8 Surprising Facts About the Stomach

The human body is an amazing thing. For each one of us, it's the most intimate object we know. And yet most of us don't know enough about it: its features, functions, quirks, and mysteries. Our series The Body explores human anatomy, part by part. Think of it as a mini digital encyclopedia with a dose of wow.

While you may only think of your stomach when you're eating or it catches your attention with a gurgle or burble, it's much more than a repository for the food you eat. Your stomach kills microbes, secretes hormones and mucus, and absorbs nutrients. Here are eight gut-clenching facts you might not have known:

1. IT HAS SOME SERIOUS STORAGE CAPACITY.

Your stomach at rest holds about 7 ounces of stomach acid and bile. However, it has the capacity to hold nearly a half-pound of food at a time if necessary. (The average capacity is about 32 ounces, or a quarter-gallon.) It normally takes from four to six hours to digest one meal, so this capacity can be important.

2. PH BALANCE AND MUCUS PREVENT ACID FROM CORRODING YOUR STOMACH.

"Thanks to the high production of hydrochloric acid, which is highly potent, the stomach regenerates its lining frequently," says Sydney Ziverts, a health and nutrition investigator for ConsumerSafety.org. The stomach cavity has a powerful protective process in place that normally keeps the pH of the stomach balanced. Potassium ions help to modulate the hydrochloric acid, and the stomach lining itself produces high numbers of goblet mucus cells to protect the lining.

3. IT ALLOWS YOU TO ABSORB THE CRUCIAL VITAMIN B12 OUT OF YOUR FOOD.

Your stomach is responsible for helping to release the crucial vitamin B12 [PDF] from the proteins you eat. Hydrochloric acid and an enzyme called pepsin break the locked B12 out of its protein so it can be absorbed into your blood stream. "The metabolism of vitamin B starts in the stomach in the parietal cells," Lisa Ganjhu, associate professor of gastroenterology and hepatology at NYU Langone Medical Center, tells Mental Floss. Vitamin B "is one of the main vitamins in our body to help with metabolism and energy production," she says.

4. IT'S A HORMONE-GENERATING MACHINE.

Eating and digesting your food is most likely something you never have to think about. Yet your GI tract is home to a veritable orchestra of hormones stimulated by epithelial cells that line the stomach and small intestine. These hormones engage in a wide range of functions, including stimulating appetite, encouraging the secretion of enzymes and gastric acid, and reminding the gall bladder to contract and empty. These hormones directly enter the blood, and eventually affect the function of other parts of the digestive system, including the liver and pancreas, and even your brain.

5. YOUR STOMACH IS ONE OF YOUR IMMUNE SYSTEM'S FIRST LINES OF DEFENSE.

Besides just digesting your food, the stomach helps protect your entire body. "The acidity in our stomach helps to sterilize whatever you're eating. It kills off bacteria and potential food toxins," says Ganjhu. Your gastrointestinal tract also has patches of lymphoid defense cells it sends out when something makes it through the stomach, such as a virus or bacterial infection.  

6. AND IT MAY PLAY A PART IN YOUR MOOD, TOO.

Your stomach may very well be a key player in keeping your mood balanced. New research suggests links between the gut microbiome—the microorganisms that live in any environment—and your mental health. A recent study in the Journal of Psychiatric Research found that transferring the gut microbiota of depressed human patients into rats induced depressive symptoms in the rodents, opening up a whole new realm of possible bacteria-based treatments.

7. STOMACH FLU ISN'T ACTUALLY A FLU.

If you've ever had the misfortune to find yourself stranded by the toilet for 24 to 48 hours purging the contents of your stomach, you may have described the cause as a stomach flu. However, actual influenza is primarily a respiratory infection. What keeps you in the bathroom is likely some form of norovirus or rotavirus, which causes gastroenteritis of the stomach and intestines, and usually resolves in one to two days.

8. THE MOST COMMON CAUSE OF STOMACH ULCERS IS LIKELY BACTERIAL.

The causes of ulcers have perplexed medical researchers for years. However, recent studies have found a link between the bacteria H. pylori and inflammation of the stomach lining, gastritis, and ulcers. In fact, new research suggests that the bacteria may also be linked to stomach cancer.

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Pierluigi Luceri, Flickr // CC BY-NC-ND 2.0
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Weird
Two Human Toes Were Stolen From an Anatomy Exhibit
Pierluigi Luceri, Flickr // CC BY-NC-ND 2.0
Pierluigi Luceri, Flickr // CC BY-NC-ND 2.0

A 28-year-old New Zealand man walked into an anatomy exhibition with 10 toes and walked out with 12. We don't know why or how he did it, but the man stole two human toes from a Body Worlds display in Auckland last month, The New Zealand Herald reports.

