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10 Scientists Who Experimented on Themselves

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Would you inject 50 hookworms under your skin for your job? Or steam in a vomit sauna for a few hours? Hopefully we non-scientists will never have to answer questions like these. But for the 11 brave souls on this list, experimenting on themselves was all in a day's work.

1. Jonas Salk

During his research at the University of Pittsburgh Medical School, Dr. Jonas Salk discovered a potential vaccine for polio. When they needed healthy human test subjects, Salk volunteered himself and his entire family for a vaccine trial. The filial gamble paid off. Everyone tested positive for anti-polio antibodies. He refused to patent the vaccine, and never received financial compensation for his discovery. (When Edward R. Murrow asked Salk who owned the patent on the vaccine, Salk responded with one of his most famous quotes: “Well, the people, I would say. There is no patent. Could you patent the sun?”)

2. David Pritchard

In 2004, after years of research in Papau New Guinea, immunologist-biologist David Pritchard wanted to test his findings, specifically that certain parasites can improve the immune system's defense against allergies, and possibly more serious autoimmune illnesses. Circumnavigating more years of red tape, Pritchard used himself as the first test subject, injecting 50 hookworms under his skin. He was able to deduce that only 10 hookworms were necessary for future test subjects.

3. John Paul Stapp

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Air Force officer and surgeon John Paul Stapp's self-experimentation earned him the nickname "the fastest man on earth." In his research, Stapp repeatedly strapped himself into a rocket sled, nicknamed the "Gee Whiz," and was propelled forward at speeds close to that of sound. He would then brake abruptly to determine the human body's ability to withstand abrupt deceleration. Many broken bones and a temporarily detached retina later, Stapp determined a human body can withstand 45 g of forward motion with an adequate harness.

4. August Bier

At the turn of the 20th century, August Bier discovered spinal anesthesia. His method involved injecting cocaine into the cerebrospinal fluid. To test its effectiveness Bier enlisted himself. During the experiment, a mix-up left Bier with a hole in his spine leaking cerebrospinal fluid. Bier's assistant stepped in. Once the assistant was properly numb, Bier kicked his shins, bludgeoned and burned him, plucked out his pubic hairs, and mashed his genitals. The assistant felt nothing – a success the two celebrated by drinking excessively that evening.

5. Werner Forssmann

Werner Forssmann (left), Getty Images

In 1929 in the basement of the Eberswaled Hospital in Germany, surgical resident Werner Forssmann inserted a ureteral catheter tube into his elbow, feeding it through a vein up to his heart. He used a mirror as his assistant, since he had restrained his nurse to the operating table. He then took an x-ray of his chest (at left) to determine the catheter had indeed made it to the right atrium. Instead of praise, Forssmann was met with condemnation. This rejection led him to abandon cardiology for urology, but he was later rewarded with the Nobel Prize in 1956.

6. Nathaniel Kleitman

In 1938, sleep researcher Nathaniel Kleitman and his assistant holed up in Mammoth Cave in Kentucky. They were attempting to manipulate their sleep cycles to adopt a 28-hour day. With constant temperature and no natural light, the conditions in the cave seemed perfect. After 32 days Kleitman's assistant had successfully adapted, but Kleitman failed. Nonetheless, the experiment's results helped to advance their study of circadian rhythms.

7. Sir Humphry Davy

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While at the Medical Pneumatic Institute of Bristol, Humphry Davy studied gases. Through a series of self-experiments with oxides of nitrous, Davy created what is known today as laughing gas. Though his initial attempts were meant to reproduce the pleasurable effects of opium and alcohol, Davy would ultimately recommend the use of nitrous oxide as an anesthetic. His recommendation would not be heeded until long after his death, but nitrous became an instant hit at fashionable parties.

8. Kevin Warwick

During the late 1990s, Kevin Warwick had his team surgically implant a silicon chip transponder into his forearm for an experiment known as Project Cyborg. Through this implant, Warwick's nervous system was monitored by a computer system. According to his website, the neural interface allowed him to "operate doors, lights, heaters and other computers without lifting a finger." In other words, the future is now.

9. Albert Hoffman

Swiss chemist Albert Hoffman was researching the fungus ergot for a pharmaceutical company when he discovered lysergic acid. His initial tests were inconclusive, but Hoffman decided to retest a synthesized version of the acid. In April of 1943, he ingested 25/1000 of a gram of a substance he called LSD-25 in his lab. Legend has it, on his bike ride home his eyes were opened up to a brave new hallucinogenic world. To this day, LSD enthusiasts observe April 19 as "Bicycle Day." Hoffman would continue to experiment with LSD until his death at 102.

