4 Diseases Caused by a Lack of Essential Vitamins and Minerals

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Companies pushing products with added vitamins and minerals can fool people into thinking that they’re eating a “healthy” food when they’re not—but it’s not like those vitamins and minerals are there for no reason. For much of human history, diseases of nutrient deficiency were the norm, and in some parts of the world, they still persist. Even into the 20th century, conditions caused by a lack of certain vitamins or minerals were endemic to North America and Europe. Artificially added nutrients may not make a food “healthy,” but they do stave off several debilitating, and sometimes fatal, diseases of malnutrition. Here are a few of those maladies.

1. Scurvy

The disease of pirates: the grey-death. Scurvy is caused by a lack of vitamin C, whose chemical name, ascorbic acid, is derived from the Latin term for scurvy, scorbutus. Even though the disease was known since ancient times (described by Hippocrates around 400 BCE), it was not a scourge to those who were largely land-bound. Even though its causes were unknown, many cultures realized that eating certain herbs could reverse the symptoms, and as long as there was access to fresh food, it was generally kept under control.

Scurvy didn’t become a significant problem until the Age of Discovery (beginning in the 15th century), when people at sea were not able to access that much-needed fresh food for months at a time. Preserved meats and carbohydrates contained no vitamin C, and unlike most animals, the human body is not able to create vitamin C on its own.

The early symptoms of scurvy include spongy gums, pain in the joints, and blood spots appearing under the skin. As the disease progressed, the teeth would become loose, extreme halitosis (bad breath) would develop, the afflicted would become too weak to walk or work, be in too much pain to eat, and would die “mid-sentence,” often from a burst blood vessel. Many of the early explorers lost great numbers of men to scurvy: Vasco de Gama lost 116 out of 170 men in 1499, and in 1520, Magellan lost 208 out of 230. A few deaths were attributable to other causes, but the vast majority were due to scurvy.

Despite not being able to pinpoint the exact cause of scurvy, in the 18th century, naval physician James Lind was able to prove, in what’s considered to be the first controlled scientific experiment, that scurvy could be prevented (and cured) by incorporating citrus fruits such as limes and oranges into the diet of sailors. Although his findings weren’t widely accepted at first, the British Navy eventually began issuing standard rations of lemon juice, and later, limes, to their sailors—which gave rise to the term “limey” in reference to the British.

These days, scurvy is an extremely rare condition, almost exclusively caused by someone eating a completely unvaried diet. In most cases, high levels of oral supplementation of vitamin C are enough to reverse the condition in a matter of weeks, and death by scurvy is almost unheard of.

2. Rickets

This condition is brought on by a lack of vitamin D, which causes the body to be unable to absorb or deposit calcium. Less commonly, it can also be caused by a lack of calcium or phosphorus, but vitamin D deficiency is by far the most common cause. Unlike vitamin C, the human body is able to produce vitamin D, but only if it has the metabolic precursors available to it.

When the skin is exposed to ultraviolet light (such as from the sun), cholesterol in the skin reacts and forms cholecalciferol, which is then processed in the liver and kidneys to create the active form of vitamin D. Even with a nominally healthy diet, without enough sun exposure, the body can’t produce the vitamin D precursors on its own. This is actually re-emerging as a health concern among some increasingly-indoor groups of people, and is one of the few hypovitaminosis (lack of vitamin) conditions not considered to be a “disease of the past.” Luckily, when the deficiency is recognized, cholecalciferol can be directly taken as a vitamin supplement or acquired from eating organ meats and oils, such as cod liver oil, allowing the body to resume producing vitamin D.

Rickets is a condition of children, as the deficiency’s most severe effects are on developing bones; in adults, “bone-softening,” or osteomalacia, can be caused by the same vitamin deficiency. But in adults, it both takes significantly longer to develop and tends to cause tip-off signs that something is wrong before bone warping sets in, such as extreme pain in the bones, and unexplained muscle weakness. In children, especially those that don’t or can’t receive regular check-ups, deformity and debilitation by the deficiency is often only noticed after significant damage has been done to their developing skeletons.

