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The Stem-Cell Breakthroughs That Won the Nobel Prize

Two scientists who each made a major discovery — four decades apart — share the science world's prestigious award.

KYODO/Reuters/Landov

On Monday, the Nobel Prize in Medicine was awarded to two biologists for their breakthroughs in the field of stem-cell research — two discoveries that happened 44 years apart. The honors go to Britain's Sir John B. Gurdon and Japan's Shinya Yamanaka for their pioneering work with the life-shaping cells, which can be reprogrammed to create any kind of tissue in the body. Here, a concise guide to Gurdon and Yamanaka's contributions to the field of medicine:

What were they awarded the prize for?

Both discoveries "concern the manipulation of living cells," says Nicholas Wade at The New York Times, which lies "at the heart of the techniques for cloning animals" and curing a wide variety of diseases, including Parkinson's and Alzheimer's. The "primitive cells" are incredibly malleable, and can be programmed to mature into other tissues, including skin, vital organs, and more.

Where do stem cells typically come from?

Embryonic stem cells are usually taken from early-stage human embryos, with the embryos being destroyed in the process. That's why stem-cell research is fraught with religious and moral issues, with critics often arguing that scientists are overstepping their boundaries by manipulating stem cells. The next generation of researchers, building upon the body of work started by Gurdon and Yamanaka, are looking into new techniques that sidestep ethical considerations by taking stem cells from other sources.

Specifically, what kind of work did Dr. Gurdon do?

In 1962, the year Yamanaka was born, Gurdon demonstrated that the DNA in frog tissue could be used to generate a fresh batch of tadpoles, says Karl Ritterlouise Nordstrom of The Associated Press. Gurdon's technique involved extracting the frog's chromosomes from an adult intestinal cell and injecting it into an empty frog egg, which was able to "reprogram" the new nucleus to switch its directive over to tadpole-making. At first his work was "greeted with skepticism," says the Times' Wade, because it "contradicted the textbook dogma" that mature cells are irrevocably set in their specific functions. The process itself was little understood, and it wasn't until more than four decades later in Dr. Yamanaka's labs that the reason behind this reprogramming was finally revealed.

And what did Dr. Yamanaka find?

In 2006, Dr. Yamanaka's research showed that four specific genes control the agents in the egg. Using mice, Yamanaka discovered that mature skin cells could be reprogrammed to become any other kind of cell, which he called inducted pluripotent stem cells (iPS) — basically the equivalent of embryonic stem cells. iPS cells can be taken from adult nerve, heart, or liver cells, and unlike their embryonic cousins, could be taken without destroying human embryos.

What do the scientists get for their discoveries?

Gurdon, 79, and Yamanaka, 50, will share the $1.2 million prize for their work, which the Nobel committee says has "revolutionized our understanding of how cells and organisms develop." In an interview, Dr. Yamanaka said, "My goal, all my life, is to bring this technology... to the bedside, to patients, to clinics." When asked if he planned to celebrate, Dr. Gurdon said he was invited to drinks at 6 o'clock. "I intend to attend those drinks," he dryly told the AP.

Every so often, we'll reprint something from our sister publication, The Week. This is one of those times.

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What Pop Culture Gets Wrong About Dissociative Identity Disorder
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From the characters in Fight Club to Dr. Jekyll and Mr. Hyde, popular culture is filled with "split" personalities. These dramatic figures might be entertaining, but they're rarely (if ever) scientifically accurate, SciShow Psych's Hank Green explains in the channel's latest video. Most representations contribute to a collective misunderstanding of dissociative identity disorder, or DID, which was once known as multiple personality disorder.

Experts often disagree about DID's diagnostic criteria, what causes it, and in some cases, whether it exists at all. Many, however, agree that people with DID don't have multiple figures living inside their heads, all clamoring to take over their body at a moment's notice. Those with DID do have fragmented personalities, which can cause lapses of memory, psychological distress, and impaired daily function, among other side effects.

