Brush Away Your Sniffles With New Allergy-Fighting Toothpaste

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For people with severe allergies, relief can cost a lot of time. Doctors can administer allergy shots, but you need them regularly, as often as multiple times a week. If you don’t complete the proper regimen, which can last for years, the treatment won’t be effective. Popular Science reports that there’s a new method for administering long-term allergy medicine that could prove a whole lot more convenient for patients, and it doesn’t involve any needles. It’s toothpaste.

Allerdent is a specially formulated toothpaste that can be customized to treat particular allergies. Typical allergy shots contain very small amounts of the allergen you’re trying to desensitize your body to—much like a vaccine contains the microbe of the disease it’s designed to inoculate you against. With Allerdent, instead of putting that allergen extract in a shot, the doctor mixes it into a toothpaste base. Patients can take that toothpaste home and use it daily, rather than coming in for a weekly allergy shot.

It’s not the first mouth-based allergy medicine. There are also under-the-tongue allergy drops that are widely used in Europe, but they can irritate the stomach and throat if you accidentally swallow them. But since the mucus membrane of the mouth has a high immune response (to protect against all the weird stuff you put in your mouth every day), it’s a great place to administer allergy medicine. Allergy toothpaste similarly allows you to put the medicine where it’s most effective, but it doesn't involve holding a squirt of oil in your mouth, and it doesn't have any gastrointestinal side effects.

The toothpaste comes with a pre-measured pump so that you get exactly the amount of medicine you need (no need to eyeball what the size of a pea is) and it can remain effective with up to 10 allergen extracts, so you could treat multiple allergies at one time. It could be especially effective to treat kids, since they're more likely to have trouble with shots or under-the-tongue drops. And, because it's something you can do at home, patients are more likely to stick to the regimen.

Allerdent isn’t easy to obtain at the moment. Your doctor has to order it, and because the FDA hasn’t approved allergen extracts in toothpaste (they’re only approved in shot form), your insurance company might not pay for it. As research into Allerdent and other oral allergy medicines progresses, though, the product might become easier to access.

[h/t Popular Science]

7 Human Body Parts That Were Once Used as Medicine

A 2300-year-old mummy from Egypt's Saqqara Pyramids complex
A 2300-year-old mummy from Egypt's Saqqara Pyramids complex
AFP/Getty Images

For hundreds of years, from at least the Renaissance through the Victorian era, medicine in England, Italy, France, and other European countries routinely involved the use of the dead human body. Bones, brains, blood, and more were believed to be able to cure everything from gout to epilepsy, thanks to the life-giving spirit imparted by the deceased. Although today the use of corpses is still an integral part of our healthcare—from tissue transplants to blood transfusions—the bulk of the practice of "medical cannibalism" has, thankfully, died out.

1. ANY PART OF A MUMMY

Arguably the most popular and the most difficult to find of the bunch, mummy was considered practically a panacea during the golden age of corpse medicine in the 16th and 17th centuries. Brought back from plundered Egyptian tombs, it was added to tinctures or plasters used to combat bleeding, venomous bites, bruising, and joint pain. Unfortunately, demand far outweighed the ill-gotten supply, and clever entrepreneurs cashed in on the craze by preparing fake mummies from the bodies of lepers, beggars, and even camels.

2. SKULLS

A 1633 image of skull moss from "The herball or, generall historie of plantes" by John Gerarde
A 1633 image of skull moss from The herball or, generall historie of plantes by John Gerarde

If powdered corpse was powerful, powdered corpse with chocolate was doubly so—at least according to Thomas Willis, a 17th-century scientist who combined skulls and cocoa in a cure for bleeding. Human skulls were also soaked in alcohol, creating a tincture called “the King’s drops,” since King Charles II of England allegedly paid £6000 for a personal recipe. The tincture was said to be good for gout, dropsy (edema), and "all fevers putrid or pestilential," among other ailments.

Nosebleeds and epilepsy were also treated with a powder made from moss growing on human skulls. Richard Sugg, the author of Mummies, Cannibals and Vampires: The History of Corpse Medicine from the Renaissance to the Victorians, says that this cure actually did work—but only because powder stimulated coagulation.

3. BRAINS

A photolithograph of brains of dissected heads, after a 1543 woodcut
A photolithograph of brains of dissected heads, after a 1543 woodcut

Brains were also used to cure epilepsy. Physician John French describes the process for making a tincture of brains in his 1651 book The Art of Distillation: “[T]ake the brains of a young man that hath died a violent death,” mash in a stone mortar, steep in wine, and “digest it half a year in horse dung” before distilling.

This remedy was supposed to work under the "like cures like" theory of medicine popular at the time, in which skulls and brains were seen as especially useful for curing illnesses thought to stem from the head. Cures taken from corpses that had died horribly were often thought to be extra powerful, because violence was seen to somehow concentrate the life force.