The most telling symptoms of rickets are at the epiphyses (growth plates) of bones: The body is unable to lengthen bones by depositing calcium, and ends up with bones that flare outward in a “cupping” appearance. This leads to costochondral swelling, or what’s known as the “rachitic rosary” along the ribcage of the child, as well as widened wrists and “thick” joints. Before widened wrists or rachitic rosary appears, the softening of the skull bones can lead to “Caput Quadratum”—a square-headed appearance, and often the first sign of skeletal growth problems. If left untreated, rickets also can cause an extremely curved back, stunted growth, and frequent fractures—all of which can lead to permanent and debilitating deformity.

3. Beriberi

This condition is largely confined to Asia, especially in countries where boiled rice is a staple. The Sinhalese term “beri-beri” means, “I cannot, I cannot,” and derives from the inability to perform even the simplest of tasks once the polyneuritis (nerve inflammation) caused by the deficiency of vitamin B1 (thiamine) has permanently damaged the neurons, when the condition has progressed to the end-stage.

Although beriberi was known to exist in rice-eating countries several centuries back, its prevalence boomed with the introduction of steam-driven rice-polishing mills from Europe. The superior taste of the milled white rice led many locals to abandon the local (unpolished) brown rice, and in doing so, abandon their primary source of thiamine. From the 1860s to the turn of the 20th century, people whose plant consumption was limited to the polished white rice would often come down with weakness, pain, weight loss, difficulty walking, and emotional disturbances. Beriberi became one of the leading causes of mortality in the region.

In the 1880s, a doctor named Christiaan Eijkman began researching the causes of this epidemic at a laboratory in the Dutch East Indies (now Jakarta, Indonesia), and initially believed that the condition was caused by a bacterial infection. However, after years of study, he came to the conclusion that “white rice is poisonous.” He discovered this by feeding a group of chickens solely white rice, and another group unpolished brown rice. The chickens that ate the white rice came down with beriberi-like symptoms, while the others stayed healthy. Eijkman also discovered that when the chickens fed white rice were subsequently fed brown rice, they recovered from their illness! Later dietary testing on prisoners confirmed his results. Even though he didn’t know the cause of the condition, Eijkman proved that white rice was the culprit, and shared the 1929 Nobel Prize in Medicine for his discovery.

Beriberi is occasionally seen in the modern world, but its primary cause is chronic alcoholism—the poor diets of some chronic alcoholics, combined with the decreased absorption of what thiamine is consumed, leads to symptoms that unfortunately are sometimes left undiagnosed until it’s too late. Recently, beriberi was also seen in Haitian prisons when the prison system began buying imported polished rice from the United States, and stopped feeding their inmates the local brown rice.

4. Pellagra

What causes blistering of the skin in the sun, pale skin, a craving for raw meat, blood dripping from the mouth, aggression, and insanity? If you answered “vampirism,” you’re close—the myth of the vampire may have its roots in the condition known as “pellagra.”

Pellagra is caused by a lack of vitamin B3 (niacin). First identified and commonly diagnosed in the Asturian Empire (now Northern Spain), it was originally called “Asturian leprosy.” However, the condition was seen throughout Europe, the Middle East, and North Africa, wherever a large percentage of food energy was derived from corn, and fresh meat was not available. The area of highest prevalence was Northern Italy, where Francesco Frapoli of Milan called it “pelle agra,” meaning “sour skin.”

It was initially believed that either the corn itself, or some insect associated with corn, was causing pellagra. This belief was reinforced when much of France eliminated corn as a food staple and virtually eradicated the condition. Between the era that corn was introduced to Europe (the early 16th century) and the late 19th century, pellagra was found almost everywhere that poor people subsisted on cornmeal and little else.

Around the turn of the 20th century, people began to notice that despite subsisting on just as much corn as poor Europeans, poor Mesoamerican natives didn’t come down with the condition. It was eventually discovered that this was because the traditional processing of corn in the Americas involved “nixtamalization,” in which the kernels were soaked in limewater before hulling them. The alkali solution freed up the niacin that was present in the grain, but previously inaccessible.

