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15 Women Who Have Won Science Nobel Prizes Since Marie Curie

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Madame Marie Curie famously snagged two Nobel Prizes—for Physics in 1903 with husband Pierre and Henri Becquerel, and again in 1911 for Chemistry after discovering radium and polonium—but many other women have also been awarded the Physics, Chemistry, and Physiology or Medicine Nobels, too. Here are their stories.

1. Irène Joliot-Curie // Chemistry (1935)

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The second woman to win a Nobel was Irène Curie, daughter of Pierre and Marie. She shared the Prize with her husband, Jean Frédéric Joliot-Curie, for their discovery of “artificial radioactivity,” which they achieved by bombarding boron, aluminum, and magnesium with alpha particles to create radioactive isotopes. The Curies have more Nobel laureates than any other family.

The pair publically adopted a hyphenated surname, but according to their daughter Hélène Langevin-Joliot, "Many people used to name my parents Joliot-Curie, but they signed their scientific papers Irène Curie and Frédéric Joliot."

2. Gerty Theresa Cori // Physiology or Medicine (1947)

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Gerty and her husband, Carl Cori, met in Prague and lived in Austria before immigrating to the United States in 1922, where the two medical doctors worked together (against the advice of their colleagues) at the Roswell Park Cancer Institute in New York. The Coris studied carbohydrate metabolism, a specialty largely driven by Gerty’s father, a diabetic who asked her to find a cure for his disease.

Though their collaboration was unusual (even called “un-American,” according to Carl’s autobiography), the Coris were an amazing team. Gerty was given first author credit on most of their papers, indicating that she did the majority of the research. In 1929, they proposed “the Cori cycle,” a hypothetical model of how the body uses chemical reactions to break down carbohydrates.

In 1947, Gerty and Carl were awarded the Nobel in Physiology or Medicine, making Gerty Cori the first woman to hold the honor. In his speech, Carl spoke of their teamwork: "Our collaboration began 30 years ago when we were still medical students at the University of Prague and has continued ever since. Our efforts have been largely complementary, and one without the other would not have gone as far as in combination."

3. Maria Goeppert-Mayer // Physics (1963)

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German-born Maria Goeppert-Mayer studied Mathematics and Physics at the University of Göttingen, where, in 1930, she earned her Doctorate in Philosophy after writing her dissertation on two-photon absorption in atoms, a work Nobel laureate E.P. Wigner called "a masterpiece of clarity and concreteness." At the time, her work was purely theoretical; the laser hadn’t been invented yet, and no foreseeable method of testing its accuracy was available. In 1961, her theory was experimentally proven, and the unit for the two-photon absorption cross section was named the Goeppert-Mayer (GM) unit.

Goeppert-Mayer moved to the U.S. with her husband, chemist Joseph Edward Mayer, in 1930. He worked at Johns Hopkins University, where she worked as an assistant to the Physics department. There, she also taught classes and conducted research in quantum physics. In 1937, they moved to Columbia University, where Maria took an unpaid position in the Physics department where she worked with Harold Urey and Enrico Fermi. In 1942, she joined the Manhattan Project, working on methods of isolating uranium-235 from natural uranium. From there, she moved on to Los Alamos Laboratory, then Argonne National Laboratory, then to Aberdeen, where she programmed the ENIAC to solve criticality problems.

While at Argonne, Goeppert-Mayer developed the nuclear shell model, a mathematical model for the structure of atomic nuclei. For this, she shared the 1963 Nobel Prize for Physics with J. Hans D. Jensen and Eugene Paul Wigner – the first woman to receive the award in 60 years.

4. Dorothy Crowfoot Hodgkin // Chemistry (1964)

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Dorothy Hodgkin’s mother fostered her love of science as a child, and at age 18, she began studying chemistry at a women-only Oxford college. She earned her PhD at the University of Cambridge, where she first took an interest in X-ray crystallography and began studying the structure of proteins. In 1934, she moved back to Oxford, where she was appointed the university’s first research chemistry fellow, a position she held until 1977. (She taught future Prime Minister Margaret Thatcher in the 1940s.)

