damage the surface of the cornea and conjunctiva, causing a condition akin to sunburn called photokeratitis. Symptoms include pain, red or swollen eyes, the sensation of a foreign body in the eyes, blurred vision, headaches, and seeing halos around lights. While the discomfort is temporary and tends to go away within 48 hours, longer exposure to UV rays can have a long-term effect on your vision and lead to macular degeneration (deterioration of the retina, which is often age-related) and cataracts (clouding of the eye's lens, which reduces the amount of light coming in).

7. Your eye muscles are the fastest muscle in your body.

Extraocular muscles are what let you look around in all directions. You have six of these muscles in each eye, and many of the motions they make are involuntary. This lets you flick your eyes to one side and notice something in your peripheral vision without consciously looking in that direction. When both of your eyes move in the same direction, the movement is called a saccade, which comes from the French word for “jerk” (the verb, not the person). These jerky movements are extremely rapid, lasting about 50 to 60 milliseconds per saccade, according to Dr. Reza Shadmehr, professor of biomedical engineering and neuroscience at Johns Hopkins University. “Saccadic eye movements are the fastest voluntary movements that we can make. The eyes move at around 500 degrees per second or more,” Shadmehr tells Mental Floss.

8. Your eye movements might give away your next move.

Shadmehr and other researchers conducted an experiment in 2015 to test the relationship between saccades and decision-making. Participants were placed in front of a computer and asked to choose between two options that appeared on the screen: an immediate reward and a delayed reward. For instance, one option might be “get $10 today,” while the other might be “wait 30 days and get $30.” Their eye movements were tracked the entire time, and researchers discovered that these movements gave away the choice they were about to make before they made it. At the last minute, their eyes would move at a faster velocity towards the option that they preferred.

“What’s interesting is that as the saccades are being made, the velocity of the eyes starts out being equal between these two stimuli, but then right before you decide ‘I like A better than B,' the saccade that you make toward A has a higher velocity than the one you make toward B,” Shadmehr explains. “The idea is that the way you’re evaluating things is reflected in the way you move toward them.”

In another experiment, Shadmehr found a correlation between faster eye movements and impatient and impulsive behaviors. Similarly, other studies have shown that our eye movements are linked to moral decisions and even our political temperament.

9. You can tell some animals' place in the food chain by looking at a part of their eye.

In 2015, vision scientist Martin Banks and his colleagues looked at the eyes of 214 species in an attempt to answer the question, “Why do animal eyes have pupils of different shapes?” By the end of their study, they noticed a few patterns. Predatory animals like big cats and snakes tend to have pupils in the shape of vertical slits. This particular shape gives them the advantage of being able to accurately judge the distance separating them and their prey, so they'll know exactly how far they have to pounce. On the other hand, horizontal pupils are more common in goats, deer, cattle, and other herbivores. This shape improves an animal’s panoramic vision, which helps them look out for predators.

10. An eye condition may have been partly responsible for Leonardo da Vinci's artistic genius.

Visual neuroscientist Christopher Tyler argued in a recent paper that the master artist behind Mona Lisa had strabismus, a disorder where the eyes are misaligned. Essentially, one of his eyes turned outwards, and he was able to use both of his eyes separately (monocular as opposed to binocular vision). Tyler believes this actually aided his art by improving his ability to render three-dimensional images on a flat canvas. “The condition is rather convenient for a painter, since viewing the world with one eye allows direct comparison with the flat image being drawn or painted,” Tyler said. We’ll never know for sure whether or not this was true for Leonardo, but it’s an intriguing theory.

11. SURGEONS HOPE TO BE PERFORMING WHOLE EYE TRANSPLANTS BY 2026. 

Currently, only cornea transplants to improve vision are possible, but a team of Pittsburgh-based transplant surgeons said in 2016 that they hoped to be performing whole eye transplants in humans within the next decade. Transferring an eye from a deceased donor to a recipient certainly won’t be easy, though. A complicated network of muscles, blood vessels, and nerves connects the eyes to the brain via the optic nerve. However, further studies into the optic nerve and recent advances in immunosuppressive drugs and surgical techniques have brought them several steps closer to achieving this goal. If successful, the surgery could restore vision to people who have suffered severe eye injuries. Their research is backed by the Department of Defense, which is concerned about the number of soldiers who sustain eye injuries in combat.

SECTIONS

arrow
LIVE SMARTER