15 Useful Facts About Lyme Disease

Stringer/Getty Images
Stringer/Getty Images

As summer nears and you spend more time outdoors in one of the many beautiful natural spots in the United States, be sure to dress for the season—tick season, that is. Some experts say 2017 may be an especially tick-infested year. Deer ticks (Ixodes scapularis) carry a bacteria that causes Lyme disease, an infection from a bacterium that coils waiting in their insect bodies. Lyme-carrying deer ticks are especially prevalent in the upper East Coast, the upper Midwest, northern California, and the Oregon coast. While not every tick carries the bacteria that lead to infection—and some carry other pathogens—it’s best to take precautions to prevent bites, and seek medical attention if you have been bitten. The infection can cause long-lasting damage if not treated early. Here are 15 facts you need to know about Lyme disease.

1. LYME DISEASE IS CAUSED BY COILED BACTERIA.

Lyme disease is caused by the bacterium Borrelia burgdorferi, a spirochete, or tightly coiled bacterium that looks like a tiny spring under a microscope. Spirochetes are very simple, slow-replicating bacteria that require a mammalian or avian host to survive. According to Timothy Sellati, chair of the infectious diseases department at Southern Research, a nonprofit research institution in Birmingham, Alabama, “It takes on the order of 18–20 hours for a single spirochete to divide into two.” That’s incredibly slow, compared to other bacteria like E. coli, which can replicate every 20 minutes. Because Borrelia replicates so slowly, and they don’t reach high numbers, “They do not show up easily in a blood test,” Sellati says.

2. TICKS PREFER A LONG MEAL.

Sellati explains that ticks are very different feeders from mosquitoes, which he calls “hit-and-run feeders.” Ticks will feed over a period of three to five days before they become fully engorged. Female ticks generally only take three “blood meals,” he says, in the duration of their lifespan. They take one blood meal after hatching from their egg into the larval stage, another after they molt into their nymphal stage—the stage where they are most likely to bite you—and a final “big meal” in preparation for laying thousands of eggs. Adult male ticks generally don’t feed, he says.

3. THEY ARE A VIRULENT DISEASE VECTOR …

When an infected tick bites a human, the waiting spirochetes—which live essentially dormant in the tick’s gut until environmental cues such as changes in temperature and oxygen availability awaken them—travel from the tick’s gut to its saliva glands. “From the saliva glands they can literally be spat into the bloodstream that the tick is feeding on,” Sellati says. Once they enter the bloodstream, spirochetes travel to various body tissues, because if they stay too long in the bloodstream, they’ll get killed by their host's immune system. “Once it gets away from site of inoculation, it shows a bias toward joints, heart, central nervous system,” Sellati says.

4. … WHICH LEADS TO INFLAMMATION.

“The bacteria has components that are very effective at eliciting an inflammatory response,” Sellati explains. While Borrelia don’t produce toxins like other bacteria, they do incite inflammation in sensitive parts of the body such as the joints, heart, and brain. “That inflammatory response is important to help kill and clear the spirochetes, but it causes collateral damage as well.”

5. INFECTIONS MAY BEGIN WITH A BULL'S-EYE.

The first symptom to look for in about 80 to 90 percent of Lyme cases is a telltale rash of an infected tick bite, called an erythema migrans (EM) rash, which looks a lot like a red bull's-eye, and usually appears at the site of a tick bite within seven to 14 days, according to the American Lyme Disease Foundation. However, the rash does not appear in every instance of Lyme disease, so if you’re bitten, you should visit a doctor immediately. You may also experience flu-like symptoms or joint pains in the first month after the bite.

6. DON'T WAIT TO GET TREATMENT.

If you don't see the tick bite, and don't treat early symptoms, the spirochetes continue to spread throughout your body and can cause more severe symptoms, including fatigue, stiff or aching neck, tingling or numbness in your extremities, and even paralysis of your face. Even more debilitating symptoms of later-stage Lyme disease can include severe headaches, painful arthritis and swelling of joints, cardiac abnormalities, and central nervous system debilitations leading to cognitive disorders.

7. IF CAUGHT EARLY, IT'S USUALLY HIGHLY TREATABLE …

When the disease is caught in its early stages, and treated with antibiotics, it’s curable, Sellati says. Even later stages of the disease can be treated, but the longer an infection goes untreated, the more severe the symptoms and damage can become.