Through those years at Oxford, Hodgkin studied and discovered the three-dimensional structures of many biomolecules using X-ray crystallography: She confirmed the structure of penicillin in 1945. Her work on mapping vitamin B12 earned her the Nobel Prize in Chemistry in 1964. Five years later, she discovered the structure of insulin, a project so far advanced beyond the then-current technology that she first spent years working with colleagues to improve their methods and tools.

5. Rosalyn Sussman Yalow // Physiology or Medicine (1977)

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In 1941, WWII had begun and many scholarships for women became available as men went off to war. In 1945, thanks to these scholarships, Yalow earned her PhD in Physics at the University of Illinois. Afterward, she moved to the Bronx Veterans Administration Hospital, where she helped set up its new radioisotope lab. With colleague Solomon Berson, she developed radioimmunoassay (RIA), a technique that measures tiny quantities of various substances in liquids, notably insulin in human blood.

RIA has since been used to trace hundreds of hormones, enzymes, and vitamins and is essential to testing for cancer and other diseases, screening donated blood for hepatitis and other infections, and identifying therapeutic levels of drugs in the bloodstream. Despite its potential and eventual success, Yalow and Berson refused to patent their method.

In 1977, Yalow was awarded the Nobel Prize for RIA, and with Roger Guillemin and Andrew V. Shally for devising the technique.

6. Barbara McClintock // Physiology or Medicine (1983)

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McClintock received her Ph.D. in Botany from Cornell University in 1927, where she began her long career in maize cytogenetics, a study she would pursue for the rest of her life.

McClintock’s research focused on chromosomal changes in maize during reproduction. Through this, she pioneered techniques for visualizing and analysis of maize chromosomes in order to illustrate how they change during reproduction. She created the first genetic map of corn, and was the first to link its chromosomes to its physical traits; she also was the first to demonstrate that the telomere and centromere are important for conserving genetic information. McClintock (pictured with William Golding) made many discoveries, but the one that won the Nobel was transposition—the theory that genes turn on and off physical characteristics. She was the first woman to win the Prize unshared in Physiology.

7. Rita Levi-Montalcini // Physiology or Medicine (1986)

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Rita Montalcini studied at the University of Turin Medical School, but her academic career ended abruptly in 1938 when Benito Mussolini barred Jews from pursuing academic and professional careers. Instead, she worked from a laboratory in her home, where she studied the nerve development of chicken embryos.

She moved to the United States in 1946 to attend Washington University in St. Louis for one semester. However, after repeating the results of experiments made in her home, she was offered a research position. Over the next 30 years, Levi-Montalcini would continue to study nerve growth, but her most important work was done in 1952. That year, she and collaborator Stanley Cohen isolated nerve growth factors (NGFs), proteins that guide the growth, maintenance and survival of nerve tissue.

Levi-Montalcini was the first Nobel laureate to reach the age of 100. She died in 2012, at 103 years old.

8. Gertrude B. Elion // Physiology or Medicine (1988)

Elion’s work, like Gerty Cori’s, was spurred by a relative’s disease: her grandfather died of stomach cancer when she was 15, and it was then that Elion decided to spend her life looking for a cure. She later said, "I had no specific bent toward science until my grandfather died of cancer. I decided nobody should suffer that much."

After obtaining her Master’s in Chemistry from New York University, Elion worked as a teacher and lab assistant before moving to what is now GlaxoSmithKline. She, sometimes in conjunction with George H. Hitchings, developed a number of new pharmaceuticals designed to kill pathogens without harming healthy cells. These include Purinethol, the first treatment for leukemia and an anti-rejection drug for organ transplant patients; Daraprim, for malaria; Zovirax, a treatment for viral herpes; Septra, a drug used to treat urinary and respiratory tract infections, meningitis, and septicemia; Nelarabine, a drug used in cancer treatment; and Imuran/AZT, the first immune-suppressive agent, which is used in organ transplantation and the treatment of AIDS.

