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New Cancer Treatment “Remembers” Tumors and Won’t Let Them Regrow

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Researchers have found a way to train the immune system to eradicate cancer cells and “remember” them in case they try to return. A report of the technique was published today in the journal Science Immunology.

Cancer is a stealthy invader. Rather than facing the body’s defenses head-on, it manipulates the sentries of our immune system, shutting them down or even turning them against us.

One commonly hijacked sentry is called the CD4+ T regulatory (Treg) cell. When they’ve been bamboozled by cancer, Treg cells tell our defenses to leave tumors alone. So if we could find a way to shut those Treg cells up, our immune systems would, theoretically, treat cancer like the intruder it is. The problem is that Treg cells are themselves kind of slippery and hard to target with drugs.

One possible way in is a molecule called LAP, which has previously been linked to worse outcomes for people with cancer.

To learn more, researchers examined interactions between Treg cells and LAP in mice with melanoma, colon cancer, and brain cancer. They found that zapping the molecule with special anti-LAP antibodies did the trick, effectively shutting the hijacked cells down so the immune system could do its work. Mice treated with these antibodies had lower levels of Treg cells and cancer cells.

Better yet, when the researchers mixed the anti-LAP antibodies with tumor vaccines, they discovered that tumors wouldn’t grow, even in mice exposed to cancer-causing proteins. The effects of this cocktail lasted for months.

Best of all, the treatment seemed to create “memories” of the tumors in the rodents’ immune systems, enabling them to recognize cancer cells more quickly and prevent relapse.

Before you get too excited, we should mention a few things about these experiments. First, as we’ve said before and will say again, mice are not people. Second, the treatments were tested under the mice’s skin, not in the places where these tumors would naturally grow.

Still, the researchers say, the anti-LAP molecules are a good step, and they are eager to explore them further.

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Space
Look Up! The Orionid Meteor Shower Peaks This Weekend
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Ethan Miller/Getty Images

October is always a great month for skywatching. If you missed the Draconids, the first meteor shower of the month, don't despair: the Orionids peak this weekend. It should be an especially stunning show this year, as the Moon will offer virtually no interference. If you've ever wanted to get into skywatching, this is your chance.

The Orionids is the second of two meteor showers caused by the debris field left by the comet Halley. (The other is the Eta Aquarids, which appear in May.) The showers are named for the constellation Orion, from which they seem to originate.

All the stars are lining up (so to speak) for this show. First, it's on the weekend, which means you can stay up late without feeling the burn at work the next day. Tonight, October 20, you'll be able to spot many meteors, and the shower peaks just after midnight tomorrow, October 21, leading into Sunday morning. Make a late-night picnic of the occasion, because it takes about an hour for your eyes to adjust to the darkness. Bring a blanket and a bottle of wine, lay out and take in the open skies, and let nature do the rest.

Second, the Moon, which was new only yesterday, is but a sliver in the evening sky, lacking the wattage to wash out the sky or conceal the faintest of meteors. If your skies are clear and light pollution low, this year you should be able to catch about 20 meteors an hour, which isn't a bad way to spend a date night.

If clouds interfere with your Orionids experience, don't fret. There will be two more meteor showers in November and the greatest of them all in December: the Geminids.

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science
11-Year-Old Creates a Better Way to Test for Lead in Water
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In the wake of the water crisis in Flint, Michigan, a Colorado middle schooler has invented a better way to test lead levels in water, as The Cut reports.

Gitanjali Rao, an 11-year-old seventh grader in Lone Tree, Colorado just won the 2017 Discovery Education 3M Young Scientist Challenge, taking home $25,000 for the water-quality testing device she invented, called Tethys.

Rao was inspired to create the device after watching Flint's water crisis unfold over the last few years. In 2014, after the city of Flint cut costs by switching water sources used for its tap water and failed to treat it properly, lead levels in the city's water skyrocketed. By 2015, researchers testing the water found that 40 percent of homes in the city had elevated lead levels in their water, and recommended the state declare Flint's water unsafe for drinking or cooking. In December of that year, the city declared a state of emergency. Researchers have found that the lead-poisoned water resulted in a "horrifyingly large" impact on fetal death rates as well as leading to a Legionnaires' disease outbreak that killed 12 people.

A close-up of the Tethys device

Rao's parents are engineers, and she watched them as they tried to test the lead in their own house, experiencing firsthand how complicated it could be. She spotted news of a cutting-edge technology for detecting hazardous substances on MIT's engineering department website (which she checks regularly just to see "if there's anything new," as ABC News reports) then set to work creating Tethys. The device works with carbon nanotube sensors to detect lead levels faster than other current techniques, sending the results to a smartphone app.

As one of 10 finalists for the Young Scientist Challenge, Rao spent the summer working with a 3M scientist to refine her device, then presented the prototype to a panel of judges from 3M and schools across the country.

The contamination crisis in Flint is still ongoing, and Rao's invention could have a significant impact. In March 2017, Flint officials cautioned that it could be as long as two more years until the city's tap water will be safe enough to drink without filtering. The state of Michigan now plans to replace water pipes leading to 18,000 households by 2020. Until then, residents using water filters could use a device like Tethys to make sure the water they're drinking is safe. Rao plans to put most of the $25,000 prize money back into her project with the hopes of making the device commercially available.

[h/t The Cut]

All images by Andy King, courtesy of the Discovery Education 3M Young Scientist Challenge.

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