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Meet Dr. Ecstasy

At the turn of the last century, there were only two psychedelic compounds known to man: cannabis and mescaline (which is what makes peyote so popular with shamans and hippies). By the 1950s, scientists had developed or uncovered LSD, psilocybin (the active ingredient in "magic mushrooms") and about 15 more compounds you've probably never heard of. These days, we're well into the hundreds, thanks in large part to the work of an organic chemist named Dr. Alexander Shulgin and many years' worth of experimentation (much of it on himself) in a tiny lab in his backyard in Northern California. (Pictured above: Shulgin and his wife, Ann.)

Shulgin is responsible for at least 200 psychedelic compounds (which weren't illegal when he created them, simply because the DEA hadn't yet heard of them), is the author of a pair of memoir/cookbooks called PHiKAL and TiHKAL, short for "Phenethylamines I Have Known and Loved" and "Tryptamines I Have Known and Loved," respectively. But he is certainly most famous for reintroducing the world to a little-known compound called MDMA in 1976. It had been patented by Merck in 1914, but thinking it useless, the drug giant had never done anything with it. Shulgin resynthesized it, wrote a paper about it in which he noted ''an easily controlled altered state of consciousness with emotional and sensual overtones," and the world had Ecstasy.

You might wonder why Shulgin was never arrested. From the 50s through the 80s, he had the full support of the DEA -- the DEA's chief was even married in Shulgin's backyard -- and frequently gave pharmacology lectures to DEA agents. He had a DEA-issued Schedule I research license. That is, until he published PHiKAL in 1993, which the agency -- deeply engaged in its now-controversial "war on drugs" -- didn't look kindly upon. The agency turned his back on him, raided his lab and yanked his license. (He's still allowed to work in his lab creating new things -- he just can't make or possess anything that's currently on the DEA's list of Schedule I drugs, which is most of his life's work.)

Shlugin views himself as a scientist in the most classical sense: his goal has been the identification and classification of a whole range of brain-altering compounds previously unknown to humankind -- much like a naturalist might name and describe new species of butterflies he discovers. Reading through the various effects of his discoveries is a bit like reading through a catalog of the many switches in your brain that can be flipped, to various effects. From the New York Times Magazine:

[Shulgin discovered] stimulants, depressants, aphrodisiacs, ''empathogens,'' convulsants, drugs that alter hearing, drugs that slow one's sense of time, drugs that speed it up, drugs that trigger violent outbursts, drugs that deaden emotion -- in short, a veritable lexicon of tactile and emotional experience. .... A compound he dubbed Aleph-1 gave him ''one of the most delicious blends of inflation, paranoia and selfishness that I have ever experienced.'' Another, Ariadne, was patented and tested under the name Dimoxamine as a drug for ''restoring motivation in senile geriatric patients.'' Still another, DIPT, created no visual hallucinations but distorted the user's sense of pitch.

Why did Shulgin choose such an unorthodox field of research? He describes a revelatory experience with mescaline in 1960, after which he realized that everything he saw and thought ''had been brought about by a fraction of a gram of a white solid, but that in no way whatsoever could it be argued that these memories had been contained within the white solid. . . . I understood that our entire universe is contained in the mind and the spirit. We may choose not to find access to it, we may even deny its existence, but it is indeed there inside us, and there are chemicals that can catalyze its availability.''

Here's a video of "Dr. Ecstacy," talking science in his backyard lab:

Note! Mental_floss recommends flossing your brain with trivia, not illegal Schedule-I drug compounds.

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10 Things We Know About The Handmaid’s Tale Season 2
Hulu
Hulu

Though Hulu has been producing original content for more than five years now, 2017 turned out to be a banner year for the streaming network with the debut of The Handmaid’s Tale on April 26, 2017. The dystopian drama, based on Margaret Atwood’s 1985 book, imagines a future in which a theocratic regime known as Gilead has taken over the United States and enslaved fertile women so that the group’s most powerful couples can procreate.

If it all sounds rather bleak, that’s because it is—but it’s also one of the most impressive new series to arrive in years (as evidenced by the slew of awards it has won, including eight Emmy and two Golden Globe Awards). Fortunately, fans left wanting more don’t have that much longer to wait, as season two will premiere on Hulu in April. In the meantime, here’s everything we know about The Handmaid’s Tale’s second season.

1. IT WILL PREMIERE WITH TWO EPISODES.

When The Handmaid’s Tale returns on April 25, 2018, Hulu will release the first two of its 13 new episodes on premiere night, then drop another new episode every Wednesday.

2. MARGARET ATWOOD WILL CONTINUE TO HELP SHAPE THE NARRATIVE.

Fans of Atwood’s novel who didn’t like that season one went beyond the original source material are in for some more disappointment in season two, as the narrative will again go beyond the scope of what Atwood covered. But creator/showrunner Bruce Miller doesn’t necessarily agree with the criticism they received in season one.

“People talk about how we're beyond the book, but we're not really," Miller told Newsweek. "The book starts, then jumps 200 years with an academic discussion at the end of it, about what's happened in those intervening 200 years. We're not going beyond the novel. We're just covering territory [Atwood] covered quickly, a bit more slowly.”

Even more importantly, Miller's got Atwood on his side. The author serves as a consulting producer on the show, and the title isn’t an honorary one. For Miller, Atwood’s input is essential to shaping the show, particularly as it veers off into new territories. And they were already thinking about season two while shooting season one. “Margaret and I had started to talk about the shape of season two halfway through the first [season],” he told Entertainment Weekly.

