Bacteria Can Turn Type A and B Blood Into a Universal Type O

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People with Type O blood might not be the only “universal donors” for much longer, according to new research showing that gut bacteria can be used to convert A and B blood types into O blood. As Newsweek reports, this discovery could provide a potentially life-saving service to people who urgently need blood transfusions in the event that O blood isn't readily available.

Steve Withers of the University of British Colombia is presenting the research this week at the American Chemical Society (ACS) national meeting. For each of the four blood types, different sugars are present on the outside of red blood cells. The immune system identifies these sugars as antigens, which can destroy cells and cause an allergic response if they’re not compatible with the transfusion recipient’s blood type. Because Type O blood has no antigens, it can be accepted by everyone.

Withers found that enzymes from one’s gut bacteria—specifically E. coli—could be used to eat away at the antigens attached to A and B blood cells, thus transforming them into O cells.

As the ACS video below explains, “The researchers homed in on the enzymes the bacteria use to pluck the sugars off and found a new family of enzymes that are 30 times more effective at removing red blood cell sugars than previously reported candidates.”

Previous research has taken a similar approach, but until now, scientists have been unable to find the right enzymes to fulfill the task safely and economically, according to Withers. 

Withers is now working with colleagues to validate these findings in hopes of potentially rolling them out in a clinical setting. “Of course, it will have to go through lots of clinical trials to make sure that it doesn’t have any adverse consequences, but it is looking very promising,” Withers said in a statement.

[h/t Newsweek]

10 Facts About Rosacea

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Rosacea, a skin condition characterized by redness and swelling, is incredibly common: A recent study found that an estimated 300 million people worldwide suffer from it. Here’s what you need to know about the condition.

1. IT HAS A LONG HISTORY.

According to the National Rosacea Society (NRS), rosacea was first described in the 14th century by a French surgeon named Dr. Guy de Chauliac; he called it goutterose (“pink drop” in French) or couperose and noted that it was characterized by “red lesions in the face, particularly on the nose and cheeks.”

2. SCIENTISTS AREN’T SURE WHAT CAUSES IT ...

But they have some theories. According to the NRS, “most experts believe it is a vascular disorder that seems to be related to flushing.” Scientists also think that because rosacea seems to run in families, it might be genetic. Other things—like mites that live on the skin, an intestinal bug called H pylori (common in those who have rosacea), and a reaction to a bacterium called bacillus oleronius—could also play a role in causing the condition. One 2015 study suggested an increased risk among smokers.

3. … BUT SOME PEOPLE ARE MORE LIKELY TO HAVE IT THAN OTHERS.

Though people of all ages and skin tones can get rosacea, fair skinned people between the ages of 30 and 50 with Celtic and Scandinavian ancestry and a family history of rosacea are more likely to develop the condition. Women are more likely to have rosacea than men, though their symptoms tend to be less severe than men’s. But men are more likely to suffer from a rare rosacea side effect known as rhinophyma, which causes the skin of the nose to thicken and become bulbous. It’s commonly—and mistakenly—associated with heavy drinking, but what exactly causes rhinophyma is unclear. According to the NRS, “The swelling that often follows a flushing reaction may, over time, lead to the growth of excess tissue (fibroplasia) around the nose as plasma proteins accumulate when the damaged lymphatic system fails to clear them. Leakage of a substance called blood coagulation factor XIII is also believed to be a potential cause of excess tissue.” Thankfully, those who have rhinophyma have options available for treatment, including surgery and laser therapy.

4. THERE ARE FOUR SUBTYPES.

According to the American Academy of Dermatology (AAD), rosacea “often begins with a tendency to blush or flush more easily than other people.” All rosacea involves redness of some kind (typically on the nose, cheeks, chin, and forehead), but other symptoms allow the condition to be divided into four subtypes: Erythematotelangiectatic rosacea is characterized by persistent redness and sometimes visible blood vessels; Papulopustular rosacea involves swelling and “acne-like breakouts”; Phymatous rosacea is characterized by thick and bumpy skin; and Ocular rosacea involves red eyes (that sometimes burn and itch, or feel like they have sand in them [PDF]), swollen eyelids, and stye-like growths.

5. IT’S NOT THE SAME AS ACNE.

Though rosacea was once considered a form of acne—"acne rosacea" first appeared in medical literature in 1814—today doctors know it’s a different condition altogether. Though there are similarities (like acne, some forms of rosacea are characterized by small, pus-filled bumps) there are key differences: Acne involves blackheads, typically occurs in the teen years, and can appear all over the body; rosacea is a chronic condition that occurs mainly on the face and the chest and typically shows up later in life.

6. YOU CAN FIND IT IN CLASSIC ART AND LITERATURE.

Both Chaucer and Shakespeare likely made references to rosacea. Domenico Ghirlandaio’s 1490 painting An Old Man and His Grandson seems to depict rhinophyma, and some believe that Rembrandt’s 1659 self-portrait shows that the artist had rosacea and rhinophyma.