The unnamed man appeared in court Monday and pleaded guilty to improperly interfering with the corpse "of an unknown person" and purloining two toes, which alone are valued at about $3800. The motivation for the human remains heist wasn't stated. (Fulfilling a dare seems a likely explanation, or maybe he's just a fan of The Big Lebowski.)

Whatever the reason may be, the story has a happy ending, at least: The digits have since been returned to their rightful place in the "Vital" exhibit, which explores the human body in motion. "Vital," which will remain open in Auckland until July 13, is one of several traveling exhibitions curated by Body Worlds. Two other Body Worlds exhibits are currently on view in the U.S., including "RX" (showcasing the effects of disease) in Toledo, Ohio, and "Animal Inside Out" (an "anatomical safari") in Richmond, Virginia.

The bodies, all of which are donated for exhibition purposes, are preserved via plastination, a process that "replaces bodily fluids and soluble fat in specimens with fluid plastics that harden after vacuum-forced impregnation," according to the Body Worlds website. More than 16,000 people around the world have signed up to donate their bodies after their deaths.

[h/t The New Zealand Herald]

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The Body
11 Facts About the Appendix
Illustration by Mental Floss / Images: iStock
Illustration by Mental Floss / Images: iStock

Despite some 500 years of study, the appendix might be one of the least understood structures in the human body. Here's what we know about this mysterious organ.

1. THE ANCIENT EGYPTIANS CALLED IT THE "WORM" OF THE BOWEL.

The human appendix is small, tube-shaped, and squishy, giving ancient Egyptians, who encountered it when preparing bodies for funerary rites, the impression of a worm. Even today, some medical texts refer to the organ as vermiform—Latin for "worm-like."

2. THE APPENDIX SHOWS UP IN LEONARDO DA VINCI’S DRAWINGS.

The earliest description of a human appendix was written by the Renaissance physician-anatomist Jacopo Berengario da Carpi in 1521. But before that, Leonardo da Vinci is believed to drawn the first depiction of the organ in his anatomical drawings in 1492. Leonardo claimed to have dissected 30 human corpses in his effort to understand the way the body worked from mechanical and physiological perspectives.

3. IT'S ABOUT THE SIZE OF A PINKY FINGER.

The appendix is a small pouch connected to the cecum—the beginning of the large intestine in the lower right-hand corner of your abdomen. The cecum’s job is to receive undigested food from the small intestine, absorb fluids and salts that remain after food is digested, and mix them with mucus for easier elimination; according to Mohamad Abouzeid, M.D., assistant professor and attending surgeon at NYU Langone Medical Center, the cecum and appendix have similar tissue structures.

4. CHARLES DARWIN THOUGHT IT WAS A VESTIGIAL ORGAN …

The appendix has an ill-deserved reputation as a vestigial organ—meaning that it allegedly evolved without a detectable function—and we can blame Charles Darwin for that. In the mid-19th century, the appendix had been identified only in humans and great apes. Darwin thought that our earlier ancestors ate mostly plants, and thus needed a large cecum in which to break down the tough fibers. He hypothesized that over time, apes and humans evolved to eat a more varied and easier-to-digest diet, and the cecum shrank accordingly. The appendix itself, Darwin believed, emerged from the folds of the wizened cecum without its own special purpose.

5. … BUT THE APPENDIX PROBABLY EVOLVED TO HELP IMMUNE FUNCTION.

The proximity and tissue similarities between the cecum and appendix suggest that the latter plays a part in the digestive process. But there’s one noticeable difference in the appendix that you can see only under a microscope. “[The appendix] has a high concentration of the immune cells within its walls,” Abouzeid tells Mental Floss.

Recent research into the appendix's connection to the immune system has suggested a few theories. In a 2015 study in Nature Immunology, Australian researchers discovered that a type of immune cells called innate lymphoid cells (ILCs) proliferate in the appendix and seem to encourage the repopulation of symbiotic bacteria in the gut. This action may help the gut recover from infections, which tend to wipe out fluids, nutrients, and good bacteria.

For a 2013 study examining the evolutionary rationale for the appendix in mammal species, researchers at Midwestern University and Duke University Medical Center concluded that the organ evolved at least 32 times among different lineages, but not in response to dietary or environmental factors.