4. FAT

Human fat was a sought-after remedy for bleeding, bruising, muscle cramps, nerve damage, joint pain, and a variety of other afflictions. It was especially popular in Germany, and was delivered to Munich’s doctors by enterprising executioners until the mid-18th century. Others sought to bypass the apothecary entirely and went straight to the executioner for their medicinal supplies. Often the fat was made into a salve (sometimes known as "hangman's salve"), but one physician to several English and French kings combined the ingredient with hemlock and opium and administered it as a pain-reducing plaster.

5. BLOOD

A crowd of spectators wait as Tom Idle is driven in a cart with his coffin to his place of execution and the gallows. Engraving by William Hogarth, 1747
Engraving of an execution by William Hogarth, 1747

Like fat and brains, blood was also often procured directly from the executioner. People who were too poor to afford the fine wares of their local apothecary went instead to the gallows, where they paid a few coins to drink the fresh blood of the recently executed. Though usually drunk straight, blood was also dried and powdered (to cure nosebleeds), sprinkled on wounds (to stop bleeding), or even made into a kind of human marmalade.

6. HAIR

According to Sugg, a tonic called “liquor of hair” was regularly used to encourage hair growth in those who were balding. Under the like cures like theory, the hair of a deceased person was believed to help with the hair of the living. However, powdered hair was also administered for complaints that had nothing to do with heads—including jaundice.

7. TEETH

Engraving of a tooth-drawer by D.J. Pound after G. Dou, 1672
Engraving of a tooth-drawer by D.J. Pound after G. Dou, 1672

Teeth, too, were an example of "like cures like." In North Hampshire, England, and other areas, people wore teeth taken from corpses in a bag around their neck as a remedy for toothache, an ailment that could also be treated by touching a cadaver’s tooth to your own. In Ireland, people went even further, and believed that toothache could be cured by rubbing the afflicted gum with the finger of a corpse, or even washing it with some water that had also been used to wash the dead body. (Makes you thankful for modern mouthwash.)

12 Facts About Kidney Stones

Illustration by Mental Floss. Images: iStock
Illustration by Mental Floss. Images: iStock

Kidney stones are more common than ever. According to Harvard Medical School, every year more than 3 million people see a doctor for relief from these hard mineral and salt deposits, which form in your kidney when urine becomes too concentrated. Here's what we know about the condition formally called nephrolithiasis.

1. KIDNEY STONES TYPICALLY CAUSE REALLY PAINFUL SYMPTOMS.

At first you may notice your urine is cloudy, bloody, and foul smelling. Your back may begin to ache, and nausea may come over you. Then, as the stone moves from your kidney into your urinary tract or bladder, sometimes becoming trapped, there’s often an intense, stabbing pain that many people say they wouldn’t wish on their worst enemy.

2. MOST PEOPLE DEVELOP ONE TYPE OF STONE …

What kind of kidney stone you get depends on your diet, fluid intake, genetics, hereditary disorders, and even whether you take certain medications, but the vast majority of people get calcium oxalate stones. They're formed from a mix of calcium in urine and the compound oxalate, which is found naturally in food like nuts, chocolate, and some vegetables, including beets and spinach; oxalate is also produced by your liver. There's some evidence that people who take the seizure medicine topiramate can develop these stones in the form of calcium phosphate.

3. … BUT THERE ARE THREE OTHER KINDS TOO.

Struvite stones are fast-growing mineral deposits that typically develop in response to a urinary tract infection, and can grow large enough to block the kidney, ureter, or bladder before you notice any symptoms; they affect women more than men. Uric acid stones turn up in people who eat a lot of red meat, shellfish, and organ meats, which contain hefty doses of an organic compound called purine that can lead to more uric acid than the kidneys can excrete. Cystine stones are caused by a rare hereditary disorder called cistinuria in which your kidneys excrete excessive amounts of the amino acid cystine.

4. THEY'RE EXTREMELY COMMON—ESPECIALLY IN MEN.

There's a solid chance you could end up with a kidney stone. The National Kidney Foundation notes that one in 10 people will develop one during the course of their life. And if you’re male, take note: Your gender alone is considered a kidney stone risk factor. Men are twice as likely as women to develop them. Another factor is age: Although stones are most common from ages 20 through 50, they tend to peak around age 30.

5. IF YOU’VE HAD A KIDNEY STONE, YOU’LL PROBABLY DEVELOP ANOTHER ONE …

Sorry to say, but simply having a kidney stone puts you at risk for a recurrence. If you’ve had one, the U.S. National Library of Medicine notes that there’s a 30 to 50 percent chance more stones will form within five years.

6. … BUT YOU CAN TAKE STEPS TO PREVENT THEM.

Cutting back on sodium (i.e. deli meats, packaged soups, and processed foods) can help, because a stone can form from excessive salt consumption. You should also avoid too much animal protein—it produces urine containing more acid, which is known to increase your risk for kidney stones—and increase your intake of fruits, vegetables, whole grains, and low-fat dairy. And be sure to drink plenty of fluids, especially water—at least 12 glasses a day. (That's good advice for everyone, not just those prone to kidney stones.)