Elion and Hitchings shared the Prize in 1988 with Sir James W. Black, who developed the beta-blocker propranolol and cimetidine, a drug used to treat stomach ulcers.

9. Christiane Nüsslein-Volhard // Physiology or Medicine (1995)

Fruit flies are useful in genetic research because they’re small, quick to reproduce, and easy to maintain in a laboratory. Using fruit flies, Christiane Nüsslein-Volhard, a German biologist, has spent her life uncovering the molecular and genetic mechanisms that allow multicellular organisms to develop from a single cell (embryogenesis).

Her research of genetic mutation in fruit flies has allowed us to understand which genes are involved in different developmental processes, an understanding that applies to many species beyond fruit flies. Additionally, Nüsslein-Volhard’s work helps us understand evolution, thanks to her discoveries about the genetic makeup of a common ancestor for protostomes and deuterostomes.

She was awarded the Prize in 1995, along with with Eric Wieschaus and Edward B. Lewis. 15811 Nüsslein-Volhard, an asteroid discovered in 1994, is named for her.

10. Linda B. Buck // Physiology or Medicine (2004)

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Believe it or not, we didn’t really know how the sense of smell worked until 1991, when Linda B. Buck and Richard Axel published their research, which revealed not only the structure of the olfactory system, but also the mechanism olfaction – how we smell. Buck and Axel were able to clone olfactory receptors and analyze rat DNA to determine how the sense of smell works in all mammals. For this, the pair shared the Nobel in 2004.

11. Françoise Barré-Sinoussi // Physiology or Medicine (2008)

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In 1975, Françoise Barré-Sinoussi earned her PhD at the Pasteur Institute in Paris, where she then began studying retroviruses. By 1983, she had discovered HIV. By 1988, she had her own research laboratory in the university and was studying the virus full-time. In addition to identifying the virus itself, Barré-Sinoussi’s research has revealed the methods by which HIV spreads and its connection to AIDS, and she has produced over 200 scientific publications regarding specific mechanisms in our immune systems and the virus itself.

In 2008, Barré-Sinoussi shared the Nobel for Physiology or Medicine with Luc Mantagnier, her mentor, and Harold zur Hausen, who discovered HPV and developed the cervical cancer vaccine. Barré-Sinoussi continues to work with developing countries to address the spread of and improve the treatment for HIV/AIDS.

12. Ada E. Yonath // Chemistry (2009)

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Ada Yonath grew up in Jerusalem with limited means; despite her family’s poverty, her parents sent her to an affluent school. In 1942, she moved to Tel Aviv after her father’s death, where she attended Tichon Hadash high school. She couldn’t afford tuition, so the school allowed her to attend if she gave math lessons to other students. By 1964, she had earned a PhD in X-ray Crystallography from the Weizmann Institute of Science. In 1970, she founded the first (and for a long time, only) protein crystallography lab in Israel.

Yonath pioneered cryo bio-crystallography, the technique she uses to study microbe ribosomes and their mechanisms, despite harsh criticism from the scientific community. Today, cryo bio-crystallography is taught as a standard technique in structural biology. Yonath’s body of research has revealed much more than the structure of microbe ribosomes; thanks to her work, we know how many antibiotics work, why some bacteria are drug-resistant, and discovered the structural basis for antibiotic selectivity—all of which are now used in research labs to design more effective drugs.

For her work on protein biosynthesis and peptide bond formation, Yonath earned the Nobel Prize for Chemistry in 2009. Today, she is the director of the Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly of the Weizmann Institute of Science.

13 and 14. Elizabeth Blackburn and Carol W. Greider // Physiology or Medicine (2009)

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Elizabeth Blackburn was born in Tasmania in 1948. She earned her Master’s degree at the University of Melbourne, then her PhD from the University of Cambridge. By 1981, she was at the University of California, Berkeley.