8. … BUT SOME PATIENTS EXPERIENCE SYMPTOMS FOR MUCH LONGER.

Scientists are not entirely sure why a subset of patients have recurrent symptoms of the illness in the months and even years following treatment, known as post-treatment Lyme disease syndrome. “It’s not clear if there is a persistence of live replicating bacteria in some immune privileged niche where they’re protected from exposure to antibiotics,” Sellati says, or if it’s simply the subsequent inflammation stirred up in the body that refuses to go back to normal. “What drives that is not entirely clear.”

9. YOUR GENETICS MAY DICTATE YOUR TREATMENT.

Sellati’s lab has been exploring whether genetics plays a role in who recovers after treatment and who doesn’t. “We have some evidence that your genetic makeup can actually predispose you to developing post-treatment Lyme disease syndrome," Sellati says, and adds it will require more research. They believe they might be able to isolate genetic markers that will tell doctors if antibiotics alone will work, or if the patient might need additional treatment.

10. FEAR THE ENGORGED TICK (BUT DON'T PANIC).

The good news is, even if a tick bites you, if it isn’t yet fully engorged on your blood, chances are good it hasn’t been there long enough to transmit the spirochetes that lead to infection. However, it’s always better to be safe, and pay attention to any symptoms that occur thereafter. “The sooner you can remove a tick from your body, whether it’s feeding or not, the better. If the tick is feeding for less than 24 hours, the likelihood of being infected with Borellia is significantly reduced,” Sellati says.

11. AREAS WITH MICE HAVE MORE LYME DISEASE.

Wherever you find mice and deer you’re very likely to find ticks as well. In fact, Sellati says, mice in all forms—but especially the white-footed mouse—are what infectious researchers call a “maintenance reservoir.” Sellati says. “They maintain the bacteria in the wild so that new ticks can acquire it.” Since spirochetes tend to stay in the bloodstream of mice much longer than they do in humans, that’s how ticks have such an endless supply of the bacteria. “If you got rid of all the mice in the world, you would either come very close to or significantly reduce the population of Borellia in the environment. You’d have a significant decrease in Lyme,” he emphasizes.

12. YOU CAN TAKE SIMPLE STEPS TO PROTECT YOURSELF.

Wear clothes with the most coverage possible. Spray yourself with anti-tick sprays. But no matter what, always do a tick check after you return from the outdoors just to be safe. And if you start to feel any of the symptoms mentioned earlier within a month of a tick bite, don’t wait to visit your doctor.

13. CHECK YOUR CREVICES.

Ticks are not opposed to biting you wherever they can reach, but they have a preference for your warm, moist crevices, such as armpits, backs of the knee, groin, base of the head, and nape of your neck.

14. SKIP SOME OF THOSE "TIPS" FOR REMOVING TICKS THAT YOU'VE HEARD ABOUT.

No matter how many YouTube tutorials you’ve watched, Sellati recommends that you do not use heat, like a match or a lighter, to burn a tick off. The same goes for “goops” such as petroleum jelly, alcohol, or hand sanitizer. Since the spirochetes are transmitted through tick saliva, Sellati warns, “If you try to do those things, you’re only going to piss the tick off, and a pissed-off tick spits a lot, and you're more likely to get more bacteria into your bloodstream.”

15. INSTEAD, USE SLOW, STEADY PRESSURE—AND SOME TWEEZERS.

Take a small pair of forceps or tweezers, Sellati instructs, and gently grasp the tick as close to the skin’s surface as possible, “then pull the tick straight up slowly, which pulls the mouth part out of the skin, and then just dab the area with alcohol to disinfect.” A tick’s mouthparts are like tiny barbed hooks, designed to pierce the skin and stay there. “Then they have secretions that cement the mouthparts to the skin, because they have to feed over a long time and they don’t want to be knocked off while they sit and sip.”

15 Gripping Facts About Galileo

Getty Images
Getty Images

Albert Einstein once said that the work of Galileo Galilei “marks the real beginning of physics.” And astronomy, too: Galileo was the first to aim a telescope at the night sky, and his discoveries changed our picture of the cosmos. Here are 15 things that you might not know about the father of modern science, who was born February 15, 1564.

