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Why Do We Tan?

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Sit out in the sun too long and ultraviolet radiation from sunlight penetrates your skin and cells, damaging their RNA and DNA. This is bad news, as DNA provides our bodies with all the genetic instructions they need to develop, survive and go about their business, and this kind of DNA damage can lead to skin cancer. To protect you from this, your body helpfully tans, darkening the the skin with a pigment called melanin that reduces UV penetration into cells.

UV radiation stimulates the darkening of existing melanin and spurs increased melanogenesis, the production of new melanin. Cells called melanocytes generate the pigment and push it out of the cell, where it darkens the skin and absorbs and transforms absorbed UV energy into heat.

Melanogenesis results in a delayed tan that only becomes visible several hours after UV exposure and lasts longer than the tanning caused by darkening of existing melanin. Over time, a tan fades as darkened skin layers are pushed upward by new cells with less melanin, and are eventually scaled off.

Why do we get sunburn?

While we might say someone with sunburn was out “baking” too long or got “fried,” sunburns are different from the burn one might get from, say, touching a hot stove. That’s a thermal burn caused by the heat of the stove. While the sun does give off heat, a sunburn is caused by ultraviolet-B radiation.

When someone’s exposure to UV radiation exceeds their body’s ability to protect the skin with tanning, the radiation  causes damage to DNA, like we talked about above. This prompts the body to try and fix things. Bloodflow to the capillary bed of the dermis (the second outermost layer of skin) increases so cells can repair the damage, which results in warmth and redness of the skin. Inflammatory immune cells also flock to the damaged tissue, causing us to perceive pain and, hopefully, consider staying out of the sun for a while. Eventually, the damaged skin cells die, and the burned skin starts to peel.

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Big Questions
What Is the Difference Between Generic and Name Brand Ibuprofen?
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What is the difference between generic ibuprofen vs. name brands?

Yali Friedman:

I just published a paper that answers this question: Are Generic Drugs Less Safe than their Branded Equivalents?

Here’s the tl;dr version:

Generic drugs are versions of drugs made by companies other than the company which originally developed the drug.

To gain FDA approval, a generic drug must:

  • Contain the same active ingredients as the innovator drug (inactive ingredients may vary)
  • Be identical in strength, dosage form, and route of administration
  • Have the same use indications
  • Be bioequivalent
  • Meet the same batch requirements for identity, strength, purity, and quality
  • Be manufactured under the same strict standards of FDA's good manufacturing practice regulations required for innovator products

I hope you found this answer useful. Feel free to reach out at www.thinkbiotech.com. For more on generic drugs, you can see our resources and whitepapers at Pharmaceutical strategic guidance and whitepapers

This post originally appeared on Quora. Click here to view.

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Big Questions
Do Cats Fart?
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Certain philosophical questions can invade even the most disciplined of minds. Do aliens exist? Can a soul ever be measured? Do cats fart?

While the latter may not have weighed heavily on some of history’s great brains, it’s certainly no less deserving of an answer. And in contrast to existential queries, there’s a pretty definitive response: Yes, they do. We just don’t really hear it.

According to veterinarians who have realized their job sometimes involves answering inane questions about animals passing gas, cats have all the biological hardware necessary for a fart: a gastrointestinal system and an anus. When excess air builds up as a result of gulping breaths or gut bacteria, a pungent cloud will be released from their rear ends. Smell a kitten’s butt sometime and you’ll walk away convinced that cats fart.

The discretion, or lack of audible farts, is probably due to the fact that cats don’t gulp their food like dogs do, leading to less air accumulating in their digestive tract.

So, yes, cats do fart. But they do it with the same grace and stealth they use to approach everything else. Think about that the next time you blame the dog.

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

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