CLOSE
iStock
iStock

Why Is Your First Instinct After Hurting Your Finger to Put It in Your Mouth?

iStock
iStock

If you close your fingers in a car door or slam your funny bone into a wall, you might find your first reaction is to suck on your fingers or rub your elbow. Not only is this an instinctive self-soothing behavior, it's a pretty effective technique for temporarily calming pain signals to the brain.

But how and why does it work? To understand, you need to know about the dominant theory of how pain is communicated in the body.

In the 17th century, French scientist and philosopher René Descartes proposed that there were specific pain receptors in the body that "rang a bell in the brain" when a stimulus interacted with the body, Lorne Mendell, a professor of neurobiology and behavior at Stony Brook University in New York, tells Mental Floss. However, no study has effectively been able to identify receptors anywhere in the body that only respond to painful stimuli.

"You can activate certain nerve fibers that can lead to pain, but under other circumstances, they don't," Mendell says. In other words, the same nerve fibers that carry pain signals also carry other sensations.

In 1965, two researchers at MIT, Patrick Wall and Ronald Melzack, proposed what they called the gate control theory of pain, which, for the most part, holds up to this day. Mendell, whose research focuses on the neurobiology of pain and who worked with both men on their pain studies, explains that their research showed that feeling pain is more about a balance of stimuli on the different types of nerve fibers.

"The idea was that certain fibers that increased the input were ones that opened the gate, and the ones that reduced the input closed the gate," Mendell says. "So you have this idea of a gate control sitting across the entrance of the spinal cord, and that could either be open and produce pain, or the gate could be shut and reduce pain."

The gate control theory was fleshed out in 1996 when neurophysiologist Edward Perl discovered that cells contain nociceptors, which are neurons that signal the presence of tissue-damaging stimuli or the existence of tissue damage.

Of the two main types of nerve fibers—large and small—the large fibers carry non-nociceptive information (no pain), while small fibers transmit nociceptive information (pain).

Mendell explains that in studies where electric stimulation is applied to nerves, as the current is raised, the first fibers to be stimulated are the largest ones. As the intensity of the stimulus increases, smaller and smaller fibers get recruited in. "When you do this in a patient at low intensity, the patient will recognize the stimulus, but it will not be painful," he says. "But when you increase the intensity of the stimulus, eventually you reach threshold where suddenly the patient will say, 'This is painful.'"

Thus, "the idea was that shutting the gate was something that the large fibers produced, and opening the gate was something that the small fibers produced."

Now back to your pain. When you suck on a jammed finger or rub a banged shin, you're stimulating the large fibers with "counter irritation," Mendell says. The effect is "a decrease in the message, or the magnitude of the barrage of signals being driven across the incoming fiber activation. You basically shut the gate. That is what reduces pain."

This concept has created "a big industry" around treating pain with mild electrical stimulation, Mendell says, with the goal of stimulating those large fibers in the hopes they will shut the gate on the pain signals from the small fibers.

While counter irritation may not help dull the pain of serious injury, it may come in handy the next time you experience a bad bruise or a stubbed toe.

nextArticle.image_alt|e
Penn Vet Working Dog Center
arrow
Stones, Bones, and Wrecks
New Program Trains Dogs to Sniff Out Art Smugglers
Penn Vet Working Dog Center
Penn Vet Working Dog Center

Soon, the dogs you see sniffing out contraband at airports may not be searching for drugs or smuggled Spanish ham. They might be looking for stolen treasures.

K-9 Artifact Finders, a new collaboration between New Hampshire-based cultural heritage law firm Red Arch and the University of Pennsylvania, is training dogs to root out stolen antiquities looted from archaeological sites and museums. The dogs would be stopping them at borders before the items can be sold elsewhere on the black market.

The illegal antiquities trade nets more than $3 billion per year around the world, and trafficking hits countries dealing with ongoing conflict, like Syria and Iraq today, particularly hard. By one estimate, around half a million artifacts were stolen from museums and archaeological sites throughout Iraq between 2003 and 2005 alone. (Famously, the craft-supply chain Hobby Lobby was fined $3 million in 2017 for buying thousands of ancient artifacts looted from Iraq.) In Syria, the Islamic State has been known to loot and sell ancient artifacts including statues, jewelry, and art to fund its operations.

But the problem spans across the world. Between 2007 and 2016, U.S. Customs and Border Control discovered more than 7800 cultural artifacts in the U.S. looted from 30 different countries.

A yellow Lab sniffs a metal cage designed to train dogs on scent detection.
Penn Vet Working Dog Center

K-9 Artifact Finders is the brainchild of Rick St. Hilaire, the executive director of Red Arch. His non-profit firm researches cultural heritage property law and preservation policy, including studying archaeological site looting and antiquities trafficking. Back in 2015, St. Hilaire was reading an article about a working dog trained to sniff out electronics that was able to find USB drives, SD cards, and other data storage devices. He wondered, if dogs could be trained to identify the scents of inorganic materials that make up electronics, could they be trained to sniff out ancient pottery?

