Scientists Grow Blood Stem Cells in the Lab for the First Time

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iStock

One little cell can go a very long way—especially if that cell is a blood stem cell. Now two research groups have developed two different methods for growing these cells, a development that could help us understand and fight cancer. The scientists published their papers in the journal Nature.

Hematopoietic, or blood-making, stem cells (HSCs) are extraordinary things, so full of creative potential that a single cell can be used to restore an entire mammal circulatory system. Unfortunately, this same generative power also makes them prone to developing cancer-causing genetic mutations. If we could figure out how these HSCs work, we might be able to separate their skills from their weaknesses.

The most efficient way to access and study these complex cells would be to grow them in the lab. The authors of the new papers present two different approaches that may get us there.


Hematopoietic stem and progenitor cells (HSPC) from human iPS cells.
Rio Sugimura

The first group, led by Boston-based cancer experts George Daley and Ryohichi Sugimura, used chemical signals and genetic tinkering to transform human pluripotent stem cells into blood cells, and then, from there, into human HSCs.

The second team, led by Weill Cornell Medicine's Shahin Rafii and Raphael Lis, started with blood cells taken from mice, then changed the cells’ genes to coax them into becoming mouse HSCs.


Guibentif & Göttgens 2017. Nature.

Both groups’ freshly minted HSCs were functional, surviving transplant and producing more blood cells once they’d settled in.

Writing in an accompanying News & Views article for Nature, researchers Carolina Guibentif and Berthold Göttgens say both teams’ progress “opens up exciting opportunities” in the field. They note that neither method solves the problem of cancer-causing mutations, and the new cells’ success was only tracked for a short period of time.

Still, “although further studies are needed,” they write, “the long journey to translate the promise of stem-cell research into direct patient benefit may just have become a little shorter.”

10 Facts About Rosacea

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iStock

Rosacea, a skin condition characterized by redness and swelling, is incredibly common: A recent study found that an estimated 300 million people worldwide suffer from it. Here’s what you need to know about the condition.

1. IT HAS A LONG HISTORY.

According to the National Rosacea Society (NRS), rosacea was first described in the 14th century by a French surgeon named Dr. Guy de Chauliac; he called it goutterose (“pink drop” in French) or couperose and noted that it was characterized by “red lesions in the face, particularly on the nose and cheeks.”

2. SCIENTISTS AREN’T SURE WHAT CAUSES IT ...

But they have some theories. According to the NRS, “most experts believe it is a vascular disorder that seems to be related to flushing.” Scientists also think that because rosacea seems to run in families, it might be genetic. Other things—like mites that live on the skin, an intestinal bug called H pylori (common in those who have rosacea), and a reaction to a bacterium called bacillus oleronius—could also play a role in causing the condition. One 2015 study suggested an increased risk among smokers.

3. … BUT SOME PEOPLE ARE MORE LIKELY TO HAVE IT THAN OTHERS.

Though people of all ages and skin tones can get rosacea, fair skinned people between the ages of 30 and 50 with Celtic and Scandinavian ancestry and a family history of rosacea are more likely to develop the condition. Women are more likely to have rosacea than men, though their symptoms tend to be less severe than men’s. But men are more likely to suffer from a rare rosacea side effect known as rhinophyma, which causes the skin of the nose to thicken and become bulbous. It’s commonly—and mistakenly—associated with heavy drinking, but what exactly causes rhinophyma is unclear. According to the NRS, “The swelling that often follows a flushing reaction may, over time, lead to the growth of excess tissue (fibroplasia) around the nose as plasma proteins accumulate when the damaged lymphatic system fails to clear them. Leakage of a substance called blood coagulation factor XIII is also believed to be a potential cause of excess tissue.” Thankfully, those who have rhinophyma have options available for treatment, including surgery and laser therapy.

4. THERE ARE FOUR SUBTYPES.

According to the American Academy of Dermatology (AAD), rosacea “often begins with a tendency to blush or flush more easily than other people.” All rosacea involves redness of some kind (typically on the nose, cheeks, chin, and forehead), but other symptoms allow the condition to be divided into four subtypes: Erythematotelangiectatic rosacea is characterized by persistent redness and sometimes visible blood vessels; Papulopustular rosacea involves swelling and “acne-like breakouts”; Phymatous rosacea is characterized by thick and bumpy skin; and Ocular rosacea involves red eyes (that sometimes burn and itch, or feel like they have sand in them [PDF]), swollen eyelids, and stye-like growths.

5. IT’S NOT THE SAME AS ACNE.

Though rosacea was once considered a form of acne—"acne rosacea" first appeared in medical literature in 1814—today doctors know it’s a different condition altogether. Though there are similarities (like acne, some forms of rosacea are characterized by small, pus-filled bumps) there are key differences: Acne involves blackheads, typically occurs in the teen years, and can appear all over the body; rosacea is a chronic condition that occurs mainly on the face and the chest and typically shows up later in life.

6. YOU CAN FIND IT IN CLASSIC ART AND LITERATURE.

Both Chaucer and Shakespeare likely made references to rosacea. Domenico Ghirlandaio’s 1490 painting An Old Man and His Grandson seems to depict rhinophyma, and some believe that Rembrandt’s 1659 self-portrait shows that the artist had rosacea and rhinophyma.

