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8 Drugs that Exist in Nature

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By Therese Oneill

Most drugs today, legal and otherwise, are synthesized in a laboratory. But most medical and recreational drugs originally began in the wild, growing naturally in forests, fields, and deserts. Some can still be found there. Here are some of the country's better known drugs, in their natural, pre-processed form.

1. Opium poppy (heroin, morphine, codeine)

Morphine is one of the many opiates that come from the opium poppy (above). The poppy is sliced while still in bud form, and the milky fluid (latex) that bleeds out is dried, becoming raw opium. Then a long process of adding dangerous chemicals, filtering, and cooking increases the potency of the drug. Heroin is a super-strong, quickly absorbed form of morphine, and the most intense use of opium. English researcher C.R. Wright accidentally created it for the first time in 1874 when he boiled morphine and acetic anhydride together on his stove.

2. Blue agave (Tequila)

Alcohol is unique in the world of drugs because it's made through the process of fermentation, not a particular basic ingredient. Fermentation occurs when yeast eats the sugars of whatever plant you're using, the by-product being ethanol (drinkable alcohol). In tequila, named for the Mexican town where it originated, the sugar comes from the beautiful blue agave. The center of the blue agave looks like pineapple. After it's roasted and mashed, it provides the sugar that, once properly rotted, leaves behind alcohol.

3. Coca leaves (cocaine)

Coca leaves, mostly grown in South America, have to go through some pretty ugly steps to become cocaine—powdered cement, gasoline soaks, and battery acid baths are all needed to condense the naturally occurring leaves into an illegal narcotic. The leaves themselves have been used by native populations for centuries as a (much milder) stimulant and medication. Spanish physician and botanist Nicolás Monardes described the effect of the leaves in 1569: "When they wished to make themselves drunk and out of judgment they chewed a mixture of tobacco and coca leaves which make them go as they were out of their wittes."

4. Ephedra sinica (Sudafed, meth)

This scraggly little bush, also called ma huang, has been used in Chinese medicine for centuries. If it sounds familiar, that's because decongestants like Sudafed once synthesized their main ingredient from ephedra (pseudoephedrine). Products containing ephedrine or pseudoephedrine are very hard to find now, as the U.S. government considers it a controlled substance. The alkaloids in the plant can be abused, most commonly in the form of weight-loss drugs and meth production. Researching the plant, I couldn't find out if this plant was legal to own. I called the DEA to ask, and, well, they weren't sure either. But they politely researched their documents, and translated them to people-speak for me. It is legal to grow and own the ephedra sinica plant. You just have to register your herb garden with the government and submit to monitoring if you do.

5. Psilocybin mushroom (shrooms)

Psilocybin, the naturally occurring compound that causes the euphoria and psychedelic trips associated with shrooms, can be found in over 200 species of mushrooms, most of which grow wild in Mexico. Different mushrooms have different concentrations of psilocybin, even varying in which part of the fungus you eat. A word of advice to the adventure seeker: Shrooms can be indistinguishable from any number of lethally poisonous mushrooms. Consuming unknown mushrooms may send you on a trip that takes you much further than you intended.

6. Willow bark (aspirin)

Salicylic acid, found in willow bark, has cooled fevered brows across the world for millennia. Even Hippocrates, the father of medicine, used to recommend chewing the bark to reduce fevers and inflammation in his patients, around 300 B.C. The willow tree has strains native to Europe, China, and North America, all of which can be used in medicine. It was from this bark that scientists at the German company Bayer developed aspirin in 1897. An interesting side note: Bayer lost all its patents and trademarks in World War I, when the U.S. government seized the firm as spoils of war and auctioned it off to an American patent medicine company.

7. Sassafras root (ecstasy)

Root beer and sarsaparilla used to have actual sassafras oil in them for flavor. They don't anymore, since the chemical in the oil, safrole, is now a controlled substance. Distilled from the roots and bark of the sassafras tree, safrole is a key ingredient in the manufacture of ecstasy. Not in its original form, of course. It is the treatments with formaldehyde, paint thinner, and drain cleaner that make sassafras oil such a delightful thing to put inside your body.