1. There's a reason why Galileo Galilei's first name echoes his last name.

You may have noticed that Galileo Galilei’s given name is a virtual carbon-copy of his family name. In her book Galileo’s Daughter, Dava Sobel explains that in Galileo’s native Tuscany, it was customary to give the first-born son a Christian name based on the family name (in this case, Galilei). Over the years, the first name won out, and we’ve come to remember the scientist simply as “Galileo.”

2. Galileo Galilei probably never dropped anything off the leaning tower of Pisa. 

With its convenient “tilt,” the famous tower in Pisa, where Galileo spent the early part of his career, would have been the perfect place to test his theories of motion, and of falling bodies in particular. Did Galileo drop objects of different weights, to see which would strike the ground first? Unfortunately, we have only one written account of Galileo performing such an experiment, written many years later. Historians suspect that if Galileo taken part in such a grand spectacle, there would be more documentation. (However, physicist Steve Shore did perform the experiment at the tower in 2009; I videotaped it and put the results on YouTube.)

3. Galileo taught his students how to cast horoscopes.

It’s awkward to think of the father of modern science mucking about with astrology. But we should keep two things in mind: First, as historians remind us, it’s problematic to judge past events by today’s standards. We know that astrology is bunk, but in Galileo’s time, astrology was only just beginning to disentangle from astronomy. Besides, Galileo wasn’t rich: A professor who could teach astrological methods would be in greater demand than one who couldn’t.

4. Galileo didn't like being told what to do.

Maybe you already knew that, based on his eventual kerfuffle with the Roman Catholic Church. But even as a young professor at the University of Pisa, Galileo had a reputation for rocking the boat. The university’s rules demanded that he wear his formal robes at all times. He refused—he thought it was pretentious and considered the bulky gown a nuisance. So the university docked his pay.

5. Galileo Galilei didn't invent the telescope.

We’re not sure who did, although a Dutch spectacle-maker named Hans Lipperhey often gets the credit (he applied for a patent in the fall of 1608). Within a year, Galileo Galilei obtained one of these Dutch instruments and quickly improved the design. Soon, he had a telescope that could magnify 20 or even 30 times. As historian of science Owen Gingerich has put it, Galileo had managed “to turn a popular carnival toy into a scientific instrument.”

6. A king leaned on Galileo to name planets after him.

Galileo rose to fame in 1610 after discovering, among other things, that the planet Jupiter is accompanied by four little moons, never previously observed (and invisible without telescopic aid). Galileo dubbed them the “Medicean stars” after his patron, Cosimo II of the Medici family, who ruled over Tuscany. The news spread quickly; soon the king of France was asking Galileo if he might discover some more worlds and name them after him.

7. Galileo didn't have trouble with the church for the first two-thirds of his life.

In fact, the Vatican was keen on acquiring astronomical knowledge, because such data was vital for working out the dates of Easter and other holidays. In 1611, when Galileo visited Rome to show off his telescope to the Jesuit astronomers there, he was welcomed with open arms. The future Pope Urban VIII had one of Galileo’s essays read to him over dinner and even wrote a poem in praise of the scientist. It was only later, when a few disgruntled conservative professors began to speak out against Galileo, that things started to go downhill. It got even worse in 1616, when the Vatican officially denounced the heliocentric (sun-centered) system described by Copernicus, which all of Galileo’s observations seemed to support. And yet, the problem wasn’t Copernicanism. More vexing was the notion of a moving Earth, which seemed to contradict certain verses in the Bible.

8. Galileo probably could have earned a living as an artist.

We think of Galileo as a scientist, but his interests—and talents—straddled several disciplines. Galileo could draw and paint as well as many of his countrymen and was a master of perspective—a skill that no doubt helped him interpret the sights revealed by his telescope. His drawings of the Moon are particularly striking. As the art professor Samuel Edgerton has put it, Galileo’s work shows “the deft brushstrokes of a practiced watercolorist”; his images have “an attractive, soft, and luminescent quality.” Edgerton writes of Galileo’s “almost impressionistic technique” more than 250 years before Impressionism developed.

