Play a Game to Help Scientists Defeat a Cancer-Causing Toxin

Habibou Kouyate, Stringer, Getty Images
Habibou Kouyate, Stringer, Getty Images

If you're used to fighting virtual zombies or flying spaceships on your computer, a new series of games available on Foldit may sound a little unconventional. The object of the Aflatoxin Challenge is to rearrange protein structures and create new enzymes. But its impact on the real world could make it the most important game you've ever played: The scientists behind it hope it will lead to a new way to fight one of the most ruthless causes of liver cancer.

As Fast Company reports, the citizen science project is a collaboration between Mars, Inc. and U.C. Davis, the University of Washington, the Partnership for Aflatoxin Control in Africa, and Thermo Fisher Scientific. The team's online puzzles, which debuted on Foldit earlier this month, invite the public to create a new enzyme capable of finding and destroying carcinogens known as aflatoxins.

Aflatoxins form when certain fungi grow on crops like corn, nuts, and grains. Developing countries often don't have the resources to detect it in food, leaving around 4.5 billion people vulnerable to it. When people do eat food with high aflatoxin levels unknowingly, they can contract liver cancer. Roughly a quarter of all liver cancer cases around the world can be traced back to aflatoxin exposure.

The toxin's connection to agriculture is why the food giant Mars is so interested in fighting it. By working on a way to stop aflatoxins on a molecular level, the company could prevent its spread more efficiently than they would with less direct methods like planting drought-resistant crops or removing mold by hand.

The easiest way for scientists to eradicate an aflatoxin before it causes real harm is by making an enzyme that does the work for them. With the Aflatoxin Challenge, the hope is that by manipulating protein structures, online players will come up with an enzyme that attacks aflatoxins at a susceptible portion of their molecular structure called a lactone ring. Destroying the lactone ring makes aflatoxin much less toxic and essentially safe to eat.

The University of Washington launched Foldit in 2008. Since then, the online puzzle platform has been used to study a wide range of diseases including AIDS and Chikungunya. Everyone is welcome to contribute to the Foldit's new aflatoxin project for the next several weeks or so, after which scientists will synthesize genes based on the most impressive results to be used in future studies.

[h/t Fast Company]

Great White Sharks May Have Led to Megalodons' Extinction

iStock.com/cdascher
iStock.com/cdascher

The megalodon has been extinct for millions of years, but the huge prehistoric shark still fascinates people today. Reaching 50 feet long, it's thought to be the largest shark to ever stalk the ocean, but according to a new study, the predator may have been brought down by familiar creature: the great white shark.

As Smithsonian reports, the analysis, published in the journal PeerJ, finds that the megalodon may have vanished from seas much earlier that previously believed. Past research showed that the last megalodons died roughly 2.6 million years ago, a time when other marine life was dying off in large numbers, possibly due to a supernova blasting Earth with radiation at the end of the Pliocene epoch.

A team of paleontologists and geologists revisited the fossils that this conclusion was originally based on for their new study. They found that many of the megalodon remains had been mislabeled, marked with imprecise dates, or dated using old techniques. After reassessing the specimens, they concluded that the species had likely gone extinct at least 1 million years earlier than past research indicates.

If the megalodon vanished 3.6 million years ago rather than 2.6 million years ago, it wasn't the victim of supernova radiation. One known factor that could explain the loss of the 13 million-year-old apex predator at this time is the rise of a new competitor: the great white shark. This predator came on the scene around the same time as the megalodon's decline, and though a full-grown great white shark is less than half the size of a mature megalodon, the species still would have been a stressor. Adult great whites likely competed with juvenile megalodons, and with the megalodon's favorite prey—small whales—becoming scarce at this time, this may have been enough to wipe the megalodons from existence.

Even if great white sharks eventually beat megalodons for dominance in the oceans, the megalodon's status as one of the most fearsome predators of all time shouldn't be contested. The giant sharks had 7-inch teeth and a bite stronger than that of a T. rex.

[h/t Smithsonian]

From Squatty Potty to Squat-N-Go: The Best Toilet Stool for Every Bathroom

iStock.com/eldemir
iStock.com/eldemir

In 2015, Squatty Potty's bathroom stool plopped into the popular conscience with a viral commercial that featured a unicorn joyfully pooping out a conveyor belt's worth of ice cream. The video racked up more than 35.9 million views on YouTube and reportedly caused a 600 percent jump in sales. "The stool for better stools" was a hit.