Despite the extensive work of Dr. Joseph Goldberger in the 1910s and 1920s, which proved that pellagra wasn’t caused by a germ but by a dietary deficiency, the condition was occurring in epidemic proportions in the rural Southern US until the 1940s.

Today, pellagra is most common in the poorest regions of the world, especially places that rely upon food aid programs. Some countries still ship unfortified cornmeal rather than corn masa (nixtamalized corn) or fortified cornmeal to developing countries or to their own impoverished populations. China, parts of Africa, Indonesia, and North Korea all have endemic pellagra among their lowest classes.

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The discovery of important vitamins and how to produce them has been so significant to human health that many of those who were integral to the discoveries have been awarded the Nobel Prize in Medicine; more than 10 Nobel Prizes have been divided among almost 20 eminent scientists for the discovery or isolation of vitamins A, B1, B12, C, D, E, and K. Over the second half of the 20th century, after the beginning of widespread supplementation to everyday food items, the incidences of the conditions covered here went down dramatically across much of the world.

Of course, the minerals essential to the human body play similarly important roles in maintaining health. However, humans have not historically had a widespread significant problem acquiring these nutrients, as most plants absorb many minerals from the soil. With the increased processing of our food throughout the 20th century, however, some of these minerals have been lost, and have had to be re-added to the average Western diet through supplementation. In the rest of the world, displacement due to war, and unfortified food from aid programs, has left survivors with enough calories, but not enough nutrients. Supplementation of assistance food and local fortification of salt and flour is beginning to help give displaced people (especially displaced children) a new chance at life without these and other nutritional diseases.

In the developed world, you won’t be the healthiest bloke on the block if you eat nothing but breakfast cereal and cartons of juice—but the food industry has ensured that you at least won’t die of malnutrition. Even people with healthy diets benefit from the supplementation of vitamins and minerals in common foodstuffs, and adding the nutrients costs next to nothing. Doctors and nutritionists still agree that the healthiest way to acquire your necessary vitamins and minerals is by eating a balanced diet and spending time outdoors each day, but in the course of modern life, that’s not always possible, and if people are going to eat poorly either way, we may as well keep them from dropping dead of scurvy!

6 Strange Maritime Mysteries

Neville Mountford-Hoare/iStock via Getty Images
Neville Mountford-Hoare/iStock via Getty Images

The oceans cover over 70 percent of our planet, so it's little wonder that their seemingly impenetrable depths have provided a series of fascinating mysteries, from missing ships to eerie monsters. Below are six mysteries of the deep—some of which scientists think they've at least partly explained, while others remain truly puzzling.

  1. The Mary Celeste

On December 5, 1872, the crew of the British ship the Dei Gratia spotted a vessel bobbing about 400 miles off the coast of the Azores. They approached the Mary Celeste to offer help, but after boarding the ship were shocked to find it completely unmanned. The crew had disappeared without a trace, their belongings still stowed in their quarters, six months' worth of food and drink untouched, and the valuable cargo of industrial alcohol still mostly in place. The only clues were three and a half feet of water in the hold, a missing lifeboat, and a dismantled pump. It was the beginning of an enduring mystery concerning what happened to the crew, and why they abandoned a seemingly sea-worthy vessel.

Numerous theories have been suggested, including by crime writer Arthur Conan Doyle, who penned a short story in 1884 suggesting the crew had fallen victim to an ex-slave intent on revenge. A more recent theory has pointed the finger at rough seas and the broken pump, arguing they forced the captain to issue an order to abandon ship. Since the missing crew have never been traced, it seems unlikely that there will ever be a satisfying answer to the enigma.

