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Seasons Affect MS Symptoms

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At the age of 45, Anne Rowling died from complications of multiple sclerosis (MS). Her daughter, J.K. Rowling, of Harry Potter fame, recently announced she was donating £10 million ($15.4 million) to form a MS and neurodegenerative disease research center at the University of Edinburgh. Scottish people suffer from the disease at a higher rate than others and the disease seems to impact more people living in northern regions. Researchers at Brigham and Women's Hospital discovered that the seasons impact MS symptoms, causing them to seriously consider the role environment plays in causing the disease.

MS is an autoimmune disease where the body destroys myelin sheaths, a fatty material that protects the nerve endings in the brain and the spine. This lessens the brain's ability to communicate and often causes scarring and lesions, leading to permanent disability. (The image at left, from Wikimedia user Marvin 101, is a photomicrograph of a demyelinating MS-Lesion.) There are no known cures for the disease but many physicians have been able to slow the disease's progression.

Researchers led by Dominik Meier examined MRI scans of 44 participants. The scientists asked participants, between ages 25 and 52, to undergo eight weekly scans, then eight scans every other week, followed by a six-month check-up. Each person averaged 22 scans. When each scan was taken, researchers recorded weather information such as temperature, precipitation, and solar radiation levels. The study took place from 1991 through 1993 before pharmaceuticals that regulate MS relapses entered the market.

Meier and his colleagues found that more brain lesions occurred from March to August. According to the paper, published in Neurology, 310 new T2 lesions were found in 31 patients and the researchers discovered more lesions during periods of higher levels of solar radiation.

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iStock // Ekaterina Minaeva
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Man Buys Two Metric Tons of LEGO Bricks; Sorts Them Via Machine Learning
May 21, 2017
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iStock // Ekaterina Minaeva

Jacques Mattheij made a small, but awesome, mistake. He went on eBay one evening and bid on a bunch of bulk LEGO brick auctions, then went to sleep. Upon waking, he discovered that he was the high bidder on many, and was now the proud owner of two tons of LEGO bricks. (This is about 4400 pounds.) He wrote, "[L]esson 1: if you win almost all bids you are bidding too high."

Mattheij had noticed that bulk, unsorted bricks sell for something like €10/kilogram, whereas sets are roughly €40/kg and rare parts go for up to €100/kg. Much of the value of the bricks is in their sorting. If he could reduce the entropy of these bins of unsorted bricks, he could make a tidy profit. While many people do this work by hand, the problem is enormous—just the kind of challenge for a computer. Mattheij writes:

There are 38000+ shapes and there are 100+ possible shades of color (you can roughly tell how old someone is by asking them what lego colors they remember from their youth).

In the following months, Mattheij built a proof-of-concept sorting system using, of course, LEGO. He broke the problem down into a series of sub-problems (including "feeding LEGO reliably from a hopper is surprisingly hard," one of those facts of nature that will stymie even the best system design). After tinkering with the prototype at length, he expanded the system to a surprisingly complex system of conveyer belts (powered by a home treadmill), various pieces of cabinetry, and "copious quantities of crazy glue."

Here's a video showing the current system running at low speed:

The key part of the system was running the bricks past a camera paired with a computer running a neural net-based image classifier. That allows the computer (when sufficiently trained on brick images) to recognize bricks and thus categorize them by color, shape, or other parameters. Remember that as bricks pass by, they can be in any orientation, can be dirty, can even be stuck to other pieces. So having a flexible software system is key to recognizing—in a fraction of a second—what a given brick is, in order to sort it out. When a match is found, a jet of compressed air pops the piece off the conveyer belt and into a waiting bin.

After much experimentation, Mattheij rewrote the software (several times in fact) to accomplish a variety of basic tasks. At its core, the system takes images from a webcam and feeds them to a neural network to do the classification. Of course, the neural net needs to be "trained" by showing it lots of images, and telling it what those images represent. Mattheij's breakthrough was allowing the machine to effectively train itself, with guidance: Running pieces through allows the system to take its own photos, make a guess, and build on that guess. As long as Mattheij corrects the incorrect guesses, he ends up with a decent (and self-reinforcing) corpus of training data. As the machine continues running, it can rack up more training, allowing it to recognize a broad variety of pieces on the fly.

Here's another video, focusing on how the pieces move on conveyer belts (running at slow speed so puny humans can follow). You can also see the air jets in action:

In an email interview, Mattheij told Mental Floss that the system currently sorts LEGO bricks into more than 50 categories. It can also be run in a color-sorting mode to bin the parts across 12 color groups. (Thus at present you'd likely do a two-pass sort on the bricks: once for shape, then a separate pass for color.) He continues to refine the system, with a focus on making its recognition abilities faster. At some point down the line, he plans to make the software portion open source. You're on your own as far as building conveyer belts, bins, and so forth.

Check out Mattheij's writeup in two parts for more information. It starts with an overview of the story, followed up with a deep dive on the software. He's also tweeting about the project (among other things). And if you look around a bit, you'll find bulk LEGO brick auctions online—it's definitely a thing!

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Name the Author Based on the Character
May 23, 2017
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