10. Galileo wrote about relativity long before Einstein.

He didn’t write about exactly the same sort of relativity that Einstein did. But Galileo understood very clearly that motion is relative—that is, that your perception of motion has to do with your own movement as well as that of the object you’re looking at. In fact, if you were locked inside a windowless cabin on a ship, you’d have no way of knowing if the ship was motionless, or moving at a steady speed. More than 250 years later, these ideas would be fodder for the mind of the young Einstein.

10. Galileo never married, but that doesn't mean he was alone.

Galileo was very close with a beautiful woman from Venice named Marina Gamba; together, they had two daughters and a son. And yet, they never married, nor even shared a home. Why not? As Dava Sobel notes, it was traditional for scholars in those days to remain single; perceived class difference may also have played a role.

11. You can listen to music composed by Galileo's dad.

Galileo’s father, Vincenzo, was a professional musician and music teacher. Several of his compositions have survived, and you can find modern recordings of them on CD (like this one). The young Galileo learned to play the lute by his father’s side; in time he became an accomplished musician in his own right. His music sense may have aided in his scientific work. With no precision clocks, Galileo was still able to time rolling and falling objects to within mere fractions of a second.

12. His discoveries may have influenced a scene in one of Shakespeare's late plays.

An amusing point of trivia is that Galileo and Shakespeare were born in the same year (1564). By the time Galileo aimed his telescope at the night sky, however, the English playwright was nearing the end of his career. But he wasn’t quite ready to put down the quill: His late play Cymbeline contains what may be an allusion to one of Galileo’s greatest discoveries—the four moons circling Jupiter. In the play’s final act, the god Jupiter descends from the heavens, and four ghosts dance around him in a circle. It could be a coincidence—or, as I suggest in my book The Science of Shakespeare, it could hint at the Bard's awareness of one of the great scientific discoveries of the time.

13. Galileo had some big-name visitors while under house arrest.

Charged with “vehement suspicion of heresy,” Galileo spent the final eight years of his life under house arrest in his villa outside of Florence. But he was able to keep writing and, apparently, to receive visitors, among them two famous Englishmen: the poet John Milton and the philosopher Thomas Hobbes.

14. Galileo's bones have not rested in peace.

When Galileo died in 1642, the Vatican refused to allow his remains to be buried alongside family members in Florence’s Santa Croce Basilica; instead, his bones were relegated to a side chapel. A century later, however, his reputation had improved, and his remains (minus a few fingers) were transferred to their present location, beneath a grand tomb in the basilica’s main chapel. Michelangelo is nearby.

15. Galileo might not have been thrilled with the Vatican's 1992 "apology."

In 1992, under Pope John Paul II, the Vatican issued an official statement admitting that it was wrong to have persecuted Galileo. But the statement seemed to place most of the blame on the clerks and theological advisers who worked on Galileo’s case—and not on Pope Urban VIII, who presided over the trial. Nor was the charge of heresy overturned.

Additional sources: The Discoveries and Opinions of Galileo; Galileo's Daughter; The Cambridge Companion to Galileo.

10 Things You Should Know About Asthma

iStock.com/Wojciech Kozielczyk
iStock.com/Wojciech Kozielczyk

To anyone with asthma, the feeling of an attack is unmistakable. Patients have compared an asthma attack's feeling of breathlessness, caused by inflammation in the lungs and airways, to being smothered by a pillow or having an elephant sit on their chest. Medical experts have already figured out some aspects of asthma, like how to diagnose and treat it, but other components, like what causes asthma and how to cure it, remain unclear. From the triggers people encounter at work to the connection to allergies, here are some facts about asthma symptoms and treatments you should know.

1. Asthma attacks are related to allergies.

The physical process that occurs when someone has a sneezing fit during pollen season is similar to what happens during an asthma attack. But while the former causes discomfort, the latter produces potentially life-threatening symptoms. When people with allergies are exposed to an allergen like pollen, they produce antibodies that bind to that allergen. This signals the body to release the chemicals that cause allergic symptoms. In most people, the symptoms are limited to the head, such as a runny nose or watery eyes, but in people with asthma, they're felt in the lungs. If the lungs are inflamed, the airways that carry air swell up and fill with mucus, constricting airflow and causing common asthma symptoms like coughing, wheezing, and shortness of breath. Such asthma attacks can be fatal when patients can’t get enough air to their lungs.