  1. The Yonaguni Monument

An underwater area known as the Twin Megaliths at the Yonaguni Monument
An area known as the Twin Megaliths at the Yonaguni Monument
Vincent Lou, Wikimedia // CC BY 2.0

In 1986, a diver looking for a good spot to watch hammerhead sharks off the coast of the Ryukyu Islands in Japan came across an extraordinary underwater landscape. The area reportedly looked like an ancient submerged village, with steps, holes, and triangles seemingly carved into the rocks. Ever since it was first discovered, controversy has surrounded the site that's become known as the Yonaguni Monument, with some researchers—such as marine geologist Masaaki Kimura—arguing it is a clearly manmade environment, perhaps a city thousands of years old and sunk in one of the earthquakes that plagues the region. Others believe it's a natural geological phenomenon reflecting the stratigraphy (layers) of sandstone in an area with tectonic activity. The area is open to scuba divers, so the really curious can strap on air tanks and decide for themselves.

  1. The Bermuda Triangle

The Bermuda Triangle has probably spawned more wild theories, column inches, and online discussion than any other ocean mystery—more than 50 ships and 20 aircraft are said to have vanished there. Although the triangle has never officially been defined, by some accounts it covers at least 500,000 square miles and lies between Bermuda, Florida, and Puerto Rico.

The mystery first caught the public imagination in December 1945 when Flight 19, consisting of five U.S. Navy TBM Avenger torpedo bombers and their 14 crewmembers, were lost without a trace during a routine training operation in the area. Interest was further piqued when it was later reported that one of the search-and-rescue planes dispatched to find the missing team had also disappeared. Articles and books such as Charles Berlitz’s The Bermuda Triangle, first published in 1974 and having since sold over 20 million copies in 30 languages, have served to keep the mystery alive, providing potential theories both natural and supernatural. Scientists—and world-renowned insurers Lloyd’s of London—have attempted to debunk the myth of the Bermuda Triangle, offering evidence that the rate of disappearance in the vast and busy triangle is no higher than other comparable shipping lanes, but such is the power of a good story that this is one story that seems likely to continue to fascinate.

  1. The Kraken

A model of a giant squid on display at the Natural History Museum in London in 1907
A model of a giant squid on display at the Natural History Museum in London in 1907
Topical Press Agency/Getty Images

For hundreds of years, sailors told tales of an enormous sea creature with huge tentacles known as the Kraken. Stories around the mythical kraken first started appearing in Scandinavia in the 12th century, and in 1555 Swedish cartographer Olaus Magnus provided an account of a sea creature with “sharp and long Horns round about, like a Tree root up by the Roots: They are ten or twelve cubits long, very black, and with huge eyes.” The stories persisted, often mentioning a creature so large it resembled an island. In his 1755 book The Natural History of Norway, Danish historian Erik Ludvigsen Pontoppidan described the kraken as “incontestably the largest Sea monster in the world."

Scientists have proposed that these stories might derive from sightings of giant squid (Architeuthis dux), although evidence for an even larger, yet extremely elusive, colossal squid (Mesonychoteuthis hamiltoni) has also come to light. The colossal squid is found in the deepest part of the Southern Ocean surrounding Antarctica, and is thought to be up to 46 feet long and 1100 pounds. The problem is that the animal is so rare very few specimens have been found intact, and no live specimen has ever been observed, which means that estimating its exact size is difficult. Researchers have also noticed that sperm whales have been observed with large scars, and have suggested that these could be the result of violent encounters with the colossal squid, which is known to have sharp rotating hooks on the ends of their tentacles.

  1. The Treasure of the Merchant Royal

The remains of the Merchant Royal are known as one of the richest shipwrecks ever. The ship set sail from the New World in 1641 laden with 100,000 pounds of gold, 400 Mexican silver bars, and thousands of precious gems—in total, a haul thought to be worth $1.3 billion today. The ship got caught in a storm and was thought to have gone down somewhere off the coast of Cornwall, England. The lost wreck became known as the “el Dorado of the seas” due to the enormous value of its cargo, and over the years numerous treasure hunters have searched fruitlessly for its final resting place, which remains undiscovered. In 2019 fishermen snagged what is thought to be the anchor from the Merchant Royal, but to date the dangerous conditions and extreme depths at which the wreck is thought to lie have meant it has remained unclaimed.

