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Fried Lettuce, Slug Entrails and Other Insomnia Cures

Today's insomnia cures are slightly more scientific than the back in the day. But they're also less interesting, which is why we've rounded up some of the weirder insomnia treatments handed down through the ages. From what to rub on your feet, to what to line your belly with, here are 6 bizarre prescriptions for when you're tired of counting sheep.

1. Rub Your Feet in Dormouse Fat

In Elizabethan England, people who couldn't sleep would often rub dormouse fat onto the soles of their feet. Why dormouse and why feet has been lost to the ages, however, the dormouse has retained its snoozy image: The dormouse slept through most of the Mad Hatter's Tea Party in Alice in Wonderland.

2. A spoonful of Sea Slug Entrails

Most cultures have their own folk remedy, usually involving food, for putting insomniacs to sleep. I remember when I was a little girl, my mom would make me hot chocolate when I couldn't sleep. Little girls in Japan, however, might have gotten a plate full of sea slug entrails. In France, it could have been fried lettuce and in places in the US, a raw onion.

3. Pay to Hear a Sleep Concert?

A new craze is sweeping Japan and while there's always a new craze sweeping Japan, this one may offer some hope to sleepless office workers. They're called sleep concerts: Basically, you buy a ticket to the concert, plunk yourself down in a comfy seat, and drift off. One such concert, titled "Dreams: Good Sleep Concert," featured major Japanese musicians playing music that had been scientifically tested to induce sleep; a CD of the concert was later sold and won Japan's 22nd annual Gold Disc Award for Best Instrumental Album of the year in 2008.

4. Ancient Ambien

Sleepless Greeks and Egyptians used opium, typically mixed with several other herbs that probably had no effect, to induce sleep. The only problem with opium is the highly addictive nature of the poppy-derived narcotic. But drugs have always played a part in helping people sleep: Cannabis, typically smoked in cigarette form, was a popular sleep aid up through the 19th century. Some, especially those in college or who maybe spent some time touring with the Grateful Dead, might say it still is. And when all else fails, there's the time-honored tradition of drinking until you pass out.

5. Toil and trouble, fire burn and cauldron bubble

Potions have long been a part of the insomniac's medicine cabinet. Tinctures made from valerian root, mandrake root, and lettuce seeds are a few of the debatably helpful but generally innocuous variety, whilst the Middle Ages prescription of "drinking a potion made from the gall of a castrated boar" is just gross. Incidentally, the castrated boar juice was also included in a concoction to knock victims "“ er, patients "“ about to undergo surgery in the Middle Ages as well. So many uses for castrated boar gall, who knew?

6. Carry a compass to bed with you

In the Victorian era, people tended to be interested in slightly dubious spiritualist theories, including those involving magnetic fields and their impact on human health. Charles Dickens, who suffered from insomnia and for a time, tried a combination of opium and alcohol that left him with a wicked hangover, ultimately found relief after placing the head of his bed due north.

Ed note: We couldn't have written this article without help from Sean Coughlin's book, The Sleepyhead's Bedside Companion. And the image comes from those wonderful Serta sheep commercials.

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Medicine
New Cancer-Fighting Nanobots Can Track Down Tumors and Cut Off Their Blood Supply
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Scientists have developed a new way to cut off the blood flow to cancerous tumors, causing them to eventually shrivel up and die. As Business Insider reports, the new treatment uses a design inspired by origami to infiltrate crucial blood vessels while leaving the rest of the body unharmed.

A team of molecular chemists from Arizona State University and the Chinese Academy of Sciences describe their method in the journal Nature Biotechnology. First, they constructed robots that are 1000 times smaller than a human hair from strands of DNA. These tiny devices contain enzymes called thrombin that encourage blood clotting, and they're rolled up tightly enough to keep the substance contained.

Next, researchers injected the robots into the bloodstreams of mice and small pigs sick with different types of cancer. The DNA sought the tumor in the body while leaving healthy cells alone. The robot knew when it reached the tumor and responded by unfurling and releasing the thrombin into the blood vessel that fed it. A clot started to form, eventually blocking off the tumor's blood supply and causing the cancerous tissues to die.

The treatment has been tested on dozen of animals with breast, lung, skin, and ovarian cancers. In mice, the average life expectancy doubled, and in three of the skin cancer cases tumors regressed completely.

Researchers are optimistic about the therapy's effectiveness on cancers throughout the body. There's not much variation between the blood vessels that supply tumors, whether they're in an ovary in or a prostate. So if triggering a blood clot causes one type of tumor to waste away, the same method holds promise for other cancers.

But before the scientists think too far ahead, they'll need to test the treatments on human patients. Nanobots have been an appealing cancer-fighting option to researchers for years. If effective, the machines can target cancer at the microscopic level without causing harm to healthy cells. But if something goes wrong, the bots could end up attacking the wrong tissue and leave the patient worse off. Study co-author Hao Yan believes this latest method may be the one that gets it right. He said in a statement, "I think we are much closer to real, practical medical applications of the technology."

[h/t Business Insider]

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New Peanut Allergy Patch Could Be Coming to Pharmacies This Year
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About 6 million people in the U.S. and Europe have severe peanut allergies, including more than 2 million children. Now, French biotechnology company DBV Technologies SA has secured an FDA review for its peanut allergy patch, Bloomberg reports.

If approved, the company aims to start selling the Viaskin patch to children afflicted with peanut allergies in the second half of 2018. The FDA's decision comes in spite of the patch's disappointing study results last year, which found the product to be less effective than DBV hoped (though it did receive high marks for safety). The FDA has also granted Viaskin breakthrough-therapy and fast-track designations, which means a faster review process.

DBV's potentially life-saving product is a small disc that is placed on the arm or between the shoulder blades. It works like a vaccine, exposing the wearer's immune system to micro-doses of peanut protein to increase tolerance. It's intended to reduce the chances of having a severe allergic reaction to accidental exposure.

The patch might have competition: Aimmune Therapeutics Inc., which specializes in food allergy treatments, and the drug company Regeneron Pharmaceuticals Inc. are working together to develop a cure for peanut allergies.

[h/t Bloomberg]

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