To find out, St. Hilaire tells Mental Floss, he contacted the Penn Vet Working Dog Center, a research and training center for detection dogs. In December 2017, Red Arch, the Working Dog Center, and the Penn Museum (which is providing the artifacts to train the dogs) launched K-9 Artifact Finders, and in late January 2018, the five dogs selected for the project began their training, starting with learning the distinct smell of ancient pottery.

“Our theory is, it is a porous material that’s going to have a lot more odor than, say, a metal,” says Cindy Otto, the executive director of the Penn Vet Working Dog Center and the project’s principal investigator.

As you might imagine, museum curators may not be keen on exposing fragile ancient materials to four Labrador retrievers and a German shepherd, and the Working Dog Center didn’t want to take any risks with the Penn Museum’s priceless artifacts. So instead of letting the dogs have free rein to sniff the materials themselves, the project is using cotton balls. The researchers seal the artifacts (broken shards of Syrian pottery) in airtight bags with a cotton ball for 72 hours, then ask the dogs to find the cotton balls in the lab. They’re being trained to disregard the smell of the cotton ball itself, the smell of the bag it was stored in, and ideally, the smell of modern-day pottery, eventually being able to zero in on the smell that distinguishes ancient pottery specifically.

A dog looks out over the metal "pinhweel" training mechanism.
Penn Vet Working Dog Center

“The dogs are responding well,” Otto tells Mental Floss, explaining that the training program is at the stage of "exposing them to the odor and having them recognize it.”

The dogs involved in the project were chosen for their calm-but-curious demeanors and sensitive noses (one also works as a drug-detection dog when she’s not training on pottery). They had to be motivated enough to want to hunt down the cotton balls, but not aggressive or easily distracted.

Right now, the dogs train three days a week, and will continue to work on their pottery-detection skills for the first stage of the project, which the researchers expect will last for the next nine months. Depending on how the first phase of the training goes, the researchers hope to be able to then take the dogs out into the field to see if they can find the odor of ancient pottery in real-life situations, like in suitcases, rather than in a laboratory setting. Eventually, they also hope to train the dogs on other types of objects, and perhaps even pinpoint the chemical signatures that make artifacts smell distinct.

Pottery-sniffing dogs won’t be showing up at airport customs or on shipping docks soon, but one day, they could be as common as drug-sniffing canines. If dogs can detect low blood sugar or find a tiny USB drive hidden in a house, surely they can figure out if you’re smuggling a sculpture made thousands of years ago in your suitcase.

nextArticle.image_alt|e
iStock
arrow
Medicine
New Cancer-Fighting Nanobots Can Track Down Tumors and Cut Off Their Blood Supply
iStock
iStock

Scientists have developed a new way to cut off the blood flow to cancerous tumors, causing them to eventually shrivel up and die. As Business Insider reports, the new treatment uses a design inspired by origami to infiltrate crucial blood vessels while leaving the rest of the body unharmed.

A team of molecular chemists from Arizona State University and the Chinese Academy of Sciences describe their method in the journal Nature Biotechnology. First, they constructed robots that are 1000 times smaller than a human hair from strands of DNA. These tiny devices contain enzymes called thrombin that encourage blood clotting, and they're rolled up tightly enough to keep the substance contained.

Next, researchers injected the robots into the bloodstreams of mice and small pigs sick with different types of cancer. The DNA sought the tumor in the body while leaving healthy cells alone. The robot knew when it reached the tumor and responded by unfurling and releasing the thrombin into the blood vessel that fed it. A clot started to form, eventually blocking off the tumor's blood supply and causing the cancerous tissues to die.

The treatment has been tested on dozen of animals with breast, lung, skin, and ovarian cancers. In mice, the average life expectancy doubled, and in three of the skin cancer cases tumors regressed completely.

Researchers are optimistic about the therapy's effectiveness on cancers throughout the body. There's not much variation between the blood vessels that supply tumors, whether they're in an ovary in or a prostate. So if triggering a blood clot causes one type of tumor to waste away, the same method holds promise for other cancers.

But before the scientists think too far ahead, they'll need to test the treatments on human patients. Nanobots have been an appealing cancer-fighting option to researchers for years. If effective, the machines can target cancer at the microscopic level without causing harm to healthy cells. But if something goes wrong, the bots could end up attacking the wrong tissue and leave the patient worse off. Study co-author Hao Yan believes this latest method may be the one that gets it right. He said in a statement, "I think we are much closer to real, practical medical applications of the technology."

[h/t Business Insider]

SECTIONS

arrow
LIVE SMARTER