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New Cancer Treatment “Remembers” Tumors and Won’t Let Them Regrow

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Researchers have found a way to train the immune system to eradicate cancer cells and “remember” them in case they try to return. A report of the technique was published today in the journal Science Immunology.

Cancer is a stealthy invader. Rather than facing the body’s defenses head-on, it manipulates the sentries of our immune system, shutting them down or even turning them against us.

One commonly hijacked sentry is called the CD4+ T regulatory (Treg) cell. When they’ve been bamboozled by cancer, Treg cells tell our defenses to leave tumors alone. So if we could find a way to shut those Treg cells up, our immune systems would, theoretically, treat cancer like the intruder it is. The problem is that Treg cells are themselves kind of slippery and hard to target with drugs.

One possible way in is a molecule called LAP, which has previously been linked to worse outcomes for people with cancer.

To learn more, researchers examined interactions between Treg cells and LAP in mice with melanoma, colon cancer, and brain cancer. They found that zapping the molecule with special anti-LAP antibodies did the trick, effectively shutting the hijacked cells down so the immune system could do its work. Mice treated with these antibodies had lower levels of Treg cells and cancer cells.

Better yet, when the researchers mixed the anti-LAP antibodies with tumor vaccines, they discovered that tumors wouldn’t grow, even in mice exposed to cancer-causing proteins. The effects of this cocktail lasted for months.

Best of all, the treatment seemed to create “memories” of the tumors in the rodents’ immune systems, enabling them to recognize cancer cells more quickly and prevent relapse.

Before you get too excited, we should mention a few things about these experiments. First, as we’ve said before and will say again, mice are not people. Second, the treatments were tested under the mice’s skin, not in the places where these tumors would naturally grow.

Still, the researchers say, the anti-LAP molecules are a good step, and they are eager to explore them further.

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Today's Wine Glasses Are Almost Seven Times Larger Than They Were in 1700
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Holiday party season (a.k.a. hangover season) is in full swing. While you likely have no one to blame but yourself for drinking that second (or third) pour at the office soiree, your glassware isn't doing you any favors—especially if you live in the UK. Vino vessels in England are nearly seven times larger today than they were in 1700, according to a new study spotted by Live Science. These findings were recently published in the English medical journal The BMJ.

Researchers at the University of Cambridge measured more than 400 wineglasses from the past three centuries to gauge whether glass size affects how much we drink. They dug deep into the history of parties past, perusing both the collections of the Ashmolean Museum of Art and Archaeology at the University of Oxford and the Royal Household's assemblage of glassware (a new set is commissioned for each monarch). They also scoured a vintage catalog, a modern department store, and eBay for examples.

After measuring these cups, researchers concluded that the average wineglass in 1700 held just 2.2 fluid ounces. For comparison's sake, that's the size of a double shot at a bar. Glasses today hold an average of 15.2 fluid ounces, even though a standard single serving size of wine is just 5 ounces.

BMJ infographic detailing increases in wine glass size from 1700 to 2017
BMJ Publishing group Ltd.

Advances in technology and manufacturing are partly to blame for this increase, as is the wine industry. Marketing campaigns promoted the beverage as it increasingly became more affordable and available for purchase, which in turn prompted aficionados to opt for larger pours. Perhaps not surprisingly, this bigger-is-better mindset was also compounded by American drinking habits: Extra-large wineglasses became popular in the U.S. in the 1990s, prompting overseas manufacturers to follow suit.

Wine consumption in both England and America has risen dramatically since the 1960s [PDF]. Cambridge researchers noted that their study doesn't necessarily prove that the rise of super-sized glassware has led to this increase. But their findings do fit a larger trend: previous studies have found that larger plate size can increase food consumption. This might be because they skew our sense of perception, making us think we're consuming less than we actually are. And in the case of wine, in particular, oversized glasses could also heighten our sensory enjoyment, as they might release more of the drink's aroma.

“We cannot infer that the increase in glass size and the rise in wine consumption in England are causally linked,” the study's authors wrote. “Nor can we infer that reducing glass size would cut drinking. Our observation of increasing size does, however, draw attention to wine glass size as an area to investigate further in the context of population health.”

[h/t Live Science]

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Researchers Pore Over the Physics Behind the Layered Latte
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The layered latte isn't the most widely known espresso drink on coffee-shop menus, but it is a scientific curiosity. Instead of a traditional latte, where steamed milk is poured into a shot (or several) of espresso, the layered latte is made by pouring the espresso into a glass of hot milk. The result is an Instagram-friendly drink that features a gradient of milky coffee colors from pure white on the bottom to dark brown on the top. The effect is odd enough that Princeton University researchers decided to explore the fluid dynamics that make it happen, as The New York Times reports.

In a new study in Nature Communications, Princeton engineering professor Howard Stone and his team explore just what creates the distinct horizontal layers pattern of layered latte. To find out, they injected warm, dyed water into a tank filled with warm salt water, mimicking the process of pouring low-density espresso into higher-density steamed milk.

Four different images of a latte forming layers over time
Xue et al., Nature Communications (2017)

According to the study, the layered look of the latte forms over the course of minutes, and can last for "tens of minutes, or even several hours" if the drink isn't stirred. When the espresso-like dyed water was injected into the salt brine, the downward jet of the dyed water floated up to the top of the tank, because the buoyant force of the low-density liquid encountering the higher-density brine forced it upward. The layers become more visible when the hot drink cools down.

The New York Times explains it succinctly:

When the liquids try to mix, layered patterns form as gradients in temperature cause a portion of the liquid to heat up, become lighter and rise, while another, denser portion sinks. This gives rise to convection cells that trap mixtures of similar densities within layers.

This structure can withstand gentle movement, such as a light stirring or sipping, and can stay stable for as long as a day or more. The layers don't disappear until the liquids cool down to room temperature.

But before you go trying to experiment with layering your own lattes, know that it can be trickier than the study—which refers to the process as "haphazardly pouring espresso into a glass of warm milk"—makes it sound. You may need to experiment several times with the speed and height of your pour and the ratio of espresso to milk before you get the look just right.

[h/t The New York Times]

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