Don't drink much apple or cranberry juice as both contain oxalates and are linked to an increased risk of developing calcium oxalate stones. High doses of Vitamin C may boost the concentration of oxalate in urine; the Cleveland Clinic recommends a daily maximum of 500 milligrams.

7. IT'S A MYTH THAT CALCIUM CREATES SOME KIDNEY STONES.

Despite the fact that the word calcium is part of the most common kind of kidney stone, you don’t need to treat calcium as the enemy. In fact, having too little calcium can actually increase the odds you’ll get these types of stones. According to the Cleveland Clinic, eating about two or three servings of calcium-rich foods daily reduces oxalate absorption, helping to keep calcium oxalate stones away. So get out the cheese.

8. IF YOU PASS A STONE, CONGRATULATIONS! NOW TAKE IT TO A DOCTOR.

Ninety percent of kidney stones are passed through urination. Getting one out this way may hurt a lot, but once the stone has finished causing you agony, it could provide clues that could help you avoid developing another one. If you’re able to retrieve the stone, bring it to your doctor, who can order an analysis. Identifying its components can reveal the kind of stone it is and potentially point to a treatment or prevention plan.

9. IF YOU CAN’T PASS A STONE, TREATMENTS ARE AVAILABLE …

In an attempt to exit the body, a stone travels from the kidney to the bladder through a narrow tube called the ureter. If the stone is larger than a quarter-inch, it's simply too big to pass through the ureter, and will get trapped there. (If it can make it through to your bladder, it's small enough to pass out out of your body through the urethra.) This causes intense pain, blocked urine flow, and possible bleeding from urinary tract walls. That's when it's time for treatment.

There are several methods for getting rid of a kidney stone, all of which aim to break the stone into smaller pieces so they can leave the body. In an extracorporeal shock wave lithotripsy (from the Greek for "crushed stone"), high-frequency sound waves are applied externally to break stones up, allowing them to pass when you pee. Laser lithotripsy takes a similar approach: Stones in the ureter are broken up with a laser and also leave the body naturally. More invasive is percutaneous ultrasonic lithotripsy, which involves passing narrow instruments (including a fiberoptic camera) through your back to your kidney; ultrasound breaks the stones up, and then fragments are removed by an instrument. Finally, a ureteroscopy is a treatment option in which a small scope is inserted in the ureter towards the bladder to determine the stone's location. Then it's broken up for natural passage or removed altogether. Luckily, you're unconscious under general anesthesia during the last procedure.

10. … AND THEY'RE FAR SUPERIOR TO THOSE USED IN THE PAST.

Kidney stones are nothing new—mentions of the painful formations go back more than 5000 years, to Mesopotamian medical texts—and medical interventions have occurred for just as long. Stones made it into the Hippocratic Oath, in which physicians swore they would "not use the knife, not even on sufferers from stone," leaving the procedure to "such men as are engaged in this work" [PDF]. Surgeons in ancient Greece and India were attempting stone removal as far back as the 7th century BCE.

The 16th to 18th centuries were a heyday for stone surgeons, who were largely self-taught. The most notorious of them was Frere Jacques Beaulieu. He pioneered the lateral perineal lithotomy—which involved making an incision in the perineum, inserting a terrifying cutting instrument into the bladder, cutting up the stone, and then extracting the pieces with the instrument or his fingers—in the late 17th century. Unfortunately for his patients, he had no technical training, and his method was often deadly; in 1698, after 25 of his 60 patients died, he was banned from doing the procedure—but he didn't stop. He's thought to have performed more than 5000 lithotomies. (And no, the song doesn't seem to be about him.)

11. IF ALL ELSE FAILS, TRY RIDING A ROLLER COASTER.

If you’re a thrill seeker who happens to have kidney stones (and some vacation time), you may be in luck. After a "notable number" of patients reported that riding the Big Thunder Mountain roller coaster at Walt Disney World in Orlando helped them to pass their kidney stones, Michigan State University urologist David Wartinger decided to investigate. He created a kidney replica—complete with kidney stones—put it in a backpack, and let it ride the roller coaster 60 times. It worked—but passing the stones depended on where the backpack was placed in the coaster. Rides in the last car were the most effective, with the stones passing 64 percent of the time, while the front few cars yielded only a 16 percent success rate.

Big Thunder Mountain was the only ride in the theme park that was effective. Neither Space Mountain nor Aerosmith's Rock 'n' Roller Coaster did the trick, likely because they were too fast, with a G-force that pinned the stones in place. Of course, while this is an interesting finding, if you suspect you have kidney stones, speak to your doctor before you high-tail it to Walt Disney World.

12. A KIDNEY STONE THE SIZE OF A MOUSE WAS REMOVED FROM A MAN IN 2004.

The stone measured 5.11 inches at its widest point—a world record. Five years later, a whopping 2.5-pound stone was surgically removed from a man in Hungary in 2009. Perhaps seeing a bunch of kidney stones in one place other than originating from your own body will put you at ease. If that’s the case, check out the International Museum of Surgical Science in Chicago, where a collection of stones is on display in glass jars.

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