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How Does Scratching Relieve an Itch?

If you have an itch, you scratch it. Scratch and itch; they go together like peas and carrots and everyone—humans, apes, dogs and cats—knows it. What we didn't understand for a very long time was the physiological connection between the two—why a good scratch relieves a bad itch.

A study by a group of neuroscientists at the University of Minnesota recently explained the itch-scratch link.* The group hypothesized that the relief mechanism doesn't take place along the nerves of itchy skin, as had been thought, but deep in the central nervous system, in the same area that the itches themselves are communicated. Previous studies showed that neurons in the spinothalamic tract (STT)—a sensory pathway originating in the spinal cord that transmits information about pain, temperature and touch to the thalamus—were activated with the application of itch-inducing chemicals, and these are the neurons that send itch sensations to the brain.

In the new study, the UM researchers implanted recording electrodes in the spinothalmic tracts (STT) of macaques monkeys (the STT is at the base of the spinal cord; most STT neurons respond to pain and some to both pain and itch). Then researchers injected itch-inducing histamines into the monkeys' legs and watched as the STT neurons fired. They then scratched the monkey's itchy legs with a device that mimicked the feel of monkey fingers, and the firing rate of the STT neurons dropped rapidly.

The sudden drop, the researchers said, is the neurological equivalent of the relief you feel after a good scratch, indicating that itching and relief sensations are both rooted in the spinal cord and relief from an itch comes from inhibiting—via scratching—the STT neurons. Scratching basically tells all those tattle-tale neurons who are whining to the brain about an itch to just shut up already.

scratchingOf course, the itch and the scratch still hold plenty of mystery. When the team scratched the monkey's legs without first inducing an itch, the STT neurons fired in a normal response to stimuli, but the scratching didn't slow the firing.

Scratching also had no effect on neurons' response to an application of capsaicin, the spicy component in hot peppers. The STT neurons, it appears, react differently to the sensation of a scratch depending on whether an itch exists, and the nerve-dampening effect of scratching only works when the neurons are firing because of an itch, not pain. Somehow, the neurons know the difference. Itching isn't all physiological, either; it can be caused by emotional and psychological factors and can even be picked up as a "contagious itch" (a study showed that itching can be induced purely by visual stimuli: watching other people scratch).

Once all that is sussed out, though, the UM team's discovery could lead to ways of duplicating the end results and benefits of scratching (quiet, polite STT neurons) without its drawbacks. That's great news for people with the sorts of chronic itching associated with AIDS, Hodgkin's disease and the side effects of some pain medications. Chronic itching, of course, leads to plenty of scratching, which can lead to skin damage, infections and worse (remember the New Yorker article with the woman who scratched right through to her brain?)

* Davidson et al. Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons. Nature Neuroscience, 2009; 12 (5): 544

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Women Suffer Worse Migraines Than Men. Now Scientists Think They Know Why
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Migraines are one of medicine's most frustrating mysteries, both causes and treatments. Now researchers believe they've solved one part of the puzzle: a protein affected by fluctuating estrogen levels may explain why more women suffer from migraines than men.

Migraines are the third most common illness in the world, affecting more than 1 in 10 people. Some 75 percent of sufferers are women, who also experience them more frequently and more intensely, and don't respond as well to drug treatments as men do.

At this year's Experimental Biology meeting in San Diego, researcher Emily Galloway presented new findings on the connection between the protein NHE1 and the development of migraine headaches. NHE1 regulates the transfer of protons and sodium ions across cell membranes, including the membranes that separate incoming blood flow from the brain.

When NHE1 levels are low or the molecule isn't working as it's supposed to, migraine-level head pain can ensue. And because irregular NHE1 disrupts the flow of protons and sodium ions to the brain, medications like pain killers have trouble crossing the blood-brain barrier as well. This may explain why the condition is so hard to treat.

When the researchers analyzed NHE1 levels in the brains of male and female lab rats, the researchers found them to be four times higher in the males than in the females. Additionally, when estrogen levels were highest in the female specimens, NHE1 levels in the blood vessels of their brains were at their lowest.

Previous research had implicated fluctuating estrogen levels in migraines, but the mechanism behind it has remained elusive. The new finding could change the way migraines are studied and treated in the future, which is especially important considering that most migraine studies have focused on male animal subjects.

"Conducting research on the molecular mechanisms behind migraine is the first step in creating more targeted drugs to treat this condition, for men and women," Galloway said in a press statement. "Knowledge gained from this work could lead to relief for millions of those who suffer from migraines and identify individuals who may have better responses to specific therapies."

The new research is part of a broader effort to build a molecular map of the relationship between sex hormones and NHE1 expression. The next step is testing drugs that regulate these hormones to see how they affect NHE1 levels in the brain.

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The Surprising Link Between Language and Depression
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Skim through the poems of Sylvia Plath, the lyrics of Kurt Cobain, or posts on an internet forum dedicated to depression, and you'll probably start to see some commonalities. That's because there's a particular way that people with clinical depression communicate, whether they're speaking or writing, and psychologists believe they now understand the link between the two.

According to a recent study published in Clinical Psychological Science, there are certain "markers" in a person's parlance that may point to symptoms of clinical depression. Researchers used automated text analysis methods to comb through large quantities of posts in 63 internet forums with more than 6400 members, searching for certain words and phrases. They also noted average sentence length, grammatical patterns, and other factors.

What researchers found was that a person's use (or overuse) of first-person pronouns can provide some insight into the state of their mental health. People with clinical depression tend to use more first-person singular pronouns, such as "I" and "me," and fewer third-person pronouns, like "they," "he," or "she." As Mohammed Al-Mosaiwi, a Ph.D. candidate in psychology at the University of Reading and the head of the study, writes in a post for IFL Science:

"This pattern of pronoun use suggests people with depression are more focused on themselves, and less connected with others. Researchers have reported that pronouns are actually more reliable in identifying depression than negative emotion words."

What remains unclear, though, is whether people who are more focused on themselves tend to depression, or if depression turns a person's focus on themselves. Perhaps unsurprisingly, people with depression also use more negative descriptors, like "lonely" and "miserable."

But, Al-Mosaiwi notes, it's hardly the most important clue when using language to assess clinical depression. Far better indicators, he says, are the presence of "absolutist words" in a person's speech or writing, such as "always," "constantly," and "completely." When overused, they tend to indicate that someone has a "black-and-white view of the world," Al-Mosaiwi says. An analysis of posts on different internet forums found that absolutist words were 50 percent more prevalent on anxiety and depression forums, and 80 percent more prevalent on suicidal ideation forums.

Researchers hope these types of classifications, supported by computerized methods, will prove more and more beneficial in a clinical setting.

[h/t IFL Science]

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