In fact, Miller said that when he first began working on the show, he sketched out a full 10 seasons worth of storylines. “That’s what you have to do when you’re taking on a project like this,” he said.

3. MOTHERHOOD WILL BE A CENTRAL THEME.

As with season one, motherhood is a key theme in the series. And June/Offred’s pregnancy will be one of the main plotlines. “So much of [Season 2] is about motherhood,” Elisabeth Moss said during the Television Critics Association press tour. “Bruce and I always talked about the impending birth of this child that’s growing inside her as a bit of a ticking time bomb, and the complications of that are really wonderful to explore. It’s a wonderful thing to have a baby, but she’s having it potentially in this world that she may not want to bring it into. And then, you know, if she does have the baby, the baby gets taken away from her and she can’t be its mother. So, obviously, it’s very complicated and makes for good drama. But, it’s a very big part of this season, and it gets bigger and bigger as the show goes on.”

4. THE RESISTANCE IS COMING.

Just because June is pregnant, don’t expect her to sit on the sidelines as the resistance to Gilead continues. “There is more than one way to resist," Moss said. “There is resistance within [June], and that is a big part of this season.”

5. WE’LL GET TO SEE THE COLONIES.

A scene from 'The Handmaid's Tale'
Hulu

Miller, understandably, isn’t eager to share too many details about the new season. “I’m not being cagey!” he swore to Entertainment Weekly. “I just want the viewers to experience it for themselves!” What he did confirm is that the new season will bring us to the colonies—reportedly in episode two—and show what life is like for those who have been sent there.

It will also delve further into what life is like for the refugees who managed to escape Gilead, like Luke and Moira.

6. MARISA TOMEI WILL APPEAR IN AN EPISODE.

Though she won’t be a regular cast member, Miller recently announced that Oscar winner Marisa Tomei will make a guest appearance in the new season’s second episode. Yes, the one that will show us the Colonies. In fact, that’s where we’ll meet her; Tomei is playing the wife of a Commander.

7. WE’LL LEARN MORE ABOUT THE ORIGINS OF GILEAD.

As a group shrouded in secrecy, we still don’t know much about how and where Gilead began. That will change a bit in season two. When discussing some of the questions viewers will have answered, executive producer Warren Littlefield promised that, "How did Gilead come about? How did this happen?” would be two of them. “We get to follow the historical creation of this world,” he said.

8. THERE WILL BE AT LEAST ONE HANDMAID FUNERAL.

A scene from 'The Handmaid's Tale'
Hulu

While Miller wouldn’t talk about who the handmaids are mourning in a teaser shot from season two that shows a handmaid’s funeral, he was excited to talk about creating the look for the scene. “Everything from the design of their costumes to the way they look is so chilling,” Miller told Entertainment Weekly. “These scenes that are so beautiful, while set in such a terrible place, provide the kind of contrast that makes me happy.”

9. ELISABETH MOSS SAYS THE TONE WILL BE DARKER.

Like season one, Miller says that The Handmaid’s Tale's second season will again balance its darker, dystopian themes with glimpses of hopefulness. “I think the first season had very difficult things, and very hopeful things, and I think this season is exactly the same way,” he told the Los Angeles Times. “There come some surprising moments of real hope and victory, and strength, that come from surprising places.”

Moss, however, has a different opinion. “It's a dark season,” she told reporters at TCA. “I would say arguably it's darker than Season 1—if that's possible.”

10. IT WILL ALSO BE BLOODIER.

A scene from 'The Handmaid's Tale'
Hulu

When pressed about how the teaser images for the new season seemed to feature a lot of blood, Miller conceded: “Oh gosh, yeah. There may be a little more blood this season.”

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NUS Environmental Research Institute, Subnero
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Researchers in Singapore Deploy Robot Swans to Test Water Quality
NUS Environmental Research Institute, Subnero
NUS Environmental Research Institute, Subnero

There's something peculiar about the new swans floating around reservoirs in Singapore. They drift across the water like normal birds, but upon closer inspection, onlookers will find they're not birds at all: They're cleverly disguised robots designed to test the quality of the city's water.

As Dezeen reports, the high-tech waterfowl, dubbed NUSwan (New Smart Water Assessment Network), are the work of researchers at the National University of Singapore [PDF]. The team invented the devices as a way to tackle the challenges of maintaining an urban water source. "Water bodies are exposed to varying sources of pollutants from urban run-offs and industries," they write in a statement. "Several methods and protocols in monitoring pollutants are already in place. However, the boundaries of extensive assessment for the water bodies are limited by labor intensive and resource exhaustive methods."

By building water assessment technology into a plastic swan, they're able to analyze the quality of the reservoirs cheaply and discreetly. Sensors on the robots' undersides measure factors like dissolved oxygen and chlorophyll levels. The swans wirelessly transmit whatever data they collect to the command center on land, and based on what they send, human pilots can remotely tweak the robots' performance in real time. The hope is that the simple, adaptable technology will allow researchers to take smarter samples and better understand the impact of the reservoir's micro-ecosystem on water quality.

Man placing robotic swan in water.
NUS Environmental Research Institute, Subnero

This isn't the first time humans have used robots disguised as animals as tools for studying nature. Check out this clip from the BBC series Spy in the Wild for an idea of just how realistic these robots can get.

[h/t Dezeen]

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