Why Do Small Dogs Live Longer Than Large Dogs?


Why do small dogs live longer than large dogs?

Adriana Heguy:

The issue of body size and lifespan is a fascinating topic in biology. It’s strange that across species, at least in mammals, large-bodied animals live longer than small-sized animals. For example, elephants live a lot longer than mice. The theory is that
bigger animals have slower metabolisms than small animals, and that faster metabolisms result in more accumulation of free radicals that damage tissue and DNA. But this doesn't always hold for all animals and the “rate of living” theory is not widely accepted. What we cannot clearly understand remains fascinating.

But now if we look at within a given species, lifespan and body size are inversely correlated. This is definitively the case for dogs and mice, and it has been proposed that this is the case for humans, too. Why would this be? A possible explanation is that larger dogs (or mice, or people) grow faster than their smaller counterparts because they reach a larger size in more or less the same time, and that faster growth could be correlated with higher cancer rates.

We do not have a clear understanding of why growing faster leads to accelerated aging. But it seems that it is an accelerated rate of aging, or senescence, that causes larger dogs to have shorter lifespans than little dogs.

The figure above is from Ageing: It’s a Dog’s Life. The data is from 32 breeds. Note that the inverse correlation is pretty good, however some large dog breeds, at around 40 to 50 kg (or about 88 to 110 pounds), live 12 or 13 years in average while some other dog breeds of equal body size live only eight or nine years on average. This is due to dogs being a special case, as they were artificially bred by humans to select for looks or behavior and not necessarily health, and that considerable inbreeding was necessary to produce “purebred” dogs. For example, boxers are big dogs, but their higher cancer rates may result in a shorter lifespan. However, the really giant breeds all consistently live eight to nine years on average. So there is something going on besides simple breeding quirks that led to bad genetics and ill health. Something more general.

A few years ago, a large study [PDF] was published using mortality data from thousands of dogs across 74 breeds, testing three hypotheses: Large dogs may die younger than small dogs because of (1) an earlier onset of senescence, (2) a higher minimum mortality hazard, or (3) an increased rate of aging. The conclusion from their study is that aging starts more or less at the same age in small and large breeds, but large breeds age faster. We do not have a clear understanding of the underlying mechanism for faster aging in dogs. It seems that when we selected for large body size, we selected for faster aging as well. But we do not know all the genetic components of this. We know that there are at least three genes that determine large body size in dogs: IRS4 and IGSF1, involved in thyroid hormone pathways which affect growth, and ACSL4, involved in muscle growth, and back fat thickness.

But how this accelerates aging is still speculation. More studies are needed, but dogs seem to be a great model to study the evolution of body size and its relationship to aging.

This post originally appeared on Quora. Click here to view.

Do Lobsters Really Mate for Life?


It's a pop culture trope that mated lobsters stay together until they die. But is it true?

Nope. While plenty of animals practice long-term monogamy, lobsters are not among them. Lobsters actually mate by a weird system of serial monogamy. It's not exactly a one-night stand, but it's not a lifelong commitment either. Instead, a bunch of females take turns having a fling with the local dominant male that lasts a week or two and, if they're not happy with the amount of genetic material he's provided, then seek a little extra action.

It works like this: A female lobster who's ready to mate (which they can only do right after they've molted) hangs out near the den of the local dominant male and fans her pheromone-laced urine into his home. This relaxes the male, making him less aggressive and more receptive to mating. Then there's a brief courtship, and the male allows the female into his den.

Anywhere from a few hours to a few days later, the female slips into something a little more comfortable by shedding her exoskeleton. (Shacking up with the neighborhood tough guy guarantees her protection during this vulnerable time.) The pair mates, and the male deposits his sperm in the female. Once her new shell has hardened a week or two later, she takes off, and another female can have her turn. Often, the females in an area will stagger the timing of their molts to make their reproductive conga line more efficient. As soon as one female is done with the stud, the next one is already waiting to pee on his doorstep.

Sometimes, the male doesn't provide enough sperm to fully fertilize all of a female's eggs. In these cases, she'll leave before her new shell finishes forming to find and mate with another male (or males) until she collects enough sperm. Usually this requires just an extra dalliance or two, but as many as 10 have been reported.

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Could an Astronaut Steal a Rocket and Lift Off, Without Mission Control?


C Stuart Hardwick:

Not with any rocket that has ever thus far carried a person into orbit from Earth, no. Large rockets are complex, their launch facilities are complex, their trajectories are complex, and the production of their propellants is complex.

Let me give you one simple example:

  • Let’s say astro-Sally is the last woman on Earth, and is fully qualified to fly the Saturn-V.
  • Further, let’s say the Rapture (which as I understand it, is some sort of hip-hop induced global catastrophe that liquefies all the people) has left a Saturn-V sitting on the pad, raring to go.
  • Further, let’s grant that, given enough time, astro-Sally can locate sufficient documentation to operate the several dozen controls needed to pump the first stage propellant tanks full of kerosene.
  • Now what? Oxidizer, right? Wrong. First, she has to attend to the batteries, oxygen, hydrogen, and helium pressurant tanks in her spacecraft, otherwise it’s going to be a short, final flight. And she’ll need to fill the hypergolics for the spacecraft propulsion and maneuvering systems. If she screws that up, the rocket will explode with her crawling on it. If she gets a single drop of either of these on her skin or in her lungs, she’ll die.
  • But okay, maybe all the hypergolics were already loaded (not safe, but possible) and assume she manages to get the LOX, H2, and HE tanks ready without going Hindenburg all over the Cape.
  • And…let’s just say Hermione Granger comes back from the Rapture to work that obscure spell, propellantus preparum.
  • All set, right? Well, no. See, before any large rocket can lift off, the water quench system must be in operation. Lift off without it, and the sound pressure generated by the engines will bounce off the pad, cave in the first stage, and cause 36 stories of rocket to go “boom.”
  • So she searches the blockhouse and figures out how to turn on the water quench system, then hops in the director’s Tesla (why not?) and speeds out to the pad, jumps in the lift, starts up the gantry—and the water quench system runs out of water ... Where’d she think that water comes from? Fairies? No, it comes from a water tower—loaded with an ample supply for a couple of launch attempts. Then it must be refilled.

Now imagine how much harder this would all be with the FBI on your tail.

Can a rocket be built that’s simple enough and automated enough to be susceptible to theft? Sure. Have we done so? Nope. The Soyuz is probably the closest—being highly derived from an ICBM designed to be “easy” to launch, but even it’s really not very close.

This post originally appeared on Quora. Click here to view.


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