8. Penicillium mold (penicillin)

Penicillin: The mighty, moldy world changer. It was the first drug to effectively combat bacterial infections, leading to cures of an untold number of afflictions, from strep to syphilis. It was discovered accidentally by Alexander Fleming in 1928. He forgot about a petri dish filled with staph bacteria he'd left out, and he discovered blue green penicillium mold growing all over it. Penicillium mold is an incredibly common species of mold, apt to grow on organic material wherever conditions are dank enough. Wherever the mold touched the staph, the bacteria was gone. Fleming didn't think it would work in people and never tried to make medicine out of it. That was done years later by Australian Nobel laureate Howard Walter Florey, together with the German Nobel laureate Ernst Chain and the English biochemist Norman Heatley.

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Fake It Until You Make It: 10 Artificial Ruins
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Ramones Karaoke, Flickr // CC BY-NC 2.0

The love of ruins, sometimes called ruinophilia, has for centuries inspired the creation of clever fakes—a host of sham facades and hollowed-out castle shells found on grand English, European, and even American estates. The popularity of constructing artificial ruins was at its peak during the 18th and 19th centuries, but architects occasionally still incorporate them today.

Why build a structure that is already crumbling? Between the 16th and 19th centuries, the popularity of counterfeit ruins was influenced by two factors—a classical education that enforced the ideals of ancient Greece and Rome, and the extended tour of Europe (known as The Grand Tour) that well-to-do young men and women took after completing their education. Travelers might start in London or France and roam as far as the Middle East, but the trip almost always included Italy and a chance to admire Roman ruins. More than a few wealthy travelers returned home longing to duplicate those ruins, either to complement a romantic landscape, to demonstrate wealth, or to provide a pretense of family history for the newly rich.

Here are a few romantic ruins constructed between the 18th and 21st centuries.

1. SHAM CASTLE // BATHAMPTON, ENGLAND

Sham Castle (shown above) is aptly named—it’s only a façade. The "castle," overlooking the English city of Bath, was created in 1762 to improve the view for Ralph Allen, a local entrepreneur and philanthropist as well as to provide jobs for local stonemasons. From a distance it looks like a castle ruin, but it's merely a wall that has two three-story circular turrets and a two-story square tower at either end. The castle is not the only folly (as such purely decorative architecture is often called) that Allen built. He also constructed a sham bridge on Serpentine Lake in what is now Prior Park Landscape Garden—the bridge can't be crossed, but provides a nice focal point for the lake. Today, Sham Castle is part of a private golf course.

2. WIMPOLE FOLLY // CAMBRIDGESHIRE, ENGLAND

Building a structure that looks as if it's crumbling does not preclude having to perform regular maintenance. The four-story Gothic tower known as Wimpole Folly in Wimpole, Cambridgeshire, England, was built 1768-72 for Philip Yorke, first Earl of Hardwicke and owner of the Wimpole Estate. Owned by Britain’s National Trust, the ruin threatened to truly crumble a few years ago, so restoration efforts were needed. The last restoration was so well done it won the 2016 European Union Prize for Cultural Heritage. The Wimpole Estate is now open to the public for walks and hikes.

3. CAPEL MANOR FOLLY // ENFIELD, ENGLAND

Capel Manor at Bulls Cross, Enfield, England has been the site of several grand homes since the estate’s first recorded mention in the 13th century, so visitors might be tempted to believe that the manor house's ruins date back at least a few centuries. But that sense of history is an illusion: The faux 15th-century house was built in 2010 to add visual appeal to the manor gardens, which have been open to the public since the 1920s.

4. ROMAN RUIN // SCHONBRUNN PALACE, VIENNA, AUSTRIA

The Roman Ruin was built as a garden ornament for the 1441-room Schonbrunn Palace in Vienna, one of the most important monuments in Austria. The ruin was once called The Ruins of Carthage, after the ancient North African city defeated by Roman military force. But despite the illusion of antiquity, the ruins were created almost 2000 years after Carthage fell in 146 B.C.E. The ruin’s rectangular pool, framed by an intricate semi-circle arch, was designed in 1778 by the architect Johann Ferdinand Hetzendorf von Hohenberg, who modeled it on the Ancient Roman temple of Vespasian and Titus, which he had seen an engraving of.

5. THE RUINEBERG // POTSDAM, GERMANY

One of the earliest examples of artificial ruins in Germany was the complex of structures known as The Ruinenberg. Frederick the Great, King of Prussia, had a summer palace in Potsdam, near Berlin, that was said to rival Versailles. In 1748 Frederick commissioned a large fountain for the palace complete with artificial ruins. The waterworks part of his plan proved too difficult and was soon abandoned, but not before designer Georg Wenzeslaus von Knobelsdorff constructed the ruins. The complex includes Roman pillars, a round temple, and the wall of a Roman theatre. Since 1927 the site has belonged to the Prussian Gardens and Palaces Foundation, Berlin-Brandenburg.