Now, it's a hit with the medical community, too. New research out of Ohio State University finds that the toilet stool—which aims to relax the puborectalis muscle and straighten out the rectum, making it easier to poop—really does help people who strain to empty their bowels. The study, published in the Journal of Clinical Gastroenterology's March 2019 issue, only involved 52 people, but it's the first clinical research into the Squatty Potty, and the results were very positive—71 percent of participants said they experienced faster bowel movements after using the stool for a month. A full 90 percent said they experienced less straining than before.

Since the Squatty Potty debuted, the company has inspired plenty of copycats, as well as launching a number of other official Squatty Potty design iterations targeted at every type of user. Here are the best toilet stool options for every bathroom.

Mental Floss has affiliate relationships with certain retailers and may receive a small percentage of any sale. But we only get commission on items you buy and don’t return, so we’re only happy if you’re happy. Thanks for helping us pay the bills!

1. If You're Hesitant to Commit: The Squatty Potty Original

At just $25, the original Squatty Potty is a great entry-level option that will allow you to try out the system without sinking a ton of money into it. (And it's a whole lot cheaper than an endless supply of Metamucil.) The white plastic isn't the most elevated decor option, but it's durable, easy to clean, and relatively unobtrusive. It's available in a 7-inch-tall version for standard toilets or a 9-inch-tall version for comfort-height porcelain thrones. If you're not sure how tall your toilet is, the company makes an adjustable height Squatty Potty that can be configured to fit anywhere.

Buy it on Amazon, from Squatty Potty's website for $25, or at these other retailers:

2. If Your Bathroom is Tiny: The Squatty Potty Curve

The original Squatty Potty can be a bit clunky, but a newer version offers all the health benefits without taking up as much space. The Curve has a thinner footprint so that it doesn't stick out quite so far from under your toilet, but still has just enough room for your feet. The 7-inch stool comes in white, pink, black, and gray.

Buy it for $25 on Squatty Potty's website.

3. If You Text on the Toilet: The Keeney Bathroom Stool

A white and blue Keeney toilet stool
Keeney, Amazon

Keeney's toilet stool offers a few unusual features. For one, it has a storage bin designed to keep your wet wipes close at hand. More importantly, it's designed to hold up more than just your feet—it has a smartphone/tablet holder, too. Though toilet stools are designed to make your bowel movements speedier, if you're the kind of person who likes to spend a lot of time on the can, you can also tuck your smartphone into the built-in groove in the stool designed to keep your screen at optimal viewing angles. Whether you're watching Netflix or looking at Tinder, it offers a hands-free option that you're not going to find on any brand-name Squatty Potty. Ergonomically, it's also got slightly angled footrests designed to put you in the optimal pooping position.

Buy it on Amazon for $21.

4. If You're Into Minimalist Design: The Squatty Potty Slim

Great bowel movements and great interior design don't have to be mutually exclusive. Squatty Potty's high-fashion option may be pricier, but it doesn't have the medical-device vibes of the original model, either. Designed for small, urban apartments, it's a bit bigger than the Curve but a lot more aesthetically pleasing. The teak finish is great if you're going for a Scandinavian minimalist vibe, while the acrylic glass Slim Ghost model has an artsy mid-century modern look.

Buy the Slim Teak or the Slim Ghost on Squatty Potty's website for $60 and $80, respectively, or on Amazon for $80 or $83.

5. If You Need to Go on the Go: Squat-N-Go Bamboo X Toilet Stool

While Squatty Potty does make a portable version of its bathroom stool (the cleverly named Porta-Squatty), the most convenient travel stool is made by a competitor. Squat-N-Go's foldable footstool comes in two different pieces for easy storage and portability. The two bamboo platforms essentially act as stilts, propping up your feet separately. They offer the most customizable fit, with 7-inch, 8-inch, and 9-inch heights and the ability to place each footstool anywhere around the toilet, at any angle. When you're done, they fold down to just an inch tall and can be stowed in the included travel bag.

Buy it on Amazon for $40 or at these other retailers:

SECTIONS

arrow
LIVE SMARTER