Learn more about DID (and what the media gets wrong about mental illness) by watching the video below.

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25 Dapper Outfit Choices for Fashionable Pets
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Lavishing your furry friends with adorable attire is a benefit of pet ownership that they don't mention on the adoption forms. Whether you prefer practical clothing like sweaters and jackets or statement pieces like bow ties and tutus, these dapper duds are perfect for a howl-iday or "gotcha day" gift, or simply for saying, "Who's the cutest little pupper in pajamas? You are!"

1. CASHMERE DOG SWEATER; FROM $165

dog in sweater
Canine Styles

This classic cable-knit cashmere sweater is a sophisticated look for Fido or Finn. Get it from Canine Styles, a luxury dog emporium in New York City that has plenty of posh and preppy outfits.

Find It: Canine Styles

2. TOGGLE DOG COAT; $85

dog in coat
Canine Styles

This toggle coat (available in orange, navy, and tan) is as fashionable as it is warm. Made of Melton wool, it has Velcro closures to make getting dressed easy. It's great for long walks in the country.

Find It: Canine Styles

3. DOG TUXEDO; FROM $90

Dog in tuxedo
Etsy

This satin tuxedo is perfect for the canine members of your wedding party, though it will brighten up any other occasion as well. The custom, handmade outfit comes complete with a snappy bow tie.

Find It: Etsy

4. DOG BELLE DRESS; FROM $45

Dog Belle Dress
Etsy

The queen of your castle can feel like a Disney princess in her very own version of Belle's iconic yellow dress from Beauty and the Beast. This ball gown is made from yellow crepe satin with chiffon overlay on the bodice and features hand-painted gold detailing on the skirt. Enchanted rose not included.

Find It: Etsy

5. POODLE SKIRT OUTFIT FOR DOGS; $26

Rubies Pink Fifties Girl Pet Costume
Amazon

What if you could buy a 1950s poodle skirt for your poodle? This retro dress is comprised of a pink poodle skirt, striped bodice, and sequined belt, and comes with a bow headband.

Find It: Amazon

6. RIBBED CROCHET BUNNY SWEATER; $25

bunny in a sweater
Etsy

Your snuggle-bunny will look like a little fancy-pants in this ribbed crochet sweater. Choose from seven colors, including this dashing deep red.

Find It: Etsy

7. BESPOKE MONOGRAM DOG SWEATER; FROM $155

Dog in sweater
Ruby Rufus

Bespoke clothing isn't just for humans: British luxury dog clothing brand Ruby Rufus will make your pooch a custom monogram sweater made with 100 percent Italian cashmere. You can even order it in your dog's favorite color.

Find It: Ruby Rufus

8. HOT PINK DOG TUTU; $17

Dog in hot pink tutu
Etsy

Tutus look absolutely adorable on tiny humans and animals alike. If your pooch wants to get in touch with its inner ballerina, then grab this hot pink number from Etsy. Rave reviews are a sure thing.

Find It: Etsy

9. PINK DOG POLO SHIRT; $35

Dog Pink Polo Shirt
Canine Styles

This pink polo shirt is perfect for your preppy fur baby. It features not one but a veritable multitude of crocodiles. They'll be the most dapper dog at the country club.

Find It: Canine Styles

10. DOG BARN COAT WITH BROWN CORDUROY COLLAR; $85

Dog in barn coat
Canine Styles

When it's time for a walk, your dog will look effortlessly chic in this fancy barn coat. It comes in navy, cranberry, orange, hot pink, and loden and features convenient pockets for anyone with opposable thumbs.

Find It: Canine Styles

11. WHITE PET NECK RUFF; $26

Pet Neck Ruff
Etsy

Your canine or kitty will look like their painting belongs in London's National Portrait Gallery with this Elizabethan neck ruff.

Find It: Etsy

12. CHICKEN SWEATER; $25

chicken wearing sweater
Etsy

Chickens can get cold when they're strutting around outside. A sweater (well, more like sweater vest) for your bird can also help prevent feather picking during molting season. Or, it can simply keep them warm while they stare pensively across a snowy landscape.