6. PARC MONCEAU // PARIS, FRANCE

Elegant Parc Monceau is located in the fashionable 8th arrondissement of Paris near the Champs-Elysees and Palais de l’Elysée. In 1778, the Duke of Chartres decided to build a mansion on land previously used for hunting. He loved English architecture and gardens, including the notion of nostalgic ruins, so he hired the architect Louis Carrogis Carmontelle to create an extravagant park complete with a Roman temple, antique statues, a Chinese bridge, a farmhouse, a Dutch windmill, a minaret, a small Egyptian pyramid, and some fake gravestones. The most notable feature of the park is a pond surrounded by Corinthian columns, now known as Colonnade de Carmontelle.

7. HAGLEY PARK CASTLE // WORCESTERSHIRE, ENGLAND

The ruins of the medieval castle at Hagley Park in Worcestershire are definitely fake, but they were built with debris from the real ruin of a neighboring abbey. The folly was commissioned by Sir George Lyttelton in 1747 and designed by Sanderson Miller, an English pioneer of Gothic revival architecture. The castle has a round tower at each corner, but by design only one is complete and decorated inside with a coat of arms. The grounds, which also feature a temple portico inspired by an ancient Greek temple, some urns, and obelisks, are now privately owned and not open to the public.

8. TATA CASTLE RUINS // TATA, HUNGARY

French architect Charles de Moreau (1758-1841) was a scholar of classical Roman architecture known for his ability to counterfeit impressive ruins. Nicholas I, Prince Esterhazy of Hungary, hired him to work on Tata Castle and to create the ruins of a Romanesque church for the palace’s English Garden. Even though the ruin Moreau created was fake, he built it with the stones of a real ruin, the remnants of the early-12th-century Benedictine and later Dominican abbey of Vértesszőlős. A third-century ancient Roman tombstone and relief were placed nearby.

9. BELVEDERE CASTLE // MANHATTAN, NEW YORK

Frederick Law Olmsted and Calvert Vaux designed Central Park in the mid-1800s, and their plan for creating romantic vistas included the construction of a folly known as Belvedere Castle. The Gothic-Romanesque style hybrid, overlooking Central Park’s Great Lawn, was completed in 1869. Although the folly was designed as a hollow shell and meant to be a ruin, it eventually served a practical purpose, housing a weather bureau and exhibit space. The castle also provides a beautiful backdrop for Shakespeare in the Park productions, evoking the royal homes that play prominent roles in the Bard’s works.

10. FOLLY WALL IN BARKING TOWN SQUARE // LONDON

In a borough known for its real historic buildings, the ancient wall found in London’s Barking Town Square might look centuries old. It’s not, and ironically, the wall is part of the square’s renovation efforts. The wall was built by bricklaying students at Barking College using old bricks and crumbling stone items found at salvage yards. Known as the "Secret Garden," named after the children’s book about a walled garden, the wall was designed to screen a nearby supermarket and was unveiled in 2007.

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11 Delicious Facts About Good Burger
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Paramount Pictures

It takes just 14 words—“Welcome to Good Burger, home of the Good Burger, can I take your order?”—to make a ‘90s kid swoon with nostalgia. Good Burger, the beloved Nickelodeon comedy about a couple of daft teens who try to save their fast food joint from corporate greed, was born out of a Kenan Thompson/Kel Mitchell sketch on All That in the mid-'90s. A year later, due to its popularity, it found itself being turned into its own live-action movie, with Brian Robbins at the helm. Today—20 years after its original release—it’s a silly cult hit that’s indelibly a part of Generation Y. Revisit the classic with these facts about Good Burger.

1. KEL MITCHELL AUDITIONED FOR ALL THAT WITH HIS CHARACTER FROM GOOD BURGER.

In an interview with The A.V. Club, Kel Mitchell explained how he came up with Ed. “I did a ‘dude’ voice, and that’s where Ed [from Good Burger] was kind of born,” he said. “I did that there at the audition. They were just cracking up.”