Carolyn Widney Greider was born in San Diego. She received her B.A. in Biology from the University of California, Santa Barbara in 1983, then studied at the University of Göttingen for a time before returning to California in 1983 to earn her PhD at UCSF, where she studied under Elizabeth Blackburn.

Both women research telomeres, the end caps of chromosomes created by repeating stacks of “extra” DNA bases. When DNA replicates, these telomeres are shortened and the chromosomes deteriorate—the cause of aging and chromosome fusion, which leads to cancer. Blackburn and Greider set out to find a hypothetical enzyme that protects the telomere.

Greider, according to Blackburn, worked diligently—often 12 hours or more a day. On Christmas Day, 1984, Greider’s results indicated that she had in fact located the mysterious telomere-protecting enzyme, which was still unnamed. Six months later, the pair published their results in the journal Cell: they had discovered telomerase. In an interview, Blackburn said:

Carol had done this experiment, and we stood, just in the lab, and I remember sort of standing there, and she had this – we call it a gel. It's an autoradiogram, because there was trace amounts of radioactivity that were used to develop an image of the separated DNA products of what turned out to be the telomerase enzyme reaction. I remember looking at it and just thinking, ‘Ah! This could be very big. This looks just right.’

Blackburn and Greider’s Prize in 2009 marked the first award shared by more than one woman.

15. May-Britt Moser // Physiology of Medicine (2014)

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Moser was honored in 2014 for the "discovery of cells that constitute a positioning system in the brain." From

"In 2005, May-Britt Moser and Edvard I. Moser discovered a type of cell that is important for determining position close to the hippocampus, an area located in the center of the brain. They found that when a rat passed certain points arranged in a hexagonal grid in space, nerve cells that form a kind of coordinate system for navigation were activated. They then went on to demonstrate how these different cell types cooperate."

This story originally ran in 2015.

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iStock // Ekaterina Minaeva
Man Buys Two Metric Tons of LEGO Bricks; Sorts Them Via Machine Learning
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iStock // Ekaterina Minaeva

Jacques Mattheij made a small, but awesome, mistake. He went on eBay one evening and bid on a bunch of bulk LEGO brick auctions, then went to sleep. Upon waking, he discovered that he was the high bidder on many, and was now the proud owner of two tons of LEGO bricks. (This is about 4400 pounds.) He wrote, "[L]esson 1: if you win almost all bids you are bidding too high."

Mattheij had noticed that bulk, unsorted bricks sell for something like €10/kilogram, whereas sets are roughly €40/kg and rare parts go for up to €100/kg. Much of the value of the bricks is in their sorting. If he could reduce the entropy of these bins of unsorted bricks, he could make a tidy profit. While many people do this work by hand, the problem is enormous—just the kind of challenge for a computer. Mattheij writes:

There are 38000+ shapes and there are 100+ possible shades of color (you can roughly tell how old someone is by asking them what lego colors they remember from their youth).

In the following months, Mattheij built a proof-of-concept sorting system using, of course, LEGO. He broke the problem down into a series of sub-problems (including "feeding LEGO reliably from a hopper is surprisingly hard," one of those facts of nature that will stymie even the best system design). After tinkering with the prototype at length, he expanded the system to a surprisingly complex system of conveyer belts (powered by a home treadmill), various pieces of cabinetry, and "copious quantities of crazy glue."

Here's a video showing the current system running at low speed:

The key part of the system was running the bricks past a camera paired with a computer running a neural net-based image classifier. That allows the computer (when sufficiently trained on brick images) to recognize bricks and thus categorize them by color, shape, or other parameters. Remember that as bricks pass by, they can be in any orientation, can be dirty, can even be stuck to other pieces. So having a flexible software system is key to recognizing—in a fraction of a second—what a given brick is, in order to sort it out. When a match is found, a jet of compressed air pops the piece off the conveyer belt and into a waiting bin.

