Adam Savage, cohost of MythBusters, gave the keynote address at this year's SXSW Interactive Conference. His topic was "Art and Science," and the speech is fantastic. But where it really gets fun is twenty minutes into the video, when he sits down with Norm Chan (of Tested.com) for an extended Q&A. Block out 54 minutes, get some popcorn, and enjoy.
My favorite part: a series of MythBusters anecdotes starting around 41:30, including Jamie getting drunk in a gutter and then attempting to instruct a blind man how to drive. (For science, of course.) Also, Savage discusses the running-versus-walking-in-the-rain myth, and the YouTube comments go nuts.