7. IT MAY BE TRIGGERED BY CERTAIN FOODS AND ACTIVITIES.

According to the National Institutes of Health (NIH) [PDF], people report that everything from the weather to what you eat can cause rosacea to flare up: Heat, cold, sunlight, and wind, strenuous exercise, spicy food, alcohol consumption, menopause, stress, and use of steroids on the skin are all triggers.

8. THERE ARE A NUMBER OF MYTHS ABOUT ROSACEA.

No, it’s not caused by caffeine and coffee (flare ups, if they occur, are due to the heat of your coffee) or by heavy drinking (though alcohol does exacerbate the condition). Rosacea isn’t caused by poor hygiene, and it’s not contagious.

9. THERE ARE SOME PRETTY FAMOUS PEOPLE WITH ROSACEA.

Sophia Bush, Cynthia Nixon, Kristin Chenoweth, Bill Clinton, and Sam Smith all have rosacea. Diana, Princess of Wales had it, too. W.C. Fields had rosacea and rhinophyma, and Andy Warhol may also have suffered from those conditions.

10. IT CAN’T BE CURED—BUT IT CAN BE TREATED.

The NRS reports that “nearly 90 percent of rosacea patients [surveyed by NRS] said this condition had lowered their self-confidence and self-esteem, and 41 percent reported it had caused them to avoid public contact or cancel social engagements.” Dr. Uwe Gieler, a professor of dermatology at the Justus-Liebig-University in Giessen, Germany, and one of the authors of the report Rosacea: Beyond the Visible, said in a press release that "People with rosacea are often judged on their appearance, which impacts them greatly in daily life. If their rosacea is severe, the symptoms are likely to be more significant also, from itching and burning to a permanently red central facial area. However, even people with less severe rosacea report a significant impact on quality of life."

Which makes it all the more unfortunate that there’s not a cure for the condition. Thankfully, though, there are treatments available.

There are no tests that will diagnose rosacea; that’s up to your doctor, who will examine your medical history and go over your symptoms. Doctors advise that those with rosacea pay attention to what triggers flare-ups, which will help them figure out how to treat the condition. Antibiotics might be prescribed; laser therapy might be used. Anyone with rosacea should always wear sunscreen [PDF] and treat their skin very, very gently—don't scrub or exfoliate it. The AAD recommends moisturizing daily and avoiding products that contain things like urea, alcohol, and glycolic and lactic acids.

The Surgeon Who Removed His Own Appendix

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On February 15, 1921, Dr. Evan O’Neill Kane decided to test a theory. At the time, people with heart conditions and other serious ailments could not undergo most basic surgeries because general anesthesia was considered too dangerous. Rather than knocking these patients out, Kane wondered if he could simply give them a local anesthetic.

There was only one way to be sure: Kane decided to give himself an appendectomy.

As the chief surgeon at Kane Summit Hospital in Pennsylvania, Kane could probably perform the procedure blindfolded. The 60-year-old physician had performed more than 4000 appendectomies over his 37-year medical career. (Besides, the timing was right: He had chronic appendicitis and the organ needed to be removed anyway.)

For his experiment, Kane decided to numb the area with novocaine. “Sitting on the operating table propped up by pillows, and with a nurse holding his head forward that he might see, he calmly cut into his abdomen, carefully dissecting the tissues and closing the blood vessels as he worked his way in,” The New York Times reported. “Locating the appendix, he pulled it up, cut [it] off, and bent the stump under.” Finished with the dirty work, he let his assistants tie up the wound.

When a reporter visited a few hours later, Kane declared he was “feeling fine” [PDF].

Overall, he was pleased with the procedure. “I now know exactly how the patient feels when being operated upon under local treatment, and that was one of the objects I had in mind when I determined to perform the operation myself,” Kane later explained to The New York Times [PDF]. “I now fully understand just how to use the anesthesia to best advantage when removing the appendix from a person who has heart or other trouble that prohibits the use of a complete anesthesia.”

This was hardly the beginning—or end—to Kane’s career as his own surgeon. Two years earlier, he had amputated his own infected finger. And 10 years after the self-appendectomy, when he was 70, Kane calmly operated on his own hernia, joking with nurses throughout the whole 50-minute operation. Thirty-six hours later, he was back in the operating room, this time patching up other people.

Kane wouldn't be the last doctor to scoop out his own appendix. In 1961, Leonid Rogozov, the sole physician at the Soviet Union's Antarctic research station, performed an emergency self-appendectomy with the station's meteorologist and mechanic as his assistants [PDF]. More recently, Beirut surgeon Dr. Ira Kahn allegedly removed the organ himself in 1986. Unlike Kane, however, Kahn didn’t put himself under the knife for the sake of a medical experiment: Stuck in a traffic jam and unable to make it to the hospital for emergency surgery, he performed the procedure from the comfort of his car.

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