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What is Rubella?

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Rubella Virus. Wikimedia Commons

Almost everyone is familiar with the measles and mumps, but the 'R' in the MMR vaccine might not ring a bell. Here's the lowdown.

Discovery and Symptoms

Rubella is a disease caused by a virus of the same name. It can be spread through the air or by close contact with a carrier and cause symptoms like fever, headache, runny nose, bruising, bloodshot eyes, muscle or joint pain and a fine, red rash, for which the disease is named.

Rubella was first described in the late 1700s by German physician Friedrich Hoffmann. Other Germans studied it and suggested that it was derivative of either measles or scarlet fever, and the disease was nicknamed "German measles," after the doctors who were most familiar with it. In 1814, another German doctor, George de Maton, was called to a school to investigate an outbreak of skin rashes. He recognized the symptoms of German measles and, while examining his patients, realized that the sickness was distinct enough from measles to be its own disease. In 1881, the German measles was recognized as an individual disease, and was named rubella (Latin for "reddish") by British Army surgeon Henry Veale in 1886.

Not So Harmless, After All

For a while, rubella didn't receive much attention. It was a relatively mild illness with symptoms that were uncomfortable but not life-threatening, and lasted only three days to a few weeks. Through the rest of the 19th century, it became a sort of rite of passage for kids not unlike, more recently, chicken pox. Almost every child got sick with it, and would just have to suffer the rash and aches for a few days. This changed in 1941 when ophthalmologist Norman Gregg noticed that a few years after a local rubella outbreak, he would always see a large number of children with cataracts, and often a few other congenital defects, too. Further research showed that, while rubella was not particularly hard on the children or adults who contracted it, the disease could be devastating to unborn babies if their pregnant mother came down with it. Babies with congenital rubella syndrome could be born blind, deaf, with heart defects or with developmental disabilities.

Rubella could not be ignored as harmless any longer, and doctors in the U.S. and Europe started looking for a preventative treatment. In 1964, the last major epidemic of rubella in the U.S. broke out. Some 20,000 infants were born with congenital defects after the disease struck them in utero, and another 11,000 died.  In 1969, Stanley Plotkin and colleagues from the Wistar Institute in Philadelphia developed a preventative rubella vaccine, which was then combined with the measles and mumps vaccines in 1972. After the vaccine's development, the number of rubella cases in the U.S. fell sharply, and today there are fewer than 1,000 cases reportedly annually. But Europe and Canada have not fared as well. In 2004, there was a rubella outbreak among an orthodox Protestant group in the Netherlands who had religious objections to vaccination; 387 cases of rubella were reported, and the disease then spread to Canada, resulting in 309 more cases there. Between the two countries, there were two fetal deaths and 14 babies born with congenital rubella syndrome.

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Big Questions
Who Was Chuck Taylor?
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From Betty Crocker to Tommy Bahama, plenty of popular labels are "named" after fake people. But one product with a bona fide backstory to its moniker is Converse's Chuck Taylor All-Star sneakers. The durable gym shoes are beloved by everyone from jocks to hipsters. But who's the man behind the cursive signature on the trademark circular ankle patch?

As journalist Abraham Aamidor recounted in his 2006 book Chuck Taylor, All Star: The True Story of the Man behind the Most Famous Athletic Shoe in History, Chuck Taylor was a former pro basketball player-turned-Converse salesman whose personal brand and tireless salesmanship were instrumental to the shoes' success.

Charles Hollis Taylor was born on July 24, 1901, and raised in southern Indiana. Basketball—the brand-new sport invented by James Naismith in 1891—was beginning to take the Hoosier State by storm. Taylor joined his high school team, the Columbus High School Bull Dogs, and was named captain.

After graduation, instead of heading off to college, Taylor launched his semi-pro career playing basketball with the Columbus Commercials. He’d go on to play for a handful of other teams across the Midwest, including the the Akron Firestone Non-Skids in Ohio, before finally moving to Chicago in 1922 to work as a sales representative for the Converse Rubber Shoe Co. (The company's name was eventually shortened to Converse, Inc.)

Founded in Malden, Massachusetts, in 1908 as a rubber shoe manufacturer, Converse first began producing canvas shoes in 1915, since there wasn't a year-round market for galoshes. They introduced their All-Star canvas sports shoes two years later, in 1917. It’s unclear whether Chuck was initially recruited to also play ball for Converse (by 1926, the brand was sponsoring a traveling team) or if he was simply employed to work in sales. However, we do know that he quickly proved himself to be indispensable to the company.

Taylor listened carefully to customer feedback, and passed on suggestions for shoe improvements—including more padding under the ball of the foot, a different rubber compound in the sole to avoid scuffs, and a patch to protect the ankle—to his regional office. He also relied on his basketball skills to impress prospective clients, hosting free Chuck Taylor basketball clinics around the country to teach high school and college players his signature moves on the court.

In addition to his myriad other job duties, Taylor played for and managed the All-Stars, a traveling team sponsored by Converse to promote their new All Star shoes, and launched and helped publish the Converse Basketball Yearbook, which covered the game of basketball on an annual basis.

After leaving the All-Stars, Taylor continued to publicize his shoe—and own personal brand—by hobnobbing with customers at small-town sporting goods stores and making “special appearances” at local basketball games. There, he’d be included in the starting lineup of a local team during a pivotal game.

Taylor’s star grew so bright that in 1932, Converse added his signature to the ankle patch of the All Star shoes. From that point on, they were known as Chuck Taylor All-Stars. Still, Taylor—who reportedly took shameless advantage of his expense account and earned a good salary—is believed to have never received royalties for the use of his name.

In 1969, Taylor was inducted into the Basketball Hall of Fame. The same year, he died from a heart attack on June 23, at the age of 67. Around this time, athletic shoes manufactured by companies like Adidas and Nike began replacing Converse on the court, and soon both Taylor and his namesake kicks were beloved by a different sort of customer.

Still, even though Taylor's star has faded over the decades, fans of his shoe continue to carry on his legacy: Today, Converse sells more than 270,000 pairs of Chuck Taylors a day, 365 days a year, to retro-loving customers who can't get enough of the athlete's looping cursive signature.

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

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Big Questions
What Is the Difference Between Generic and Name Brand Ibuprofen?
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What is the difference between generic ibuprofen vs. name brands?

Yali Friedman:

I just published a paper that answers this question: Are Generic Drugs Less Safe than their Branded Equivalents?

Here’s the tl;dr version:

Generic drugs are versions of drugs made by companies other than the company which originally developed the drug.

To gain FDA approval, a generic drug must:

  • Contain the same active ingredients as the innovator drug (inactive ingredients may vary)
  • Be identical in strength, dosage form, and route of administration
  • Have the same use indications
  • Be bioequivalent
  • Meet the same batch requirements for identity, strength, purity, and quality
  • Be manufactured under the same strict standards of FDA's good manufacturing practice regulations required for innovator products

I hope you found this answer useful. Feel free to reach out at www.thinkbiotech.com. For more on generic drugs, you can see our resources and whitepapers at Pharmaceutical strategic guidance and whitepapers

This post originally appeared on Quora. Click here to view.

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