What Is the Difference Between Generic and Name Brand Ibuprofen?

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What is the difference between generic ibuprofen vs. name brands?

Yali Friedman:

I just published a paper that answers this question: Are Generic Drugs Less Safe than their Branded Equivalents?

Here’s the tl;dr version:

Generic drugs are versions of drugs made by companies other than the company which originally developed the drug.

To gain FDA approval, a generic drug must:

  • Contain the same active ingredients as the innovator drug (inactive ingredients may vary)
  • Be identical in strength, dosage form, and route of administration
  • Have the same use indications
  • Be bioequivalent
  • Meet the same batch requirements for identity, strength, purity, and quality
  • Be manufactured under the same strict standards of FDA's good manufacturing practice regulations required for innovator products

I hope you found this answer useful. Feel free to reach out at www.thinkbiotech.com. For more on generic drugs, you can see our resources and whitepapers at Pharmaceutical strategic guidance and whitepapers

This post originally appeared on Quora. Click here to view.

Why Are There 10 Hot Dogs to a Pack But Only 8 Buns?

tacar/iStock via Getty Images
tacar/iStock via Getty Images

Watching competitive eating champion Joey Chestnut cram dozens of hot dogs down his throat would make anyone crave a grilled log of processed meat this summer. But shopping for hot dogs can be a confusing experience. The dogs are typically sold in packs of 10, but the buns are sold in packs of eight. What's behind this strange dog and bun inequality?

According to the National Hot Dog and Sausage Council—yes, there is a National Hot Dog and Sausage Council—there’s a good reason for the discrepancy. For starters, distributors of hot dogs are almost always different from manufacturers of baked goods like rolls. The hot dogs are sold in packs of 10 because producers of meat (or meat-like) products selected that quantity when hot dogs started to sell at retail grocery stores in the 1940s. Oscar Mayer, which led the charge into direct-to-consumer hot dog packaging, sold hot dogs by the pound in accordance with how meat is typically priced. Having 10 dogs that weighed 1.6 ounces each seemed like the ideal distribution of weight.

Bakeries, meanwhile, have standards of their own. Buns and sandwich rolls are usually sold eight to a pack because the baking trays for the elongated buns are typically sized to fit that number. Two sets of four buns come off the tray, which is the reason why buns are often still attached to one another when you open a bag.

These standards were created independently of one another: Bakeries weren’t too preoccupied with hot dogs when they were settling on a four-roll tray standard, and hot dog manufacturers weren’t thinking about how difficult it would be for bakeries to break from their conveyor system to offer 10 buns to a pack.

It can be frustrating if you buy just one or two packages of each, but if you’re hosting a big enough party, the uneven number doesn’t matter. You just need to buy five packages of buns and four packages of hot dogs to have 40 matching pairs. No complicated calculations required.

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

When Are the Dog Days of Summer?

Dorottya_Mathe/iStock via Getty Images
Dorottya_Mathe/iStock via Getty Images

The official “dog days” of summer begin on July 3 and end on August 11. So how did this time frame earn its canine nickname? It turns out the phrase has nothing to do with the poor pooches who are forever seeking shade in the July heat, and everything to do with the nighttime sky.

Sirius, the Dog Star, is the brightest star in the sky. The ancient Greeks noticed that in the summer months, Sirius rose and set with the Sun, and they theorized that it was the bright, glowing Dog Star that was adding extra heat to the Earth in July and August.

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

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