New Cancer Treatment “Remembers” Tumors and Won’t Let Them Regrow

iStock
iStock

Researchers have found a way to train the immune system to eradicate cancer cells and “remember” them in case they try to return. A report of the technique was published today in the journal Science Immunology.

Cancer is a stealthy invader. Rather than facing the body’s defenses head-on, it manipulates the sentries of our immune system, shutting them down or even turning them against us.

One commonly hijacked sentry is called the CD4+ T regulatory (Treg) cell. When they’ve been bamboozled by cancer, Treg cells tell our defenses to leave tumors alone. So if we could find a way to shut those Treg cells up, our immune systems would, theoretically, treat cancer like the intruder it is. The problem is that Treg cells are themselves kind of slippery and hard to target with drugs.

One possible way in is a molecule called LAP, which has previously been linked to worse outcomes for people with cancer.

To learn more, researchers examined interactions between Treg cells and LAP in mice with melanoma, colon cancer, and brain cancer. They found that zapping the molecule with special anti-LAP antibodies did the trick, effectively shutting the hijacked cells down so the immune system could do its work. Mice treated with these antibodies had lower levels of Treg cells and cancer cells.

Better yet, when the researchers mixed the anti-LAP antibodies with tumor vaccines, they discovered that tumors wouldn’t grow, even in mice exposed to cancer-causing proteins. The effects of this cocktail lasted for months.

Best of all, the treatment seemed to create “memories” of the tumors in the rodents’ immune systems, enabling them to recognize cancer cells more quickly and prevent relapse.

Before you get too excited, we should mention a few things about these experiments. First, as we’ve said before and will say again, mice are not people. Second, the treatments were tested under the mice’s skin, not in the places where these tumors would naturally grow.

Still, the researchers say, the anti-LAP molecules are a good step, and they are eager to explore them further.

The Psychology Behind Kids' L.O.L. Surprise! Doll Obsession

Jack Taylor, Getty Images
Jack Taylor, Getty Images

Isaac Larian, the founder and CEO of toymaker MGA Entertainment, is an insomniac. Fortunately for him, that inability to sleep forced him to get up out of bed one night—a move that ended up being worth $4 billion.

Larian’s company is the architect of L.O.L. Surprise!, a line of dolls with a clever conceit. The product, which retails for about $10 to $20, is encased in a ball-shaped plastic shell and buried under layers of packaging, forcing children to tear through a gauntlet of wrapping before they’re able to see it. The inspiration came on that highly profitable sleepless night, which Larian spent watching unboxing videos on YouTube. It resulted in the first toy made for a generation wired for delayed gratification.

The dolls first went on sale in test markets at select Target stores in late 2016. MGA shipped out 500,000 of them, all of which sold out within two months. A Cabbage Patch Kid-esque frenzy came the following year. By late 2018, L.O.L. Surprise! (the acronym stands for the fancifully redundant Little Outrageous Little) had moved 800 million units, accounted for seven of the top 10 toys sold in the U.S., and was named Toy of the Year by the Toy Association. Videos of kids and adults unboxing them garner millions of views on YouTube, which is precisely where Larian knew his marketing would be most effective.

A woman holds a L.O.L. Surprise doll and packaging in her hand
Cindy Ord, Getty Images for MGA Entertainment

The dolls themselves are nothing revolutionary. Once freed from their plastic prisons, they stare at their owner with doe-eyed expressions. Some “tinkle,” while others change color in water. They can be dressed in accessories found in the balls or paired with tiny pets (which also must be "unboxed"). Larger bundles, like last year’s $89.99 L.O.L. Bigger Surprise! capsule, feature a plethora of items, each individually wrapped. It took a writer from The New York Times 59 minutes to uncover everything inside.

This methodical excavation is what makes L.O.L. Surprise! so appealing to its pint-sized target audience. Though MGA was advised that kids wouldn’t want to buy something they couldn’t see, Larian and his executives had an instinctual understanding of what child development experts already knew: Kids like looking forward to things.

Dr. Rachel Barr, director of Georgetown University’s Early Learning Project, told The Atlantic that unboxing videos tickle the part of a child’s brain that enjoys anticipation. By age 4 or 5, they have a concept of “the future,” or events that will unfold somewhere other than the present. However, Barr said, they’re also wary of being scared by an unforeseen outcome. In an unboxing video, they know the payoff will be positive and not, say, a live tarantula.

L.O.L. Surprise! is engineered to prolong that anticipatory joy, with kids peeling away wrapping like an onion for up to 20 minutes at a time. The effect is not entirely novel—baseball card collectors have been buying and unwrapping card packs without knowing exactly what’s inside for decades—but paired with social media, MGA was able to strike oil. The dolls now have 350 licensees making everything from bed sheets to apparel. Collectors—or their parents—can buy a $199.99 doll house. So-called “boy toys” are now lurking inside the wrappers, with one, the mohawk-sporting Punk Boi, causing a mild stir for being what MGA calls “anatomically correct.” His tiny plastic genital area facilitates a peeing function.

Whether L.O.L. Surprise! bucks conventional toy trends and continues its popularity beyond a handful of holiday seasons remains to be seen. Already, MGA is pushing alternative products like Poopsie Slime Surprise, a unicorn that can be fed glitter and poops a viscous green slime. An official unboxing video has been viewed 4.2 million times and counting.

More Than Half of Wild Coffee Species Could Go Extinct

iStock.com/Alfribeiro
iStock.com/Alfribeiro

Your morning cup of coffee is under threat. A study published today in Science Advances asserts that a majority of the world’s wild coffee species are at risk of extinction. The main two types we rely on for our caffeine fix—arabica and robusta beans—are both threatened by climate change and deforestation.

The team of UK-based researchers used Red List of Threatened Species criteria from the International Union for the Conservation of Nature to classify the risks facing the world’s 124 known species of wild coffee. About 60 percent of them—or 75 different species—face possible extinction in the coming decades. This represents “one of the highest levels recorded for a plant group,” researchers write in their paper.

Partly to blame are the severe droughts associated with climate change, as well as deforestation. Other threats include the spread of fungal pathogens and coffee wilt disease in Central and South America and Africa, respectively, as well as social and economic factors for growers.

“Considering threats from human encroachment and deforestation, some [coffee species] could be extinct in 10 to 20 years, particularly with the added influence of climate change," lead author Aaron P. Davis, of the Royal Botanic Gardens, Kew, tells CNN.

Davis’s previous research stressed that arabica, which is already listed as an endangered species, could be extinct within 60 years. Most of the coffee plants we rely on are farmed, but wild coffee is no less important. Some wild species are resistant to disease and have other useful genes that could be introduced to commercial crops. That way, the cultivated varieties might endure the effects of climate change better and stick around a little longer.

Consumers aren’t the only ones concerned, either. Coffee farming is an industry that supports about 100 million workers around the world. One way of conserving the plants is to store their seeds and genes, but Hanna Neuschwander, the director of communications for the industry group World Coffee Research, tells Mashable that these seed banks aren’t well established yet. For now, the focus is on preserving the plants themselves.

SECTIONS

arrow
LIVE SMARTER