10. Stubbins Ffirth

Stubbins Ffirth would have been a shoe-in for the world's wackiest name contest. Instead, he found his own unique path to historical notoriety. After witnessing the devastating 1793 Yellow Fever Epidemic, Ffirth hypothesized the viral hemorrhagic disease was not contagious. To prove his thesis, he tested the disease's characteristic black vomit. On himself. This included, but certainly was not limited to, pouring vomit into his open cuts or onto his eyeballs, drinking infected black vomit by the glassful, and stewing up to his waist in a veritable sauna of vomit. He would later rub blood and urine on his body as well, but ultimately avoided infection. In his 1804 book A Treatise on Malignant Fever; with an Attempt to Prove Its Non-Contagious Nature, he declared Yellow Fever not contagious. Turns out, Yellow Fever was contagious, but only through blood transmission via mosquito bite. Whoops.

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Stones, Bones, and Wrecks
Amateur Archaeologists in England Unearth Rare Roman Mosaic
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Cotswold Archaeology

For the past three years, amateur archaeologists and historians in southern England have been working side-by-side with volunteers to excavate several seemingly related local Roman sites. Now, just two weeks before the dig's scheduled conclusion, they've made a fantastic discovery: a rare 4th-century CE mosaic that is being hailed as "the most important of its type in Britain in more than half a century," according to The New York Times.

Dating to roughly 380 CE, the mosaic was unearthed near the village of Boxford in Berkshire. The project—which included a rotating assembly of 55 members—involved local interest groups like the Boxford History Project and the Berkshire Archaeological Research Group, and was overseen by Cotswold Archaeology, a company that helps builders preserve archaeological finds. Funding was provided by the Heritage Lottery Fund, which gives grants to heritage projects across the UK.

In the project's first two years, the group members discovered a large Roman villa, a bathhouse, and a farmstead. In 2017, they began excavating the main villa, a site that yielded pottery, jewelry, coins, and other ancient objects. None of these artifacts, however, were as spectacular as the mosaic, which volunteers unearthed in a moment of serendipity shortly before funding for the dig ended.

Revealed sections of the artwork depict scenes featuring Bellerophon, a mythological Greek hero, along with other fabled figures. Bellerophon is famous in legends for capturing the winged horse Pegasus and for defeating the Chimera, a fire-breathing creature with a lion's head, a goat's body, and a serpent's tail.

Citizen archaeologists in Boxford, England unearth a Roman mosaic thought to date from 380 CE.
Cotswold Archaeology

"The range and style of imagery is very rare in the UK, where simple geometric patterns are the norm," Duncan Coe, a principal heritage consultant with Cotswold Archaeology, tells Mental Floss. "The combination of artwork and inscriptions is unique in this country. The range of imagery is also unique, with at least two scenes from the story of Bellerophon, a character from Greek mythology, augmented by Hercules and the Centaur, Cupid and telamones [male statues used as a column]—and we only have half of the mosaic revealed so far."

Excavators uncovered nearly 20 feet of the mosaic, but ultimately reburied it to deter looters and prevent damage. Members of Boxford's local archaeological community hope to secure funding and return to the site—now dubbed the Boxford villa—to dig up the entire scene.

A Roman mosaic thought to date from 380 CE, unearthed by citizen archaeologists in Boxford England.
Cotswold Archaeology

In addition to teaching experts about the villa's owners—who were evidently sophisticated and wealthy—and Boxford's ancient heritage, the newly discovered mosaic isn't just any ordinary artwork, according to Coe: "This isn't just an isolated mosaic, but a small, but very important, part of a bigger jigsaw that advances our understanding of what was happening in southern England just before the Roman government abandoned Britain," he says.

[h/t The New York Times]

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15 Riveting Facts About Alan Turing
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More than six decades after his death, Alan Turing’s life remains a point of fascination, even for people who have no interest in his groundbreaking work in computer science. He has been the subject of a play and an opera, and referenced in multiple novels and numerous musical albums. The Benedict Cumberbatch film about his life, The Imitation Game, received eight Oscar nominations. But just who was he in real life? Here are 15 facts you should know about Alan Turing.

1. HE’S THE FATHER OF MODERN COMPUTER SCIENCE.

Turing essentially pioneered the idea of computer memory. In 1936, Turing published a seminal paper called “On Computable Numbers” [PDF], which The Washington Post has called “the founding document of the computer age.” In the philosophical article, he hypothesized that one day, we could build machines that could compute any problem that a human could, using 0s and 1s. Turing proposed single-task machines called Turing machines that would be capable of solving just one type of math problem, but a “universal computer” would be able to tackle any kind of problem thrown at it by storing instructional code in the computer’s memory. Turing’s ideas about memory storage and using a single machine to carry out all tasks laid the foundation for what would become the digital computer.