2. Asthma is the most prevalent chronic disease among children.

Asthma is common, affecting 25 million in the U.S. alone, and of those patients, about 7 million are children. Most people with the disease develop it during childhood. Asthma is the most prevalent chronic illness among kids, and each year, students miss 13.8 million school days because of it.

3. Asthma may be inherited.

Doctors aren’t entirely sure what causes asthma, but they know it sometimes runs in families. A 2010 study found that people with one parent with the condition were nearly twice as likely to have it themselves, and people with a parent and a grandparent with asthma were four times more likely to develop it. Because asthma is connected to allergies, a genetic disposition toward allergies, known as atopy, may explain some inherited asthma cases.

4. Asthma is surprisingly easy to diagnose.

One of the simplest ways to diagnose asthma is through a lung function test. If a patient is reporting asthma symptoms (coughing, chest tightness, a feeling of not getting enough air), their doctor may check the strength of their exhalations before and after having them use an inhaler. If their breathing improves with the medicine, they likely have asthma. An X-ray of the patient’s chest can also be used to reach an asthma diagnosis.

5. Kids who grow up around germs are less likely to have asthma.

A person’s environment early in life may also play a role in whether or not they develop asthma. People who grew up in rural areas, around animals, and in large families are less likely to have asthma than those who did not. One possible explanation is the hygiene hypothesis: According to this theory, kids who were exposed to germs and pathogens while their immune systems were developing are better equipped to deal with allergens, while kids who were sheltered from germs may be more likely to have an exaggerated (and in the case of asthma, potentially deadly) immune response to harmless substances. The hygiene hypothesis hasn’t been proven, however, and it’s definitely not an excuse to expose children to infections in an attempt to strengthen them against asthma attacks in the future.

6. Asthma triggers are everywhere.

To manage their symptoms, doctors tell asthma patients to limit exposure to their triggers when possible. Common asthma triggers include irritants and allergens like dust, tobacco smoke, car exhaust, mold, pet dander, and smoke from burning wood. Triggers that don’t come from the environment, like colds, sinus infections, acid reflux, and hyperventilation brought on by stress, can be even harder to avoid.

7. There's one asthma trigger patients shouldn't avoid.

Physical activity causes fast breathing, which can provoke asthma attacks in some people with the condition. There’s even a type of asthma called exercise-induced bronchoconstriction that specifically describes people who suffer from these kinds of attacks. But the risks of living a sedentary lifestyle outweigh those of exercising carefully, even with asthma. Instead of cutting out cardio altogether, doctors work with patients to come up with an exercise plan that’s safe for them. This might include warming up and using an inhaler before working out, practicing cool-down activities afterward, and wearing scarves or masks to limit exposure to irritants that may also trigger asthma symptoms.

8. There are two types of asthma treatments.

Long-term controllers and quick-relievers are the two types of medications used to treat asthma. Immediate medicines like short-acting beta agonists and anticholinergics relax muscles in the airways when flare-ups occur, and they’re typically administered directly to the lungs with an inhaler. Long-term medications help keep asthma symptoms under control over time are taken as often as once a day, regardless of whether symptoms are present. They include inhaled long-acting beta agonists and corticosteroids, biologic injections, and theophylline and leukotriene modifier pills and liquids. All of these medications suppress asthma symptoms by either relaxing muscles, reducing swelling, or preventing inflammation in the airways.

9. Asthma can be an occupational hazard.

Occupational asthma develops when a patient’s triggers come from their work environment. According to the National Institutes of Health, wood dust, grain dust, animal dander, fungi, and various chemicals are some of the most common asthma triggers that patients encounter in the workplace. Bakers, farmers, laboratory workers, millers, and woodworkers predisposed to asthma are all at higher risk.

10. There's no cure for asthma, but symptoms can lessen over time.

Though asthma is treatable, there’s no cure for the chronic illness. Some people, however, do appear to grow out of the condition after suffering from it as kids. It’s possible for asthma symptoms to become less severe and go into remission as patients get older, but once someone is diagnosed with asthma, the risk of an episode never goes away completely. Changes in hormone levels are a factor that could possibly bring asthma symptoms back in patients who haven’t experienced an attack in years.

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