What Is the Difference Between Generic and Name Brand Ibuprofen?

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iStock

What is the difference between generic ibuprofen vs. name brands?

Yali Friedman:

I just published a paper that answers this question: Are Generic Drugs Less Safe than their Branded Equivalents?

Here’s the tl;dr version:

Generic drugs are versions of drugs made by companies other than the company which originally developed the drug.

To gain FDA approval, a generic drug must:

  • Contain the same active ingredients as the innovator drug (inactive ingredients may vary)
  • Be identical in strength, dosage form, and route of administration
  • Have the same use indications
  • Be bioequivalent
  • Meet the same batch requirements for identity, strength, purity, and quality
  • Be manufactured under the same strict standards of FDA's good manufacturing practice regulations required for innovator products

I hope you found this answer useful. Feel free to reach out at www.thinkbiotech.com. For more on generic drugs, you can see our resources and whitepapers at Pharmaceutical strategic guidance and whitepapers

This post originally appeared on Quora. Click here to view.

What's the Difference Between Straw and Hay?

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iStock.com/dusipuffi

The words straw and hay are often used interchangeably, and it's easy to see why: They're both dry, grassy, and easy to find on farms in the fall. But the two terms actual describe different materials, and once you know what to look for, it's easy to tell the difference between them.

Hay refers to grasses and some legumes such as alfalfa that are grown for use as animal feed. The full plant is harvested—including the heads, leaves, and stems—dried, and typically stored in bales. Hay is what livestock like cattle eat when there isn't enough pasture to go around, or when the weather gets too cold for them to graze. The baled hay most non-farmers are familiar with is dry and yellow, but high-quality hay has more of a greenish hue.

The biggest difference between straw and hay is that straw is the byproduct of crops, not the crop itself. When a plant, such as wheat or barley, has been stripped of its seeds or grains, the stalk is sometimes saved and dried to make straw. This part of the plant is lacking in nutrients, which means it doesn't make great animal fodder. But farmers have found other uses for the material throughout history: It what's used to weave baskets, thatch roofs, and stuff mattresses.

Today, straw is commonly used to decorate pumpkin-picking farms. It's easy to identify (if it's being used in a way that would be wasteful if it were food, chances are it's straw), but even the farms themselves can confuse the two terms. Every hayride you've ever taken, for example, was most likely a straw-ride.

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

How and Why Did Silent Letters Emerge in English?

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iStock/Bychykhin_Olexandr

Kory Stamper:

The easy answer is “"because English can’t leave well enough alone."

When we first started speaking English around 600 AD, it was totally phonetic: every letter had a sound, and we sounded every letter in a word. But English—and England itself—were influenced quite a bit by the French, who conquered the island in 1066 and held it for a long time. And then later by Dutch and Flemish printers, who were basically the main publishers in England for a solid two centuries, and then by further trading contact with just about every continent on the planet. And while we’re shaking hands and stealing language from every single people-group we meet, different parts of the language started changing at uneven rates.

By the 1400s, English started to lose its phonetic-ness: the way we articulated vowels in words like “loud” changed slowly but dramatically, and that had an effect on the rest of the word. (This is called “The Great Vowel Shift,” and it took place over a few hundred years.) Somewhere in the middle of the GVS, though, English spelling became fixed primarily because of the printing press and the easy distribution/availability of printed materials. In short: we have silent letters because the spelling of words stopped changing to match their pronunciations.

This post originally appeared on Quora. Click here to view.

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