The same researchers analyzed 533 mammal species for a 2017 study and found that those with appendices had more lymphatic (immune) tissue in the cecum. That suggests that the nearby appendix could serve as "a secondary immune organ," the researchers said in a statement. "Lymphatic tissue can also stimulate growth of some types of beneficial gut bacteria, providing further evidence that the appendix may serve as a 'safe house' for helpful gut bacteria." This good bacteria may help to replenish healthy flora in the gut after infection or illness.

6. ABOUT 7 PERCENT OF AMERICANS WILL GET APPENDICITIS DURING THEIR LIFETIMES.

For such a tiny organ, the appendix gets infected easily. According to Abouzeid, appendicitis occurs when the appendix gets plugged by hardened feces (called a fecalith or appendicolith), too much mucus, or the buildup of immune cells after a viral or bacterial infection. In the United States, the lifetime risk of getting appendicitis is one in 15, and incidence in newly developed countries is rising. It's most common in young adults, and most dangerous in the elderly.

When infected, the appendix swells up as pus fills its interior cavity. It can grow several times larger than its average 3-inch size: One inflamed appendix removed from a British man in 2004 measured just over 8 inches, while another specimen, reported in 2007 in the Journal of Clinical Pathology, measured 8.6 inches. People with appendicitis might feel generalized pain around the bellybutton that localizes on the right side of the abdomen, and experience nausea or vomiting, fever, or body aches. Some people also get diarrhea.

7. APPENDECTOMIES ARE ALMOST 100 PERCENT EFFECTIVE FOR TREATING APPENDICITIS.

Treatment for appendicitis can go two ways: appendectomy, a.k.a. surgical removal of the appendix, or a first line of antibiotics to treat the underlying infection. Appendectomies are more than 99 percent effective against recurring infection, since the organ itself is removed. (There have been cases of "stump appendicitis," where an incompletely removed appendix becomes infected, which often require further surgery.)

Studies show that antibiotics produce about a 72 percent initial success rate. “However, if you follow these patients out for about a year, they often get recurrent appendicitis,” Abouzeid says. One 2017 study in the World Journal of Surgery followed 710 appendicitis patients for a year after antibiotic treatment and found a 26.5 percent recurrence rate for subsequent infections.

8. AN INFECTED APPENDIX DOESN’T ACTUALLY BURST.

You might imagine a ruptured appendix, known formally as a perforation, being akin to the "chestbuster" scene in Alien. Abouzeid says it's not quite that dramatic, though it can be dangerous. When the appendix gets clogged, pressure builds inside the cavity of the appendix, called the lumen. That chokes off blood supply to certain tissues. “The tissue dies off and falls apart, and you get perforation,” Abouzeid says. But rather than exploding, the organ leaks fluids that can infect other tissues.

A burst appendix is a medical emergency. Sometimes the body can contain the infection in an abscess, Abouzeid says, which may be identified through CT scans or X-rays and treated with IV antibiotics. But if the infection is left untreated, it can spread to other parts of the abdomen, a serious condition called peritonitis. At that point, the infection can become life-threatening.

9. SURGEONS CAN REMOVE AN APPENDIX THROUGH A TINY INCISION.

In 1894, Charles McBurney, a surgeon at New York's Roosevelt Hospital, popularized an open-cavity, muscle-splitting technique [PDF] to remove an infected appendix, which is now called an open appendectomy. Surgeons continued to use McBurney's method until the advent of laparoscopic surgery, a less invasive method in which the doctor makes small cuts in the patient's abdomen and threads a thin tube with a camera and surgical tools into the incisions. The appendix is removed through one of those incisions, which are usually less than an inch in length.

The first laparoscopic appendectomies were performed by German physician Kurt Semm in the early 1980s. Since then, laparoscopic appendectomies have become the standard treatment for uncomplicated appendicitis. For more serious infections, open appendectomies are still performed.

10. AN APPENDIX ONCE POSTPONED A ROYAL CORONATION.

When the future King Edward VII of Great Britain came down with appendicitis (or "perityphlitis," as it was called back then) in June 1902, mortality rates for the disease were as high as 26 percent. It was about two weeks before his scheduled coronation on June 26, 1902, and Edward resisted having an appendectomy, which was then a relatively new procedure. But surgeon and appendicitis expert Frederick Treves made clear that Edward would probably die without it. Treves drained Edward's infected abscess, without removing the organ, at Buckingham Palace; Edward recovered and was crowned on August 9, 1902.

11. THE WORLD'S LONGEST APPENDIX MEASURED MORE THAN 10 INCHES.

On August 26, 2006, during an autopsy at a Zagreb, Croatia hospital, surgeons obtained a 10.24-inch appendix from 72-year-old Safranco August. The deceased currently holds the Guinness World Record for "largest appendix removed."

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