In 1945, while working for the UK’s National Physical Laboratory, he came up with the Automatic Computing Machine, the first digital computer with stored programs. Previous computers didn’t have electric memory storage, and had to be manually rewired to switch between different programs.

2. HE PLAYED A HUGE ROLE IN WINNING WORLD WAR II.

Turing began working at Bletchley Park, Britain’s secret headquarters for its codebreakers during World War II, in 1939. By one estimate, his work there may have cut the war short by up to two years. He’s credited with saving millions of lives.

Turing immediately got to work designing a codebreaking machine called the Bombe (an update of a previous Polish machine) with the help of his colleague Gordon Welchman. The Bombe shortened the steps required in decoding, and 200 of them were built for British use over the course of the war. They allowed codebreakers to decipher up to 4000 messages a day.

His greatest achievement was cracking the Enigma, a mechanical device used by the German army to encode secure messages. It proved nearly impossible to decrypt without the correct cipher, which the German forces changed every day. Turing worked to decipher German naval communications at a point when German U-boats were sinking ships carrying vital supplies across the Atlantic between Allied nations. In 1941, Turing and his team managed to decode the German Enigma messages, helping to steer Allied ships away from the German submarine attacks. In 1942, he traveled to the U.S. to help the Americans with their own codebreaking work.

3. HE BROKE THE RULES TO WRITE TO CHURCHILL.

Early on, Bletchley Park’s operations were hampered by a lack of resources, but pleas for better staffing were ignored by government officials. So, Alan Turing and several other codebreakers at Bletchley Park went over their heads to write directly to Prime Minister Winston Churchill. One of the codebreakers from Bletchley Park delivered the letter by hand in October 1941.

“Our reason for writing to you direct is that for months we have done everything that we possibly can through the normal channels, and that we despair of any early improvement without your intervention,” they wrote to Churchill [PDF]. “No doubt in the long run these particular requirements will be met, but meanwhile still more precious months will have been wasted, and as our needs are continually expanding we see little hope of ever being adequately staffed.”

In response, Churchill immediately fired off a missive to his chief of staff: “Make sure they have all they want on extreme priority and report to me that this had been done.”

4. HE HAD SOME ODD HABITS.

Like many geniuses, Turing was not without his eccentricities. He wore a gas mask while riding his bike to combat his allergies. Instead of fixing his bike’s faulty chain, he learned exactly when to dismount to secure it in place before it slipped off. He was known around Bletchley Park for chaining his tea mug to a radiator to prevent it from being taken by other staffers.

5. HE RODE HIS BIKE 60 MILES TO GET TO THE FIRST DAY OF SCHOOL.

Though he was considered an average student, Turing was dedicated enough to his schooling that when a general strike prevented him from taking the train to his first day at his new elite boarding school, the 14-year-old rode his bike the 62 miles instead.

6. HE TRIED OUT FOR THE OLYMPICS.

Turing started running as a schoolboy and continued throughout his life, regularly running the 31 miles between Cambridge and Ely while he was a fellow at King’s College. During World War II, he occasionally ran the 40 miles between London and Bletchley Park for meetings.

He almost became an Olympic athlete, too. He came in fifth place at a qualifying marathon for the 1948 Olympics with a 2-hour, 46-minute finish (11 minutes slower than the 1948 Olympic marathon winner). However, a leg injury held back his athletic ambitions that year.

Afterward, he continued running for the Walton Athletic Club, though, and served as its vice president. ”I have such a stressful job that the only way I can get it out of my mind is by running hard,” he once told the club’s secretary. “It's the only way I can get some release."

7. HE WAS PROSECUTED FOR BEING GAY.

In 1952, Turing was arrested after reporting a burglary in his home. In the course of the investigation, the police discovered Turing’s relationship with another man, Arnold Murray. Homosexual relationships were illegal in the UK at the time, and he was charged with “gross indecency.” He pled guilty on the advice of his lawyer, and opted to undergo chemical castration instead of serving time in jail.

8. THE GOVERNMENT ONLY RECENTLY APOLOGIZED FOR HIS CONVICTION …

In 2009, UK Prime Minister Gordon Brown issued a public apology to Turing on behalf of the British government. “Alan and the many thousands of other gay men who were convicted as he was convicted under homophobic laws were treated terribly,” Brown said. "This recognition of Alan's status as one of Britain's most famous victims of homophobia is another step towards equality and long overdue." Acknowledging Britain’s debt to Turing for his vital contributions to the war effort, he announced, “on behalf of the British government, and all those who live freely thanks to Alan's work I am very proud to say: we're sorry, you deserved so much better."