2. ED’S FIRST APPEARANCE WAS IN THE JOSH SERVER SKETCH, “DREAM REMOTE.”

Essentially, Good Burger was born out of a random character decision made during one little sketch. “It was where [Josh] could have a remote control that could control his entire life,” Mitchell told The A.V. Club. “So, he could fast-forward through his sister nagging, he could make pizza come really quickly. I was the pizza guy. I came to the door, and the pizza guy didn’t really have a voice, so I was like, ‘Mleh, here’s your pizza! That was the first time we saw Ed, and so they created Good Burger.”

3. ED’S LOOK WAS INSPIRED BY MILLI VANILLI.

When prepping for Ed’s debut on All That, Kel Mitchell spotted what would become the character’s signature look. “I remember I went to the hair room, and I saw these braids. It was like these early Brandy ’90s Milli Vanilli braids. I put those on, and it came to life,” he told The A.V. Club.

4. THOUSANDS OF POUNDS OF MEAT STUNK UP THE SET.

Nickelodeon

For a movie all about burgers, you better believe the production had a ton of them sitting around on set. "At one point, there was over 1750 pounds of meat on the set," Kenan Thompson told The Morning Call. "Some of it was old meat. It was so nasty. Some of the burgers would stay out there for a long time. I felt sorry for the extras who had to eat them with cold, clammy fries. But on screen, those burgers look good."

5. ELMER’S GLUE WAS USED TO KEEP THE FOOD LOOKING FRESH.

In order to keep the food looking good on screen, the production resorted to old, albeit inedible, tricks. "It was so gross, because when I scoop out ice cream in the movie, it was really vegetable shortening with food coloring,” Mitchell told The Morning Call. “When I poured milk on cereal, we used Elmer's Glue so the flakes wouldn't get soggy."

6. KENAN AND KEL CONTRIBUTED TO THE GOOD BURGER SOUNDTRACK.

Good Burger was their baby, so of course Kenan and Kel took the reins on more than just the creation of the characters, according to a 1997 interview with The Morning Call. Specifically, Kel partnered up with Less Than Jake on the hit song, “We’re All Dudes.” Because of this, the soundtrack actually charted at 101 on the Billboard 200.

7. GOOD BURGER WAS LINDA CARDELLINI’S FEATURE FILM DEBUT.

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In an interview with The A.V. Club, the Freaks and Geeks star reminisced about her breakout role in the Nickelodeon movie. “That’s my sister’s favorite role that I’ve ever played! It was so much fun. It was my first film, and it was a fantastic part,” Cardellini said. “I got to play crazy! Nobody knew who I was, and I got the part from the table read.”

8. WRITER DAN SCHNEIDER INTENDED TO GIVE UP ACTING WHEN HE WROTE GOOD BURGER, BUT HE PLAYED MR. BAILY IN THE FILM.

On creating Good Burger, writer/producer/actor Dan Schneider explained to The A.V. Club: “I’ve always wanted to write, and after I was doing All That and Kenan & Kel, I got the opportunity to do another TV show—I was still going on auditions. I realized that if I took that show, I was going to have to give up All That and Kenan & Kel. I really didn’t want to do [that] ... I passed on the acting role, and that was really the turning point, I guess, in 1996, when I was like, ‘You know what? I’m going to put my acting career on the back burner, and I’m going to be a writer-producer.’ Then I wrote the movie Good Burger.” However, if you watch the movie, you’ll notice Schneider starring as Mr. Baily.

9. THE ORIGINAL TRAILER FEATURED A SCENE THAT DIDN’T MAKE THE MOVIE.

For reasons that remain a mystery, a scene where a Good Burger customer orders “a good shake” from Ed (Mitchell), only to receive an actual bodily shaking from the Good Burger employee, didn’t make the final cut. It did, however, feature for a few seconds in the theatrical trailer.

10. KENAN AND KEL REUNITED FOR A GOOD BURGER SKETCH ON THE TONIGHT SHOW.

In 2015, Kenan and Kel reunited for a Good Burger sketch with Jimmy Fallon. This time, however, Fallon played Ed’s co-worker, while Kenan came in as a construction worker as a surprise. "We've been wanting to get back together," Mitchell told E! News. "It was just about the right project ... it felt like home."

11. THE FIRST LINE IN THE FILM IS THE SAME AS THE LAST LINE.

Appropriately, the line is, “Welcome to Good Burger, home of the Good Burger, can I take your order?”—just watch the movie.

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