  1. Attack of the Sea Foam

In December 2011, residents of Cleveleys, England, awoke to what appeared to be a soft blanket of snow. But as locals ventured out into the streets it soon became clear that this was no snowstorm, but instead something far more puzzling. Trees, cars, roads, and houses were all wrapped in a thick, white layer of foam. The Environment Agency were quickly deployed to take samples of the sea foam, since residents were understandably concerned as to the origin of the strange, gloopy substance, fearing it might be caused by pollutants.

The dramatic images of the foam-soaked town soon had journalists flocking to the region to investigate the phenomena, but as quickly as it appeared the foam disappeared, leaving behind only a salty residue. Scientists analyzing the foam confirmed it was not caused by detergents, and instead suspected that it was caused by a rare combination of decomposing algae out at sea and strong winds, which whipped up the viscous foam and blew it into land. The phenomena has apparently occurred at other times before and since, and researchers are now working to try and understand the exceptional conditions that cause it to form so that residents can be warned when another thick blanket is set to descend.

Bonus: The Bloop—Mystery Solved

Over the years, the oceans have produced a number of eerie and often unexplained sounds. In 1997, researchers from NOAA listening for underwater volcanic activity using hydrophones (underwater microphones) noticed an extremely loud, powerful series of noises in the Pacific Ocean. The unusual din excited researchers, who soon named it “The Bloop” in reference to its unique sound.

Theories abounded as to the origin of the bloop—secret military facility, reverberations from a ship’s engine, or an enormous sea creature. The most fanciful suggestion stem from H. P. Lovecraft fans who noticed that the noise came from an area off South America where the sci-fi writer’s fictional sunken city of R’lyeh was supposed to be. They proposed that the bloop might have originated from Lovecraft’s “dead but dreaming” sea creature, Cthulhu. In 2005, however, scientists found that the mysterious sound was in fact the noise made by an icequake—or an iceberg shearing off from a glacier.

10 Clever Stranger Things Season 3 Easter Eggs You Might Have Missed

Dacre Montgomery as Billy Hargrove in Stranger Things.
Dacre Montgomery as Billy Hargrove in Stranger Things.
Netflix

Warning: This story includes spoilers for all aired episodes of Stranger Things.

After waiting nearly two years for the latest season of Stranger Things, most fans couldn’t help but binge all eight episodes in a row. But now that we know how it all went down, with Billy Hargrove being taken over by the Mind Flayer and Jim Hopper’s tragic (maybe) death, it's time for us to reprocess the season ... and rewatch it all over again.

While giving the season a second watch, keep an eye out for all the clever Easter eggs sprinkled into each episode, including several references to classic 1980s movies, earlier Stranger Things episodes, and unexpected connections we had never imagined were possible.

1. Peter Gabriel could be hinting at a major plot twist.

Arguably the most heartbreaking scene in Stranger Things history came in the final episode of season 3, “The Battle of Starcourt,” when Eleven reads the scrapped letter Hopper wrote for her and Mike. Viewers at home cried along with Millie Bobby Brown's character as she prepared for life without her “dad,” but one element in the scene might be a hint that Hopper isn’t really dead.

The song that starts playing just as Eleven finishes up reading the letter is Peter Gabriel’s cover of David Bowie’s “Heroes,” which is the same rendition of the song that played in the season 1 episode “Holly, Jolly,” when it was believed that Will had been killed. Of course, he turned out to be very much alive, meaning the same could (hopefully) happen for Hopper.

2. Jim Hopper is channeling Martin Brody.

Stranger Things has never shied away from paying homage to classic movies. And Redditor LucasLeArtist noticed that one of Hopper's season 3 lines was a direct quote from Jaws. When Hopper is about to leave Enzo’s after Joyce stands him up, he’s told he can’t take the alcohol with him, to which he drunkenly responds, “I can do anything I want, I’m chief of police.” This mimics a scene in Jaws where Chief Brody said the same line before taking a swig of his drink.

3. Murray Bauman’s phone number is real.

Brett Gelman, Natalia Dyer, and Charlie Heaton in Stranger Things
Netflix

One of the more eccentric characters in Stranger Things, Murray Bauman, turned out to be extremely helpful this season, as he served as translator for Hopper and the Russian scientist Alexei. In one scene, Murray’s phone number is shown—and it turns out that it's a working phone number ... which does indeed belong to Murray. As CNET reported, when you dial 618-625-8313, you get a lengthy, and hilarious, answering machine message from the character.