His conviction was not actually pardoned, though, until 2013, when he received a rare royal pardon from the Queen of England.

9. … AND NAMED A LAW AFTER HIM.

Turing was only one of the many men who suffered after being prosecuted for their homosexuality under 19th-century British indecency laws. Homosexuality was decriminalized in the UK in 1967, but the previous convictions were never overturned. Turing’s Law, which went into effect in 2017, posthumously pardoned men who had been convicted for having consensual gay sex before the repeal. According to one of the activists who campaigned for the mass pardons, around 15,000 of the 65,000 gay men convicted under the outdated law are still alive.

10. HE POISONED HIMSELF … MAYBE.

There is still a bit of mystery surrounding Turing’s death at the age of 41. Turing died of cyanide poisoning, in what is widely believed to have been a suicide. Turing’s life had been turned upside down by his arrest. He lost his job and his security clearance. By order of the court, he had to take hormones intended to “cure” his homosexuality, which caused him to grow breasts and made him impotent. But not everyone is convinced that he died by suicide.

In 2012, Jack Copeland, a Turing scholar, argued that the evidence used to declare Turing’s death a suicide in 1954 would not be sufficient to close the case today. The half-eaten apple by his bedside, thought to be the source of his poisoning, was never tested for cyanide. There was still a to-do list on his desk, and his friends told the coroner at the time that he had seemed in good spirits. Turing’s mother, in fact, maintained that he probably accidentally poisoned himself while experimenting with the chemical in his home laboratory. (He was known to taste chemicals while identifying them, and could be careless with safety precautions.)

That line of inquiry is far more tame than some others, including one author’s theory that he was murdered by the FBI to cover up information that would have been damaging to the U.S.

11. HIS FULL GENIUS WASN’T KNOWN IN HIS LIFETIME.

Alan Turing was a well-respected mathematician in his time, but his contemporaries didn’t know the full extent of his contributions to the world. Turing’s work breaking the Enigma machine remained classified long after his death, meaning that his contributions to the war effort and to mathematics were only partially known to the public during his lifetime. It wasn’t until the 1970s that his instrumental role in the Allies' World War II victory became public with the declassification of the Enigma story. The actual techniques Turing used to decrypt the messages weren’t declassified until 2013, when two of his papers from Bletchley Park were released to the British National Archives.

12. THE TURING TEST IS STILL USED TO MEASURE ARTIFICIAL INTELLIGENCE …

Can a machine fool a human into thinking they are chatting with another person? That’s the crux of the Turing test, an idea developed by Turing in 1950 regarding how to measure artificial intelligence. Turing argued in his paper “Computing Machinery and Intelligence” [PDF] that the idea of machines “thinking” is not a useful way to evaluate artificial intelligence. Instead, Turing suggests “the imitation game,” a way to assess how successfully a machine can imitate human behavior. The best measure of artificial intelligence, then, is whether or not a computer can convince a person that it is human.

13. … BUT SOME CONSIDER IT TO BE AN OUTDATED IDEA.

As technology has progressed, some feel the Turing test is no longer a useful way to measure artificial intelligence. It’s cool to think about computers being able to talk just like a person, but new technology is opening up avenues for computers to express intelligence in other, more useful ways. A robot’s intelligence isn’t necessarily defined by whether it can fake being human—self-driving cars or programs that can mimic sounds based on images might not pass the Turing test, but they certainly have intelligence.

14. HE CREATED THE FIRST COMPUTER CHESS PROGRAM.

Inspired by the chess champions he worked with at Bletchley Park, Alan Turing created an algorithm for an early version of computer chess—although at that time, there was no computer to try it out on. Created with paper and pencil, the Turochamp program was designed to think two moves ahead, picking out the best moves possible. In 2012, Russian chess grandmaster Garry Kasparov played against Turing’s algorithm, beating it in 16 moves. “I would compare it to an early caryou might laugh at them but it is still an incredible achievement," Kasparov said in a statement after the match-up.

15. THERE IS ALAN TURING MONOPOLY.

In 2012, Monopoly came out with an Alan Turing edition to celebrate the centennial of his birth. Turing had enjoyed playing Monopoly during his life, and the Turing-themed Monopoly edition was designed based on a hand-drawn board created in 1950 by his friend William Newman. Instead of hotels and houses, it featured huts and blocks inspired by Bletchley Park, and included never-before-published photos of Turing. (It’s hard to find, but there are still a few copies of the game on Amazon.)

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