After much experimentation, Mattheij rewrote the software (several times in fact) to accomplish a variety of basic tasks. At its core, the system takes images from a webcam and feeds them to a neural network to do the classification. Of course, the neural net needs to be "trained" by showing it lots of images, and telling it what those images represent. Mattheij's breakthrough was allowing the machine to effectively train itself, with guidance: Running pieces through allows the system to take its own photos, make a guess, and build on that guess. As long as Mattheij corrects the incorrect guesses, he ends up with a decent (and self-reinforcing) corpus of training data. As the machine continues running, it can rack up more training, allowing it to recognize a broad variety of pieces on the fly.

Here's another video, focusing on how the pieces move on conveyer belts (running at slow speed so puny humans can follow). You can also see the air jets in action:

In an email interview, Mattheij told Mental Floss that the system currently sorts LEGO bricks into more than 50 categories. It can also be run in a color-sorting mode to bin the parts across 12 color groups. (Thus at present you'd likely do a two-pass sort on the bricks: once for shape, then a separate pass for color.) He continues to refine the system, with a focus on making its recognition abilities faster. At some point down the line, he plans to make the software portion open source. You're on your own as far as building conveyer belts, bins, and so forth.

Check out Mattheij's writeup in two parts for more information. It starts with an overview of the story, followed up with a deep dive on the software. He's also tweeting about the project (among other things). And if you look around a bit, you'll find bulk LEGO brick auctions online—it's definitely a thing!

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Cs California, Wikimedia Commons // CC BY-SA 3.0
How Experts Say We Should Stop a 'Zombie' Infection: Kill It With Fire
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Cs California, Wikimedia Commons // CC BY-SA 3.0

Scientists are known for being pretty cautious people. But sometimes, even the most careful of us need to burn some things to the ground. Immunologists have proposed a plan to burn large swaths of parkland in an attempt to wipe out disease, as The New York Times reports. They described the problem in the journal Microbiology and Molecular Biology Reviews.

Chronic wasting disease (CWD) is a gruesome infection that’s been destroying deer and elk herds across North America. Like bovine spongiform encephalopathy (BSE, better known as mad cow disease) and Creutzfeldt-Jakob disease, CWD is caused by damaged, contagious little proteins called prions. Although it's been half a century since CWD was first discovered, scientists are still scratching their heads about how it works, how it spreads, and if, like BSE, it could someday infect humans.

Paper co-author Mark Zabel, of the Prion Research Center at Colorado State University, says animals with CWD fade away slowly at first, losing weight and starting to act kind of spacey. But "they’re not hard to pick out at the end stage," he told The New York Times. "They have a vacant stare, they have a stumbling gait, their heads are drooping, their ears are down, you can see thick saliva dripping from their mouths. It’s like a true zombie disease."

CWD has already been spotted in 24 U.S. states. Some herds are already 50 percent infected, and that number is only growing.

Prion illnesses often travel from one infected individual to another, but CWD’s expansion was so rapid that scientists began to suspect it had more than one way of finding new animals to attack.

Sure enough, it did. As it turns out, the CWD prion doesn’t go down with its host-animal ship. Infected animals shed the prion in their urine, feces, and drool. Long after the sick deer has died, others can still contract CWD from the leaves they eat and the grass in which they stand.

As if that’s not bad enough, CWD has another trick up its sleeve: spontaneous generation. That is, it doesn’t take much damage to twist a healthy prion into a zombifying pathogen. The illness just pops up.

There are some treatments, including immersing infected tissue in an ozone bath. But that won't help when the problem is literally smeared across the landscape. "You cannot treat half of the continental United States with ozone," Zabel said.

And so, to combat this many-pronged assault on our wildlife, Zabel and his colleagues are getting aggressive. They recommend a controlled burn of infected areas of national parks in Colorado and Arkansas—a pilot study to determine if fire will be enough.

"If you eliminate the plants that have prions on the surface, that would be a huge step forward," he said. "I really don’t think it’s that crazy."

[h/t The New York Times]