7. IT MAY BE TRIGGERED BY CERTAIN FOODS AND ACTIVITIES.

According to the National Institutes of Health (NIH) [PDF], people report that everything from the weather to what you eat can cause rosacea to flare up: Heat, cold, sunlight, and wind, strenuous exercise, spicy food, alcohol consumption, menopause, stress, and use of steroids on the skin are all triggers.

8. THERE ARE A NUMBER OF MYTHS ABOUT ROSACEA.

No, it’s not caused by caffeine and coffee (flare ups, if they occur, are due to the heat of your coffee) or by heavy drinking (though alcohol does exacerbate the condition). Rosacea isn’t caused by poor hygiene, and it’s not contagious.

9. THERE ARE SOME PRETTY FAMOUS PEOPLE WITH ROSACEA.

Sophia Bush, Cynthia Nixon, Kristin Chenoweth, Bill Clinton, and Sam Smith all have rosacea. Diana, Princess of Wales had it, too. W.C. Fields had rosacea and rhinophyma, and Andy Warhol may also have suffered from those conditions.

10. IT CAN’T BE CURED—BUT IT CAN BE TREATED.

The NRS reports that “nearly 90 percent of rosacea patients [surveyed by NRS] said this condition had lowered their self-confidence and self-esteem, and 41 percent reported it had caused them to avoid public contact or cancel social engagements.” Dr. Uwe Gieler, a professor of dermatology at the Justus-Liebig-University in Giessen, Germany, and one of the authors of the report Rosacea: Beyond the Visible, said in a press release that "People with rosacea are often judged on their appearance, which impacts them greatly in daily life. If their rosacea is severe, the symptoms are likely to be more significant also, from itching and burning to a permanently red central facial area. However, even people with less severe rosacea report a significant impact on quality of life."

Which makes it all the more unfortunate that there’s not a cure for the condition. Thankfully, though, there are treatments available.

There are no tests that will diagnose rosacea; that’s up to your doctor, who will examine your medical history and go over your symptoms. Doctors advise that those with rosacea pay attention to what triggers flare-ups, which will help them figure out how to treat the condition. Antibiotics might be prescribed; laser therapy might be used. Anyone with rosacea should always wear sunscreen [PDF] and treat their skin very, very gently—don't scrub or exfoliate it. The AAD recommends moisturizing daily and avoiding products that contain things like urea, alcohol, and glycolic and lactic acids.

Endeavour, Captain Cook's Lost Ship, Might Have Been Found—Solving a Centuries-Old Mystery

Wellcome Images, Wikimedia Commons // CC BY-SA 4.0
Wellcome Images, Wikimedia Commons // CC BY-SA 4.0

The exact location of the final resting place of Captain James Cook’s HMS Endeavour, which was sunk off the coast of Rhode Island 200 years ago, is considered one of maritime history’s greatest mysteries. Now, after a 25-year effort to pinpoint its remains among 13 sunken vessels, The Age reports that the Endeavour might have finally been identified.

British explorer James Cook left England on the Endeavour in 1768 headed for the South Pacific. He and his crew became the first European expedition to map the entire coast of New Zealand, and later, the first to reach Australia’s east coast. Along the way, they collected hundreds of previously unknown plant species, became the first Europeans to record a kangaroo sighting, and gathered evidence that would help disprove the existence of the long-speculated southern continent, Terra Australis, that hypothetically extended all the way up to the equator.

A replica of the 18th-century 'Endeavour' in the ocean
A replica of the Endeavour in 2004
Dennis4trigger, Wikimedia Commons // CC BY-SA 3.0

After that three-year journey, Cook and his crew returned to England. Though Cook became a legend, the Endeavour didn’t receive the star treatment. The British Royal Navy used it to ferry supplies to and from the Falkland Islands for several years before selling it to a private buyer. The ship was renamed the Lord Sandwich, and was eventually put into service transporting German mercenaries to fight on Britain's side in the American Revolution.

That’s how the ship ended up in Rhode Island, where it was stationed as part of the Royal Navy’s fleet in Newport Harbor and used as a prison ship for captured American soldiers. When French reinforcements came to assist American revolutionaries in Rhode Island, the British decided to sink their ships rather than allow them to be captured, creating a blockade out of scuttled vessels to block the French from getting into the harbor. They sank 12 transport vessels and set another on fire. Over the ensuing years, locals and French forces took equipment from the wrecks, but it’s never been entirely clear what happened to the remains.

The Rhode Island Marine Archaeology Project began to try to map and identify those remains starting in the early 1990s, and eventually figured out that the Lord Sandwich was the same ship as the HMS Endeavour. As the ship played a vital role in Australian history, the Australian National Maritime Museum then got involved with the project.

The two organizations have announced that they have lowered the number of potential wrecks that could be the Endeavour from 14 to five—and perhaps down to just one—by inspecting the area and measuring the wrecks against historic information about Cook's vessel. The researchers think the final resting place of the ship is located off the coast of Goat Island in Narragansett Bay, but to be absolutely certain, they’ll have to excavate the remains of the ship and examine its timbers. The researchers hope to have that work done by the 250th anniversary of Cook’s arrival in Australia’s Botany Bay—and his claiming of Australia as British territory—in 2020.

And there may be a battle over the remains. While the ship is considered a vital artifact of Australian history, the state of Rhode Island claimed ownership of all of the sunken ships in 1999, and they are overseen by the Rhode Island Historical Preservation and Heritage Commission.

[h/t The Age]

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