Find It: Etsy

13. PET CIRCLE SCARF; $15

dog in scarf
Etsy

An infinity scarf is a perfect burst of color on a dreary early morning walk. The proprietor of Mitten Made on Etsy originally designed this wool snood for her miniature Dachshund to help keep her warm during the long, cold winters in Michigan.

Find It: Etsy

14. FAB DOG TRAVEL RAINCOAT; FROM $18

Fab Dog Travel Raincoat
Chewy

This timeless yellow rain slicker will look great on any puppy when it's raining cats and dogs. It's made of 100 percent waterproof nylon shell that keeps fur dry. Bonus: It's perfect for an It Halloween costume.

Find It: Chewy

15. LACE CAT OR DOG COLLAR; FROM $10

cat in lace collar
Etsy

This handmade, white lace collar is a must-have for fancy felines. It's also embellished with a large rhinestone.

Find It: Etsy

16. FITWARM PENGUIN PAJAMAS FOR DOGS; FROM $10

Fitwarm Cute Penguin Xmas Dog Pajamas
Amazon

Keep your pupper warm on cold winter nights with these penguin PJs. They're great for doggie sleepovers or lazy weekends on the couch watching Netflix.

Find It: Amazon

17. PLAID CASHMERE DOG COAT; FROM $225

dog in plaid coat
Canine Styles

Your dog will look like a proper gentleman in this smart plaid peacoat. This fine garment is made of cashmere with a faux fur lining and leather buttons, and is a perfect shield against chill and fog.

Find It: Canine Styles

18. SATIN PET BOW TIE; FROM $8

Satin Bow Tie for Dog
Etsy

This satin doggie bow tie is perfect for any occasion. It comes in several colors and features a Velcro fastener that makes it easy to attach to a collar. Plus, 10 percent of every sale goes to charity: specifically to SPCA (Society for the Prevention of Cruelty to Animals) and Feeding Pets of the Homeless.

Find It: Etsy

19. RED DOG DRESS; FROM $34

dog in dress
Etsy

Your good boy or girl will look red carpet-ready in this elegant gown. The voluminous tulle skirt is to die for, and each bow is embellished with beads. Custom orders are also available.

Find It: Etsy

20. DOG TIE; FROM $13

Dog tie
Etsy

Your pooch will be ready to stun at any black tie event. This tie is designed like a collar, making it easy to dress your four-legged friend. This Etsy store gives back: 10 perfect of all sales are donated to an animal protection association.

Find It: Etsy

21. NAUTICAL DOG DRESS WITH MATCHING LEASH; $20

Dog sailor dress
BaxterBoo

Perfect for a day on the town or setting sail in a schooner, this is the sailor outfit you never knew your best furry friend needed. This vintage throwback also comes with a matching leash.

Find It: BaxterBoo

22. TARTAN FLANNEL PET BOW TIE; $5.50

tartan pet bow tie
Etsy

Your dog or cat will turn heads in this flannel tartan bow tie. It has a convenient elastic loop that slides over your pup's collar.

Find It: Etsy

23. PUCCI DOG SHIRT; $23

dog in Pucci dog shirt
Etsy

Only the fanciest dogs wear, err, Pucci. Grab this punny "designer" t-shirt for your pup. This high-quality cotton statement piece is perfect for small breeds.

Find It: Etsy

24. PINK POLKA DOT AND LACE DOG HARNESS DRESS; $20

Pink Polka Dot and Lace Designer Dog Harness Dress
BaxterBoo

This feminine pink polka dot dress is simply adorable. It features a convenient built-in harness and comes with a matching leash.

Find It: BaxterBoo

25. PET SWEATER VEST; $6

pet sweater vest
Amazon

Your dog or cat will look like an erudite Oxford professor in this sweater vest. Note that the button on the pocket is shaped like a bone.

Find It: Amazon

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