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Courtesy of Nature
Courtesy of Nature

Scientists Create Three Puppy Clones of 'Snuppy,' the World's First Cloned Dog

Courtesy of Nature
Courtesy of Nature

Snuppy, the world's first cloned dog, died in 2015, but his genetic legacy lives on. As the National Post reports, South Korean scientists recently described in the journal Scientific Reports the birth of three clone puppies, all of which are identical replicas of the famous Afghan hound.

Those who lived through the 1990s might remember Dolly, the Scottish sheep that gained fame for being the very first mammal to be cloned from an adult cell. Following Dolly's 1996 cloning, scientists managed to replicate other animals, including cats, mice, cows, and horses. But dog cloning initially stymied scientists, Time reports, as their breeding period is limited and their eggs are also hard to extract.

Ultimately, researchers ended up using somatic cell nuclear transfer (SCNT) to clone a dog, the same method that was used to make Dolly. In the early 2000s, a team of South Korean scientists inserted DNA harvested from an Afghan hound's skin cells into a dog egg from which the DNA had been removed. The egg divided, which produced multiple cloned embryos.

The scientists implanted 1095 of these embryos in 123 dogs, an exhaustive initiative that yielded just three pregnancies, according to NPR. Of these, Snuppy—whose name is a combination of "puppy" and Seoul National University's initials—was the only survivor.

Snuppy died from cancer in April 2015, just shortly after his 10th birthday. To celebrate his successful life, the same South Korean researchers decided to re-clone him using mesenchymal stem cells from the dog's belly fat, which were taken when he was five. This time around, they transferred 94 reconstructed embryos to seven dogs. Four clones were later born, although one ended up dying shortly after birth.

The tiny Snuppy clones are now more than a year old, and researchers say that they don't think that the pups face the risk of accelerated aging, nor are they more disease-prone than other dogs. (Dolly died when she was just six years old, while cloned mice have also experienced shorter lifespans.) Snuppy's somatic cell donor, Tai, lived just two years longer than Snuppy, dying at age 12, the average lifespan of an Afghan hound.

Researchers say that this new generation of Snuppys will yield new insights into the health and longevity of cloned animals. Meanwhile, in other animal cloning news, a Texas-based company called ViaGen Pets is now offering to clone people's beloved pets, according to CBS Pittsburgh—a service that costs a cool $50,000 for dogs.

[h/t National Post]

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Today's Wine Glasses Are Almost Seven Times Larger Than They Were in 1700
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Holiday party season (a.k.a. hangover season) is in full swing. While you likely have no one to blame but yourself for drinking that second (or third) pour at the office soiree, your glassware isn't doing you any favors—especially if you live in the UK. Vino vessels in England are nearly seven times larger today than they were in 1700, according to a new study spotted by Live Science. These findings were recently published in the English medical journal The BMJ.

Researchers at the University of Cambridge measured more than 400 wineglasses from the past three centuries to gauge whether glass size affects how much we drink. They dug deep into the history of parties past, perusing both the collections of the Ashmolean Museum of Art and Archaeology at the University of Oxford and the Royal Household's assemblage of glassware (a new set is commissioned for each monarch). They also scoured a vintage catalog, a modern department store, and eBay for examples.

After measuring these cups, researchers concluded that the average wineglass in 1700 held just 2.2 fluid ounces. For comparison's sake, that's the size of a double shot at a bar. Glasses today hold an average of 15.2 fluid ounces, even though a standard single serving size of wine is just 5 ounces.

BMJ infographic detailing increases in wine glass size from 1700 to 2017
BMJ Publishing group Ltd.

Advances in technology and manufacturing are partly to blame for this increase, as is the wine industry. Marketing campaigns promoted the beverage as it increasingly became more affordable and available for purchase, which in turn prompted aficionados to opt for larger pours. Perhaps not surprisingly, this bigger-is-better mindset was also compounded by American drinking habits: Extra-large wineglasses became popular in the U.S. in the 1990s, prompting overseas manufacturers to follow suit.

Wine consumption in both England and America has risen dramatically since the 1960s [PDF]. Cambridge researchers noted that their study doesn't necessarily prove that the rise of super-sized glassware has led to this increase. But their findings do fit a larger trend: previous studies have found that larger plate size can increase food consumption. This might be because they skew our sense of perception, making us think we're consuming less than we actually are. And in the case of wine, in particular, oversized glasses could also heighten our sensory enjoyment, as they might release more of the drink's aroma.

“We cannot infer that the increase in glass size and the rise in wine consumption in England are causally linked,” the study's authors wrote. “Nor can we infer that reducing glass size would cut drinking. Our observation of increasing size does, however, draw attention to wine glass size as an area to investigate further in the context of population health.”

[h/t Live Science]

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Researchers Pore Over the Physics Behind the Layered Latte
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The layered latte isn't the most widely known espresso drink on coffee-shop menus, but it is a scientific curiosity. Instead of a traditional latte, where steamed milk is poured into a shot (or several) of espresso, the layered latte is made by pouring the espresso into a glass of hot milk. The result is an Instagram-friendly drink that features a gradient of milky coffee colors from pure white on the bottom to dark brown on the top. The effect is odd enough that Princeton University researchers decided to explore the fluid dynamics that make it happen, as The New York Times reports.

In a new study in Nature Communications, Princeton engineering professor Howard Stone and his team explore just what creates the distinct horizontal layers pattern of layered latte. To find out, they injected warm, dyed water into a tank filled with warm salt water, mimicking the process of pouring low-density espresso into higher-density steamed milk.

Four different images of a latte forming layers over time
Xue et al., Nature Communications (2017)

According to the study, the layered look of the latte forms over the course of minutes, and can last for "tens of minutes, or even several hours" if the drink isn't stirred. When the espresso-like dyed water was injected into the salt brine, the downward jet of the dyed water floated up to the top of the tank, because the buoyant force of the low-density liquid encountering the higher-density brine forced it upward. The layers become more visible when the hot drink cools down.

The New York Times explains it succinctly:

When the liquids try to mix, layered patterns form as gradients in temperature cause a portion of the liquid to heat up, become lighter and rise, while another, denser portion sinks. This gives rise to convection cells that trap mixtures of similar densities within layers.

This structure can withstand gentle movement, such as a light stirring or sipping, and can stay stable for as long as a day or more. The layers don't disappear until the liquids cool down to room temperature.

But before you go trying to experiment with layering your own lattes, know that it can be trickier than the study—which refers to the process as "haphazardly pouring espresso into a glass of warm milk"—makes it sound. You may need to experiment several times with the speed and height of your pour and the ratio of espresso to milk before you get the look just right.

[h/t The New York Times]

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