One word is all it takes to answer today's mentalfloss.com Think Thursday Brain Game challenge, Can you do it?

What common six-letter English word begins and ends
with a vowel, but contains no other vowels?

Here is the SOLUTION. 

SOLUTION:

ASTHMA

(While far less common, the plural "ISTHMI" is also acceptable.)

Thanks for playing. Tomorrow, it's Free-for-All Friday!