4. Billy Hargrove’s nod to Stand By Me.

While Billy Hargrove surprisingly turned into a character you felt sorry for by the end of season 3, his scenes in the first episode proved he was still just as much of a bully as he was in season 2. One example of this is when he’s lifeguarding and yells at a kid for running by the pool. Billy calls him a “lard-ass,” which doesn’t just remind you of how mean of a person he is, but is also a borrowed line from Rob Reiner's classic 1986 film Stand By Me. As IndieWire pointed out, that particular insult was famously used in the movie during the scene in which Gordie tells his friends a memorable story about a pie-eating contest.

5. Dustin Henderson is crushing on Phoebe Cates.

When Dustin returns to Hawkins from camp, he shocks everyone with the reveal that he now has a girlfriend. Of course, the first reaction from his friends (Steve included) is that she isn’t real. Dustin keeps the story going, however, telling everyone that her name is Suzy and that she's better looking than Phoebe Cates—as in the actress best known for her role in 1982’s Fast Times at Ridgemont High. In the season’s final episode, we learn that Suzy is indeed real. And when Robin is trying to get Steve a job at the video store, he falls into a cardboard cutout of Cates as Linda Barrett (her Fast Times character) before stopping to admire it.

6. Dustin and Robin recreated a scene from 1992's Sneakers.

A Twitter user pointed out an unexpected callback to the 1992 River Phoenix film Sneakers, as Dustin and Robin recreate one of its scenes when getting the “complete blueprints” of the Starcourt Mall. It's almost word-for-word, with the only difference being that in Sneakers, they’re looking at the Playtronics Corporate Headquarters.

7. Eleven visits the house from A Nightmare on Elm Street.

During Eleven’s scariest venture into the Void this season, she tries to find the missing lifeguard Heather. As she approaches Heather's home, the red door is reminiscent of the house that belonged to Nancy Thompson’s family in 1984’s A Nightmare on Elm Street. A Twitter user claimed the number on both doors was the same, but Stranger Things changed it by one number, as Heather lives at 1438. We’re not sure if they had to change it because of legal matters or if was just a coincidence—but in a show full of horror movie references, the similarity would seem a little too coincidental.

8. Steve Harrington can't keep his Michael J. Fox projects straight.

When Dustin, Erica, Steve, and Robin manage to escape the Russians in the seventh episode, “The Bite,” they end up in the movie theater at the mall, which is showing Back to the Future (1985). Steve and Robin soon leave, and while very high—and trying to analyze what they just watched—Robin hilariously says she’s pretty sure “that mom was trying to bang her son,” referring to Marty McFly and his mom, Lorraine. A confused Steve replies, “Wait, wait, the hot chick was Alex P. Keaton’s mom?” Alex P. Keaton, of course, was the name of Michael J. Fox’s character in the hit NBC series Family Ties, not Back to the Future.

9. "Weird" Al Yankovic's Reality Bites link.

In episode 2, “The Mall Rats,” Winona Ryder's Joyce ends up ditching Hopper to go find the kids’ science teacher Mr. Clarke, only to find him jamming out to "Weird" Al Yankovic’s parody song “My Bologna.” A Twitter user pointed out that this could be a nod to 1994’s Reality Bites, which features a memorable scene of Ryder dancing to the original song, “My Sharona.” Ethan Hawke is also in the scene, who is the real-life dad of Maya Hawke, who plays Robin in Stranger Things.

10. The post-credits scene that hints at Hopper's survival.

Perhaps the most important detail in the entire season comes during the post-credits scene, which includes another major hint that Hopper is still alive. Viewers are taken to the Russian base, where prisoners are being fed to the Demogorgon. One soldier then says, “No, not the American,” before moving on to the next person held captive. Fans are convinced the American would have to be Hopper, although there are plenty of theories floating around about other Americans that character could be. Now we’ll just have to wait until season 4, which has not been announced yet, to know who it is for sure.

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