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How Deadly Would Extraterrestrial Bacteria Be to Humans?

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How deadly would a bacterium be to humans if it was brought from a completely different star system?

Drew Smith:

The chance that extraterrestrial bacteria would be deadly to humans is zero. Not just very, very small. Zero.

Pathogenesis requires intimacy. This intimacy is attained through millions of years of co-evolution. The need for intimacy is apparent when you look at how bacteria and viruses cause infections and disease.

Infection requires binding to a cell surface. Bacteria (and viruses) bind to human cells through proteins that recognize human proteins and carbohydrates. The structure of these human proteins and carbohydrates is, to a first approximation, arbitrary. There are an almost infinite number of permutations of them that could exist and work just fine. But only one does exist. The chance that an alien bacteria would have evolved to stick to that protein is infinitesimally small.

Even if this alien bacterium were able to stick to a cell surface, this alone would not establish an infection. Infecting bacteria secrete all kinds of toxins and virulence factors. These toxins and factors bind to specific human proteins. They block or modify their activity in ways that degrade cells and tissues, releasing nutrients that the bacteria can feed upon.

Again, the target proteins have fairly arbitrary structures. They are the result of billions of years of evolutionary history and their precise structure—and even their existence is not at all predictable. The chance that an alien bacterium would have evolved toxins that precisely target them is infinitesimally small.

Pathogenicity is extremely rare on Earth. There are millions, perhaps billions, of species of bacteria. The number of potential human pathogens among them is very small, no more than a couple hundred. And only a couple dozen are able to infect otherwise healthy humans. These are bacteria that have been with us for millions of years, evolving as we evolve, becoming intimately familiar with our proteins, our cells, our immune systems.

This knowledge is stamped into their genomes; it is a diary of their long association with us. It is not a book that could be written in an alien language. Alien bacteria are no more likely to be human pathogens than intelligent aliens are likely to speak Urdu as their native tongue. It just isn’t possible.

This post originally appeared on Quora. Click here to view.

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Man Buys Two Metric Tons of LEGO Bricks; Sorts Them Via Machine Learning
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iStock // Ekaterina Minaeva

Jacques Mattheij made a small, but awesome, mistake. He went on eBay one evening and bid on a bunch of bulk LEGO brick auctions, then went to sleep. Upon waking, he discovered that he was the high bidder on many, and was now the proud owner of two tons of LEGO bricks. (This is about 4400 pounds.) He wrote, "[L]esson 1: if you win almost all bids you are bidding too high."

Mattheij had noticed that bulk, unsorted bricks sell for something like €10/kilogram, whereas sets are roughly €40/kg and rare parts go for up to €100/kg. Much of the value of the bricks is in their sorting. If he could reduce the entropy of these bins of unsorted bricks, he could make a tidy profit. While many people do this work by hand, the problem is enormous—just the kind of challenge for a computer. Mattheij writes:

There are 38000+ shapes and there are 100+ possible shades of color (you can roughly tell how old someone is by asking them what lego colors they remember from their youth).

In the following months, Mattheij built a proof-of-concept sorting system using, of course, LEGO. He broke the problem down into a series of sub-problems (including "feeding LEGO reliably from a hopper is surprisingly hard," one of those facts of nature that will stymie even the best system design). After tinkering with the prototype at length, he expanded the system to a surprisingly complex system of conveyer belts (powered by a home treadmill), various pieces of cabinetry, and "copious quantities of crazy glue."

Here's a video showing the current system running at low speed:

The key part of the system was running the bricks past a camera paired with a computer running a neural net-based image classifier. That allows the computer (when sufficiently trained on brick images) to recognize bricks and thus categorize them by color, shape, or other parameters. Remember that as bricks pass by, they can be in any orientation, can be dirty, can even be stuck to other pieces. So having a flexible software system is key to recognizing—in a fraction of a second—what a given brick is, in order to sort it out. When a match is found, a jet of compressed air pops the piece off the conveyer belt and into a waiting bin.

After much experimentation, Mattheij rewrote the software (several times in fact) to accomplish a variety of basic tasks. At its core, the system takes images from a webcam and feeds them to a neural network to do the classification. Of course, the neural net needs to be "trained" by showing it lots of images, and telling it what those images represent. Mattheij's breakthrough was allowing the machine to effectively train itself, with guidance: Running pieces through allows the system to take its own photos, make a guess, and build on that guess. As long as Mattheij corrects the incorrect guesses, he ends up with a decent (and self-reinforcing) corpus of training data. As the machine continues running, it can rack up more training, allowing it to recognize a broad variety of pieces on the fly.

Here's another video, focusing on how the pieces move on conveyer belts (running at slow speed so puny humans can follow). You can also see the air jets in action:

In an email interview, Mattheij told Mental Floss that the system currently sorts LEGO bricks into more than 50 categories. It can also be run in a color-sorting mode to bin the parts across 12 color groups. (Thus at present you'd likely do a two-pass sort on the bricks: once for shape, then a separate pass for color.) He continues to refine the system, with a focus on making its recognition abilities faster. At some point down the line, he plans to make the software portion open source. You're on your own as far as building conveyer belts, bins, and so forth.

Check out Mattheij's writeup in two parts for more information. It starts with an overview of the story, followed up with a deep dive on the software. He's also tweeting about the project (among other things). And if you look around a bit, you'll find bulk LEGO brick auctions online—it's definitely a thing!

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Why Your iPhone Doesn't Always Show You the 'Decline Call' Button
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When you get an incoming call to your iPhone, the options that light up your screen aren't always the same. Sometimes you have the option to decline a call, and sometimes you only see a slider that allows you to answer, without an option to send the caller straight to voicemail. Why the difference?

A while back, Business Insider tracked down the answer to this conundrum of modern communication, and the answer turns out to be fairly simple.

If you get a call while your phone is locked, you’ll see the "slide to answer" button. In order to decline the call, you have to double-tap the power button on the top of the phone.

If your phone is unlocked, however, the screen that appears during an incoming call is different. You’ll see the two buttons, "accept" or "decline."

Either way, you get the options to set a reminder to call that person back or to immediately send them a text message. ("Dad, stop calling me at work, it’s 9 a.m.!")

[h/t Business Insider]

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